LOCUS       NM_031752               2390 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus basal cell adhesion molecule (Lutheran blood
            group) (Bcam), mRNA.
ACCESSION   NM_031752
VERSION     NM_031752.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2390)
  AUTHORS   Liu,M., Liao,L., Gao,Y., Yin,Y., Wei,X., Xu,Q., Gao,L. and Zhou,R.
  TITLE     BCAM Deficiency May Contribute to Preeclampsia by Suppressing the
            PIK3R6/p-STAT3 Signaling
  JOURNAL   Hypertension 79 (12), 2830-2842 (2022)
   PUBMED   36252138
  REMARK    GeneRIF: BCAM Deficiency May Contribute to Preeclampsia by
            Suppressing the PIK3R6/p-STAT3 Signaling.
REFERENCE   2  (bases 1 to 2390)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 2390)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 2390)
  AUTHORS   Piteau,M., Papatheodorou,P., Schwan,C., Schlosser,A., Aktories,K.
            and Schmidt,G.
  TITLE     Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli
            Cytotoxic Necrotizing Factor 1 (CNF1)
  JOURNAL   PLoS Pathog 10 (1), e1003884 (2014)
   PUBMED   24453976
  REMARK    Erratum:[PLoS Pathog. 2014 Jan;10(1).
            doi:10.1371/annotation/6eec6403-e090-4283-aa34-34cc58ca0bbb]
REFERENCE   5  (bases 1 to 2390)
  AUTHORS   Akiyama,H., Iwahana,Y., Suda,M., Yoshimura,A., Kogai,H.,
            Nagashima,A., Ohtsuka,H., Komiya,Y. and Tashiro,F.
  TITLE     The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene
  JOURNAL   PLoS One 8 (11), e78716 (2013)
   PUBMED   24223164
  REMARK    GeneRIF: Data indicate that the 14-3-3beta-FBI1/Akirin2 complex
            bound to the basal cell adhesion molecule (BCAM) promoter and
            repressed transcription.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2390)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 2390)
  AUTHORS   Vainionpaa,N., Kikkawa,Y., Lounatmaa,K., Miner,J.H., Rousselle,P.
            and Virtanen,I.
  TITLE     Laminin-10 and Lutheran blood group glycoproteins in adhesion of
            human endothelial cells
  JOURNAL   Am J Physiol Cell Physiol 290 (3), C764-C775 (2006)
   PUBMED   16236823
REFERENCE   8  (bases 1 to 2390)
  AUTHORS   Moulson,C.L., Li,C. and Miner,J.H.
  TITLE     Localization of Lutheran, a novel laminin receptor, in normal,
            knockout, and transgenic mice suggests an interaction with laminin
            alpha5 in vivo
  JOURNAL   Dev Dyn 222 (1), 101-114 (2001)
   PUBMED   11507772
REFERENCE   9  (bases 1 to 2390)
  AUTHORS   El Nemer,W., Gane,P., Colin,Y., D'Ambrosio,A.M., Callebaut,I.,
            Cartron,J.P. and Van Kim,C.L.
  TITLE     Characterization of the laminin binding domains of the Lutheran
            blood group glycoprotein
  JOURNAL   J Biol Chem 276 (26), 23757-23762 (2001)
   PUBMED   11319237
REFERENCE   10 (bases 1 to 2390)
  AUTHORS   Rahuel,C., Colin,Y., Goossens,D., Gane,P., El Nemer,W.,
            Cartron,J.P. and Le Van Kim,C.
  TITLE     Characterization of a mouse liminin receptor gene homologous to the
            human blood group Lutheran gene
  JOURNAL   Immunogenetics 50 (5-6), 271-277 (1999)
   PUBMED   10630290
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072479.1.
            
            On Jun 20, 2004 this sequence version replaced NM_031752.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072479.1, AB035510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676788, SAMN16676789
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..2390
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /note="basal cell adhesion molecule (Lutheran blood
                     group)"
                     /db_xref="GeneID:78958"
                     /db_xref="RGD:68378"
     exon            1..73
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1884
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /note="Lutheran blood group (Auberger b antigen included);
                     lutheran antigen; B-CAM cell surface glycoprotein"
                     /codon_start=1
                     /product="basal cell adhesion molecule precursor"
                     /protein_id="NP_113940.1"
                     /db_xref="GeneID:78958"
                     /db_xref="RGD:68378"
                     /translation="MEPPDARAGLLWLTLLLSGYSGAQAELHVSVPPRVEVMRGEQIA
                     LDCTPREHPENYVLEWLLVDASGARHRLASVEPQGSEFLGTIHNSRGRRPPYKIDSLG
                     RLVIAEAQVGDERDYVCVVKAGAAGTSEATSSVRVFATPEATEVAPNKGTLSVMEQFA
                     QEIATCSSNNGNPVPRITWYQNGQRLDVPMELNSKGYMTSRTVREASGLYSLTSTLYL
                     RLHKEDRDASFHCAAHYDLPSGQHGRLDSHTFRLTLHYPTEHVEFWVGSPSTTEGWVR
                     EGDAVQLLCQGDGSPSPEYSFFREQGNQEEQLNVNLKGNLTLEGVHRSQSGIYGCRVE
                     DYDADEEVQLVKKLKLHVAYLDPLELSVPEEFSVFLNSSGTVVNCSARGLPAPIVRWT
                     KDSVTVADGPILSLDSVTFDSAGTYTCEASTPTVPLLSRTQSFQLVVQGAPELKPNEI
                     KPKSGTSWTEGDEVMLTCSARGFPEPKLTWSQRGDTTPAEPPFEGRGWMSSSLTLKVT
                     SALSREGVSCEASNIHGKNGHVFHFGSVAPQTAQAGVAVMAVAVSVGLLLLVVAAFYC
                     MRRKGRPGCCQRAEKGAPPAREPELSHSGSERPEHTGLLMGGPSGGGRGGNGGFGDEC
                     "
     exon            74..195
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            196..424
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            425..495
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            496..592
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            593..775
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            776..912
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1069
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1188
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1330
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1470
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1615
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1760
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1878
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2359
                     /gene="Bcam"
                     /gene_synonym="Lu"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagggaata tggaaccccc tgacgcccgc gcagggctac tgtggctcac cctcctgctg
       61 tcgggctact caggtgccca ggctgagctg cacgtgtccg ttcccccacg ggtggaggtg
      121 atgcgagggg agcaaattgc cctggactgc acaccacggg agcatcctga gaattacgtg
      181 ctggagtggt tgcttgttga tgcttccggg gctcgacacc gtctggcttc tgtggaacca
      241 cagggctcag agttcctggg cacaatccac aactctcggg gccgcagacc cccatacaaa
      301 atagactccc ttgggcgttt ggtgatagca gaggcccagg tgggcgatga acgggactac
      361 gtgtgcgtag tgaaggctgg ggcagcaggt acctcagagg ccacttcaag tgtccgtgtg
      421 tttgcaacac cagaggctac ggaggtggct cccaacaaag ggacgctgtc cgtgatggaa
      481 cagtttgccc aggagatcgc cacctgcagc agcaacaacg gaaacccggt gcctcggatc
      541 acatggtacc agaacgggca gcgtctggat gtacccatgg agctgaactc aaagggctat
      601 atgaccagcc gaactgtccg ggaagcctca ggactgtatt ccctgaccag caccctctac
      661 ctgaggctcc acaaagagga tcgggatgcc agcttccact gtgctgctca ctacgacttg
      721 ccctcaggcc aacatggccg cctagacagc cataccttcc gcctcaccct gcactatccc
      781 acggagcatg tagaattctg ggtagggagc ccatctacca cagagggctg ggtacgtgag
      841 ggtgatgctg tccagctgct ctgccagggt gatggcagcc ccagcccgga gtattcattt
      901 tttcgagaac agggaaacca ggaggaacag ctgaatgtca acctcaaggg aaacttgacc
      961 ctggaggggg tgcatcggag ccagagcggg atctacggct gcagagtgga ggattacgat
     1021 gctgacgagg aggtgcaact tgtcaagaag ctaaagctgc acgtggccta cctggatccg
     1081 ttggagctga gcgtgcctga ggagttctct gtatttctga acagcagtgg cacggtggtg
     1141 aactgctctg ccagaggcct gcctgctcct attgtgcgct ggaccaagga ttctgtgacc
     1201 gttgcagatg gtcccatact ctctcttgac tctgtgacct tcgactcagc tggcacgtac
     1261 acgtgtgagg cgtccacacc cacagtcccc ctcctgagcc gcacacagag tttccagctt
     1321 gtggtccaag gagctccaga gttaaaacca aatgaaataa aacccaaatc aggcactagc
     1381 tggacggaag gcgatgaagt catgctgacc tgctctgccc ggggcttccc agagcccaaa
     1441 ctcacctgga gtcagcgagg agatactact ccagcagagc cgcccttcga gggtagaggc
     1501 tggatgagca gctcgctgac cttgaaagtc accagcgccc tgagccgaga gggcgtgtcc
     1561 tgcgaagctt ctaacatcca cggcaagaac ggtcacgtgt tccactttgg ctctgtggcc
     1621 cctcagactg cccaggctgg cgtggctgtc atggccgtgg cagtcagcgt cggtctcttg
     1681 ctactcgtag tcgctgcttt ctactgcatg agacgcaagg gacgccccgg ctgctgccag
     1741 cgagcagaga aaggggctcc gccagccagg gaaccggagt tgagccactc cgggtcagag
     1801 cgtccagaac acaccggcct tctcatgggt gggccctccg gaggaggcag aggtggcaac
     1861 gggggctttg gagatgagtg ttgaggctga ggacctccca gaggcagtct ctggatctgg
     1921 aactttgggc atcgtcagag gacctgctct gagcacgtct ctgcctcagc gcatgcctcc
     1981 gcctccttcc ttctccagcc tcggccctcc cttccttcct ctgcctgctg ggcagggacc
     2041 cacagtggcc agcggccttg gggagggaaa gagggaggtg ggggctggga gggggccttc
     2101 ctccagggaa tgtaactctc ccaggcccca gaatagctcc tggacccaag cccagggccc
     2161 ggcctgggac acagcgctga gggtcggcag gccggggtta tttttacctc ctgtctccct
     2221 tgctgggcac taccccccac ctgataccct gctgtgtagt ctgacactgg agtccccaac
     2281 ccaccccttc cctgccttca tcctcagccc atcatttgtg aacactggac tctgaaataa
     2341 atgctgtctg tcacgtggaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
