LOCUS       NM_001012180            2719 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Bardet-Biedl syndrome 7 (Bbs7), mRNA.
ACCESSION   NM_001012180 XM_342230
VERSION     NM_001012180.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2719)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2719)
  AUTHORS   Zhang,Y., Seo,S., Bhattarai,S., Bugge,K., Searby,C.C., Zhang,Q.,
            Drack,A.V., Stone,E.M. and Sheffield,V.C.
  TITLE     BBS mutations modify phenotypic expression of CEP290-related
            ciliopathies
  JOURNAL   Hum Mol Genet 23 (1), 40-51 (2014)
   PUBMED   23943788
REFERENCE   3  (bases 1 to 2719)
  AUTHORS   Zhang,Q., Yu,D., Seo,S., Stone,E.M. and Sheffield,V.C.
  TITLE     Intrinsic protein-protein interaction-mediated and
            chaperonin-assisted sequential assembly of stable bardet-biedl
            syndrome protein complex, the BBSome
  JOURNAL   J Biol Chem 287 (24), 20625-20635 (2012)
   PUBMED   22500027
REFERENCE   4  (bases 1 to 2719)
  AUTHORS   Zhang,Q., Seo,S., Bugge,K., Stone,E.M. and Sheffield,V.C.
  TITLE     BBS proteins interact genetically with the IFT pathway to influence
            SHH-related phenotypes
  JOURNAL   Hum Mol Genet 21 (9), 1945-1953 (2012)
   PUBMED   22228099
REFERENCE   5  (bases 1 to 2719)
  AUTHORS   Gascue,C., Tan,P.L., Cardenas-Rodriguez,M., Libisch,G.,
            Fernandez-Calero,T., Liu,Y.P., Astrada,S., Robello,C., Naya,H.,
            Katsanis,N. and Badano,J.L.
  TITLE     Direct role of Bardet-Biedl syndrome proteins in transcriptional
            regulation
  JOURNAL   J Cell Sci 125 (Pt 2), 362-375 (2012)
   PUBMED   22302990
REFERENCE   6  (bases 1 to 2719)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 2719)
  AUTHORS   Seo,S., Baye,L.M., Schulz,N.P., Beck,J.S., Zhang,Q., Slusarski,D.C.
            and Sheffield,V.C.
  TITLE     BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family
            chaperonins and mediate BBSome assembly
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1488-1493 (2010)
   PUBMED   20080638
REFERENCE   8  (bases 1 to 2719)
  AUTHORS   Nachury,M.V., Loktev,A.V., Zhang,Q., Westlake,C.J., Peranen,J.,
            Merdes,A., Slusarski,D.C., Scheller,R.H., Bazan,J.F.,
            Sheffield,V.C. and Jackson,P.K.
  TITLE     A core complex of BBS proteins cooperates with the GTPase Rab8 to
            promote ciliary membrane biogenesis
  JOURNAL   Cell 129 (6), 1201-1213 (2007)
   PUBMED   17574030
REFERENCE   9  (bases 1 to 2719)
  AUTHORS   Forti,E., Aksanov,O. and Birk,R.Z.
  TITLE     Temporal expression pattern of Bardet-Biedl syndrome genes in
            adipogenesis
  JOURNAL   Int J Biochem Cell Biol 39 (5), 1055-1062 (2007)
   PUBMED   17379567
REFERENCE   10 (bases 1 to 2719)
  AUTHORS   Badano,J.L., Ansley,S.J., Leitch,C.C., Lewis,R.A., Lupski,J.R. and
            Katsanis,N.
  TITLE     Identification of a novel Bardet-Biedl syndrome protein, BBS7, that
            shares structural features with BBS1 and BBS2
  JOURNAL   Am J Hum Genet 72 (3), 650-658 (2003)
   PUBMED   12567324
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081968.1.
            
            On Feb 11, 2005 this sequence version replaced XM_342230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081968.1, SRR8487227.206661.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..2719
                     /gene="Bbs7"
                     /note="Bardet-Biedl syndrome 7"
                     /db_xref="GeneID:361930"
                     /db_xref="RGD:1309264"
     exon            1..138
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2250
                     /gene="Bbs7"
                     /codon_start=1
                     /product="Bardet-Biedl syndrome 7 protein"
                     /protein_id="NP_001012180.1"
                     /db_xref="GeneID:361930"
                     /db_xref="RGD:1309264"
                     /translation="MDLTLSRADYLQVGVTSQKTMKLLPTSRQRATQKVVIGDQDGVV
                     MCFGMKKGEAVSVFKTLPGQKVSRLELGGALNTPQEKIFIAAGSEIRGFTKRGKQFLS
                     FETNLTESIKAMYISGSDLFLSASYIYNHYCDCKDQNYYLSGDKINDVICLPVERLSR
                     VTPVLACQDRVLRVLQGSDVTYEIEVPGPPTVLALHNGDGGDSGEGLLFGTSDGRLGL
                     IQITASKPIHKWEIRNDKKRGGILCLDSFDIMGDGVKDLLVGRDDGMVEVYSFENANE
                     PVLRFDQMLSESVTSVQGGCVGKDGYDEIVLATYSGWVTGLTTEPTHKESGPGEELKL
                     NQEMQNKIASLRTELEHLQLKVLQERENYQQSSQSSQAKSTVPSFSINDKFTLNKDDA
                     SYSLVLEVRTAIDNVLIQSDVPIDLLDVDKNSAVVSFSSCDTESNDNFLLATYRCQAN
                     TTRLELKIRSIEGQYGTLQAYVTPRIQPKTCQVRQYHIKPLSLHQRTHFIDHDRPMNT
                     LTLTGQFSFAEVHSWAVLCLPEVPEKPPAGECATFYFQNTFLDTQLECAYRKGEGIFK
                     SDNISTISILKDVLSKEATKRKINLNISYEINEVSVKHTLKLIHPKLEYQLLLAKKVQ
                     LIDALKELQVHEGNTSFLIPEYRCILEEADHLQEEYKKQPAHLERLYGMITDLFIDKF
                     KFKGTNVKTKVPVLLEILDSYDQNTLISFFDAA"
     exon            139..204
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            205..267
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            268..443
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            444..630
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            631..703
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            704..820
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            821..951
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1036
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1139
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1332
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1407
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1473
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1613
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1778
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1888
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1992
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2116
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2262
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2695
                     /gene="Bbs7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgcccca acactagcgc ctagtcctag gtctagtggt gggctctccg ggggaaggct
       61 tcctctttag caagcgggtc cggccccttc cttgcggtcg ccatggatct gacgttaagc
      121 cgagcagact atctccaggt aggagtgacc tctcagaaga ctatgaagtt gcttcctacc
      181 tcaagacaaa gagctacaca aaaggtggtc attggagatc aagatggggt ggtgatgtgc
      241 ttcggcatga agaaaggcga ggcggtgtca gtgttcaaga ctttaccagg gcagaaggtt
      301 tccaggctgg aactaggagg ggctctgaat acgcctcagg agaaaatctt cattgctgca
      361 gggtccgaga ttagaggctt tacaaagaga gggaaacagt ttctctcttt tgaaacaaac
      421 ctcacagaaa gcattaaagc tatgtatata tctggctccg acctcttcct cagtgccagc
      481 tacatctata atcactactg tgactgcaaa gaccaaaact attacctttc tggggacaaa
      541 atcaatgatg tcatctgcct tcctgtggaa aggttatccc gtgtgacacc ggtgttggcc
      601 tgccaggaca gggttctccg agtcttacag ggatctgatg tgacgtatga aatcgaggtt
      661 cctggtccac ccactgtctt agcgctgcat aatggagacg gaggtgactc tggggaaggt
      721 cttctgttcg gcacatcaga tggaaggctt gggcttattc agatcacagc atccaaacca
      781 atacacaaat gggaaattcg aaatgacaaa aagcggggag gtatcttgtg tcttgacagc
      841 tttgatatca tgggtgatgg ggttaaagat ttacttgttg ggagagatga tggaatggtg
      901 gaagtgtata gttttgagaa tgcaaatgaa cccgtgctac gatttgatca gatgctgtct
      961 gaaagtgtca catcagtcca gggtggctgt gtagggaaag atggttatga cgaaatcgtg
     1021 ctggccacgt attcaggctg ggtgacaggg ctgactacag agcccactca taaggaaagt
     1081 gggccaggag aagaactgaa actcaatcag gaaatgcaga ataagattgc ttctttaagg
     1141 actgaattag aacatctgca gttgaaggtg cttcaggaga gagaaaatta ccaacagtct
     1201 tcacagtcga gccaagcaaa gtcaacagtc ccttcattca gtataaacga caagttcaca
     1261 ttgaataaag atgatgctag ctacagcctt gtgttagagg tgcggactgc aatagataat
     1321 gtcttaatac agagtgatgt tccaatagac ctactcgatg tggataagaa ttctgctgtt
     1381 gtgagcttta gcagctgtga cacagagtca aacgacaact tccttctcgc cacttatcgg
     1441 tgccaggcaa acaccaccag gctggagctc aagatccgtt caattgaagg ccagtatggc
     1501 acactccagg catatgtgac tccaagaatc caaccgaaaa cctgtcaggt tcgccagtac
     1561 cacatcaaac ctctgtcgct ccatcaaaga actcacttta ttgaccacga caggcccatg
     1621 aacacgctga ctctaacagg ccagttcagc ttcgccgagg ttcactcctg ggccgtgctc
     1681 tgcctgcctg aagtgccgga aaagcctcca gcgggggaat gtgcaacttt ctactttcag
     1741 aatacctttc tggacacaca gctggagtgt gcatacagaa aaggagaagg aatctttaaa
     1801 tctgacaaca tctctacaat atccatccta aaagatgtgc tttctaaaga agctacaaaa
     1861 aggaaaatta atctcaacat atcatacgag ataaatgaag tgtcagtcaa gcatacttta
     1921 aagctaattc acccaaagtt ggagtaccag ttgcttctgg ctaagaaagt acagttaatt
     1981 gatgccttga aggaattaca ggttcatgag ggaaatacaa gctttctgat tccagagtat
     2041 cgctgtatcc tagaagaggc tgatcatcta caagaggaat acaaaaagca gcctgcccat
     2101 cttgaaagac tctatggtat gattactgat cttttcatag ataaatttaa gttcaaaggc
     2161 actaatgtaa aaaccaaagt acctgtactc ctggagattc tcgacagcta tgaccagaac
     2221 acactgattt ctttctttga tgcagcatga aagataaaca aggatttgga aggattccca
     2281 ttttctcttc cttggtgaca tgatcctcct gaaatctgaa atacttggct tagtgctgta
     2341 gactgtggcc agcaaagtaa gcagagcctg atcagacctg agggacctca gatggatgtc
     2401 tttcctgtgt gtaaccagaa gagtgatggc ttcaaagatt cccccctact agtatccaca
     2461 aaactccttc ttattgtaca cgtgagggaa aaaagaagac ttaaaagcaa cagaagtttt
     2521 agtcattcat ttcaggggaa tattgcattg aaagttttaa aatactaaaa aaataagaga
     2581 aaataagctg tcttttgttt tcaaagggta aatatgaatt tttcagaaaa caataattac
     2641 attttattat attttatgtg caattcttaa atattaaata cgaacattta aggcaaaaaa
     2701 aaaaaaaaaa aaaaaaaaa
//
