LOCUS       NM_022942               1878 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Rattus norvegicus butyrylcholinesterase (Bche), mRNA.
ACCESSION   NM_022942
VERSION     NM_022942.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Szmicsekova,K., Bies Pivackova,L., Kilianova,Z., Slobodova,L.,
            Krenek,P. and Hrabovska,A.
  TITLE     Aortic butyrylcholinesterase is reduced in spontaneously
            hypertensive rats
  JOURNAL   Physiol Res 70 (5), 809-813 (2021)
   PUBMED   34505519
  REMARK    GeneRIF: Aortic butyrylcholinesterase is reduced in spontaneously
            hypertensive rats.
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Munir,S., Habib,R., Awan,S., Bibi,N., Tanveer,A., Batool,S. and
            Nurulain,S.M.
  TITLE     Biochemical Analysis and Association of Butyrylcholinesterase SNPs
            rs3495 and rs1803274 with Substance Abuse Disorder
  JOURNAL   J Mol Neurosci 67 (3), 445-455 (2019)
   PUBMED   30707402
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Tonin,A.A., da Silva,A.S., Thorstenberg,M.L., Castilhos,L.G.,
            Franca,R.T., Leal,D.B., Duarte,M.M., Vogel,F.S., de La Rue,M.L. and
            dos Anjos Lopes,S.T.
  TITLE     Influence of Toxoplasma gondii acute infection on cholinesterase
            activities of Wistar rats
  JOURNAL   Korean J Parasitol 51 (4), 421-426 (2013)
   PUBMED   24039284
  REMARK    GeneRIF: No significant difference was observed in the activity of
            BChE in serum after Toxoplasma gondii infection.
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Koohestani,F., Brown,C.M. and Meisami,E.
  TITLE     Differential effects of developmental hypo- and hyperthyroidism on
            acetylcholinesterase and butyrylcholinesterase activity in the
            spinal cord of developing postnatal rat pups
  JOURNAL   Int J Dev Neurosci 30 (7), 570-577 (2012)
   PUBMED   22982053
  REMARK    GeneRIF: the neurochemical development of glia and other
            non-neuronal cells, where BuChE is mainly localized, is
            comparatively unaffected cy hypo- and hyperthyroidism
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Koohestani,F., Brown,C.M. and Meisami,E.
  TITLE     Postnatal growth hormone deficiency in growing rats causes marked
            decline in the activity of spinal cord acetylcholinesterase but not
            butyrylcholinesterase
  JOURNAL   Int J Dev Neurosci 30 (7), 578-583 (2012)
   PUBMED   22922167
  REMARK    GeneRIF: the absence of any effects on BuChE activity implies that
            growth hormone does not affect the development of non-neuronal
            elements
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Basu,P.S., Batabyal,S.K., Bhattacharya,A. and Datta,T.K.
  TITLE     Cholinesterase activities in cerebrospinal fluid of patients with
            idiopathic convulsive disorders
  JOURNAL   Clin Chim Acta 235 (1), 107-112 (1995)
   PUBMED   7634486
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   McGuire,M.C., Nogueira,C.P., Bartels,C.F., Lightstone,H., Hajra,A.,
            Van der Spek,A.F., Lockridge,O. and La Du,B.N.
  TITLE     Identification of the structural mutation responsible for the
            dibucaine-resistant (atypical) variant form of human serum
            cholinesterase
  JOURNAL   Proc Natl Acad Sci U S A 86 (3), 953-957 (1989)
   PUBMED   2915989
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   Ruberg,M., Villageois,A., Bonnet,A.M., Pillon,B., Rieger,F. and
            Agid,Y.
  TITLE     Acetylcholinesterase and butyrylcholinesterase activity in the
            cerebrospinal fluid of patients with neurodegenerative diseases
            involving cholinergic systems
  JOURNAL   J Neurol Neurosurg Psychiatry 50 (5), 538-543 (1987)
   PUBMED   2953866
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Godfrey,D.A. and Matschinsky,F.M.
  TITLE     Enzymes of the cholinergic system in islets of Langerhans
  JOURNAL   J Histochem Cytochem 23 (9), 645-651 (1975)
   PUBMED   126256
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Flumerfelt,B.A. and Lewis,P.R.
  TITLE     Cholinesterase activity in the hypoglossal nucleus of the rat and
            the changes produced by axotomy: a light and electron microscopic
            study
  JOURNAL   J Anat 119 (Pt 2), 309-331 (1975)
   PUBMED   1133098
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF244349.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF244349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q32"
     gene            1..1878
                     /gene="Bche"
                     /note="butyrylcholinesterase"
                     /db_xref="GeneID:65036"
                     /db_xref="RGD:619996"
     exon            1..58
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
     exon            59..1586
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1878
                     /gene="Bche"
                     /EC_number="3.1.1.8"
                     /note="cholinesterase"
                     /codon_start=1
                     /product="cholinesterase precursor"
                     /protein_id="NP_075231.1"
                     /db_xref="GeneID:65036"
                     /db_xref="RGD:619996"
                     /translation="MVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPIL
                     GGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGS
                     EMWNPNTNLSEDCLYLNVWIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVE
                     RVIVVSMNYRVGALGFLAFPGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLF
                     GESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCS
                     KENEKEIITCLRSKDPQEILLNEKLVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGK
                     VKTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMYFPGVSSLGKEAI
                     LFYYVDWLGDQTPEVYREAFDDIIGDYNIICPALEFTKKFAELEINAFFYYFEHRSSK
                     LPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQG
                     NSTVWPVFTSTEQKYLTLNTEKSKINSKLRAPQCQFWRLFFPKVLEITGDIDEREQEW
                     KAGFHRWSNYMMDWKNQFNDYTSKKETCTDL"
     exon            1587..1753
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1878
                     /gene="Bche"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagcattac aagattgcca ctttgcaaac tccctcttcc ttttctgcag cgattcggaa
       61 atcaatctgc agactcagca taccatggtc acagaaattc acttcctcct atggattctt
      121 ctgctctgca tgctttttgg gaagtcacac actgaagaag acgtcataat tacaaccaag
      181 actggaagag tccgagggct gagcatgccc attctaggtg gcacagtgac tgcctttctc
      241 ggtatcccct atgcacagcc tcctctgggt agcctaagat tcaaaaagcc acaaccttta
      301 aacaaatggc ctgatgtcta taatgccact aaatatgcaa attcttgtta tcagaatata
      361 gatcaagcct tcccaggctt ccaggggtca gaaatgtgga atccaaacac gaacctcagt
      421 gaagactgct tgtatctgaa tgtttggatt ccagtaccta agcccaagaa tgcgactgtc
      481 atggtgtggg tctatggtgg tggctttcaa actgggacct cctctctacc cgtttatgat
      541 gggaaatttc tcactcgtgt tgaaagagtt attgtagttt caatgaacta tagggtaggt
      601 gccctaggat tcctagcttt tccaggaaat tctgaggctc caggaaacat gggtttattt
      661 gatcaacagt tggcacttca gtggatccaa agaaatatag ctgctttcgg agggaatcct
      721 aaaagtgtaa cactttttgg agaaagtgca ggagctgctt cagttagctt acatttgcta
      781 tgtccccaaa gttacccttt gtttactaga gccattctag aaagtggctc ctctaatgcc
      841 ccctgggcag taaagcatcc agaggaagcc agaaacagaa ccttaacctt agctaaattt
      901 attggttgct caaaggagaa tgagaaggag ataattacat gccttcgaag taaagatcct
      961 caggaaattc ttctgaatga aaagttagtt ctcccctctg attccatcag atcgattaat
     1021 tttggtccaa cagtggatgg cgattttctc actgatatgc cccacacact actccaactt
     1081 ggaaaagtga aaacagctca gatcttagtg ggcgttaaca aggatgaagg gacagctttc
     1141 ctagtgtacg gtgctcctgg tttcagcaaa gacaatgata gtcttatcac acggagggaa
     1201 tttcaagaag gtttaaatat gtatttccct ggagtgagca gcttgggaaa ggaagcaatc
     1261 cttttctact atgtggactg gttaggtgac cagacaccgg aagtctaccg tgaagctttc
     1321 gatgatatta ttggagatta caacatcata tgccctgcac tggagtttac caagaaattt
     1381 gcagaactag aaattaatgc ctttttctac tattttgaac accgatcttc caaactacct
     1441 tggccagaat ggatgggagt aatgcatggc tatgaaattg aatttgtatt tggcttaccc
     1501 ctggaaagaa gagttaatta cacaagggct gaggaaatct ttagtcgatc cataatgaaa
     1561 acttgggcaa attttgcaaa atatggacat cccaatggga ctcagggcaa tagcacagtg
     1621 tggcctgtct tcacaagtac tgaacaaaaa tacctaacct tgaacacaga gaagtcaaaa
     1681 ataaactcta aactccgggc tccccagtgc caattctgga gactattttt tccaaaagtc
     1741 ttggaaataa caggagatat tgatgaaagg gagcaagagt ggaaggcagg attccatcgc
     1801 tggagcaatt acatgatgga ctggaaaaat caatttaacg attacactag caagaaagag
     1861 acttgtacag atctctaa
//
