LOCUS       NM_171988               5092 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus Bcl2-like 11 (Bcl2l11), mRNA.
ACCESSION   NM_171988 XM_006234986
VERSION     NM_171988.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5092)
  AUTHORS   Zhang,X., Ge,J., Zhu,X., Zhang,H., Wang,Y., Xu,T., Jiang,W. and
            Zhang,B.
  TITLE     Effects and Mechanism of Oxymatrine Combined with Compound Yinchen
            Granules on the Apoptosis of Hepatocytes through the Akt/FoxO3a/Bim
            Pathway
  JOURNAL   Biomed Res Int 2022, 8644356 (2022)
   PUBMED   35036441
  REMARK    GeneRIF: Effects and Mechanism of Oxymatrine Combined with Compound
            Yinchen Granules on the Apoptosis of Hepatocytes through the
            Akt/FoxO3a/Bim Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5092)
  AUTHORS   Huang,J., Huang,Y., Feng,Z., Guo,W., Wang,X. and Liao,Z.
  TITLE     MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2
  JOURNAL   J Recept Signal Transduct Res 41 (1), 6-14 (2021)
   PUBMED   32605511
  REMARK    GeneRIF: MiR-1247-3p protects rat cardiomyocytes against
            hypoxia/reoxygenation-induced injury via targeting BCL2L11 and
            caspase-2.
REFERENCE   3  (bases 1 to 5092)
  AUTHORS   Qin,X., Gao,S., Yang,Y., Wu,L. and Wang,L.
  TITLE     microRNA-25 promotes cardiomyocytes proliferation and migration via
            targeting Bim
  JOURNAL   J Cell Physiol 234 (12), 22103-22115 (2019)
   PUBMED   31058341
  REMARK    GeneRIF: our study demonstrates that miR-25 downregulation inhibits
            cardiomyocytes proliferation and migration...by targeting Bim
REFERENCE   4  (bases 1 to 5092)
  AUTHORS   Kennedy,D., Mnich,K., Oommen,D., Chakravarthy,R., Almeida-Souza,L.,
            Krols,M., Saveljeva,S., Doyle,K., Gupta,S., Timmerman,V.,
            Janssens,S., Gorman,A.M. and Samali,A.
  TITLE     HSPB1 facilitates ERK-mediated phosphorylation and degradation of
            BIM to attenuate endoplasmic reticulum stress-induced apoptosis
  JOURNAL   Cell Death Dis 8 (8), e3026 (2017)
   PUBMED   29048431
  REMARK    GeneRIF: HSPB1 facilitates ERK-mediated phosphorylation and
            degradation of BIM to attenuate endoplasmic reticulum
            stress-induced apoptosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5092)
  AUTHORS   Gilley,J. and Ham,J.
  TITLE     Evidence for increased complexity in the regulation of Bim
            expression in sympathetic neurons: involvement of novel
            transcriptional and translational mechanisms
  JOURNAL   DNA Cell Biol 24 (9), 563-573 (2005)
   PUBMED   16153157
REFERENCE   6  (bases 1 to 5092)
  AUTHORS   Gilley,J., Coffer,P.J. and Ham,J.
  TITLE     FOXO transcription factors directly activate bim gene expression
            and promote apoptosis in sympathetic neurons
  JOURNAL   J Cell Biol 162 (4), 613-622 (2003)
   PUBMED   12913110
REFERENCE   7  (bases 1 to 5092)
  AUTHORS   Harris,C.A. and Johnson,E.M. Jr.
  TITLE     BH3-only Bcl-2 family members are coordinately regulated by the JNK
            pathway and require Bax to induce apoptosis in neurons
  JOURNAL   J Biol Chem 276 (41), 37754-37760 (2001)
   PUBMED   11495903
REFERENCE   8  (bases 1 to 5092)
  AUTHORS   Leo,C.P., Hsu,S.Y., Chun,S.Y., Bae,H.W. and Hsueh,A.J.
  TITLE     Characterization of the antiapoptotic Bcl-2 family member myeloid
            cell leukemia-1 (Mcl-1) and the stimulation of its message by
            gonadotropins in the rat ovary
  JOURNAL   Endocrinology 140 (12), 5469-5477 (1999)
   PUBMED   10579309
REFERENCE   9  (bases 1 to 5092)
  AUTHORS   Bouillet,P., Metcalf,D., Huang,D.C., Tarlinton,D.M., Kay,T.W.,
            Kontgen,F., Adams,J.M. and Strasser,A.
  TITLE     Proapoptotic Bcl-2 relative Bim required for certain apoptotic
            responses, leukocyte homeostasis, and to preclude autoimmunity
  JOURNAL   Science 286 (5445), 1735-1738 (1999)
   PUBMED   10576740
REFERENCE   10 (bases 1 to 5092)
  AUTHORS   Hsu,S.Y., Lin,P. and Hsueh,A.J.
  TITLE     BOD (Bcl-2-related ovarian death gene) is an ovarian BH3
            domain-containing proapoptotic Bcl-2 protein capable of
            dimerization with diverse antiapoptotic Bcl-2 members
  JOURNAL   Mol Endocrinol 12 (9), 1432-1440 (1998)
   PUBMED   9731710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000118.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_171988.4.
            
            On Feb 10, 2021 this sequence version replaced NM_171988.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF065433.1, AF065431.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132269, SAMD00132270 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            regulatory uORF           :: PMID: 16153157
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               JACYVU010000118.1  39233848-39234097
            251-645             JACYVU010000118.1  39236495-39236889
            646-755             JACYVU010000118.1  39256120-39256229
            756-5092            JACYVU010000118.1  39266797-39271133
FEATURES             Location/Qualifiers
     source          1..5092
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..5092
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="Bcl2-like 11"
                     /db_xref="GeneID:64547"
                     /db_xref="RGD:628774"
     exon            1..250
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
     regulatory      215..283
                     /regulatory_class="uORF"
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:16153157]"
                     /note="this uORF is predicted to encode a 22 aa peptide
                     (PMID:16153157)"
     exon            251..645
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..854
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /note="bcl-2-related ovarian death protein;
                     bcl2-interacting mediator of cell death; Bcl-2 related
                     apoptotic gene product BimL; BCL2-like 11 (apoptosis
                     facilitator)"
                     /codon_start=1
                     /product="bcl-2-like protein 11"
                     /protein_id="NP_741985.1"
                     /db_xref="GeneID:64547"
                     /db_xref="RGD:628774"
                     /translation="MAKQPSDVNSECDREGGQLQPAERPPQLRPGAPTSLQTESQGNP
                     DGEGDRCPHGSPQGPLAPPASPGPFATRSPLFIFVRRSSLLSRSSSGYFSFDTDRSPA
                     PMSCDKSTQTPSPPCQAFNHYLSAMASIRQSQEEPEDLRPEIRIAQELRRIGDEFNET
                     YTRRAFANDYREAEDHPQMVILQLLRFIFRLVWRRH"
     exon            646..755
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
     exon            756..5092
                     /gene="Bcl2l11"
                     /gene_synonym="Bim; BimL; Bod"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggctggg gcaggctgct ttcacttcgc tccccgcagg cactgggtca acagcttgtt
       61 ggagctctgc ggtccttgcc gccgccgccg ttgtcgttgc agtcaccgga ttcctgcagc
      121 cgctccgcga gctgtgttcc acttggattc acaccacctc cgctgccccc gccgccaccg
      181 cctcggcgcc cttcccctgg ccctcgtcca cccaatgtct gactctgatt ctcggactga
      241 gaaacgcaag aaaaaaagac caaatggcca agcaaccttc tgatgtaaat tctgagtgtg
      301 acagagaagg tggacaattg cagcctgctg agaggcctcc ccagctcagg cctggggccc
      361 ctacctccct acagacagaa tcgcaaggta atcccgacgg cgaaggggac cgctgccccc
      421 acggcagccc tcagggcccg ctggccccac cggccagccc tggtcctttt gctaccagat
      481 ccccactttt catctttgtg agaagatctt ctctgctgtc ccggtcctcc agtgggtatt
      541 tctcttttga cacagacagg agcccggcac ccatgagttg tgacaagtca acacaaaccc
      601 caagtcctcc ttgccaggcc ttcaaccatt atctcagtgc aatggcttcc ataaggcagt
      661 ctcaggagga acctgaagat ctgcgcccag agatacggat cgcacaggag ctgcggcgga
      721 tcggagacga gttcaatgag acttacacga ggagggcgtt tgcaaacgat taccgagagg
      781 cggaagacca cccgcaaatg gttatcttac aactgttacg attcatcttc cgtctggtct
      841 ggagaaggca ctgacaggag cttcgtgcag ccaggacaaa tggcggacat cgctcttgtt
      901 cagaccggga gaaccccagc acctccatct cttggcgctg cgacagtccg gccggtggct
      961 ctgtcccaga gaggcgtgcg gagcacggac agcgctcagc actgtgtcga tgtggacgga
     1021 acctctgtcc atcaccacat ggccggattt tcagtaaata attgttgtga atgtaaacaa
     1081 gggagggttt ttctctttta aatgtacaga tcctagggac agagaaatat gcaagagagg
     1141 tgtttacatg tggtgtgtta atttttttaa acccactttc tttgataact gttttttgtt
     1201 tttttttttt tttttttggt cttgtttttg tttcagaaag gaaaactttt agacaattta
     1261 tggataattt ttttatactc attcttaacc cattaccttc tcagaggact gcgtaaccct
     1321 gcagtgggaa ctgagccagc cgatttataa ggctgcctta gtttattttt agatattact
     1381 gtacagaatt ttttaaacag gaagagtatg gcgttgccct ctctcctctg ccatgcctcc
     1441 gagtttcctt ttgaattttt actaccaaaa cagttgttat gaaatggaat gggctcgagt
     1501 ggcagagggt ctgttctggt acgccacttc cgttttgtaa atatttacct ccttagctca
     1561 gttgctcctg tggcaaaaaa gttcacactt ttcatgcttt ccctcaactc ttcggacccc
     1621 tcggtctgtc tccacaccga tgcacaggtt cagcccaggg tcctttccaa tgtgtttgtg
     1681 tcggcaaggg ctaggggctg cccggattgt tcccagctcc atcaatcagg ctgacttcat
     1741 gggaagggct cctgggcact tcacttcact gcggtggctt cgtttgtctc tcttatcctg
     1801 agagaacgtg ggcttgcacg ccacttgcta aagctgttgg ctcttctggt tgcccgctct
     1861 gctgcctgcc gcaggctctg ctggctgtgt gtaccagatg agctggagcc cacactttct
     1921 ccgggattgg ccaggtcatt tcaggagcaa ggagctcagg tgatcctttt ccgtgcttct
     1981 tggtatgtag ccccgctcat ccctcctggc ctgtggctcc tggatttcgt ctccattccc
     2041 atgagtcagg ggctggctct acttcatcag tttccataca caggaaacct ccattttacc
     2101 aagtaaaaca tttgtcttca caagatgtct gcctgctttg ctctctccca ttttcttaac
     2161 acctgaacct tcttgggcct cctgtgtctg gggcgggggt ggggtgctat ttcttggtac
     2221 cctgcctctt aggaccagca gcccatacat tggtcagtta tttcaagagc aggcaggact
     2281 ggtctagtgg aagagcgctt cctaatgtgt agaggccctg tgtcctatcc ccggcacctc
     2341 ctaaaacaac agcacacctg tcagacagac agacaaacgg gagattaaaa aagggggggg
     2401 gggcaaagaa gaaagaacat aggaggggtg gggggcagtg acaaaccctc taacttgtga
     2461 gaacgtcaga cattaggcag cttgcttaga gaggtgtatg cgtttccaag caagtcagcg
     2521 gtgccaatga ctgtgtgctt tgggcctgta gacagccagt gttttttctt atgtaaagga
     2581 atccatttat tcctactttc ctgcgtgtgt gtgtgtgtgt gtgtctgtgt gtgtctgtgt
     2641 gtgtctgtgt gtgtctgtac atttccttct agattgaaat catccgattc caaataatgt
     2701 ttataaatgc tttcccagct tccatagatt tgtaatagac tgaaagctgt tttggcattc
     2761 acctcctttc ctaatgcatt gagcctgctc atgggttccc atgaggccta tggttgtaag
     2821 ttggtgttaa gagtgcaacc atggctctgc tacacacact cacacacaca cacacactca
     2881 cataaacaca cacacacaca cacacacaca cacaccccaa agacatactt ggttctgggc
     2941 catcccctcc ctaggacctc cattctcatg tgccagtctc cccgactgga gcactttact
     3001 gtctcagccc cgtggctctg tggtactgcc taggcgggtg cagaaggctc ccagagccag
     3061 gtgccagtgg catgtgtggc ccctaaaacg tgcttacctc cagcctgggg ctggccgctg
     3121 aagcagctca tagggtagta agagagtcta tgaattgtag aagtattcaa gaacaggatg
     3181 cggcacccag aacttaaaca tgatgactgg atgtccctgt actgtatctg tttcttaaaa
     3241 tgcaagtgtc tcctgcagaa agtgtctcag cttactgtgg gtagggcttt gtgcttaatt
     3301 gttagtttat cattctctct tctgtgctag aacagaaact agatctccct cctccgtgtg
     3361 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta aacataatgc gggttttgtg
     3421 ccttgacaac ctccccatgt gaggtttgta aatagtgtcc tgtgacttca cctcaagttg
     3481 gaataaacgt acaaaatggc gtcctgagtg attcttcaaa ttttctttcc agaaaagagt
     3541 tgagttcggg ggagggaggg tgtctgaaaa atcagcttaa agtccctctt tattaaagtc
     3601 tgtaatggat aatgtctgct tctcctgttt cctccttcca gtgttgtata tattctgact
     3661 atttattaga ttaggaagtc atgtttcact cgtcaactga gccaaatgtc tgtgtgcaat
     3721 tgtattctcg ttacctttct ttgtaaaata ttgtacagca taaatgagta aaaaaaaaat
     3781 cactgttttt tcaaacttct cattattaag gattgtaaat accgtaggtt ctccttctgt
     3841 gtaatgtgcc ctactgttcc ataatgctgt aacttgtaga gtcattgtat atttattttc
     3901 tgcttattta atgtcttacg ttcttgaaag tgttgacatc cctatccctg acaccccagc
     3961 catgccatga attgcttcag ctcctgataa aggggggcac tgactgactg gctctgttcc
     4021 ccaacatggc ttctgctttg gcttctggca ttcagtgctt ggattctgct gcctctctga
     4081 ggaaacgagt atttgctgcc gatgagatac cctagctaca gtagcctgga agatcggact
     4141 ctaagaaaat acccatcaaa cccatttata aagcagctgg cttctgagga aagcagattt
     4201 accaataagt tggccatatc tttagagaag tattagcaac agatggggaa ggtttttttc
     4261 tttaattgag agtgtatctt tgacaactca gtgttgaaag aaatcctgcc tcttgaggta
     4321 ctgctgaatg gccgccctgg gtaagaaaag ggcaggtggg gcctgttttt agagcattca
     4381 acaaggccac ttatgtcacc aggacacttg ctggctacct tccccacctg ctgtgtgctt
     4441 ctggtgtttt gaggtctgtg gactgaactt acctgtgcca ttcagctccc tccccaccct
     4501 gttcactgca tttggccagc ttgctcctgc ttcgctcaac agaggccccc actggcctgg
     4561 gtgtcaagat ggaaaaaagc tcactgaagc tctagagcca tgtgacttca tgtaaatggt
     4621 tttgtcctcc ctgctgattt agcctggtgc ctgtgtgtgt ccatccactc agtacgtctg
     4681 tgtgcgggtt gtgtccacac gtgtcgctac atcagcgggg aatccttctc aaacagcgtt
     4741 gcacaaagca tcctcaagtt cccagcaaag tacttgatct ctttcaaatg tgttttatcg
     4801 tctaggttct gtgaccactg gtttctgtat ccagaactgt caggtatcct ttggtaaaca
     4861 gcactgatct ctgtattgta ccccatcact aacgtgtcag aacccagcgt atgtagcatt
     4921 tgtattgcag tttccctggc ttcctttatg ttttgcactg atgaattttg acagggtaat
     4981 tgccactgta cctgtgcaat actgctgtaa ataactgcag atttttttaa gaaactcaat
     5041 cttttatgtt cttaatgaat tttatataaa taaaacttgc gactagctct ca
//
