LOCUS       NM_053733               1074 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus Bcl2-like 10 (Bcl2l10), mRNA.
ACCESSION   NM_053733
VERSION     NM_053733.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1074)
  AUTHORS   Hamouda,M.A., Jacquel,A., Robert,G., Puissant,A., Richez,V.,
            Cassel,R., Fenouille,N., Roulland,S., Gilleron,J., Griessinger,E.,
            Dubois,A., Bailly-Maitre,B., Goncalves,D., Mallavialle,A.,
            Colosetti,P., Marchetti,S., Amiot,M., Gomez-Bougie,P., Rochet,N.,
            Deckert,M., Avet-Loiseau,H., Hofman,P., Karsenti,J.M.,
            Jeandel,P.Y., Blin-Wakkach,C., Nadel,B., Cluzeau,T., Anderson,K.C.,
            Fuzibet,J.G., Auberger,P. and Luciano,F.
  TITLE     BCL-B (BCL2L10) is overexpressed in patients suffering from
            multiple myeloma (MM) and drives an MM-like disease in transgenic
            mice
  JOURNAL   J Exp Med 213 (9), 1705-1722 (2016)
   PUBMED   27455953
REFERENCE   2  (bases 1 to 1074)
  AUTHORS   Fabiani,E., Fianchi,L., Falconi,G., Boncompagni,R., Criscuolo,M.,
            Guidi,F., La Brocca,A., Hohaus,S., Leone,G. and Voso,M.T.
  TITLE     The BCL2L10 Leu21Arg variant and risk of therapy-related myeloid
            neoplasms and de novo myelodysplastic syndromes
  JOURNAL   Leuk Lymphoma 55 (7), 1538-1543 (2014)
   PUBMED   24047476
REFERENCE   3  (bases 1 to 1074)
  AUTHORS   Tvrdik,D., Skalova,H., Dundr,P., Povysil,C., Velenska,Z.,
            Berkova,A., Stanek,L. and Petruzelka,L.
  TITLE     Apoptosis - associated genes and their role in predicting responses
            to neoadjuvant breast cancer treatment
  JOURNAL   Med Sci Monit 18 (1), BR60-BR67 (2012)
   PUBMED   22207111
REFERENCE   4  (bases 1 to 1074)
  AUTHORS   Liu,N.S., Du,X., Lu,J. and He,B.P.
  TITLE     Diva reduces cell death in response to oxidative stress and
            cytotoxicity
  JOURNAL   PLoS One 7 (8), e43180 (2012)
   PUBMED   22905226
  REMARK    GeneRIF: Diva plays an important role in controlling the survival
            of BMSCs
REFERENCE   5  (bases 1 to 1074)
  AUTHORS   Voso,M.T., Fabiani,E., Piciocchi,A., Matteucci,C., Brandimarte,L.,
            Finelli,C., Pogliani,E., Angelucci,E., Fioritoni,G., Musto,P.,
            Greco,M., Criscuolo,M., Fianchi,L., Vignetti,M., Santini,V.,
            Hohaus,S., Mecucci,C. and Leone,G.
  TITLE     Role of BCL2L10 methylation and TET2 mutations in higher risk
            myelodysplastic syndromes treated with 5-azacytidine
  JOURNAL   Leukemia 25 (12), 1910-1913 (2011)
   PUBMED   21760590
REFERENCE   6  (bases 1 to 1074)
  AUTHORS   Kim,J.H., Yoon,S., Won,M., Sim,S.H., Ko,J.J., Han,S., Lee,K.A.,
            Lee,K. and Bae,J.
  TITLE     HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces
            BAK-dependent cell death
  JOURNAL   Cell Physiol Biochem 23 (1-3), 43-52 (2009)
   PUBMED   19255499
REFERENCE   7  (bases 1 to 1074)
  AUTHORS   Itoh,T., Itoh,A. and Pleasure,D.
  TITLE     Bcl-2-related protein family gene expression during
            oligodendroglial differentiation
  JOURNAL   J Neurochem 85 (6), 1500-1512 (2003)
   PUBMED   12787069
REFERENCE   8  (bases 1 to 1074)
  AUTHORS   Ke,N., Godzik,A. and Reed,J.C.
  TITLE     Bcl-B, a novel Bcl-2 family member that differentially binds and
            regulates Bax and Bak
  JOURNAL   J Biol Chem 276 (16), 12481-12484 (2001)
   PUBMED   11278245
REFERENCE   9  (bases 1 to 1074)
  AUTHORS   Song,Q., Kuang,Y., Dixit,V.M. and Vincenz,C.
  TITLE     Boo, a novel negative regulator of cell death, interacts with
            Apaf-1
  JOURNAL   EMBO J 18 (1), 167-178 (1999)
   PUBMED   9878060
REFERENCE   10 (bases 1 to 1074)
  AUTHORS   Inohara,N., Gourley,T.S., Carrio,R., Muniz,M., Merino,J.,
            Garcia,I., Koseki,T., Hu,Y., Chen,S. and Nunez,G.
  TITLE     Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces
            BH3-independent cell death
  JOURNAL   J Biol Chem 273 (49), 32479-32486 (1998)
   PUBMED   9829980
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY029163.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY029163.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132267, SAMD00132271
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1074
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1074
                     /gene="Bcl2l10"
                     /note="Bcl2-like 10"
                     /db_xref="GeneID:114552"
                     /db_xref="RGD:621015"
     exon            1..446
                     /gene="Bcl2l10"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..569
                     /gene="Bcl2l10"
                     /note="bcl2-L-10; BCL2-like 10 (apoptosis facilitator);
                     apoptosis regulator Bcl-B; anti-apoptotic protein Boo"
                     /codon_start=1
                     /product="bcl-2-like protein 10"
                     /protein_id="NP_446185.1"
                     /db_xref="GeneID:114552"
                     /db_xref="RGD:621015"
                     /translation="MGDPLQDRTRRLLTDYILFCARAPNTPEPLPTSVEAALLRSVTS
                     QIQQEHQDLFNSFRDYQGNRLELVTQMADELLSNDQEFNWGRLVMLLAFVGTLMNQDR
                     TVKRRRDQRNRLLLERDCYLIVSLLYNRLTGRHRSWLEAHGGWDGFCQFFKNPLPPGF
                     WRRLLIRAILSCFFATAIFYIWKCL"
     exon            447..1074
                     /gene="Bcl2l10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggccaaaa gatgggtgac ccgctgcagg atcgcactag acggctgctg actgactaca
       61 tattgttctg cgcacgggcg ccgaacaccc ctgagccact gcccacgtct gttgaggcgg
      121 ccttgctgcg ctctgtgact agtcagatcc aacaggagca ccaggatctt ttcaactcct
      181 tccgcgacta ccagggcaac cgcctggagc tggtgacaca gatggcggat gagttgctct
      241 ccaatgacca agagttcaac tggggccgcc tggtgatgct cctggccttc gtggggacgc
      301 taatgaacca agacaggact gttaagcgga ggagggatca aagaaaccgt ctcctactgg
      361 agcgagactg ctatctcata gtgagcttgc tgtacaatcg actcacagga cggcatcgct
      421 cctggctgga ggctcacggt ggctgggatg gcttttgcca attcttcaag aaccccttac
      481 cacccggctt ctggagaaga ttgctgatcc gggctattct gtcctgtttc tttgcaacgg
      541 ccatctttta tatctggaaa tgtttataag ttttaaattt ttaaatcgat cttacctgcc
      601 taactgcggg ccctctaagg gacaattctg ggtagttgga taagaactga ggaaatcctc
      661 ctgcctagag acatttctac ctgcatgcta cacggagttc cgggtttggg atgggcctaa
      721 gtagctcttt gctaagtggg gagatggtct atatcactcc aaagaacttc agaaaaacgc
      781 tgcacccact cactagatgt gttgttgtct gcatttggct gcaggcacag cagagccact
      841 cccatctgtt gcagggttct cagctgctgt taagtagcca ggggcagggc agggggtcct
      901 aaaccccaga gcccagagcc cggagcaatg aagaatgcaa taggaaacct gaaggaatcc
      961 tttgaaacct aaatccttcc atgcctcatt cccagggctt ctgaatttat aatgctcccc
     1021 ttaatacagt tttaagtaac ttcgaattct taataaatgt atacatttaa aaag
//
