LOCUS       NM_019244               1816 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus branched chain ketoacid dehydrogenase kinase
            (Bckdk), mRNA.
ACCESSION   NM_019244 XM_346558
VERSION     NM_019244.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1816)
  AUTHORS   Zigler,J.S. Jr., Hodgkinson,C.A., Wright,M., Klise,A., Sundin,O.,
            Broman,K.W., Hejtmancik,F., Huang,H., Patek,B., Sergeev,Y.,
            Hose,S., Brayton,C., Xaiodong,J., Vasquez,D., Maragakis,N.,
            Mori,S., Goldman,D., Hoke,A. and Sinha,D.
  TITLE     A Spontaneous Missense Mutation in Branched Chain Keto Acid
            Dehydrogenase Kinase in the Rat Affects Both the Central and
            Peripheral Nervous Systems
  JOURNAL   PLoS One 11 (7), e0160447 (2016)
   PUBMED   27472223
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1816)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   3  (bases 1 to 1816)
  AUTHORS   Muller,E.A. and Danner,D.J.
  TITLE     Tissue-specific translation of murine branched-chain alpha-ketoacid
            dehydrogenase kinase mRNA is dependent upon an upstream open
            reading frame in the 5'-untranslated region
  JOURNAL   J Biol Chem 279 (43), 44645-44655 (2004)
   PUBMED   15302860
REFERENCE   4  (bases 1 to 1816)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1816)
  AUTHORS   Machius,M., Chuang,J.L., Wynn,R.M., Tomchick,D.R. and Chuang,D.T.
  TITLE     Structure of rat BCKD kinase: nucleotide-induced domain
            communication in a mitochondrial protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 98 (20), 11218-11223 (2001)
   PUBMED   11562470
REFERENCE   6  (bases 1 to 1816)
  AUTHORS   Doering,C.B., Coursey,C., Spangler,W. and Danner,D.J.
  TITLE     Murine branched chain alpha-ketoacid dehydrogenase kinase; cDNA
            cloning, tissue distribution, and temporal expression during
            embryonic development
  JOURNAL   Gene 212 (2), 213-219 (1998)
   PUBMED   9611264
REFERENCE   7  (bases 1 to 1816)
  AUTHORS   Davie,J.R., Wynn,R.M., Meng,M., Huang,Y.S., Aalund,G., Chuang,D.T.
            and Lau,K.S.
  TITLE     Expression and characterization of branched-chain alpha-ketoacid
            dehydrogenase kinase from the rat. Is it a histidine-protein
            kinase?
  JOURNAL   J Biol Chem 270 (34), 19861-19867 (1995)
   PUBMED   7649998
REFERENCE   8  (bases 1 to 1816)
  AUTHORS   Popov,K.M., Zhao,Y., Shimomura,Y., Kuntz,M.J. and Harris,R.A.
  TITLE     Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular
            cloning, expression, and sequence similarity with histidine protein
            kinases
  JOURNAL   J Biol Chem 267 (19), 13127-13130 (1992)
   PUBMED   1377677
REFERENCE   9  (bases 1 to 1816)
  AUTHORS   Harris,R.A., Popov,K.M., Shimomura,Y., Zhao,Y., Jaskiewicz,J.,
            Nanaumi,N. and Suzuki,M.
  TITLE     Purification, characterization, regulation and molecular cloning of
            mitochondrial protein kinases
  JOURNAL   Adv Enzyme Regul 32, 267-284 (1992)
   PUBMED   1496922
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK479351.1, U27456.1 and BM392152.1.
            
            On Oct 20, 2007 this sequence version replaced NM_019244.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: M93271.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-677               CK479351.1         1-677
            678-1495            U27456.1           332-1149
            1496-1816           BM392152.1         1-321               c
FEATURES             Location/Qualifiers
     source          1..1816
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1816
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /note="branched chain ketoacid dehydrogenase kinase"
                     /db_xref="GeneID:29603"
                     /db_xref="RGD:2198"
     exon            1..81
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            82..451
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..1495
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.4"
                     /note="[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]
                     kinase, mitochondrial; BCKDHKIN; BCKD-kinase;
                     branched-chain alpha-ketoacid dehydrogenase kinase; BCKDH
                     kinase"
                     /codon_start=1
                     /product="branched-chain alpha-ketoacid dehydrogenase
                     kinase precursor"
                     /protein_id="NP_062117.2"
                     /db_xref="GeneID:29603"
                     /db_xref="RGD:2198"
                     /translation="MILTSVLGSGPRSGSSLWPLLGSSLSLRVRSTSATDTHHVELAR
                     ERSKTVTSFYNQSAIDVVAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRI
                     AHRIKGFRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIKDQADEAQYCQLVRQLLD
                     DHKDVVTLLAEGLRESRKHIEDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFV
                     GIICTRLSPKKIIEKWVDFARRLCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPEL
                     LKNAMRATMESHLDTPYNVPDVVITIANNDVDLIIRISDRGGGIAHKDLDRVMDYHFT
                     TAEASTQDPRISPLFGHLDMHSGGQSGPMHGFGFGLPTSRAYAEYLGGSLQLQSLQGI
                     GTDVYLRLRHIDGREESFRI"
     exon            452..520
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            521..631
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            632..679
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            680..799
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            800..898
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            899..972
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1191
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1350
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1801
                     /gene="Bckdk"
                     /gene_synonym="BDK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgaaggcgg gctcggccag ccgggcgggt cgactgctcc cgcggttccg ctcggacccc
       61 ggcccagcgt ctggcctcgc gatggaagct gctgtggcgg cgccgagcat gtcagcatcc
      121 tcgagggagc cacatccctg aaatccggag aaaaccctgt ccactcactc tctctctact
      181 cctgctttgg ggtcaccgtt gcctgtcgag cccttagtcc catagtatca ccctagttca
      241 acaaagaagc gggacaatga tactgacttc agtgctgggc agcggccctc ggagcgggtc
      301 ttcactttgg cccctcttgg ggtcctcact gtcactccgg gttcgctcaa catcagccac
      361 cgatacacac catgtagagc tggccaggga acgctccaag actgttacct ccttttacaa
      421 ccagtcagct attgacgtgg tagcagagaa gccctcagtc cgcctcactc ccaccatgat
      481 gctctattct ggtcgctcac aggatggcag ccaccttctg aaaagtggtc gctacttgca
      541 gcaagagtta ccggtgagga tcgctcaccg catcaagggc ttccgtagtc ttcctttcat
      601 cattggttgc aaccctacca tactgcatgt gcacgagcta tacatccggg ccttccagaa
      661 gttgacagac ttccctccga tcaaggacca ggcagacgaa gcccagtatt gccagctggt
      721 gcgacagctg ctagatgacc acaaggatgt ggtaaccctg ttagctgagg gtctgcgtga
      781 gagccggaaa cacatagagg atgaaaagct ggtccgctac ttcctggata aaacactaac
      841 gtccagactt gggatccgaa tgctggctac tcaccacttg gcgctacatg aagacaagcc
      901 tgattttgtt ggcatcatct gcactcgtct gtcacccaag aagattattg agaagtgggt
      961 ggattttgcc agacgcctgt gcgagcacaa gtatggcaat gcccctagag tccgcatcaa
     1021 tgggcacgtg gctgcccgtt tccccttcat tcctatgccg ctggactata tcctgcctga
     1081 gctgctcaag aacgccatga gagccacaat ggagagtcac ctagacacgc cctacaatgt
     1141 tcctgatgtg gtcatcacca tcgccaataa cgatgtggat ctcatcatca ggatctcaga
     1201 ccggggtgga ggaatcgctc ataaggacct ggatcgggtc atggactacc acttcaccac
     1261 agctgaggcc agcacccagg acccccgaat cagccccctc ttcggccacc tggatatgca
     1321 cagtggtggc caatcaggac ctatgcatgg ctttggcttc gggttgccca cgtccagggc
     1381 ctatgcggag tatctcggtg gctccctgca gctgcagtcc ctgcagggca ttggcacaga
     1441 tgtctaccta cggctccgcc acattgatgg ccgggaggaa agcttcagaa tctgatggtg
     1501 gattttggcc agctagcctg ccacactcct cgtaggacct actgggcctg gcagggggcc
     1561 gctgtgctcc atacactgct gcttcgtgga gcttagggcc tcagacaggt ggacttagat
     1621 ggagctgggc accactcctc ctcaacaggg ctcattgctt tctgcctcct ggtctcggag
     1681 gggaggaagc aggagcctct gaggcctcca ataccagctg tgctgtgctt actcttgagg
     1741 agtacttatt tgacctgctg ttattaaagt ttgcattttg aatgccctct tgggcctcaa
     1801 aaaaaaaaaa aaaaaa
//
