LOCUS       NM_001108583            1393 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Bardet-Biedl syndrome 5 (Bbs5), mRNA.
ACCESSION   NM_001108583 XM_001057589 XM_342442
VERSION     NM_001108583.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1393)
  AUTHORS   Zhang,B., Wang,G., Xu,X., Yang,S., Zhuang,T., Wang,G., Ren,H.,
            Cheng,S.Y., Jiang,Q. and Zhang,C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   2  (bases 1 to 1393)
  AUTHORS   Karlstetter,M., Sorusch,N., Caramoy,A., Dannhausen,K.,
            Aslanidis,A., Fauser,S., Boesl,M.R., Nagel-Wolfrum,K., Tamm,E.R.,
            Jagle,H., Stoehr,H., Wolfrum,U. and Langmann,T.
  TITLE     Disruption of the retinitis pigmentosa 28 gene Fam161a in mice
            affects photoreceptor ciliary structure and leads to progressive
            retinal degeneration
  JOURNAL   Hum Mol Genet 23 (19), 5197-5210 (2014)
   PUBMED   24833722
REFERENCE   3  (bases 1 to 1393)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1393)
  AUTHORS   Zhang,Q., Yu,D., Seo,S., Stone,E.M. and Sheffield,V.C.
  TITLE     Intrinsic protein-protein interaction-mediated and
            chaperonin-assisted sequential assembly of stable bardet-biedl
            syndrome protein complex, the BBSome
  JOURNAL   J Biol Chem 287 (24), 20625-20635 (2012)
   PUBMED   22500027
REFERENCE   5  (bases 1 to 1393)
  AUTHORS   Gascue,C., Tan,P.L., Cardenas-Rodriguez,M., Libisch,G.,
            Fernandez-Calero,T., Liu,Y.P., Astrada,S., Robello,C., Naya,H.,
            Katsanis,N. and Badano,J.L.
  TITLE     Direct role of Bardet-Biedl syndrome proteins in transcriptional
            regulation
  JOURNAL   J Cell Sci 125 (Pt 2), 362-375 (2012)
   PUBMED   22302990
REFERENCE   6  (bases 1 to 1393)
  AUTHORS   Seo,S., Zhang,Q., Bugge,K., Breslow,D.K., Searby,C.C., Nachury,M.V.
            and Sheffield,V.C.
  TITLE     A novel protein LZTFL1 regulates ciliary trafficking of the BBSome
            and Smoothened
  JOURNAL   PLoS Genet 7 (11), e1002358 (2011)
   PUBMED   22072986
REFERENCE   7  (bases 1 to 1393)
  AUTHORS   Jin,H., White,S.R., Shida,T., Schulz,S., Aguiar,M., Gygi,S.P.,
            Bazan,J.F. and Nachury,M.V.
  TITLE     The conserved Bardet-Biedl syndrome proteins assemble a coat that
            traffics membrane proteins to cilia
  JOURNAL   Cell 141 (7), 1208-1219 (2010)
   PUBMED   20603001
REFERENCE   8  (bases 1 to 1393)
  AUTHORS   Seo,S., Baye,L.M., Schulz,N.P., Beck,J.S., Zhang,Q., Slusarski,D.C.
            and Sheffield,V.C.
  TITLE     BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family
            chaperonins and mediate BBSome assembly
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1488-1493 (2010)
   PUBMED   20080638
REFERENCE   9  (bases 1 to 1393)
  AUTHORS   Nachury,M.V., Loktev,A.V., Zhang,Q., Westlake,C.J., Peranen,J.,
            Merdes,A., Slusarski,D.C., Scheller,R.H., Bazan,J.F.,
            Sheffield,V.C. and Jackson,P.K.
  TITLE     A core complex of BBS proteins cooperates with the GTPase Rab8 to
            promote ciliary membrane biogenesis
  JOURNAL   Cell 129 (6), 1201-1213 (2007)
   PUBMED   17574030
REFERENCE   10 (bases 1 to 1393)
  AUTHORS   Li,J.B., Gerdes,J.M., Haycraft,C.J., Fan,Y., Teslovich,T.M.,
            May-Simera,H., Li,H., Blacque,O.E., Li,L., Leitch,C.C., Lewis,R.A.,
            Green,J.S., Parfrey,P.S., Leroux,M.R., Davidson,W.S., Beales,P.L.,
            Guay-Woodford,L.M., Yoder,B.K., Stormo,G.D., Katsanis,N. and
            Dutcher,S.K.
  TITLE     Comparative genomics identifies a flagellar and basal body proteome
            that includes the BBS5 human disease gene
  JOURNAL   Cell 117 (4), 541-552 (2004)
   PUBMED   15137946
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC167024.1.
            
            On May 11, 2008 this sequence version replaced NM_001108583.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167024.1, SRR8487230.36548.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132264
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1393
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1393
                     /gene="Bbs5"
                     /note="Bardet-Biedl syndrome 5"
                     /db_xref="GeneID:362142"
                     /db_xref="RGD:1310718"
     exon            1..91
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1058
                     /gene="Bbs5"
                     /note="Bardet-Biedl syndrome 5 homolog"
                     /codon_start=1
                     /product="Bardet-Biedl syndrome 5 protein"
                     /protein_id="NP_001102053.1"
                     /db_xref="GeneID:362142"
                     /db_xref="RGD:1310718"
                     /translation="MSVLDVLWEDRDVRFDVSSQQMKTRPGEVLIDCLDSIEDTKGNN
                     GDRGRLLVTNLRIIWHSLALPRVNLSIGYNCILNITTRTANSKLRGQTEALYILTKCN
                     TTRFEFIFTNLVPGSPRLFTSVIAVHRAYETSKMYRDFKLRSAVIQNKQLRLLPQEHV
                     YDKINGVWNLSSDQGNLGTFFITNVRIVWHANMNDSFNVSIPYLQIRSIKIRDSKFGL
                     ALVIESSQQSGGYVLGFKIDPVEKLQESVKEINSLHKVYSASPIFGVNYEMEEKPQPL
                     EALTVEQIQDDVEIDSDDHTDAFVAYFADGNKQQDREPVFSEELGLAIEKLKDGVTLQ
                     GLWEVMS"
     exon            92..174
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            175..240
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            241..290
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            291..418
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            419..554
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            555..650
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            651..713
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            714..848
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            849..932
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            933..956
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1369
                     /gene="Bbs5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggatttta acggcgggct ccctcggtca ccatgtctgt gctggacgtg ttgtgggagg
       61 accgcgacgt gcgcttcgac gtgtcctcgc aacagatgaa aacaagacct ggggaagtcc
      121 ttattgattg tttagattct attgaagaca caaaaggaaa taatggagac agaggcagac
      181 tcttagtcac aaacttaagg atcatctggc attccttggc attacccaga gtcaatcttt
      241 ctattggcta caactgcata ttgaatatta caacaagaac tgccaactct aaactccgag
      301 gccagacgga agctctttat atattaacaa aatgcaacac cacccggttt gagtttatat
      361 tcacaaatct ggttcccggg agccccagac tttttacttc tgtgattgca gtgcacagag
      421 cctatgaaac atctaaaatg taccgtgatt ttaagctgag aagtgcagtc attcagaaca
      481 agcagctgag gttattacca caggaacatg tgtatgataa gatcaatggt gtgtggaatt
      541 tatccagcga ccaggggaat ttaggaactt tttttattac caatgtgaga attgtgtggc
      601 atgcaaatat gaatgacagt tttaatgtca gcataccata cctgcaaatc cgttcaataa
      661 agatcagaga ttcaaaattt ggcttggctc ttgtcataga aagctctcag cagagtggag
      721 gatatgttct tggctttaaa atagacccag tggaaaaact acaggaatca gttaaggaga
      781 tcaactcact tcacaaagtc tattctgcca gcccgatatt tggagtgaat tatgaaatgg
      841 aagagaagcc acagccactt gaagctctga ctgttgaaca aattcaagat gatgtggaaa
      901 tagactctga tgaccacacg gatgcttttg tggcttactt tgctgatggg aataagcaac
      961 aagaccgtga acctgtattt tcagaagagc tggggcttgc catagagaag ctgaaggacg
     1021 gagtcacact acaggggctt tgggaagtga tgagttgatc ttgagttgag ctggatctct
     1081 gtttaaagat atctcacgat taaaagatac tgcttgcctg ctataggcat gagacagtta
     1141 tctatttata gcttttatat tttatatttt aagacttttt aataattaag gaaaaactcc
     1201 ttaattttag aaaactatca gttttctaaa agttacatta aaaattgtaa ctgaaatgta
     1261 ccagatctat aaatgtaaat attgtacctg acacttgtaa aaatagtaat tttcagatat
     1321 taaacaattg tatcatgttg catttaataa agatttttat gcagtaccaa aaaaaaaaaa
     1381 aaaaaaaaaa aaa
//
