LOCUS       NM_001033670            2393 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Bcl2-like 1 (Bcl2l1), transcript variant 3, mRNA.
ACCESSION   NM_001033670
VERSION     NM_001033670.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2393)
  AUTHORS   Perez-Serna,A.A., Dos Santos,R.S., Ripoll,C., Nadal,A.,
            Eizirik,D.L. and Marroqui,L.
  TITLE     BCL-XL Overexpression Protects Pancreatic beta-Cells against
            Cytokine- and Palmitate-Induced Apoptosis
  JOURNAL   Int J Mol Sci 24 (6), 5657 (2023)
   PUBMED   36982731
  REMARK    GeneRIF: BCL-XL Overexpression Protects Pancreatic beta-Cells
            against Cytokine- and Palmitate-Induced Apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2393)
  AUTHORS   Alam,M. and Mishra,R.
  TITLE     Bcl-xL expression and regulation in the progression, recurrence,
            and cisplatin resistance of oral cancer
  JOURNAL   Life Sci 280, 119705 (2021)
   PUBMED   34111459
REFERENCE   3  (bases 1 to 2393)
  AUTHORS   Rozier,R., Paul,R., Madji Hounoum,B., Villa,E., Mhaidly,R.,
            Chiche,J., Verhoeyen,E., Marchetti,S., Vandenberghe,A.,
            Raucoules,M., Carles,M. and Ricci,J.E.
  TITLE     Pharmacological preconditioning protects from
            ischemia/reperfusion-induced apoptosis by modulating Bcl-xL
            expression through a ROS-dependent mechanism
  JOURNAL   FEBS J 288 (11), 3547-3569 (2021)
   PUBMED   33340237
  REMARK    GeneRIF: Pharmacological preconditioning protects from
            ischemia/reperfusion-induced apoptosis by modulating Bcl-xL
            expression through a ROS-dependent mechanism.
REFERENCE   4  (bases 1 to 2393)
  AUTHORS   Liang,J.R. and Yang,H.
  TITLE     Ginkgolic acid (GA) suppresses gastric cancer growth by inducing
            apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS
  JOURNAL   Biomed Pharmacother 125, 109585 (2020)
   PUBMED   32106377
REFERENCE   5  (bases 1 to 2393)
  AUTHORS   Sadek,K., Abouzed,T., Nasr,S. and Shoukry,M.
  TITLE     Licochalcone B Ameliorates Liver Cancer via Targeting of Apoptotic
            Genes, DNA Repair Systems, and Cell Cycle Control
  JOURNAL   Iran J Pharm Res 19 (4), 372-386 (2020)
   PUBMED   33841550
REFERENCE   6  (bases 1 to 2393)
  AUTHORS   Chao,D.T., Linette,G.P., Boise,L.H., White,L.S., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bcl-XL and Bcl-2 repress a common pathway of cell death
  JOURNAL   J Exp Med 182 (3), 821-828 (1995)
   PUBMED   7650488
REFERENCE   7  (bases 1 to 2393)
  AUTHORS   Broome,H.E., Dargan,C.M., Krajewski,S. and Reed,J.C.
  TITLE     Expression of Bcl-2, Bcl-x, and Bax after T cell activation and
            IL-2 withdrawal
  JOURNAL   J Immunol 155 (5), 2311-2317 (1995)
   PUBMED   7650367
REFERENCE   8  (bases 1 to 2393)
  AUTHORS   Gonzalez-Garcia,M., Garcia,I., Ding,L., O'Shea,S., Boise,L.H.,
            Thompson,C.B. and Nunez,G.
  TITLE     bcl-x is expressed in embryonic and postnatal neural tissues and
            functions to prevent neuronal cell death
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4304-4308 (1995)
   PUBMED   7753802
REFERENCE   9  (bases 1 to 2393)
  AUTHORS   Tilly,J.L., Tilly,K.I., Kenton,M.L. and Johnson,A.L.
  TITLE     Expression of members of the bcl-2 gene family in the immature rat
            ovary: equine chorionic gonadotropin-mediated inhibition of
            granulosa cell apoptosis is associated with decreased bax and
            constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels
  JOURNAL   Endocrinology 136 (1), 232-241 (1995)
   PUBMED   7828536
REFERENCE   10 (bases 1 to 2393)
  AUTHORS   Gonzalez-Garcia,M., Perez-Ballestero,R., Ding,L., Duan,L.,
            Boise,L.H., Thompson,C.B. and Nunez,G.
  TITLE     bcl-XL is the major bcl-x mRNA form expressed during murine
            development and its product localizes to mitochondria
  JOURNAL   Development 120 (10), 3033-3042 (1994)
   PUBMED   7607090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC094213.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR,
            and 3' coding sequence compared to variant 1. The resulting isoform
            (2) has a shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094213.1, SRR8487231.164919.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2393              BC094213.1         1-2393
FEATURES             Location/Qualifiers
     source          1..2393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2393
                     /gene="Bcl2l1"
                     /gene_synonym="bcl-X; Bcl-xl; Bcl2l; Bclx"
                     /note="Bcl2-like 1"
                     /db_xref="GeneID:24888"
                     /db_xref="RGD:2200"
     exon            1..66
                     /gene="Bcl2l1"
                     /gene_synonym="bcl-X; Bcl-xl; Bcl2l; Bclx"
                     /inference="alignment:Splign:2.1.0"
     exon            67..742
                     /gene="Bcl2l1"
                     /gene_synonym="bcl-X; Bcl-xl; Bcl2l; Bclx"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..880
                     /gene="Bcl2l1"
                     /gene_synonym="bcl-X; Bcl-xl; Bcl2l; Bclx"
                     /note="isoform 2 is encoded by transcript variant 3;
                     bcl-2-like protein 1; B cell lymphoma like X; bcl2-L-1;
                     apoptosis regulator Bcl-X; B cell lymphoma 2 like"
                     /codon_start=1
                     /product="bcl-2-like protein 1 isoform 2"
                     /protein_id="NP_001028842.1"
                     /db_xref="GeneID:24888"
                     /db_xref="RGD:2200"
                     /translation="MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEPE
                     RETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYR
                     RAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQ
                     VLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGM
                     TVAGVVLLGSLFSRK"
     exon            743..2370
                     /gene="Bcl2l1"
                     /gene_synonym="bcl-X; Bcl-xl; Bcl2l; Bclx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccggtctc ttcaggggaa actgaggccg gcttctccgg gagattcggc acgagcagtc
       61 agccagaacc ctatcttggc tttggatcct ggaagagaat cgctaaacac agagcagacc
      121 cagtgagtga gcaggtgttt tggacaatgg actggttgag cccatctcta ttataaaaat
      181 gtctcagagc aaccgggagc tggtggttga ctttctctcc tacaagctct cccagaaagg
      241 atacagctgg agtcagttta gcgatgtcga agagaacagg actgaagccc cagaagaaac
      301 tgaaccagaa agggagaccc ccagtgccat caatggcaac ccatcctggc acctggcgga
      361 tagccccgcg gtgaatggag ccactggcca cagcagcagt ttggatgcgc gggaggtaat
      421 ccccatggca gcagtgaagc aagcgctgag agaggctggc gatgagtttg aactgcggta
      481 ccggagagca ttcagtgatc taacatccca gcttcatata accccaggga cagcatatca
      541 gagctttgaa caggtagtga atgaactctt tcgggatggg gtaaactggg gtcgcattgt
      601 ggccttcttc tcctttggcg gggcactgtg cgtggaaagc gtagacaagg agatgcaggt
      661 attggtgagt cggattgcaa gttggatggc cacctacctg aatgaccacc tagagccttg
      721 gatccaggag aacggcggct gggacacttt tgtggatctc tacgggaaca atgcagcagc
      781 cgagagccgg aaaggccagg agcgtttcaa ccgctggttc ctgacgggca tgactgtggc
      841 tggtgtagtt ctgctgggct cactcttcag tcggaagtga ccagacactg accgtccact
      901 cacctctcac ctcccacctt gcccccacca caactctctc ttcagccacc attgctacca
      961 ggagaaccac tacatgcaac tcacgcccct tcccctatta tagggttggg cctagacgga
     1021 gtcccctgca gttagctttc tagaatctac cacgcttctg tgaaagccac cttcccccca
     1081 catctcagtt cccttggcct caaaactcac aaggtttttc ctcagatcag ctccttggag
     1141 gctggcagga gtgggaaggg gtgtgctaga gggagaagag cctgccttgt tggtgggacc
     1201 ctgattaccc ctgagcctct cgggaatgct tttctggcag ggagctggag agctctctaa
     1261 acctcttccc ccagagacta gattgccttg gttttgatgt gtgtggcctc agaattgatc
     1321 atttcccatt ctgctgtgtc cctggggcgg ctcctccttc ccatctccac cccccccccc
     1381 cccagagcca ttgagtgagg tgcttttagc ccttttgact aactaaaaat gcaggctgct
     1441 tgggataacg aggcaaggac ctcctcccca cctgtggcct ggccaagccc ccactcctgg
     1501 tctgaatgtt ctcctgaggc ctctggctag agtccagccc cacccaggag gagggacgga
     1561 gctgcggaaa gtccaccctg cgagagcctg agcggctctt gcggcttagc accaccccag
     1621 atccttctcc acccctcccc tggctccatg gtgaccatga ctgagggacc aactgggccc
     1681 acgctaggtg ccccagagct gttaatgact tcagctgcct cacttcctgc aagatcagcc
     1741 tgtggcatct ttgccttggg tgctggccac agggtccagg gactctggcc ttagcccaga
     1801 agtgagagga agcttacagc gcagctatgg gagccctggg ggcttcccta cctcaggcag
     1861 gaagggcagg aagaagagcc tggtgcacag gtgaggagga ctgcaagggc ctgtctgtgc
     1921 cctgtcccca cctgtctgca gcagggctgc caaggtcaga atgccctggc caggagccct
     1981 tcaggcctct cctctgctcc acccttggcc tgtctcatcc ctgtgggtcc cagctcagct
     2041 ctggccaccc cgggctctct gctgtacata tctgagacta gtttttattc cttgtgaaga
     2101 tgatatacta tttttgttaa gcgtgtctgt atttatgtat gaggagctgc tggcttgctg
     2161 tgcgcgtgcc cgtggagagc tggtgcccag agactgacag cctgacgctc cctccctgcc
     2221 ctgcctgggg aagcccactg agggtcgtgg cttctgagag gcacctgtcc ctctcctccc
     2281 ctcaccctac actttttcca gctctttgaa atagtttgtg tgaaggtgaa agtgcagttc
     2341 agtaataaat ggtgtctgtg actctgtgaa aaaaaaaaaa aaaaaaaaaa aaa
//
