LOCUS       NM_001395122            3151 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus BCAR1 scaffold protein, Cas family member
            (Bcar1), transcript variant 1, mRNA.
ACCESSION   NM_001395122 XM_006255628
VERSION     NM_001395122.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Oh,M.J., Yi,S.J., Kim,H.S., Kim,J.H., Jeong,Y.H., van Agthoven,T.
            and Jhun,B.H.
  TITLE     Functional roles of BCAR3 in the signaling pathways of insulin
            leading to DNA synthesis, membrane ruffling and GLUT4 translocation
  JOURNAL   Biochem Biophys Res Commun 441 (4), 911-916 (2013)
   PUBMED   24216110
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Evans,I.M., Yamaji,M., Britton,G., Pellet-Many,C., Lockie,C.,
            Zachary,I.C. and Frankel,P.
  TITLE     Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is
            essential for growth factor-dependent migration of glioma and
            endothelial cells
  JOURNAL   Mol Cell Biol 31 (6), 1174-1185 (2011)
   PUBMED   21245381
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Tazaki,T., Sasaki,T., Uto,K., Yamasaki,N., Tashiro,S., Sakai,R.,
            Tanaka,M., Oda,H., Honda,Z. and Honda,H.
  TITLE     p130Cas, Crk-associated substrate plays essential roles in liver
            development by regulating sinusoidal endothelial cell fenestration
  JOURNAL   Hepatology 52 (3), 1089-1099 (2010)
   PUBMED   20623582
  REMARK    GeneRIF: Cas plays pivotal roles in liver development through the
            reorganization of the actin cytoskeleton and formation of fenestrae
            in sinusoidal endothelial cells.
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Rufanova,V.A., Alexanian,A., Wakatsuki,T., Lerner,A. and Sorokin,A.
  TITLE     Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and
            regulates human glomerular mesangial cell adhesion and spreading
  JOURNAL   J Cell Physiol 219 (1), 45-56 (2009)
   PUBMED   19086031
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Yudin,D., Hanz,S., Yoo,S., Iavnilovitch,E., Willis,D., Gradus,T.,
            Vuppalanchi,D., Segal-Ruder,Y., Ben-Yaakov,K., Hieda,M., Yoneda,Y.,
            Twiss,J.L. and Fainzilber,M.
  TITLE     Localized regulation of axonal RanGTPase controls retrograde injury
            signaling in peripheral nerve
  JOURNAL   Neuron 59 (2), 241-252 (2008)
   PUBMED   18667152
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Liu,F., Hill,D.E. and Chernoff,J.
  TITLE     Direct binding of the proline-rich region of protein tyrosine
            phosphatase 1B to the Src homology 3 domain of p130(Cas)
  JOURNAL   J Biol Chem 271 (49), 31290-31295 (1996)
   PUBMED   8940134
REFERENCE   7  (bases 1 to 3151)
  AUTHORS   Harte,M.T., Hildebrand,J.D., Burnham,M.R., Bouton,A.H. and
            Parsons,J.T.
  TITLE     p130Cas, a substrate associated with v-Src and v-Crk, localizes to
            focal adhesions and binds to focal adhesion kinase
  JOURNAL   J Biol Chem 271 (23), 13649-13655 (1996)
   PUBMED   8662921
REFERENCE   8  (bases 1 to 3151)
  AUTHORS   Vuori,K., Hirai,H., Aizawa,S. and Ruoslahti,E.
  TITLE     Introduction of p130cas signaling complex formation upon
            integrin-mediated cell adhesion: a role for Src family kinases
  JOURNAL   Mol Cell Biol 16 (6), 2606-2613 (1996)
   PUBMED   8649368
REFERENCE   9  (bases 1 to 3151)
  AUTHORS   Ribon,V. and Saltiel,A.R.
  TITLE     Nerve growth factor stimulates the tyrosine phosphorylation of
            endogenous Crk-II and augments its association with p130Cas in
            PC-12 cells
  JOURNAL   J Biol Chem 271 (13), 7375-7380 (1996)
   PUBMED   8631760
REFERENCE   10 (bases 1 to 3151)
  AUTHORS   Sakai,R., Iwamatsu,A., Hirano,N., Ogawa,S., Tanaka,T., Mano,H.,
            Yazaki,Y. and Hirai,H.
  TITLE     A novel signaling molecule, p130, forms stable complexes in vivo
            with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
  JOURNAL   EMBO J 13 (16), 3748-3756 (1994)
   PUBMED   8070403
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Jun 4, 2021 this sequence version replaced XM_006255628.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212404.1, FQ221713.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760494,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000019.1  56623059-56623190   c
            133-765             JAXUCZ010000019.1  56600837-56601469   c
            766-927             JAXUCZ010000019.1  56593784-56593945   c
            928-1044            JAXUCZ010000019.1  56593463-56593579   c
            1045-2142           JAXUCZ010000019.1  56591385-56592482   c
            2143-2232           JAXUCZ010000019.1  56590646-56590735   c
            2233-3151           JAXUCZ010000019.1  56588500-56589418   c
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..3151
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /note="BCAR1 scaffold protein, Cas family member"
                     /db_xref="GeneID:25414"
                     /db_xref="RGD:2406"
     exon            1..132
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2745
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast cancer anti-estrogen resistance protein 1;
                     CRK-associated substrate; v-crk-associated tyrosine kinase
                     substrate; breast cancer anti-estrogen resistance 1;
                     BCAR1, Cas family scaffolding protein; BCAR1, Cas family
                     scaffold protein"
                     /codon_start=1
                     /product="breast cancer anti-estrogen resistance protein 1
                     isoform 1"
                     /protein_id="NP_001382051.1"
                     /db_xref="GeneID:25414"
                     /db_xref="RGD:2406"
                     /translation="MTVPNVLAKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWW
                     LCSLHGRQGIVPGNRLKILVGMYDKKPAAPGPGPPATPPQPQPSLPQGVHTPVPPASQ
                     YSPMLPTAYQPQPDNVYLVPTPSKTQQGLYQAPGPNPQFQSPPAKQTSTFSKQTPHHS
                     FPSPATDLYQVPPGPGSPAQDIYQVPPSAGTGHDIYQVPPSLDTRSWEGTKPPAKVVV
                     PTRVGQGYVYEASQAEQDEYDTPRHLLAPGSQDIYDVPPVRGLLPNQYGQEVYDTPPM
                     AVKGPNGRDPLLDVYDVPPSVEKGLPPSNHHSVYDVPPSVSKDVPDGPLLREETYDVP
                     PAFAKPKPFDPTRHPLILAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYD
                     VPRERVLPPEVADGSVIDDGVYAVPPPAEREAPTDGKRLSASSTGSTRSSQSASSLEV
                     VVPGREPLELEVAVETLARLQQGVSTTVAHLLDLVGSASGPGGWRSTSEPQEPPVQDL
                     KAAVAAVHGAVHELLEFARSAVSSATHTSDRTLHAKLSRQLQKMEDVYQTLVVHGQVL
                     DSGRGGPGFTLDDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKAPGPGPEGSSS
                     LHLNPTDKASSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKT
                     QKELLEKGNIVRQGKGQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLVPGRTGGL
                     GPSDRQLLLFYLEQCEANLTTLTDAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVF
                     IGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVDRVKE
                     LGHSTQQFRRVLGQLAAA"
     exon            133..765
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /inference="alignment:Splign:2.1.0"
     exon            766..927
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1044
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..2142
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2232
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..3151
                     /gene="Bcar1"
                     /gene_synonym="Cas; Crkas; P130CAS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcaacccgc gggcagcgga gagcgccggg accccgcgcc gggggctgtg agcggcgcgg
       61 gcccaccgag cccgagctag cccgcgccgc tgccgcaggg ccccgggagc ggtggccaag
      121 atgaccgtgc cgaacgtgct ggccaaagcc ctctatgaca acgtagctga gtctccggat
      181 gaactctcct tccgaaaggg tgacatcatg acagtgctcg agcgggacac tcagggcctg
      241 gatggctggt ggctctgctc actgcatggg cgccagggca ttgtgcctgg taaccgcctc
      301 aagattctgg ttggcatgta tgacaagaag ccagcagcac ctggaccagg cccacctgcc
      361 accccacccc agccccagcc cagccttccc cagggcgtcc atactccagt gcctccagct
      421 tcccagtaca gtcccatgct ccccactgca taccaacccc aacctgacaa tgtgtacctg
      481 gtacccactc ccagcaagac tcagcaaggt ctctaccaag cccctgggcc caacccacag
      541 ttccagtcac ccccagccaa acaaacatcc acattctcaa agcaaacacc tcatcactca
      601 tttcccagcc ctgccacaga cctttaccag gtgcctccag ggcctggaag tccagcccag
      661 gacatttacc aggtgccacc ttccgctggc acagggcatg acatctacca agtccctcca
      721 tctttggaca cccgcagctg ggagggaacg aagccaccgg caaaggtggt ggtacctact
      781 cgagtgggac agggctatgt gtacgaggcc tcccaggcag aacaggatga gtacgacacc
      841 ccgcgccacc tgctagctcc aggttcccag gacatctatg atgtgccccc tgttcgagga
      901 ctgcttccca accagtatgg ccaggaggta tatgacaccc cgcctatggc agtcaaaggc
      961 cccaatggcc gagacccgtt gttggatgtg tatgacgtgc cccctagtgt ggagaaaggc
     1021 ctgccgccgt ccaaccatca ttcggtgtat gatgttcctc cttctgtgag caaggatgtg
     1081 cctgatggcc cactgctgcg tgaggaaaca tatgatgtac cccctgcctt cgccaaaccc
     1141 aagccttttg atccgacccg acatccatta atcctcgctg cacctcctcc ggactcccca
     1201 ccagctgagg atgtgtatga tgtgccaccc cctgctcctg acctctatga tgtgccccct
     1261 ggtttgcggc ggcctggccc tggaacactg tatgacgtgc ctcgagagcg ggtgctccct
     1321 cctgaggtgg ctgatgggag tgtaattgat gatggtgtgt atgctgtgcc cccaccagcc
     1381 gagcgagagg cgccaacaga tggcaagcgc ctgtcggcct ctagcacggg cagcacacgc
     1441 agcagccaat cggcgtcttc cttggaggta gtggtgccag gtcgggagcc cctggagctg
     1501 gaagttgctg tggagaccct ggctcggcta cagcagggtg tgagcaccac cgtagcccac
     1561 cttctggacc tggtgggcag tgccagtggc cccgggggct ggcgtagtac ctctgagccc
     1621 caggagcctc ccgtgcagga cctgaaagct gcagtggccg cagttcatgg ggcagtacat
     1681 gagctcctgg agtttgcccg cagtgcagtg agcagtgcca ctcacacttc tgaccgcact
     1741 ttgcacgcca agcttagccg gcagctacag aagatggagg atgtgtacca gacactggtg
     1801 gtccatggtc aggtccttga cagtggccgg ggaggtccag gattcactct ggacgacctg
     1861 gaccgcctgg tggcctgctc acgggctgtg cccgaggatg ccaagcagct ggcctccttt
     1921 ttgcatggta atgcctcgct gcttttcaga cggaccaaag cccctggccc cgggcctgag
     1981 ggcagcagct ccctgcacct caaccccacc gataaagcca gcagcatcca gtcacgccct
     2041 ctaccctcac ctccaaagtt cacctcccag gactctccgg atggccagta tgagaacagt
     2101 gaagggggtt ggatggagga ctatgactac gttcatctgc aggggaagga ggaatttgag
     2161 aagacccaga aggaactgct ggaaaagggc aacatcgtgc gacagggaaa aggccaactg
     2221 gagctgcagc agctgaaaca gtttgagcga ctggagcagg aggtgtctcg tcccatagac
     2281 catgacctgg ccaactggac accagcccag ccccttgtgc cggggcggac agggggactg
     2341 gggccttcag accgacagct gctgctcttc tacttggagc agtgtgaggc caacctgacc
     2401 acactgacag atgcggtgga cgccttcttc accgcagtgg ccaccaacca gccacccaag
     2461 atctttgtgg cacacagcaa gtttgtcatt cttagtgcac acaagcttgt gttcattggg
     2521 gacacactgt cacggcaggc aaaggcagct gatgtgcgaa gccaagtgac ccactacagc
     2581 aatctgctgt gtgacctcct gcgtggcatc gtggccacca ccaaggccgc tgccctgcag
     2641 tacccatccc catctgctgc ccaggacatg gtagacaggg tcaaggagct aggccacagc
     2701 actcagcagt tccgccgtgt cctgggccag ctggctgccg cctgaaagca gaagactggg
     2761 ctgtgaggct ggggagtggg tagcggtggt gtgagctacc caggcgctcg tcttgaagtg
     2821 gagatcctgc aggtttgggg acaggtaacc ccagctctgc tttgggcctg gtgccctcaa
     2881 ctgtccaggg atttgtacat atttatatca aggcaggatg cagaatgcct cctcggagag
     2941 gctgaggagc cccgtcagag tggaccatgg gctgggatca ccagggttgg ggcacatggg
     3001 ctccagtcca cagggctccc tgggacagga agtacagtgt ggtgtacacc tctgcaccaa
     3061 gaaaacctaa agaactattt ttcactattg atttttttcc aatcatttga ctaatagtct
     3121 acatttaata aaattttaaa aatgagaagg a
//
