LOCUS       NM_001108505            1231 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus BRCA2 and CDKN1A interacting protein (Bccip),
            mRNA.
ACCESSION   NM_001108505 XM_001055516 XM_341947
VERSION     NM_001108505.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1231)
  AUTHORS   Huhn,S.C., Liu,J., Ye,C., Lu,H., Jiang,X., Feng,X., Ganesan,S.,
            White,E. and Shen,Z.
  TITLE     Regulation of spindle integrity and mitotic fidelity by BCCIP
  JOURNAL   Oncogene 36 (33), 4750-4766 (2017)
   PUBMED   28394342
REFERENCE   2  (bases 1 to 1231)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 1231)
  AUTHORS   Lu,H., Huang,Y.Y., Mehrotra,S., Droz-Rosario,R., Liu,J.,
            Bhaumik,M., White,E. and Shen,Z.
  TITLE     Essential roles of BCCIP in mouse embryonic development and
            structural stability of chromosomes
  JOURNAL   PLoS Genet 7 (9), e1002291 (2011)
   PUBMED   21966279
REFERENCE   4  (bases 1 to 1231)
  AUTHORS   Ash,S.C., Yang,D.Q. and Britt,D.E.
  TITLE     LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in
            prostate tumor cells
  JOURNAL   Biochem Biophys Res Commun 371 (2), 333-338 (2008)
   PUBMED   18440304
REFERENCE   5  (bases 1 to 1231)
  AUTHORS   Ono,T., Kitaura,H., Ugai,H., Murata,T., Yokoyama,K.K.,
            Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     TOK-1, a novel p21Cip1-binding protein that cooperatively enhances
            p21-dependent inhibitory activity toward CDK2 kinase
  JOURNAL   J Biol Chem 275 (40), 31145-31154 (2000)
   PUBMED   10878006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 19, 2011 this sequence version replaced NM_001108505.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227185.1, FQ228402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               JAXUCZ010000001.1  197942535-197942721
            188-262             JAXUCZ010000001.1  197947932-197948006
            263-343             JAXUCZ010000001.1  197948625-197948705
            344-433             JAXUCZ010000001.1  197950871-197950960
            434-621             JAXUCZ010000001.1  197951623-197951810
            622-796             JAXUCZ010000001.1  197952807-197952981
            797-1231            JAXUCZ010000001.1  197954514-197954948
FEATURES             Location/Qualifiers
     source          1..1231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1231
                     /gene="Bccip"
                     /note="BRCA2 and CDKN1A interacting protein"
                     /db_xref="GeneID:361666"
                     /db_xref="RGD:1307362"
     exon            1..187
                     /gene="Bccip"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..967
                     /gene="Bccip"
                     /codon_start=1
                     /product="BRCA2 and CDKN1A-interacting protein"
                     /protein_id="NP_001101975.2"
                     /db_xref="GeneID:361666"
                     /db_xref="RGD:1307362"
                     /translation="MASKAKKRAVGNGVQRPLEAPSQREEEEEDELEDEEEDDEDSEE
                     EEDDEDDEIVDEEVNIEFEAYSISDNDYGGIKKLLQQLFLKAPVNTAELANLLIQQNH
                     IGSVIKQTDVSEDSDGEVDEDEIFGFISLLNLSERKGTQCAEQIKELVLSSCEKSCEQ
                     SMVEQLDKLLNDTSKPVGLLLSERFINVPPQIALPMHQQLQKELAEARRTNKPCGKCC
                     FYLLISKTFVEAGKSTSRKRRDGLPQEALMFANAEEEFFYEKAVLKFSYSVQGESDTC
                     LGGRWSFDDVPMKPLRTVMLIPDDKMSEIMETLKDHLSI"
     exon            188..262
                     /gene="Bccip"
                     /inference="alignment:Splign:2.1.0"
     exon            263..343
                     /gene="Bccip"
                     /inference="alignment:Splign:2.1.0"
     exon            344..433
                     /gene="Bccip"
                     /inference="alignment:Splign:2.1.0"
     exon            434..621
                     /gene="Bccip"
                     /inference="alignment:Splign:2.1.0"
     exon            622..796
                     /gene="Bccip"
                     /inference="alignment:Splign:2.1.0"
     exon            797..1231
                     /gene="Bccip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcagtgtg accggcaaca tggcatccaa ggctaagaag cgagcagtgg gaaatggggt
       61 ccagcggccg cttgaagcac cgagccagcg ggaagaggaa gaagaggatg aattggagga
      121 tgaggaagaa gacgatgaag acagtgaaga agaagaagac gatgaagacg acgaaatcgt
      181 ggatgaggaa gtgaatattg aatttgaagc ttattccatc tcagataatg attatggagg
      241 aattaagaag ttactgcaac agcttttcct aaaagcccct gtgaacactg cagagctggc
      301 caatctcctg attcagcaga accacatcgg gagtgtgatt aagcaaacag atgtttcaga
      361 agacagtgat ggtgaagtgg atgaagatga gatctttggc ttcatcagcc ttttaaattt
      421 aagtgaaaga aaggggactc aatgtgctga acaaattaaa gagttggttc taagctcctg
      481 tgagaagagc tgtgagcaga gcatggttga acagctggac aagcttttga atgacaccag
      541 caagcctgtg ggccttctgc tgagtgaaag attcattaac gttcctccac agattgctct
      601 gcctatgcac cagcagcttc agaaagaact ggctgaggca cgaagaacca acaagccatg
      661 tggcaagtgc tgcttctacc tgctgattag taagacattt gtggaggcag gaaagtctac
      721 ttccagaaag aggcgggatg gccttccaca ggaagcactg atgtttgcaa atgcagagga
      781 agagttcttc tatgagaagg cagtcctgaa gttcagctac tccgttcagg gagagagcga
      841 cacttgtctg ggaggcagat ggtccttcga tgatgttccg atgaagccgt tgcgaactgt
      901 gatgttaatt ccagatgaca agatgagtga gatcatggaa accctgaaag accatctatc
      961 catctagtcc atgtcccccg gacagtgaca ggcttgttta tgtataatta ccaagaaacc
     1021 cattggagag atactgaaaa actcattatt ttattcagat tcaagtcctc tacaaaaagt
     1081 agggctctgt tccacgtgtc tgtgacacat ttacaaaatg gttttttctt tattttggtc
     1141 aaattatgat tggttaaaaa tttccaataa gaaaagcgtg gaatagtaat tttaagaact
     1201 taataaaaac tattttttta ttttaaaatc a
//
