LOCUS       NM_001107722            3337 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus BCAR3 adaptor protein, NSP family member (Bcar3),
            mRNA.
ACCESSION   NM_001107722 XM_001074184 XM_227657
VERSION     NM_001107722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3337)
  AUTHORS   Oh,M.J., Yi,S.J., Kim,H.S., Kim,J.H., Jeong,Y.H., van Agthoven,T.
            and Jhun,B.H.
  TITLE     Functional roles of BCAR3 in the signaling pathways of insulin
            leading to DNA synthesis, membrane ruffling and GLUT4 translocation
  JOURNAL   Biochem Biophys Res Commun 441 (4), 911-916 (2013)
   PUBMED   24216110
REFERENCE   2  (bases 1 to 3337)
  AUTHORS   Sun,G., Cheng,S.Y., Chen,M., Lim,C.J. and Pallen,C.J.
  TITLE     Protein tyrosine phosphatase alpha phosphotyrosyl-789 binds BCAR3
            to position Cas for activation at integrin-mediated focal adhesions
  JOURNAL   Mol Cell Biol 32 (18), 3776-3789 (2012)
   PUBMED   22801373
  REMARK    GeneRIF: study described a molecular complex of
            PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha
            Tyr789 phosphorylation and mediates Cas localization to focal
            adhesions and Cas downstream signaling to promote cell migration
REFERENCE   3  (bases 1 to 3337)
  AUTHORS   Rufanova,V.A., Alexanian,A., Wakatsuki,T., Lerner,A. and Sorokin,A.
  TITLE     Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and
            regulates human glomerular mesangial cell adhesion and spreading
  JOURNAL   J Cell Physiol 219 (1), 45-56 (2009)
   PUBMED   19086031
REFERENCE   4  (bases 1 to 3337)
  AUTHORS   Near,R.I., Smith,R.S., Toselli,P.A., Freddo,T.F., Bloom,A.B.,
            Vanden Borre,P., Seldin,D.C. and Lerner,A.
  TITLE     Loss of AND-34/BCAR3 expression in mice results in rupture of the
            adult lens
  JOURNAL   Mol Vis 15, 685-699 (2009)
   PUBMED   19365570
REFERENCE   5  (bases 1 to 3337)
  AUTHORS   Oh,M.J., van Agthoven,T., Choi,J.E., Jeong,Y.J., Chung,Y.H.,
            Kim,C.M. and Jhun,B.H.
  TITLE     BCAR3 regulates EGF-induced DNA synthesis in normal human breast
            MCF-12A cells
  JOURNAL   Biochem Biophys Res Commun 375 (3), 430-434 (2008)
   PUBMED   18722344
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074184.1, XM_227657.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..3337
                     /gene="Bcar3"
                     /note="BCAR3 adaptor protein, NSP family member"
                     /db_xref="GeneID:310838"
                     /db_xref="RGD:1311688"
     exon            1..414
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            415..741
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..2902
                     /gene="Bcar3"
                     /note="breast cancer anti-estrogen resistance 3; BCAR3,
                     NSP family adaptor protein 3; novel SH2-containing protein
                     2; p130Cas-binding protein AND-34; SH2 domain-containing
                     protein 3B; BCAR3 adapter protein, NSP family member"
                     /codon_start=1
                     /product="breast cancer anti-estrogen resistance protein 3
                     homolog"
                     /protein_id="NP_001101192.1"
                     /db_xref="GeneID:310838"
                     /db_xref="RGD:1311688"
                     /translation="MAAGKFASLPRHMPVNHQFPLASSMDLLSSKSPLAEHRTEAYPD
                     VSIHGTLPRKKKGPPPIRSCDSASHMGTLPHSKSPRQSSPLTQDLILEKPLPDWKGDS
                     FAFRDPYLLDPTLEYVKFSKERHIMDRTPERLKKELEEELLLSSEDLRSHAWYHGRIP
                     RQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQ
                     FEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLWCLEERYGTSPGRGREG
                     SFAEGRPDVVKRLSLTTGGIQARDHSLPRGNLLRNKDKSGSQPACLDHVQDRKAATLK
                     AHQSESHLPIGCKLPPQSPSVDTSPCPNSPVFRTGSEPTLSPALVRRFSSDARAGEAL
                     RGSDSQLCPKPPPKPCKVPFLKVPPSPSPWLNSEANYCELNPAFAVGCDRGAKLLSQA
                     LDSHEMLLTAKQNGASGPRNSGINYSILDGDDQGRHWDPLAVQTDEGQEDETKFVPPV
                     METVSSFRPNDFESKLLPPENKPLETAMLKHAKELFTNHDARVIAQHMLSVDCKVARI
                     LEVSEDMKRSMGVSSGLELITLPHGRQLRLDIIERHNTMAIGIAVDILGCTGTLENRA
                     GTLNKIIQVAMELKDTMGDLYSFSAIMKALEMPQITRLEKTWTALRHHYTQTAILYEK
                     QLKPFSKILHEGRESTYVPASSVSVPLLMPLVTLMERQAVTFEGTDMWEKNDESCEIM
                     LSHLATARFMAEASESYRMNAERVLADFQPDEEMTEILKTEFQMRLLWGSKGAEVNQN
                     ERYDKFNQILTALSRKLEPPSGKQAEL"
     exon            742..781
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..910
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1353
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1457
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..2110
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2226
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2398
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2510
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2723
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..3337
                     /gene="Bcar3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtccggt tgagtgaggc tcagtgagga agaggttgag ctacacttga agtctagctt
       61 cttgggggag ataaggggga gtcaaaactc tcaaatcccg gagatccaga cgaggtcacc
      121 gaatgtaaat gtctcagggg ttcggctcag cccggcgaat cggctgagcg gggtggggcc
      181 gcgaagccgc aaatcaccag ttgagggcca gagagcgcgc cgccggctca gagctgagcc
      241 tgcggcagcc gggccaagca gcagccggag tgggacagcc gcgcgcactg accgaccgtc
      301 ccggcctctc ggcggacgcc cgcagaccat gagccgcccg agctcccgga gcagtgcggt
      361 gcaggcagcc cggcgctgaa ccgcaaatcc ggaccccgag cgcggcgcag ggagattaag
      421 aatcatggct gcgggaaaat ttgcaagcct tcccagacac atgcccgtga atcaccagtt
      481 ccctttggcc tcgtccatgg acctcctgag cagcaagtcc cctctcgctg agcatcgcac
      541 agaggcctat ccagacgtgt ccatacacgg cactcttcca cggaagaaaa aaggccctcc
      601 tcccatacgg tcctgtgaca gtgccagtca catgggcacc ctccctcact ccaagtcccc
      661 acgacagagc tcacctctga cccaggacct catcctggaa aaaccactgc cagactggaa
      721 aggggacagc ttcgccttca gggatcccta tcttctggac ccaactctgg agtacgtgaa
      781 gttctccaag gagaggcaca tcatggacag gacccctgag aggctgaaaa aggaactgga
      841 ggaggagcta ctgctgagca gcgaggacct acgcagccat gcctggtacc acggccggat
      901 ccccagacag gtgtctgaaa accttgtgca gcgggatggg gacttcctgg ttcgtgactc
      961 cctgtctagc cctggaaact ttgtcctgac ctgtcagtgg aagaaccttg ctcagcactt
     1021 taagatcaac cggactgttc tgcggctcag cgaggcctac agccgtgtgc agtaccaatt
     1081 cgagatggag agctttgact ccatccccgg gctggtacgc tgctacgtgg gaaaccggag
     1141 gcccatctcc cagcagagcg gcgccatcat cttccagcct atcaatagga cagtgcccct
     1201 ttggtgtctg gaggagcgtt atggcacctc accaggccga ggccgggagg gcagctttgc
     1261 tgagggaaga ccagatgtgg tgaagagact gagcctcacc acaggtggca tccaggctcg
     1321 ggaccacagc ttgcccagag gaaacctcct caggaataag gacaagagtg gcagccagcc
     1381 cgcctgcctg gatcacgtgc aggaccggaa ggccgcaaca ctcaaggctc accagtctga
     1441 gagtcacctg cccatcggct gcaagctgcc accccagtct ccgagtgtgg acacaagccc
     1501 ttgccccaac tctcccgtgt tcaggactgg cagcgagccc actctgagtc cggcactggt
     1561 acgaaggttc tcttcggacg ctagggcagg ggaggcactt cggggatcag acagtcaact
     1621 gtgccccaag ccacccccaa agccctgcaa ggtgcccttc ctcaaggttc ctccctctcc
     1681 atctccctgg ctaaactcag aggccaacta ctgtgaactg aaccctgctt ttgcggtggg
     1741 ctgtgacagg ggagccaagc ttctctcaca ggctctcgac agccacgaga tgctgctgac
     1801 agccaaacag aatggggcat cgggtccccg gaactctggc atcaactact cgatacttga
     1861 tggggatgac caagggagac attgggatcc cctggccgtg cagacggatg agggtcagga
     1921 ggacgagacc aagtttgtac cacctgtcat ggagacagtg tcatcattca gacccaatga
     1981 ctttgagtcg aagcttcttc ctccagagaa caagcccctg gaaacagcca tgctaaagca
     2041 tgccaaggaa ctgttcacca accatgacgc gagggtcatt gcacagcaca tgctgagcgt
     2101 ggactgcaag gttgctagga tactggaagt ctctgaagac atgaagagga gcatgggcgt
     2161 gagctcggga ctggaactca ttaccttgcc tcacggacgc cagctgcgcc tggacattat
     2221 tgaaagacac aacaccatgg ccattggcat tgctgtggac attctgggct gcacgggcac
     2281 attggagaac cgggcaggaa cccttaataa gatcatccag gtggcaatgg aactgaagga
     2341 caccatggga gacctctatt ccttctcagc catcatgaaa gccctcgaga tgcctcagat
     2401 cacaaggtta gaaaaaacat ggacggctct gaggcaccac tacacgcaaa cagccatcct
     2461 ctacgaaaag cagttgaagc cctttagcaa aatcctgcat gaaggcagag agtcgacata
     2521 tgtcccagca agcagtgtgt ccgtcccact gctgatgcct cttgtgacct taatggaacg
     2581 gcaggctgtc acttttgaag gaaccgacat gtgggaaaaa aatgacgaga gctgtgaaat
     2641 catgctgagt cacttggcca cagccaggtt catggccgag gcttcggaga gctacaggat
     2701 gaatgctgag agggtcctgg cagatttcca accggatgaa gaaatgactg aaatcctaaa
     2761 gactgagttc cagatgcgat tgttgtgggg cagcaagggt gctgaagtca accagaacga
     2821 gagatatgac aagttcaacc agatcctaac tgccctctca cggaaactgg aacctccttc
     2881 tggaaagcag gctgagctgt gagaaccttc tggaggaccc cggggcacaa cctggagctt
     2941 ccccagcccc tcctccggga atgcttatca tctgataaag taataccgtg caaaatctaa
     3001 cgagatgcaa gccatcaata tccgtaggat attaaatgtg tagattgcac agagcacact
     3061 tatttatgaa ttgtttaaaa ttactactga tttttaaatg aatgttaatt tattattaag
     3121 ataactattg ctaatgtgga tcagcaaatt taagacccag ctatgttgct ggttgtttaa
     3181 tatcatggta tttgaccatc ttagttttaa ttccatgtca catacatgta aacagaggca
     3241 tttaaaagga aagcatgaaa cattgaagag ggtatcagtt atatgatatt ctttgatatg
     3301 aaactgtaaa tagtgaatgg aaatatatct ttttgtg
//
