LOCUS       NM_031328               1667 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus BCL10, immune signaling adaptor (Bcl10), mRNA.
ACCESSION   NM_031328
VERSION     NM_031328.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Ma,C.A., Stinson,J.R., Zhang,Y., Abbott,J.K., Weinreich,M.A.,
            Hauk,P.J., Reynolds,P.R., Lyons,J.J., Nelson,C.G., Ruffo,E.,
            Dorjbal,B., Glauzy,S., Yamakawa,N., Arjunaraja,S., Voss,K.,
            Stoddard,J., Niemela,J., Zhang,Y., Rosenzweig,S.D., McElwee,J.J.,
            DiMaggio,T., Matthews,H.F., Jones,N., Stone,K.D., Palma,A.,
            Oleastro,M., Prieto,E., Bernasconi,A.R., Dubra,G., Danielian,S.,
            Zaiat,J., Marti,M.A., Kim,B., Cooper,M.A., Romberg,N., Meffre,E.,
            Gelfand,E.W., Snow,A.L. and Milner,J.D.
  TITLE     Germline hypomorphic CARD11 mutations in severe atopic disease
  JOURNAL   Nat Genet 49 (8), 1192-1201 (2017)
   PUBMED   28628108
  REMARK    Erratum:[Nat Genet. 2017 Oct 27;49(11):1661. doi:
            10.1038/ng1117-1661b.. PMID: 29074947]
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Torres,J.M., Martinez-Barricarte,R., Garcia-Gomez,S.,
            Mazariegos,M.S., Itan,Y., Boisson,B., Rholvarez,R.,
            Jimenez-Reinoso,A., del Pino,L., Rodriguez-Pena,R., Ferreira,A.,
            Hernandez-Jimenez,E., Toledano,V., Cubillos-Zapata,C.,
            Diaz-Almiron,M., Lopez-Collazo,E., Unzueta-Roch,J.L.,
            Sanchez-Ramon,S., Regueiro,J.R., Lopez-Granados,E., Casanova,J.L.
            and Perez de Diego,R.
  TITLE     Inherited BCL10 deficiency impairs hematopoietic and
            nonhematopoietic immunity
  JOURNAL   J Clin Invest 124 (12), 5239-5248 (2014)
   PUBMED   25365219
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Gringhuis,S.I., Kaptein,T.M., Wevers,B.A., Theelen,B., van der
            Vlist,M., Boekhout,T. and Geijtenbeek,T.B.
  TITLE     Dectin-1 is an extracellular pathogen sensor for the induction and
            processing of IL-1beta via a noncanonical caspase-8 inflammasome
  JOURNAL   Nat Immunol 13 (3), 246-254 (2012)
   PUBMED   22267217
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Smith,A.J., Karpova,Y., D'Agostino,R. Jr., Willingham,M. and
            Kulik,G.
  TITLE     Expression of the Bcl-2 protein BAD promotes prostate cancer growth
  JOURNAL   PLoS One 4 (7), e6224 (2009)
   PUBMED   19593445
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Ye,H., Dogan,A., Karran,L., Willis,T.G., Chen,L., Wlodarska,I.,
            Dyer,M.J., Isaacson,P.G. and Du,M.Q.
  TITLE     BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear
            localization in MALT lymphoma
  JOURNAL   Am J Pathol 157 (4), 1147-1154 (2000)
   PUBMED   11021819
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   Yoneda,T., Imaizumi,K., Maeda,M., Yui,D., Manabe,T., Katayama,T.,
            Sato,N., Gomi,F., Morihara,T., Mori,Y., Miyoshi,K., Hitomi,J.,
            Ugawa,S., Yamada,S., Okabe,M. and Tohyama,M.
  TITLE     Regulatory mechanisms of TRAF2-mediated signal transduction by
            Bcl10, a MALT lymphoma-associated protein
  JOURNAL   J Biol Chem 275 (15), 11114-11120 (2000)
   PUBMED   10753917
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Guiet,C. and Vito,P.
  TITLE     Caspase recruitment domain (CARD)-dependent cytoplasmic filaments
            mediate bcl10-induced NF-kappaB activation
  JOURNAL   J Cell Biol 148 (6), 1131-1140 (2000)
   PUBMED   10725326
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Costanzo,A., Guiet,C. and Vito,P.
  TITLE     c-E10 is a caspase-recruiting domain-containing protein that
            interacts with components of death receptors signaling pathway and
            activates nuclear factor-kappaB
  JOURNAL   J Biol Chem 274 (29), 20127-20132 (1999)
   PUBMED   10400625
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Thome,M., Martinon,F., Hofmann,K., Rubio,V., Steiner,V.,
            Schneider,P., Mattmann,C. and Tschopp,J.
  TITLE     Equine herpesvirus-2 E10 gene product, but not its cellular
            homologue, activates NF-kappaB transcription factor and c-Jun
            N-terminal kinase
  JOURNAL   J Biol Chem 274 (15), 9962-9968 (1999)
   PUBMED   10187771
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 27, 2020 this sequence version replaced NM_031328.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB016069.1, BC061772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000002.1  237501181-237501362
            183-471             JAXUCZ010000002.1  237507199-237507487
            472-1667            JAXUCZ010000002.1  237509626-237510821
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1667
                     /gene="Bcl10"
                     /note="BCL10, immune signaling adaptor"
                     /db_xref="GeneID:83477"
                     /db_xref="RGD:620544"
     exon            1..182
                     /gene="Bcl10"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..827
                     /gene="Bcl10"
                     /note="RCD; R-RCD1; bcl-10; B-cell leukemia/lymphoma 10;
                     B-cell CLL/lymphoma 10"
                     /codon_start=1
                     /product="B-cell lymphoma/leukemia 10"
                     /protein_id="NP_112618.1"
                     /db_xref="GeneID:83477"
                     /db_xref="RGD:620544"
                     /translation="MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAK
                     KILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDE
                     VLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRSNSDESNFSEKQRPSTVIYHPEGES
                     STAPFFSTESSLNLPVLEVGRLENSSFSSASLPRPGDPGAPPLPPDLRLEEGGSCGNS
                     SEMFLPLRSRALSRQ"
     exon            183..471
                     /gene="Bcl10"
                     /inference="alignment:Splign:2.1.0"
     exon            472..1667
                     /gene="Bcl10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaaccggc ggttcccccg cttctgttcc tagtcctccc aagtcacagc ccgattcccg
       61 gaggcccgag cccttagcca gggcggggtg gcgcgggccg aaaggacgcc atcccggcct
      121 cggccatgga ggctcccgcg ccgtctctca cggaggagga cttaactgaa gtgaagaagg
      181 acgctttaga gaatttgcga gtttacctgt gtgagaaaat catagctgag agacattttg
      241 atcatctacg agcaaaaaaa attctaagta gagaagacac agaagaaatt tcttgccgaa
      301 cttcaagtag aaaaagggct gggaagttgt tagactactt acaggaaaac cccaagggac
      361 tggacaccct tgtggaatcc attcgcaggg agaaaacaca gaacttcctg attcagaaga
      421 taacggatga ggtgctaaag cttcggaata taaaactgga gcacctcaaa ggcctgaagt
      481 gcagtagctg tgagcccttc gcagctggag ccaccaacaa cctttctagg tccaattctg
      541 atgagagcaa cttctccgag aaacagagac catccacggt catctaccat ccagagggag
      601 agtcgagcac tgctcccttc ttctctaccg agtcatccct gaatctgccg gtcctggaag
      661 ttggcaggct ggaaaacagc agcttctctt cagcctcgct tcctcggcct ggggaccctg
      721 gggccccccc tttgccccca gacctgcggt tagaagaggg ggggagttgt ggaaactcaa
      781 gtgagatgtt tctcccctta cggtcacggg ctctttcacg gcagtgacag gtcactgcga
      841 gttgttctaa tagtggtgca aatggtgtgg tggatatcat ctttttataa atcacgggat
      901 gcgagtctta aatcacaggt gcacataaca ttctctgtaa ataggattgg aagtgtaatg
      961 gagcacactc taggggcagc ttggtgtaaa tcatggtggt cgtgtacttt tcagcattgt
     1021 ccttttttat tattttaagt gttttggtat tttgaacttt tttataagac taattttatc
     1081 aaaatatttc tcaatttgag aaaacaactt gtggaccgaa aaccctacaa gttttccgcc
     1141 tggttgtgtt tcctggtgat ctgacagtac attttagcag taagctgttc tgactttcag
     1201 gaaagccaga catggggaga gctgctgaca caccctcagg agaatgtccc actccgtgct
     1261 tctgagaagc cgtcaggttc tgaggaaaca cctgatggcg ttgagccttg tgatctcagt
     1321 tggccagaat ttgttgtata ccttgccagt atgattgtct ttgcctttta cagaccttgt
     1381 gtcctcagtc ttggcctgaa gaatgttatc ccggcagggc gctccttgta attaattggt
     1441 aacacttgta attagctaaa gtccttgctc tgagcctttc cttctctgcc gatgagcact
     1501 gccatgtgga gttactgtat tacaaagttg gctaacttta cacatttaaa aagtgctgat
     1561 tattttcttt taaattatac ctatttctga catctaactc ctatatattt ctattattta
     1621 aaaattaaga aatgaaaagt ttctattaac aataaaagtt tttttaa
//
