LOCUS       NM_001191683            2750 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus BCL11 transcription factor A (Bcl11a), mRNA.
ACCESSION   NM_001191683 XM_223693
VERSION     NM_001191683.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2750)
  AUTHORS   Zhang,Y., Shen,Y., Zhao,L., Zhao,Q., Zhao,L. and Yi,S.
  TITLE     Transcription Factor BCL11A Regulates Schwann Cell Behavior During
            Peripheral Nerve Regeneration
  JOURNAL   Mol Neurobiol 60 (9), 5352-5365 (2023)
   PUBMED   37316757
  REMARK    GeneRIF: Transcription Factor BCL11A Regulates Schwann Cell
            Behavior During Peripheral Nerve Regeneration.
REFERENCE   2  (bases 1 to 2750)
  AUTHORS   Basak,A., Hancarova,M., Ulirsch,J.C., Balci,T.B., Trkova,M.,
            Pelisek,M., Vlckova,M., Muzikova,K., Cermak,J., Trka,J.,
            Dyment,D.A., Orkin,S.H., Daly,M.J., Sedlacek,Z. and Sankaran,V.G.
  TITLE     BCL11A deletions result in fetal hemoglobin persistence and
            neurodevelopmental alterations
  JOURNAL   J Clin Invest 125 (6), 2363-2368 (2015)
   PUBMED   25938782
REFERENCE   3  (bases 1 to 2750)
  AUTHORS   Al-Allawi,N.A., Puehringer,H., Raheem,R.A. and Oberkanins,C.
  TITLE     Genetic Modifiers in beta-Thalassemia Intermedia: A Study on 102
            Iraqi Arab Patients
  JOURNAL   Genet Test Mol Biomarkers 19 (5), 242-247 (2015)
   PUBMED   25751242
REFERENCE   4  (bases 1 to 2750)
  AUTHORS   De Rubeis,S., He,X., Goldberg,A.P., Poultney,C.S., Samocha,K.,
            Cicek,A.E., Kou,Y., Liu,L., Fromer,M., Walker,S., Singh,T.,
            Klei,L., Kosmicki,J., Shih-Chen,F., Aleksic,B., Biscaldi,M.,
            Bolton,P.F., Brownfeld,J.M., Cai,J., Campbell,N.G., Carracedo,A.,
            Chahrour,M.H., Chiocchetti,A.G., Coon,H., Crawford,E.L.,
            Curran,S.R., Dawson,G., Duketis,E., Fernandez,B.A., Gallagher,L.,
            Geller,E., Guter,S.J., Hill,R.S., Ionita-Laza,J., Jimenz
            Gonzalez,P., Kilpinen,H., Klauck,S.M., Kolevzon,A., Lee,I., Lei,I.,
            Lei,J., Lehtimaki,T., Lin,C.F., Ma'ayan,A., Marshall,C.R.,
            McInnes,A.L., Neale,B., Owen,M.J., Ozaki,N., Parellada,M.,
            Parr,J.R., Purcell,S., Puura,K., Rajagopalan,D., Rehnstrom,K.,
            Reichenberg,A., Sabo,A., Sachse,M., Sanders,S.J., Schafer,C.,
            Schulte-Ruther,M., Skuse,D., Stevens,C., Szatmari,P., Tammimies,K.,
            Valladares,O., Voran,A., Li-San,W., Weiss,L.A., Willsey,A.J.,
            Yu,T.W., Yuen,R.K., Cook,E.H., Freitag,C.M., Gill,M., Hultman,C.M.,
            Lehner,T., Palotie,A., Schellenberg,G.D., Sklar,P., State,M.W.,
            Sutcliffe,J.S., Walsh,C.A., Scherer,S.W., Zwick,M.E., Barett,J.C.,
            Cutler,D.J., Roeder,K., Devlin,B., Daly,M.J. and Buxbaum,J.D.
  CONSRTM   DDD Study; Homozygosity Mapping Collaborative for Autism; UK10K
            Consortium
  TITLE     Synaptic, transcriptional and chromatin genes disrupted in autism
  JOURNAL   Nature 515 (7526), 209-215 (2014)
   PUBMED   25363760
REFERENCE   5  (bases 1 to 2750)
  AUTHORS   Chu,N.L., Wu,Z.K., Zhang,X.H., Fang,S.P., Wang,W.J. and Cheng,Y.L.
  TITLE     Molecular mechanism of yisui shengxue granule, a complex chinese
            medicine, on thalassemia patients suffering from hemolysis and
            anemia of erythrocytes
  JOURNAL   Evid Based Complement Alternat Med 2014, 213782 (2014)
   PUBMED   25574177
REFERENCE   6  (bases 1 to 2750)
  AUTHORS   Lettre,G., Sankaran,V.G., Bezerra,M.A., Araujo,A.S., Uda,M.,
            Sanna,S., Cao,A., Schlessinger,D., Costa,F.F., Hirschhorn,J.N. and
            Orkin,S.H.
  TITLE     DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci
            associate with fetal hemoglobin levels and pain crises in sickle
            cell disease
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 11869-11874 (2008)
   PUBMED   18667698
REFERENCE   7  (bases 1 to 2750)
  AUTHORS   Kuo,T.Y. and Hsueh,Y.P.
  TITLE     Expression of zinc finger transcription factor Bcl11A/Evi9/CTIP1 in
            rat brain
  JOURNAL   J Neurosci Res 85 (8), 1628-1636 (2007)
   PUBMED   17455301
  REMARK    GeneRIF: regional and subcellular distributions of
            Bcl11A/Evi9/CTIP1 in rat brain were investigated by immunostaining
            and biochemical fractionation
REFERENCE   8  (bases 1 to 2750)
  AUTHORS   Liu,P., Keller,J.R., Ortiz,M., Tessarollo,L., Rachel,R.A.,
            Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Bcl11a is essential for normal lymphoid development
  JOURNAL   Nat Immunol 4 (6), 525-532 (2003)
   PUBMED   12717432
REFERENCE   9  (bases 1 to 2750)
  AUTHORS   Satterwhite,E., Sonoki,T., Willis,T.G., Harder,L., Nowak,R.,
            Arriola,E.L., Liu,H., Price,H.P., Gesk,S., Steinemann,D.,
            Schlegelberger,B., Oscier,D.G., Siebert,R., Tucker,P.W. and
            Dyer,M.J.
  TITLE     The BCL11 gene family: involvement of BCL11A in lymphoid
            malignancies
  JOURNAL   Blood 98 (12), 3413-3420 (2001)
   PUBMED   11719382
REFERENCE   10 (bases 1 to 2750)
  AUTHORS   Avram,D., Fields,A., Pretty On Top,K., Nevrivy,D.J., Ishmael,J.E.
            and Leid,M.
  TITLE     Isolation of a novel family of C(2)H(2) zinc finger proteins
            implicated in transcriptional repression mediated by chicken
            ovalbumin upstream promoter transcription factor (COUP-TF) orphan
            nuclear receptors
  JOURNAL   J Biol Chem 275 (14), 10315-10322 (2000)
   PUBMED   10744719
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_223693.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.47681.1, DY315645.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-297               JAXUCZ010000014.1  102231680-102231976
            298-627             JAXUCZ010000014.1  102238870-102239199
            628-729             JAXUCZ010000014.1  102310193-102310294
            730-2750            JAXUCZ010000014.1  102315159-102317179
FEATURES             Location/Qualifiers
     source          1..2750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..2750
                     /gene="Bcl11a"
                     /note="BCL11 transcription factor A"
                     /db_xref="GeneID:305589"
                     /db_xref="RGD:1309923"
     exon            1..297
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2750
                     /gene="Bcl11a"
                     /note="B-cell CLL/lymphoma 11A (zinc finger protein);
                     BCL11A, BAF complex component; BAF chromatin remodeling
                     complex subunit BCL11A"
                     /codon_start=1
                     /product="B-cell lymphoma/leukemia 11A"
                     /protein_id="NP_001178612.1"
                     /db_xref="GeneID:305589"
                     /db_xref="RGD:1309923"
                     /translation="MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHD
                     LLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKGVDKPPSPSPIEMKKASNPVEVG
                     IQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQ
                     GICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLG
                     AECPSQPSLHGIPIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDP
                     HRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPG
                     RPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNL
                     VVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEP
                     GTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTES
                     ERVDYGFGLSLEAARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVL
                     GEKHKRSHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLG
                     SPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLTFGDSRQS
                     PFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRR
                     SDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKD
                     VYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE"
     exon            298..627
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
     exon            628..729
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
     exon            730..2750
                     /gene="Bcl11a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctcttcc tctctctctc tttttttttt cttaaaaaaa aaaaaaagcc atgacggctc
       61 tcccacaatt catcttccct gcgccatctt tgtattattt ctaatttatt ttggatgtca
      121 aaaggcactg atgaagatat tttctctgga gtctccttct ttctaacccg gctctcccga
      181 tgtgaaccga gccgtcgtcc gcacgccgcc gccgccgccg cccgcccgcc ccgcagccca
      241 ccatgtctcg ccgcaagcaa ggcaaacccc agcacttaag caaacgggaa ttctcgcccg
      301 aacctctcga agccattctt acagatgatg aaccagacca cggcccattg ggagctccag
      361 aaggggacca tgaccttctc acctgtgggc agtgccagat gaatttccca ttgggggaca
      421 ttcttatttt tatcgagcac aaacggaaac aatgcaatgg cagcctctgc ttagaaaaag
      481 gtgtggataa gccgccttcc ccttctccca tcgagatgaa aaaggcgtcc aatcccgtgg
      541 aggttggcat ccaggtgaca ccagaagatg acgattgttt atcaacgtca tctagaggaa
      601 tttgccccaa acaggaacac atagcagata aacttctgca ctggaggggc ctgtcctctc
      661 ctcggtctgc acacggagcc ctaatcccca cgcccgggat gagtgcagaa tatgccccgc
      721 agggtatttg taaagatgag cccagcagct acacatgtac aacttgcaaa cagccattca
      781 ccagtgcatg gtttctcttg caacacgcac agaacactca tggattaaga atctacttag
      841 aaagcgaaca cggaagcccc ctgaccccgc gggttggtat cccttcagga ctaggtgcag
      901 aatgtccttc ccagccatct ctccatggga ttcctattgc agacaataac ccctttaacc
      961 tgctaagaat accaggatca gtatccagag aggcttccgg cctggcagaa gggcgctttc
     1021 cacccactcc ccccctgttt agtccaccac cgagacatca cttggacccc caccgcatag
     1081 agcgcctggg ggcggaagag atggccctgg ccacccatca cccgagtgcc tttgacaggg
     1141 tgctgcggtt gaatccaatg gctatggagc ctccggccat ggatttctct aggagactta
     1201 gagagctggc agggaacacg tctagtccac cgctgtcccc aggccggccc agccctatgc
     1261 aaaggttact gcaaccattc cagccaggta gcaagccacc cttcctggcg acgccccccc
     1321 tccctcctct gcaatccgcc cctcctccct cccagccccc ggtcaagtcc aagtcatgcg
     1381 agttctgcgg caagacgttc aaatttcaga gcaacttggt ggtgcaccgg cgcagccata
     1441 ctggtgagaa gccctacaag tgcaacctgt gcgatcacgc gtgcacgcag gccagcaagc
     1501 tgaagcgtca catgaagaca cacatgcaca agtcgtcccc catgacagtt aagtccgacg
     1561 acggcctctc cacagccagc tccccggaac ctggcaccag cgacctggta ggcagcgcca
     1621 gcagtgcgct caagtcagtg gtggccaagt tcaagagtga gaacgacccc aacttgatcc
     1681 cggagaacgg ggatgaggag gaagaggagg acgacgagga agaagaggaa gaggaggaag
     1741 aggaggagga ggagctgacg gagagcgaga gggtggacta cggcttcggg ctgagcctgg
     1801 aggctgcgcg ccaccacgag aacagctctc ggggcgcagt ggtgggcgtg ggcgacgagg
     1861 gccgcgccct gcccgatgtc atgcagggca tggtgctcag ctccatgcag cacttcagcg
     1921 aggccttcca ccaggtcctg ggcgagaagc ataagcgcag ccacctggcc gaggccgagg
     1981 gccataggga cacttgcgac gaagactcgg tggccggcga gtcggaccgc atagacgatg
     2041 gcactgttaa tggtcgtggc tgctcccctg gcgaatcggc ttcggggggt ctgtccaaaa
     2101 agctcctgct gggtagcccc agctcgctga gccccttctc caagcgcatc aagctggaga
     2161 aggagtttga cctgcccccg gctgcgatgc ctaacacgga gaacgtgtac tcgcagtggc
     2221 tcgctggcta tgcagcctcc aggcagctca aagatccctt ccttaccttc ggagactcca
     2281 gacaatcgcc ttttgcctcc tcgtcagagc actcctcgga gaacgggagc ttgcgcttct
     2341 ccacgccgcc cggggagctg gacggaggga tctcggggcg cagcggcacg ggaagtggag
     2401 ggagcacgcc ccatattagt ggtccgggcc cgggcaggcc cagctcaaaa gagggcagac
     2461 gcagcgacac ttgtgagtac tgtgggaaag tcttcaagaa ctgtagcaat ctcactgtcc
     2521 acaggagaag ccacacgggc gaaaggcctt ataaatgcga gctgtgcaac tatgcctgtg
     2581 cccagagtag caagctcacc aggcacatga aaacgcatgg ccaggtgggg aaggacgttt
     2641 acaaatgtga aatttgtaag atgcctttta gcgtgtacag taccctggag aaacacatga
     2701 aaaaatggca cagtgaccga gtgttgaata atgatataaa aactgaatag
//
