LOCUS       NM_001079938            2991 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus BBX high mobility group box domain containing
            (Bbx), mRNA.
ACCESSION   NM_001079938 XM_001058096 XM_001058155 XM_001058221 XM_001058282
            XM_001058348 XM_001058412 XM_221497
VERSION     NM_001079938.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Wang,C.Y., Tang,M.C., Chang,W.C., Furushima,K., Jang,C.W.,
            Behringer,R.R. and Chen,C.M.
  TITLE     PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial
            Role of Bbx in Growth and Male Fertility
  JOURNAL   Biol Reprod 95 (3), 51 (2016)
   PUBMED   27465138
  REMARK    GeneRIF: These results suggest that loss of BBX induces apoptosis
            of postmeiotic spermatids and results in spermiogenesis defects and
            infertility.
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Bassett,J.H., Gogakos,A., White,J.K., Evans,H., Jacques,R.M., van
            der Spek,A.H., Ramirez-Solis,R., Ryder,E., Sunter,D., Boyde,A.,
            Campbell,M.J., Croucher,P.I. and Williams,G.R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid-throughput skeletal phenotyping of 100 knockout mice
            identifies 9 new genes that determine bone strength
  JOURNAL   PLoS Genet 8 (8), e1002858 (2012)
   PUBMED   22876197
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129113.1.
            
            On or before Jan 11, 2007 this sequence version replaced
            XM_221497.4, XM_001058155.1, XM_001058348.1, XM_001058221.1,
            XM_001058282.1, XM_001058412.1, XM_001058096.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132266, SAMD00132286
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2991
                     /gene="Bbx"
                     /note="BBX high mobility group box domain containing"
                     /db_xref="GeneID:303970"
                     /db_xref="RGD:1309769"
     exon            1..189
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            190..360
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..2925
                     /gene="Bbx"
                     /note="bobby sox homolog; BBX, HMG-box containing; HMG box
                     transcription factor BBX-like"
                     /codon_start=1
                     /product="HMG box transcription factor BBX"
                     /protein_id="NP_001073407.1"
                     /db_xref="GeneID:303970"
                     /db_xref="RGD:1309769"
                     /translation="MKGSNRNKDHSAEGEGAGKRPKRKCLQWHPLLAKKLLDFSEEEE
                     EDEEEEDIDKVQLVEADGLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEH
                     PRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYRWCPTTNKPVKSP
                     TPTVNPRKKLWAFPSDSSRDLPTAKKAKTEEVPQLNFGMADPTQMGGLSMLLLAGEHA
                     LGTPEASSGTCRPDISESPELRQKSPLFQFAEISSRTSHPDAPSKQCQASALFQFAEI
                     SSSTSQLGGTEPVKRCGNSALFQLAEMCLASEGVKMEGTELTKSKDSDGGRIEEMEKG
                     KEERDMKMEKTIETAFQAEAEFGKSAKGNIREPKDLRDIEQLQSDNVMAIKVEDPKDS
                     RKESDDDQKYSHFPDFSYSASSKIIISDVPSRKDHMCHPHGIMIIEDPTALNKPEKIK
                     KKKKKNKLDRHGNDRSTPKKACKKRQSSESDIESVMYTIEAVAKGDWGADRLGETPRK
                     KVRTSSSGKGGILDAKPPKKKVKSKEKKVSKEKCSDITKESRPPDFLNISASKSVPGE
                     VPESMKAEPLTPTEDALPPSLPGQAKPEDSDCHRKTETCGSRKSERSCKGALYKTLVS
                     EGMLTSLRANVDRGKRSSGKGNSSDHEGCWSEESWTFNQSGTSGSKKFKKKLREDSFL
                     GSAKLDEEFEKKFNSLPQYSPITFDRKCVSIPRKKKKTGNMSSESTKASKGSGDKWSH
                     KQFFLDAIHPTEAIFSEDKNTTEPAYKVKNALSIPNTPEPTAMQEPLVGSQKRKARKT
                     KITHLVRTADGRVSPAGGTLDDKPKEQLQRRLPKVPETFCGDNCSHTTVEEPRSSTPE
                     MPAVSAFFSLAALAEVAAMENVHRGQRSTQLTHDGQPKEMPQAPVLISCADQ"
     exon            361..603
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            604..799
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            800..867
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            868..948
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1023
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1104
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..2110
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2246
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2395
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2455
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2653
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2837
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2964
                     /gene="Bbx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctctgg acatgcatct tactttctta cctggaagca gtgaggcagt caagaaccat
       61 gtgctatcag agctggtctc agccctttct catccgatgg attcaccttt catgttgatc
      121 ggggaagtgt gacccttgta cagtttttca tgtcagtgtt tttgtgtgta acattttaat
      181 cttcatcaag tcacagtaat gaaaggcagt aatagaaata aagatcattc agcagaagga
      241 gaaggggccg gaaaacgacc aaaacggaag tgtcttcagt ggcatccgtt gctagccaag
      301 aaacttctgg acttttcaga agaggaggag gaagacgagg aagaagaaga tattgataaa
      361 gttcaacttg ttgaggcgga tggcctagag caagatgttg gtgagactga agatgatgag
      421 tcaccagagc agcgagcccg gagaccaatg aatgcgtttc ttttattttg caagcgccat
      481 cgatcccttg tccgacagga acacccaagg cttgataacc gaggtgctac caagatacta
      541 gctgactggt gggctgttct tgatccaaag gaaaagcaga aatatacaga catggccaag
      601 gagtataaag atgcatttat gaaagcaaat cctggctaca gatggtgccc taccacaaac
      661 aagcccgtga agtcgccaac acccactgtc aatccacgga agaaactctg ggccttccca
      721 tctgactcct caagagactt gccaaccgct aagaaggcaa agacagaaga agttcctcag
      781 cttaactttg gaatggcaga tcctactcag atgggaggcc tgagcatgtt gctgctagct
      841 ggagaacatg ctcttggaac gccagaggca tcctctggga cttgcaggcc tgatatttca
      901 gagtcacctg agttgcgtca gaagtcacca ttgtttcagt ttgccgagat atcctccagg
      961 acatcccacc ccgatgctcc ttcaaaacag tgtcaagcat cagccttgtt tcagtttgca
     1021 gagatctctt caagcacttc gcagttgggt ggcactgagc ctgtgaaacg ctgtggaaat
     1081 tctgcactct ttcaactggc agagatgtgc ctggcgtcag agggcgtaaa aatggaaggc
     1141 acagagctaa ccaagtccaa agactccgac ggaggacgaa tcgaggagat ggaaaagggg
     1201 aaggaagagc gagacatgaa aatggagaaa accattgaaa ctgcgttcca ggcggaagca
     1261 gaattcggga agtcagcaaa gggcaacatc agagagccca aggacttaag agacattgaa
     1321 cagctacagt cggataacgt aatggctatc aaagtggaag accccaaaga cagtagaaag
     1381 gagtcagacg acgatcagaa atacagccac ttccctgatt tttcttactc tgccagtagc
     1441 aagataataa ttagtgatgt ccccagtaga aaggaccaca tgtgccaccc tcacggaatc
     1501 atgattattg aggaccccac tgcactaaac aaaccagaaa agataaaaaa gaagaagaag
     1561 aaaaacaaac tggatcgaca tggaaacgac aggtccaccc ccaagaaggc ctgcaagaag
     1621 aggcagtctt cagagtcgga catcgagagt gtcatgtaca ccatcgaagc ggtagcgaag
     1681 ggagactggg gtgctgacag actcggagaa accccaagaa agaaagtccg cacctcctca
     1741 agtggcaagg ggggcatttt ggatgccaag ccaccaaaga aaaaagtgaa atccaaggag
     1801 aagaaggttt ccaaggagaa gtgctcagac atcaccaaag agtctcgacc tccagatttc
     1861 cttaacattt ctgccagcaa gagtgttcct ggggaggtgc cagagagcat gaaagcagaa
     1921 cccttgacgc ctacagagga tgcactgcca cctagcctac caggacaggc taagcctgag
     1981 gacagtgact gccacagaaa aacggagacc tgtggctcca ggaaatctga gaggtcttgc
     2041 aaaggtgctc tttataaaac cctggtgtcc gagggcatgc tcacctccct gcgagctaat
     2101 gttgacagag ggaaacgaag ctcaggaaaa ggaaactcct ctgatcatga agggtgttgg
     2161 agtgaagaga gctggacatt taatcagagt gggaccagtg gaagcaagaa gtttaaaaag
     2221 aagctaaggg aagactcctt ccttggttct gcaaagctgg atgaggaatt tgaaaagaaa
     2281 ttcaacagcc tccctcaata tagtcctatt acatttgacc ggaaatgtgt atctattcca
     2341 aggaaaaaga agaagactgg aaacatgtcc tcagaatcga ctaaagccag caaaggaagt
     2401 ggggataaat ggtcacacaa gcaatttttc ttggatgcca ttcaccctac agaagccata
     2461 ttttcagaag ataaaaacac cacagagcct gcttataaag ttaaaaatgc cctatccatt
     2521 cccaacactc cagagccaac agcaatgcaa gaacctttgg tgggcagcca aaagagaaaa
     2581 gcaaggaaaa ccaagatcac acaccttgtc aggactgcag atggccgagt ctcaccagca
     2641 ggaggtacac tggatgacaa accaaaggag cagctgcaga ggcgtctccc caaagtcccc
     2701 gagacattct gcggtgataa ttgctcacac actacggttg aggagccacg gagcagtact
     2761 ccagaaatgc ctgctgtgtc tgcattcttt agtctcgctg cactggctga ggttgcagcc
     2821 atggagaatg tgcacagagg tcagaggtca actcaactca cccatgatgg acagccaaaa
     2881 gaaatgccgc aggctcctgt acttatttct tgcgctgacc agtgacgcgc cctttaattg
     2941 taaaacattg tgctttacct tctaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
