LOCUS       NM_001033665            3280 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus brevican (Bcan), transcript variant 1, mRNA.
ACCESSION   NM_001033665 XM_579358
VERSION     NM_001033665.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3280)
  AUTHORS   Wohl,S.G., Jorstad,N.L., Levine,E.M. and Reh,T.A.
  TITLE     Muller glial microRNAs are required for the maintenance of glial
            homeostasis and retinal architecture
  JOURNAL   Nat Commun 8 (1), 1603 (2017)
   PUBMED   29150673
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3280)
  AUTHORS   Favuzzi,E., Marques-Smith,A., Deogracias,R., Winterflood,C.M.,
            Sanchez-Aguilera,A., Mantoan,L., Maeso,P., Fernandes,C., Ewers,H.
            and Rico,B.
  TITLE     Activity-Dependent Gating of Parvalbumin Interneuron Function by
            the Perineuronal Net Protein Brevican
  JOURNAL   Neuron 95 (3), 639-655 (2017)
   PUBMED   28712654
REFERENCE   3  (bases 1 to 3280)
  AUTHORS   Dwyer,C.A., Bi,W.L., Viapiano,M.S. and Matthews,R.T.
  TITLE     Brevican knockdown reduces late-stage glioma tumor aggressiveness
  JOURNAL   J Neurooncol 120 (1), 63-72 (2014)
   PUBMED   25052349
  REMARK    GeneRIF: High Brevican expression is associated with glioma tumor
            aggressiveness.
REFERENCE   4  (bases 1 to 3280)
  AUTHORS   Lu,R., Wu,C., Guo,L., Liu,Y., Mo,W., Wang,H., Ding,J., Wong,E.T.
            and Yu,M.
  TITLE     The role of brevican in glioma: promoting tumor cell motility in
            vitro and in vivo
  JOURNAL   BMC Cancer 12, 607 (2012)
   PUBMED   23253190
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3280)
  AUTHORS   Morales,D.M., Townsend,R.R., Malone,J.P., Ewersmann,C.A.,
            Macy,E.M., Inder,T.E. and Limbrick,D.D. Jr.
  TITLE     Alterations in protein regulators of neurodevelopment in the
            cerebrospinal fluid of infants with posthemorrhagic hydrocephalus
            of prematurity
  JOURNAL   Mol Cell Proteomics 11 (6), M111.011973 (2012)
   PUBMED   22186713
REFERENCE   6  (bases 1 to 3280)
  AUTHORS   Aspberg,A., Miura,R., Bourdoulous,S., Shimonaka,M., Heinegard,D.,
            Schachner,M., Ruoslahti,E. and Yamaguchi,Y.
  TITLE     The C-type lectin domains of lecticans, a family of aggregating
            chondroitin sulfate proteoglycans, bind tenascin-R by
            protein-protein interactions independent of carbohydrate moiety
  JOURNAL   Proc Natl Acad Sci U S A 94 (19), 10116-10121 (1997)
   PUBMED   9294172
REFERENCE   7  (bases 1 to 3280)
  AUTHORS   Yamada,H., Watanabe,K., Shimonaka,M., Yamasaki,M. and Yamaguchi,Y.
  TITLE     cDNA cloning and the identification of an aggrecanase-like cleavage
            site in rat brevican
  JOURNAL   Biochem Biophys Res Commun 216 (3), 957-963 (1995)
   PUBMED   7488217
REFERENCE   8  (bases 1 to 3280)
  AUTHORS   Seidenbecher,C.I., Richter,K., Rauch,U., Fassler,R., Garner,C.C.
            and Gundelfinger,E.D.
  TITLE     Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs
            as secreted and cell surface glycosylphosphatidylinositol-anchored
            isoforms
  JOURNAL   J Biol Chem 270 (45), 27206-27212 (1995)
   PUBMED   7592978
REFERENCE   9  (bases 1 to 3280)
  AUTHORS   Jaworski,D.M., Kelly,G.M. and Hockfield,S.
  TITLE     The CNS-specific hyaluronan-binding protein BEHAB is expressed in
            ventricular zones coincident with gliogenesis
  JOURNAL   J Neurosci 15 (2), 1352-1362 (1995)
   PUBMED   7869103
REFERENCE   10 (bases 1 to 3280)
  AUTHORS   Jaworski,D.M., Kelly,G.M. and Hockfield,S.
  TITLE     BEHAB, a new member of the proteoglycan tandem repeat family of
            hyaluronan-binding proteins that is restricted to the brain
  JOURNAL   J Cell Biol 125 (2), 495-509 (1994)
   PUBMED   7512973
  REMARK    Erratum:[J Cell Biol 1997 Apr 21;137(2):521]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z28366.1, CB577797.1, U37142.1, CB784255.1 and CB810773.1.
            
            On Sep 22, 2005 this sequence version replaced XM_579358.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U37142.1, X79881.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                Z28366.1           6-21
            17-210              CB577797.1         26-219
            211-2679            U37142.1           15-2483
            2680-2811           CB784255.1         100-231
            2812-3026           U37142.1           2616-2830
            3027-3280           CB810773.1         152-405
FEATURES             Location/Qualifiers
     source          1..3280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3280
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /note="brevican"
                     /db_xref="GeneID:25393"
                     /db_xref="RGD:2194"
     exon            1..237
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            238..346
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2907
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; brevican (brain specific proteoglycan in the
                     aggrecan family); brevican core protein; brain-enriched
                     hyaluronan-binding protein; brevican core protein-like"
                     /codon_start=1
                     /product="brevican core protein isoform 1 precursor"
                     /protein_id="NP_001028837.1"
                     /db_xref="GeneID:25393"
                     /db_xref="RGD:2194"
                     /translation="MIPLLLSLLAALVLTQAPAALADDLKEDSSEDRAFRVRIGAAQL
                     RGVLGGALAIPCHVHHLRPPPSRRAAPGFPRVKWTFLSGDREVEVLVARGLRVKVNEA
                     YRFRVALPAYPASLTDVSLVLSELRPNDSGVYRCEVQHGIDDSSDAVEVKVKGVVFLY
                     REGSARYAFSFAGAQEACARIGARIATPEQLYAAYLGGYEQCDAGWLSDQTVRYPIQN
                     PREACYGDMDGYPGVRNYGVVGPDDLYDVYCYAEDLNGELFLGAPPGKLTWEEARDYC
                     LERGAQIASTGQLYAAWNGGLDRCSPGWLADGSVRYPIITPSQRCGGGLPGVKTLFLF
                     PNQTGFPSKQNRFNVYCFRDSAHPSAFSEASSPASDGLEAIVTVTEKLEELQLPQEAV
                     ESESRGAIYSIPITEDGGGGSSTPEDPAEAPRTPLESETQSVAPPTGSSEEEGEALEE
                     EERFKDTETPKEEKEQENLWVWPTELSSPLPTGLETEHSLSQVSPPAQAVLQLGASPS
                     PRPPRVHGPPAETLQPPREGSLTSTPDGAREVAGETGSPELSGVPRESEEAGSSSLED
                     GPSLLPATWAPVGTRELETPSEEKSGRTVLTGTSVQAQPVLPTDSASRGGVAVAPSSG
                     DCIPSPCHNGGTCLEEKEGFRCLCLPGYGGDLCDVGLHFCSPGWEAFQGACYKHFSTR
                     RSWEEAESQCRALGAHLTSICTPEEQDFVNDRYREYQWIGLNDRTIEGDFLWSDGAPL
                     LYENWNPGQPDSYFLSGENCVVMVWHDQGQWSDVPCNYHLSYTCKMGLVSCGPPPQLP
                     LAQIFGRPRLRYAVDTVLRYRCRDGLAQRNLPLIRCQENGLWEAPQISCVPRRPARAL
                     RSMTAPEGPRGQLPRQRKALLTPPSSL"
     exon            347..718
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            719..893
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1021
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1315
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1537
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..2125
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2233
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2392
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2475
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2620
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2811
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..3269
                     /gene="Bcan"
                     /gene_synonym="ALPBRE; BEHAB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgcgcaga gaagggagcg ggtcccgtga ccgcgcagag ccccccacgg gggcggcaaa
       61 ggccggggac ggcggggaag gcggggcgcg tgggaagaaa gggggttttg tgcggctccc
      121 ggcgagctgg cgcccccgtc tgcgtcccgc gcgcccggcc ctgctcgcgc ccgcgcattg
      181 cgccgcagtc tcggctgcgg ctgcgggacg cgcggtgtgt ggaggggacc tcacaagttc
      241 ttccaagttt gcagcatgat cccattgctt ctgtccctgc tggcagctct ggtcctgacc
      301 caagcccctg cagccctcgc tgatgacctg aaagaagaca gctcagagga tcgagccttt
      361 cgggtgcgca tcggtgccgc gcagctgcgg ggtgtgctgg gcggtgccct ggccatccca
      421 tgccacgtcc accacctgag gccgccgccc agccgccggg ccgcgccggg ctttccccga
      481 gtcaaatgga ccttcctgtc cggggaccgg gaggtggagg tgctggtggc gcgcgggctg
      541 cgcgtcaagg taaacgaagc ctatcggttc cgcgtggcgc tgcctgccta ccccgcatcg
      601 ctcacagatg tgtctttagt attgagcgaa ctgcggccca atgattccgg ggtctatcgc
      661 tgcgaggtcc agcacggtat cgacgacagc agtgatgctg tggaagtcaa ggtcaaaggg
      721 gtcgtcttcc tctaccgaga gggctctgcc cgctatgctt tctccttcgc tggagcccag
      781 gaagcctgtg ctcgcatcgg agcccgaatt gccacccctg agcagctgta tgctgcctac
      841 ctcggcggct atgaacagtg tgatgctggc tggctgtccg accaaaccgt gaggtacccc
      901 atccagaacc cacgagaagc ctgttatgga gacatggatg gctaccctgg agtgcggaat
      961 tacggagtgg tgggtcctga tgatctctac gatgtctact gttatgccga agacctaaat
     1021 ggagaactgt tcctaggtgc ccctcccggc aagctgacgt gggaggaggc tcgggactac
     1081 tgtctggaac gcggtgctca gatcgctagc acgggccagc tatacgcggc atggaatggc
     1141 ggcttggaca gatgtagccc tggctggctg gctgatggca gtgtgcggta ccccatcatc
     1201 acgcccagcc aacgctgtgg gggaggcctg ccaggagtca agaccctctt cctctttccc
     1261 aaccagactg gcttccccag caagcagaac cgcttcaatg tctactgctt ccgagactct
     1321 gcccatccct ctgccttctc tgaggcctcc agcccagcct ctgatggact agaggccatt
     1381 gtcacagtga cagagaagct ggaggaactg cagttgcctc aggaagctgt ggagagcgag
     1441 tctcgtgggg cgatctactc catccccatc acagaagatg ggggaggagg aagctctacc
     1501 ccagaagacc cagcagaggc ccccaggact cctctagaat cagaaaccca atccgttgca
     1561 ccacctaccg ggtcctcaga agaggaaggc gaagccctgg aggaagaaga aagattcaaa
     1621 gacacagaga ctccgaagga agagaaggag caggagaacc tgtgggtgtg gcccacggag
     1681 ctcagcagcc ctctccctac tggcttggaa acagagcact cactctccca ggtgtcccca
     1741 ccagcccagg cagttctaca gctgggtgca tcaccttctc ccaggcctcc aagggtccat
     1801 ggaccgcctg cagagacttt gcaaccccca agggagggaa gcctcacatc tactccagat
     1861 ggggcaagag aagtagcggg ggaaactggg agccctgagc tctctggggt tcctcgagaa
     1921 agcgaggagg caggaagctc cagcttggag gatggccctt ccctccttcc agcgacatgg
     1981 gcccctgtgg gtaccaggga gctggagacc ccctcagaag agaagtctgg aagaactgtt
     2041 ctgacaggca catcagtgca ggcccagcca gtgctgccca ccgacagtgc cagccgaggt
     2101 ggagtggctg tggctccctc atcaggtgac tgtatcccca gcccctgcca caatggtggg
     2161 acatgcttgg aggagaagga gggtttccgc tgcctctgtt tgccaggcta tgggggggac
     2221 ctgtgcgatg ttggcctcca cttctgcagc ccgggctggg aggccttcca gggtgcctgc
     2281 tacaagcact tttccacacg aaggagttgg gaggaggcag aaagccagtg ccgagcgcta
     2341 ggggctcatc tgaccagcat ctgcacccct gaggagcagg actttgtcaa cgatcgatac
     2401 agggagtacc agtggattgg gctcaatgac aggaccatcg agggtgactt cctgtggtca
     2461 gatggtgccc ctctgctcta tgaaaactgg aaccctgggc agcctgacag ctacttcctg
     2521 tctggggaga actgtgtggt catggtgtgg catgaccagg gacagtggag tgatgtaccc
     2581 tgcaactacc acctatccta cacctgcaag atggggcttg tgtcatgtgg acctccacca
     2641 cagctgcccc tggctcaaat atttggtcgc cctcggctgc gctacgcggt ggacactgtg
     2701 cttcgatatc ggtgccgaga cgggctggcc cagcgcaact tgccgttgat ccgctgccag
     2761 gagaatgggc tttgggaggc ccctcagatt tcttgcgtgc cccgaagacc tgcccgtgct
     2821 ctccgctcaa tgaccgcccc agaaggacca cggggacagc tcccgaggca gaggaaagca
     2881 ctgttgacac ctccctccag tctctaggga acaggcgtgg aagactactg cccccaccag
     2941 ggccctctca cttcaactgc ctgtgctctt ccctatgata gggggttgac aagagagggg
     3001 tgggactgga attcagagga caagcgcccg aaggggtttc tgggaaacac ttgggtgact
     3061 ccgcccaacc tagaccccgc cccctcatac aagggcctca ggttttaccc ggtaagtccc
     3121 taagtgcctc aactgccttc tgctgtcagc tgcctccttg tttctcgatt tctttagggg
     3181 acactgtgct actcgttctt aattttcaaa gggtttttag gatggagtac cagcaaaacc
     3241 aggtggaaat aaagttgttt gaacccaaaa aaaaaaaaaa
//
