LOCUS       NM_016993               1179 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus BCL2, apoptosis regulator (Bcl2), mRNA.
ACCESSION   NM_016993
VERSION     NM_016993.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1179)
  AUTHORS   Abdelmonem,M., Ali,S.O., Al-Mokaddem,A.K. and Ghaiad,H.R.
  TITLE     Ameliorating diabetes-induced testicular dysfunction by modulating
            PKC/Nrf2/Bcl-2 signaling: Protective role of sulbutiamine
  JOURNAL   Biofactors 50 (4), 845-862 (2024)
   PUBMED   38344831
  REMARK    GeneRIF: Ameliorating diabetes-induced testicular dysfunction by
            modulating PKC/Nrf2/Bcl-2 signaling: Protective role of
            sulbutiamine.
REFERENCE   2  (bases 1 to 1179)
  AUTHORS   Tan,W., Li,Y., Ma,L., Fu,X., Long,Q., Yan,F., Li,W., Liu,X.,
            Ding,H., Wang,Y. and Zhang,W.
  TITLE     Exosomes of endothelial progenitor cells repair injured vascular
            endothelial cells through the Bcl2/Bax/Caspase-3 pathway
  JOURNAL   Sci Rep 14 (1), 4465 (2024)
   PUBMED   38396011
  REMARK    GeneRIF: Exosomes of endothelial progenitor cells repair injured
            vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1179)
  AUTHORS   Liu,Y., Zhang,H., Fan,C., Liu,F., Li,S., Li,J., Zhao,H. and Zeng,X.
  TITLE     Potential role of Bcl2 in lipid metabolism and synaptic dysfunction
            of age-related hearing loss
  JOURNAL   Neurobiol Dis 187, 106320 (2023)
   PUBMED   37813166
  REMARK    GeneRIF: Potential role of Bcl2 in lipid metabolism and synaptic
            dysfunction of age-related hearing loss.
REFERENCE   4  (bases 1 to 1179)
  AUTHORS   Wang,Y., Wang,Y., Wang,X., Ma,Y., Li,Z. and Di,Y.
  TITLE     LncRNA TUG1 Promotes Apoptosis, Invasion, and Angiogenesis of
            Retinal Endothelial Cells in Retinopathy of Prematurity via
            MiR-145-5p
  JOURNAL   Front Med (Lausanne) 9, 803214 (2022)
   PUBMED   35445044
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1179)
  AUTHORS   Zhai,Y., Liu,B.G., Mo,X.N., Zou,M., Mei,X.P., Chen,W., Huang,G.D.
            and Wu,L.
  TITLE     Gingerol ameliorates neuronal damage induced by
            hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic
            factor axis
  JOURNAL   Kaohsiung J Med Sci 38 (4), 367-377 (2022)
   PUBMED   34962339
REFERENCE   6  (bases 1 to 1179)
  AUTHORS   Sagot,Y., Dubois-Dauphin,M., Tan,S.A., de Bilbao,F., Aebischer,P.,
            Martinou,J.C. and Kato,A.C.
  TITLE     Bcl-2 overexpression prevents motoneuron cell body loss but not
            axonal degeneration in a mouse model of a neurodegenerative disease
  JOURNAL   J Neurosci 15 (11), 7727-7733 (1995)
   PUBMED   7472523
REFERENCE   7  (bases 1 to 1179)
  AUTHORS   Alnemri,E.S., Robertson,N.M., Fernandes,T.F., Croce,C.M. and
            Litwack,G.
  TITLE     Overexpressed full-length human BCL2 extends the survival of
            baculovirus-infected Sf9 insect cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7295-7299 (1992)
   PUBMED   1502141
REFERENCE   8  (bases 1 to 1179)
  AUTHORS   Borzillo,G.V., Endo,K. and Tsujimoto,Y.
  TITLE     Bcl-2 confers growth and survival advantage to interleukin
            7-dependent early pre-B cells which become factor independent by a
            multistep process in culture
  JOURNAL   Oncogene 7 (5), 869-876 (1992)
   PUBMED   1373874
REFERENCE   9  (bases 1 to 1179)
  AUTHORS   Ngan,B.Y., Chen-Levy,Z., Weiss,L.M., Warnke,R.A. and Cleary,M.L.
  TITLE     Expression in non-Hodgkin's lymphoma of the bcl-2 protein
            associated with the t(14;18) chromosomal translocation
  JOURNAL   N Engl J Med 318 (25), 1638-1644 (1988)
   PUBMED   3287162
REFERENCE   10 (bases 1 to 1179)
  AUTHORS   Dublanchet,A. and Durieux,R.
  TITLE     [Isolation of a strain of Streptococcus pneumoniae multiresistant
            to antibiotics]
  JOURNAL   Nouv Presse Med 8 (11), 872 (1979)
   PUBMED   36599
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_016993.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L14680.1, U34964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840114, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-812               JAXUCZ010000013.1  23366089-23366900   c
            813-1179            JAXUCZ010000013.1  23204464-23204830   c
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..1179
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2"
                     /note="BCL2, apoptosis regulator"
                     /db_xref="GeneID:24224"
                     /db_xref="RGD:2199"
     exon            1..812
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..947
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2"
                     /note="Bcl2-like protein; B-cell leukemia/lymphoma 2;
                     Bcl-2alpha; B cell lymphoma 2 associated oncogene; B-cell
                     CLL/lymphoma 2"
                     /codon_start=1
                     /product="apoptosis regulator Bcl-2"
                     /protein_id="NP_058689.2"
                     /db_xref="GeneID:24224"
                     /db_xref="RGD:2199"
                     /translation="MAQAGRTGYDNREIVMKYIHYKLSQRGYEWDTGDEDSAPLRAAP
                     TPGIFSFQPESNRTPAVHRDTAARTSPLRPLVATAGPALSPVPPVVHLTLRRAGDDFS
                     RRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVN
                     REMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLL
                     SLALVGACITLGAYLGHK"
     exon            813..1179
                     /gene="Bcl2"
                     /gene_synonym="Bcl-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcatgaaa taaaaagctg aaaggaattt gaataaaaat tttctgcatc tcatgccaag
       61 ggggaaacac cagaatcaag tgttcgtcat aactaaagac accccttcat ccaagaatgc
      121 aaagcacatc caataaaagc gctggattat aacttctttt ttctctcttt cgggccgtgg
      181 ggcgggagcc gggacgcgaa gtgctattgg tacctgcagc ttctttcccc ggaaggatgg
      241 cgcaagccgg gagaacaggg tatgataacc gggagatcgt gatgaagtac atccattata
      301 agctgtcaca gaggggctac gagtgggata ctggagatga agactccgcg cccctgaggg
      361 ctgcccccac ccctggcatc ttctccttcc agcctgagag caaccggacg cccgctgtgc
      421 accgagacac ggctgccagg acgtcgcctc tacggcccct tgtcgccacc gctgggcctg
      481 cgctcagccc tgtgccacct gtggtccacc tgaccctccg ccgggctggg gatgacttct
      541 ctcgtcgcta ccgtcgcgac tttgcagaga tgtccagtca gctgcacctg acgcccttca
      601 ccgcgagggg acgctttgcc acggtggtgg aggaactctt cagggatggg gtgaactggg
      661 ggaggattgt ggccttcttt gagttcggtg gggtcatgtg tgtggagagc gtcaacaggg
      721 agatgtcacc cctggtggac aacatcgctc tgtggatgac tgagtacctg aaccggcatc
      781 tgcacacctg gatccaggat aacggaggct gggatgcctt tgtggaacta tatggcccca
      841 gcatgcgacc tctgtttgat ttctcctggc tgtctctgaa gacgctgctc agcctggccc
      901 tggtgggggc ctgcatcact ctgggtgcat acctgggcca caagtgaggt cagcagacct
      961 gccccaaaca aatatgcaaa aggttcacta aagcagtaga aattatatgc attatcaagg
     1021 atggaccatg aaacaaagtt gtgatttttt tttaaagcag aacacacaca cacacacaca
     1081 cacacacaca cacacacaca cacacacaca cattcaggca aatggtcaaa tcagctattt
     1141 actgccaaag ggaaatatca tttatttttt acattattt
//
