LOCUS       NM_001277287            5419 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus BCL11 transcription factor B (Bcl11b), transcript
            variant 1, mRNA.
ACCESSION   NM_001277287
VERSION     NM_001277287.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5419)
  AUTHORS   Li,Z., Chen,G., Yang,Y., Guo,W. and Tian,W.
  TITLE     Bcl11b regulates enamel matrix protein expression and dental
            epithelial cell differentiation during rat tooth development
  JOURNAL   Mol Med Rep 15 (1), 297-304 (2017)
   PUBMED   27959403
  REMARK    GeneRIF: The present study suggested that Bcl11b serves a
            potentially important role in the regulation of ameloblast
            differentiation and enamel matrix protein expression. In addition,
            a complex feedback regulatory network may exist between Bcl11b and
            Msx2.
REFERENCE   2  (bases 1 to 5419)
  AUTHORS   Punwani,D., Zhang,Y., Yu,J., Cowan,M.J., Rana,S., Kwan,A.,
            Adhikari,A.N., Lizama,C.O., Mendelsohn,B.A., Fahl,S.P.,
            Chellappan,A., Srinivasan,R., Brenner,S.E., Wiest,D.L. and
            Puck,J.M.
  TITLE     Multisystem Anomalies in Severe Combined Immunodeficiency with
            Mutant BCL11B
  JOURNAL   N Engl J Med 375 (22), 2165-2176 (2016)
   PUBMED   27959755
REFERENCE   3  (bases 1 to 5419)
  AUTHORS   Chao,M.W., Chen,C.P., Yang,Y.H., Chuang,Y.C., Chu,T.Y. and
            Tseng,C.Y.
  TITLE     N-acetylcysteine attenuates lipopolysaccharide-induced impairment
            in lamination of Ctip2-and Tbr1- expressing cortical neurons in the
            developing rat fetal brain
  JOURNAL   Sci Rep 6, 32373 (2016)
   PUBMED   27577752
  REMARK    GeneRIF: An increase in fetal cortical thickness was noted in the
            LPS-treated group. In the enlarged fetal cortex, laminar
            positioning of the early born cortical cells expressing Tbr1 and
            Ctip2 was disrupted, with a scattered distribution
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5419)
  AUTHORS   Liao,C.K., Fang,K.M., Chai,K., Wu,C.H., Ho,C.H., Yang,C.S. and
            Tzeng,S.F.
  TITLE     Depletion of B cell CLL/Lymphoma 11B Gene Expression Represses
            Glioma Cell Growth
  JOURNAL   Mol Neurobiol 53 (6), 3528-3539 (2016)
   PUBMED   26096706
  REMARK    GeneRIF: this is the first study to show that the inhibition of
            Bcl11b suppresses glioma cell growth by regulating the expression
            of the cell cycle regulator p21 and stemness-associated genes
            (Sox-2/Bmi-1).
REFERENCE   5  (bases 1 to 5419)
  AUTHORS   Gil-Sanz,C., Landeira,B., Ramos,C., Costa,M.R. and Muller,U.
  TITLE     Proliferative defects and formation of a double cortex in mice
            lacking Mltt4 and Cdh2 in the dorsal telencephalon
  JOURNAL   J Neurosci 34 (32), 10475-10487 (2014)
   PUBMED   25100583
REFERENCE   6  (bases 1 to 5419)
  AUTHORS   Cismasiu,V.B., Ghanta,S., Duque,J., Albu,D.I., Chen,H.M.,
            Kasturi,R. and Avram,D.
  TITLE     BCL11B participates in the activation of IL2 gene expression in
            CD4+ T lymphocytes
  JOURNAL   Blood 108 (8), 2695-2702 (2006)
   PUBMED   16809611
REFERENCE   7  (bases 1 to 5419)
  AUTHORS   Inoue,J., Kanefuji,T., Okazuka,K., Watanabe,H., Mishima,Y. and
            Kominami,R.
  TITLE     Expression of TCR alpha beta partly rescues developmental arrest
            and apoptosis of alpha beta T cells in Bcl11b-/- mice
  JOURNAL   J Immunol 176 (10), 5871-5879 (2006)
   PUBMED   16670294
REFERENCE   8  (bases 1 to 5419)
  AUTHORS   Arlotta,P., Molyneaux,B.J., Chen,J., Inoue,J., Kominami,R. and
            Macklis,J.D.
  TITLE     Neuronal subtype-specific genes that control corticospinal motor
            neuron development in vivo
  JOURNAL   Neuron 45 (2), 207-221 (2005)
   PUBMED   15664173
REFERENCE   9  (bases 1 to 5419)
  AUTHORS   Wakabayashi,Y., Watanabe,H., Inoue,J., Takeda,N., Sakata,J.,
            Mishima,Y., Hitomi,J., Yamamoto,T., Utsuyama,M., Niwa,O., Aizawa,S.
            and Kominami,R.
  TITLE     Bcl11b is required for differentiation and survival of alphabeta T
            lymphocytes
  JOURNAL   Nat Immunol 4 (6), 533-539 (2003)
   PUBMED   12717433
REFERENCE   10 (bases 1 to 5419)
  AUTHORS   Wakabayashi,Y., Inoue,J., Takahashi,Y., Matsuki,A.,
            Kosugi-Okano,H., Shinbo,T., Mishima,Y., Niwa,O. and Kominami,R.
  TITLE     Homozygous deletions and point mutations of the Rit1/Bcl11b gene in
            gamma-ray induced mouse thymic lymphomas
  JOURNAL   Biochem Biophys Res Commun 301 (2), 598-603 (2003)
   PUBMED   12565905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JF520429.1 and JAXUCZ010000006.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF520429.1, SRR26643292.27217.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2643              JF520429.1         1-2643
            2644-5419           JAXUCZ010000006.1  132598968-132601743 c
FEATURES             Location/Qualifiers
     source          1..5419
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHRSP"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..5419
                     /gene="Bcl11b"
                     /gene_synonym="Ctip2"
                     /note="BCL11 transcription factor B"
                     /db_xref="GeneID:314423"
                     /db_xref="RGD:1311128"
     CDS             1..2643
                     /gene="Bcl11b"
                     /gene_synonym="Ctip2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-cell leukemia/lymphoma 11B; BAF chromatin remodeling
                     complex subunit BCL11B; COUP-TF-interacting protein 2 long
                     form; B-cell CLL/lymphoma 11B (zinc finger protein);
                     BCL11B, BAF complex component"
                     /codon_start=1
                     /product="B-cell lymphoma/leukemia 11B isoform 1"
                     /protein_id="NP_001264216.1"
                     /db_xref="GeneID:314423"
                     /db_xref="RGD:1311128"
                     /translation="MSRRKQGNPQHLSQRELITPEADHVEAAILEEDEGLEIEEPSSL
                     GLMVGGPDPDLLTCGQCQMNFPLGDILVFIEHKKKQCGGLGSCYDKVLDKGSPPPSSR
                     SELRRVSEPVEIGIQVTPDEDDHLLSPTKGICPKQENIAGPCRPAQLPSMAPIAASSS
                     HPPTSVITSPLRALGVLPPCFPLPCCGARPISGDGTQGEGQMEAPFGCQCKDEPSSYI
                     CTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASTSLTPRLTIPPPLGPEAVAQSPLM
                     NFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPPPRHHLDPHRLSAEEMGLV
                     AQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPVSPGRGNPMHRLLNPFQ
                     PSPKSPFLSTPPLPPMPTGTPPPQPPAKSKSCEFCGKTFKFQSNLIVHRRSHTGEKPY
                     KCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELPGDLKAAD
                     GDFRHHESDPSLGPEPEDDEDEEEEEEELLLENESRPESSFSMDSELGRGRENGGGVP
                     PGVAGAGAAAAALADEKALALGKVMEDAGLGALPQYGEKRGAFLKRAGDAGDTGAGGC
                     GDAGAPGAVNGRGGAFAPGAEPFPALFPRKPAPLPSPGLGGPALHAAKRIKVEKDLEL
                     PPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFST
                     PPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLT
                     VHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLE
                     KHMKKWHGEHLLTNDVKIEQAERS"
     exon            1..58
                     /gene="Bcl11b"
                     /gene_synonym="Ctip2"
                     /inference="alignment:Splign:2.1.0"
     exon            59..424
                     /gene="Bcl11b"
                     /gene_synonym="Ctip2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..628
                     /gene="Bcl11b"
                     /gene_synonym="Ctip2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..5419
                     /gene="Bcl11b"
                     /gene_synonym="Ctip2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcccgcc gcaaacaggg caacccgcag cacttgtccc agagggaact catcacgcca
       61 gaggctgacc atgtggaggc tgctatcctc gaggaagatg agggtctgga gatagaagag
      121 cctagcagcc tggggctgat ggtgggcggc cccgaccctg acctactcac ctgtggccag
      181 tgtcagatga acttcccgct gggggacatc ctggttttta tagagcacaa gaagaaacag
      241 tgtgggggcc tgggctcctg ctacgacaag gtactggaca agggaagccc tccgccttcc
      301 tctcgctctg agctcaggag agtgtctgaa ccagtggaga tcgggatcca ggtcaccccc
      361 gatgaagatg accatctact gtcacccacg aaaggcatct gtcccaagca ggagaacatt
      421 gcagggccgt gcaggcctgc ccagctgcca tcgatggccc ccatagctgc ctcctcttcc
      481 caccctccca cctccgtgat tacttcacct ctgcgtgccc tgggcgttct cccaccctgt
      541 ttcccgctgc cttgctgtgg tgcacgcccc atctcgggcg acgggactca gggtgagggt
      601 cagatggagg ctccctttgg atgccagtgt aaagatgagc cttccagcta catttgcaca
      661 acatgtaagc agcccttcaa cagcgcctgg ttcctgctgc aacatgcgca gaacacgcat
      721 ggcttccgca tctacctgga gcccgggccc gccagcacct cgctcacgcc caggctcacc
      781 atcccgccgc cgctcgggcc ggaggccgtg gcgcagtccc cactcatgaa tttcctcggg
      841 gacagcaatc ctttcaacct gctgcgcatg acgggcccca tcctgcggga ccaccccggc
      901 ttcggagagg gccgcctgcc cggtacgcca ccgctcttca gcccaccgcc acgccatcac
      961 ttggacccac accgcctcag tgcagaggag atggggctcg tggcccagca ccccagtgcc
     1021 ttcgaccgag tcatgcgcct gaaccccatg gccatagact ctcccgccat ggacttctct
     1081 cggcggctgc gagaactggc cggtaacagc tccacaccgc cgcccgtgtc cccaggccgt
     1141 ggcaacccta tgcaccggct gctgaaccct tttcagccca gccccaagtc cccgttcctc
     1201 agcacgccac cgctgccacc catgcccacg ggcacgccgc caccgcagcc gcctgccaag
     1261 agcaagtcct gtgagttctg cggcaagacc ttcaaattcc agagcaatct catcgtgcac
     1321 cggcgcagcc acacgggcga gaagccctac aagtgccagc tgtgcgacca cgcgtgctcg
     1381 caggcgagca agctcaagcg ccacatgaag acgcacatgc acaaggcggg ctcgctggct
     1441 ggccgctcag acgatgggct ctcggccgcc agctccccag agcccggcac cagcgagctg
     1501 ccaggtgacc tcaaagcggc cgatggcgac ttccgccacc atgagagcga cccatctctg
     1561 ggacccgagc ctgaggacga cgaggacgag gaggaggaag aagaagagct gctgctggag
     1621 aatgaaagcc gacctgagtc gagcttcagc atggactcgg agctgggccg tggccgcgag
     1681 aatgggggtg gtgtgccacc aggggtggcg ggcgcggggg ctgcagctgc ggctctggca
     1741 gatgagaagg cgctggcatt gggcaaggtg atggaggacg cagggctggg cgcactgccg
     1801 cagtatgggg agaagcgagg cgccttcctg aagcgtgcag gcgacgcggg tgacaccgga
     1861 gctggtggct gcggggatgc aggtgcaccg ggcgcagtga acgggcgtgg cggggccttc
     1921 gcgccaggcg cagagccctt cccagcgctc ttcccacgca agcccgcacc gctgcccagc
     1981 ccggggcttg gtggtcctgc gctacacgcg gccaagcgca tcaaggtgga gaaggacctg
     2041 gagctgccac ccgccgccct catcccatcc gagaacgtgt actcgcagtg gctcgtgggc
     2101 tacgcggcgt cgcgccactt catgaaggac ccgttcctgg gcttcacgga tgcgcgccag
     2161 tcgcctttcg ccacgtcgtc ggaacattcc tctgagaacg gcagcctgcg cttctccacg
     2221 ccacccgggg acctgctgga cggcgggctg tcggggcgca gtggcacggc gagcgggggc
     2281 agcacgcctc acctgggtgg cccgggtcct gggcggccga gctccaagga gggccgccgc
     2341 agcgacacgt gcgagtactg cggcaaggtc ttcaaaaact gtagcaacct gacggtgcac
     2401 cggaggagcc acaccggcga gcggccttac aagtgcgagc tgtgcaacta cgcgtgcgcg
     2461 cagagcagca agcttacgcg ccacatgaag acgcacggtc agatcggcaa ggaggtgtac
     2521 cgctgcgata tctgccagat gcccttcagt gtctacagta ccctggagaa acacatgaaa
     2581 aagtggcacg gtgaacactt gctgactaat gatgtcaaaa tcgagcaggc tgagaggagc
     2641 taagcgtgta cgcgggggac gccgcgtgcg tgcatctgta cagcgtgacc atcgccaacc
     2701 ttcgccaacg ggacccggtg accggactgg cctctgcatc cccggggctc agggaggcgg
     2761 cagtccaacc taacctgtgt ctgcgaagtc ctatggaaac ctgagggttg attaaggcag
     2821 taaaaaatta aaaaaaaaat tgtggagcct tttaactgtg caataatttc tgtatttatt
     2881 gggttttgta atttttttgg catgtacgtg caggtaccta ttattattat tatttctgtt
     2941 taaattcctt taaaagattt tgttgagtat ccatcccttc atttttttta agaacccagt
     3001 agtagtctga gcaatgactc gcaagtgatg tagagggaag ctatctttta aattataatt
     3061 ttttttgtgt gtgtgtgtgg ggggggtgct gcttttttga aatttaagct aagcatgtgt
     3121 aatttcttgt caagaagcca acacttaaat gacttttaaa gttgtttgcg ttttcatcat
     3181 ttattttgtt ctgaaatgaa aagtggcatg tgggattttt tttttcgggg gaggggggag
     3241 gggtggcttt caaaaaccat tttttttttc cgggaggtgg atgtacagcg gattacaatc
     3301 tttaaaattg tagcactttg ttttagcatc gcattggaga ggtagcactg atgtcctcct
     3361 gacccacaga ggcttctctg tgcggaattc aactttcatg ctatggaagg aaaactttga
     3421 ggggggcgcg gcaaacgagc ctctccccca ctcgggaccc cgagaatctt ttccagggtg
     3481 actctaggaa tagcccccga attctgcaat tgtgcattac caggagatac gatactgtcc
     3541 ttttctggag ggagcttggc gtattctggg aagccacctc tgccctgtgc tgtagacttg
     3601 gctgcataaa atgggctgag ggcacccact gggtagacag cagtggcctg tagtggcagg
     3661 aagaaggaga gtagcaatgc tctctctctg gcaccatggg ttctcttttc agcccccagc
     3721 ctacagataa atcccaggtg tccattgcta cggtggtaat tgaccatgtc ccaagcagac
     3781 aactggccct tgtggtgtac tggagaagtt agctgcgggg tcgctgatct cacgctgata
     3841 ggcacttagg gcaggggaat ctcgcctgtt ctcttcccgg aggagttggg aagagttctg
     3901 cccaaggtgc ccccacgctg cttccatttc tgtattgtgt cttttcctcc ctccgcttag
     3961 ttgggacata actatacatt ggacttgttg ggatttgatg tttgaattct gttgacccgc
     4021 actttaaagc ttttgtttgc atttaaatta aatggcttct aaacaagaaa ttgcagcata
     4081 ttcttgtctt tggcccagag gtgggttaaa ctgtaaggga cagctgagat tgagtgtcag
     4141 tgttgctaag cgtggcattc acaatactgg cactataaag aacaaaatta aataatttat
     4201 tggacagttt ctctactgcc attcaatttg atgtgcgtgc cttgaaaact gatcttccta
     4261 tttgagtctc ttgagacaaa tgcaaaactc tctctctctt tttttttgag atgaaaagac
     4321 tttttaaaaa gcaaacaaga gaagtacatt ctttagaaac aaagccacat ttactttaaa
     4381 ttaaaaaaaa aaaacaattc ctggttgaag atagaggacg ggaaaatgtc ataagatcca
     4441 gtcaaatgaa gaattaaacc cagcacagcc ctggacatcc attagcagac ttgttttcag
     4501 accccccccc cccttttttg ggacaaagct gcttagatac ggagtggagg tgacttactg
     4561 ctgaattaaa agtcatgtga tacaagctga tatcgttgaa tgaaaaaaaa caaacaacaa
     4621 aaacaattca ggaacaatgg ctaatttttt ttctcctaaa tataaattta gtgcactctg
     4681 tcttaaaaat acgtttacag tattggatac atacaagggt aaaataaatc gtgtgtatgt
     4741 gtgttggagc gatcttttta ttttatttta ttttcagcgt ttgcttaata ggttatacag
     4801 aaatgccaca atggctgggt gtatgttgtt ttcctttggt gacgggattt tagtatacat
     4861 tatatatatt gaaatttctt gattactgtc aaagtggacc agtatttgta ataattgaga
     4921 ttgcctgggc attttacaaa aatgagaaga aaaaaaagtc ctttttcttt tccttgaaac
     4981 cgttacagta agttttaaat ggtgggtcta taaaatctgt tctgtcatag taacctgtaa
     5041 agtcggagtt ttagtataaa tttttttctg cctcgggtgt tgaattttta ttttgaaaac
     5101 aaaatgtata gaaacttgta tttggggaat taaaggggga ttgctacaat gtgtagaaaa
     5161 agtatgtaga gaaagtgctt aatattgtta ctgctttgca gaagaagaaa aaaaaatcac
     5221 acttctggcc tgtacttatt ttctctctcc cacctccctc tggaatggat atattggtcg
     5281 gttcatatga tgtaggctct cgctgtattt ttactggagc ttgtaatttt ttaactgtaa
     5341 gcttgtcctt ttaaagggat ttaatgtacc tttttgttag tgaatttgga aataaaaaga
     5401 aaaaaaaaac aaaacccaa
//
