LOCUS       NM_133416                699 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus BCL2-related protein A1 (Bcl2a1), mRNA.
ACCESSION   NM_133416
VERSION     NM_133416.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 699)
  AUTHORS   Ye,B., Yin,L., Wang,Q. and Xu,C.
  TITLE     ACC1 is overexpressed in liver cancers and contributes to the
            proliferation of human hepatoma Hep G2 cells and the rat liver cell
            line BRL 3A
  JOURNAL   Mol Med Rep 19 (5), 3431-3440 (2019)
   PUBMED   30816537
  REMARK    GeneRIF: the results of present study indicated that overexpression
            of ACC1 is significantly associated with the survival time of
            patients with liver cancer, and may provide insight into the
            association between ACC1 and cell proliferation in BRL 3A cells.
REFERENCE   2  (bases 1 to 699)
  AUTHORS   Manohar,S., Jamesdaniel,S. and Salvi,R.
  TITLE     Cisplatin inhibits hippocampal cell proliferation and alters the
            expression of apoptotic genes
  JOURNAL   Neurotox Res 25 (4), 369-380 (2014)
   PUBMED   24277158
REFERENCE   3  (bases 1 to 699)
  AUTHORS   Miani,M., Barthson,J., Colli,M.L., Brozzi,F., Cnop,M. and
            Eizirik,D.L.
  TITLE     Endoplasmic reticulum stress sensitizes pancreatic beta cells to
            interleukin-1beta-induced apoptosis via Bim/A1 imbalance
  JOURNAL   Cell Death Dis 4 (7), e701 (2013)
   PUBMED   23828564
  REMARK    GeneRIF: IL-1beta sensitizes pancreatic beta cells to apoptosis
            mainly via an imbalance in the ratio of the anti-apoptotic A1 and
            the pro-apoptotic BH3-only protein Bim.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 699)
  AUTHORS   Adams,J.M. and Cory,S.
  TITLE     The Bcl-2 apoptotic switch in cancer development and therapy
  JOURNAL   Oncogene 26 (9), 1324-1337 (2007)
   PUBMED   17322918
  REMARK    Review article
REFERENCE   5  (bases 1 to 699)
  AUTHORS   Itoh,T., Itoh,A. and Pleasure,D.
  TITLE     Bcl-2-related protein family gene expression during
            oligodendroglial differentiation
  JOURNAL   J Neurochem 85 (6), 1500-1512 (2003)
   PUBMED   12787069
REFERENCE   6  (bases 1 to 699)
  AUTHORS   Leo,C.P., Hsu,S.Y., Chun,S.Y., Bae,H.W. and Hsueh,A.J.
  TITLE     Characterization of the antiapoptotic Bcl-2 family member myeloid
            cell leukemia-1 (Mcl-1) and the stimulation of its message by
            gonadotropins in the rat ovary
  JOURNAL   Endocrinology 140 (12), 5469-5477 (1999)
   PUBMED   10579309
REFERENCE   7  (bases 1 to 699)
  AUTHORS   Shimohama,S., Fujimoto,S., Sumida,Y. and Tanino,H.
  TITLE     Differential expression of rat brain bcl-2 family proteins in
            development and aging
  JOURNAL   Biochem Biophys Res Commun 252 (1), 92-96 (1998)
   PUBMED   9813151
REFERENCE   8  (bases 1 to 699)
  AUTHORS   Hsu,S.Y., Lin,P. and Hsueh,A.J.
  TITLE     BOD (Bcl-2-related ovarian death gene) is an ovarian BH3
            domain-containing proapoptotic Bcl-2 protein capable of
            dimerization with diverse antiapoptotic Bcl-2 members
  JOURNAL   Mol Endocrinol 12 (9), 1432-1440 (1998)
   PUBMED   9731710
REFERENCE   9  (bases 1 to 699)
  AUTHORS   Kitamura,Y., Shimohama,S., Kamoshima,W., Ota,T., Matsuoka,Y.,
            Nomura,Y., Smith,M.A., Perry,G., Whitehouse,P.J. and Taniguchi,T.
  TITLE     Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax,
            Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease
  JOURNAL   Brain Res 780 (2), 260-269 (1998)
   PUBMED   9507158
REFERENCE   10 (bases 1 to 699)
  AUTHORS   Hsu,S.Y., Kaipia,A., McGee,E., Lomeli,M. and Hsueh,A.J.
  TITLE     Bok is a pro-apoptotic Bcl-2 protein with restricted expression in
            reproductive tissues and heterodimerizes with selective
            anti-apoptotic Bcl-2 family members
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12401-12406 (1997)
   PUBMED   9356461
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF378332.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF378332.1, FM094896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..699
                     /gene="Bcl2a1"
                     /gene_synonym="Bcl2a1d"
                     /note="BCL2-related protein A1"
                     /db_xref="GeneID:170929"
                     /db_xref="RGD:620621"
     exon            1..440
                     /gene="Bcl2a1"
                     /gene_synonym="Bcl2a1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..548
                     /gene="Bcl2a1"
                     /gene_synonym="Bcl2a1d"
                     /note="B-cell leukemia/lymphoma 2 related protein A1;
                     B-cell leukemia/lymphoma 2 related protein A1d;
                     BCL2-related protein A1d"
                     /codon_start=1
                     /product="bcl-2-related protein A1"
                     /protein_id="NP_596907.1"
                     /db_xref="GeneID:170929"
                     /db_xref="RGD:620621"
                     /translation="MTDCEFMYIHSLAENYLQYVLQVPAFESAPSKTSRVLQRVAFSV
                     QKEVEKNLKPYLDDFHVESIDTARIIFNQVMEKEFEDGIINWGRIVTIFAFGGVLLKK
                     LPQEQIGLDVDTYKQVSSFVAEFIMNNTGEWIQQNGGWEDGFTKKFEPKSGWLTFLQM
                     TGKIWEMLFLLKQHY"
     exon            441..699
                     /gene="Bcl2a1"
                     /gene_synonym="Bcl2a1d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcagctct gcctgggaag atgacagact gtgagttcat gtatatccac tccctggctg
       61 agaactatct tcagtatgtc ctgcaggtac ctgcctttga atcggctcca agcaaaacgt
      121 ccagagtgct acagagagtt gctttctctg tacaaaagga agttgaaaag aatctgaagc
      181 catacttgga tgactttcac gtggaatcca tagatactgc cagaataata ttcaaccaag
      241 tgatggaaaa agaatttgaa gatggcatca ttaactgggg aaggattgtg actatatttg
      301 cctttggggg tgttctcctg aaaaagcttc cacaagagca gattggcctg gatgtggata
      361 cttacaagca agtttccagt tttgtggcgg aattcataat gaataacaca ggagaatgga
      421 tacagcagaa tggaggctgg gaagatggct tcacaaagaa gtttgaacct aaatctggct
      481 ggctgacttt tctgcagatg acagggaaga tctgggaaat gctctttctc ctcaagcaac
      541 actactgacc agagagaacc ctggctccct tgagaatggt gatcagcact tggtgtttcc
      601 atttacaaac agataacatg gacaatgaaa cttgactttc cagagttgca gatattttgt
      661 ttctacttta atgaataaac tactaatatt tgtttctgt
//
