LOCUS       NM_001106826            2510 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus Bardet-Biedl syndrome 4 (Bbs4), mRNA.
ACCESSION   NM_001106826 XM_001074984 XM_217154
VERSION     NM_001106826.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Zhang,B., Wang,G., Xu,X., Yang,S., Zhuang,T., Wang,G., Ren,H.,
            Cheng,S.Y., Jiang,Q. and Zhang,C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Agassandian,K., Patel,M., Agassandian,M., Steren,K.E., Rahmouni,K.,
            Sheffield,V.C. and Card,J.P.
  TITLE     Ciliopathy is differentially distributed in the brain of a
            Bardet-Biedl syndrome mouse model
  JOURNAL   PLoS One 9 (4), e93484 (2014)
   PUBMED   24695551
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Chamling,X., Seo,S., Searby,C.C., Kim,G., Slusarski,D.C. and
            Sheffield,V.C.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Ye,X., Zeng,H., Ning,G., Reiter,J.F. and Liu,A.
  TITLE     C2cd3 is critical for centriolar distal appendage assembly and
            ciliary vesicle docking in mammals
  JOURNAL   Proc Natl Acad Sci U S A 111 (6), 2164-2169 (2014)
   PUBMED   24469809
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Zhang,Y., Seo,S., Bhattarai,S., Bugge,K., Searby,C.C., Zhang,Q.,
            Drack,A.V., Stone,E.M. and Sheffield,V.C.
  TITLE     BBS mutations modify phenotypic expression of CEP290-related
            ciliopathies
  JOURNAL   Hum Mol Genet 23 (1), 40-51 (2014)
   PUBMED   23943788
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Nishimura,D.Y., Fath,M., Mullins,R.F., Searby,C., Andrews,M.,
            Davis,R., Andorf,J.L., Mykytyn,K., Swiderski,R.E., Yang,B.,
            Carmi,R., Stone,E.M. and Sheffield,V.C.
  TITLE     Bbs2-null mice have neurosensory deficits, a defect in social
            dominance, and retinopathy associated with mislocalization of
            rhodopsin
  JOURNAL   Proc Natl Acad Sci U S A 101 (47), 16588-16593 (2004)
   PUBMED   15539463
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Kulaga,H.M., Leitch,C.C., Eichers,E.R., Badano,J.L., Lesemann,A.,
            Hoskins,B.E., Lupski,J.R., Beales,P.L., Reed,R.R. and Katsanis,N.
  TITLE     Loss of BBS proteins causes anosmia in humans and defects in
            olfactory cilia structure and function in the mouse
  JOURNAL   Nat Genet 36 (9), 994-998 (2004)
   PUBMED   15322545
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Mykytyn,K., Mullins,R.F., Andrews,M., Chiang,A.P., Swiderski,R.E.,
            Yang,B., Braun,T., Casavant,T., Stone,E.M. and Sheffield,V.C.
  TITLE     Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in
            flagella formation but not global cilia assembly
  JOURNAL   Proc Natl Acad Sci U S A 101 (23), 8664-8669 (2004)
   PUBMED   15173597
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Kim,J.C., Badano,J.L., Sibold,S., Esmail,M.A., Hill,J.,
            Hoskins,B.E., Leitch,C.C., Venner,K., Ansley,S.J., Ross,A.J.,
            Leroux,M.R., Katsanis,N. and Beales,P.L.
  TITLE     The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar
            region and is required for microtubule anchoring and cell cycle
            progression
  JOURNAL   Nat Genet 36 (5), 462-470 (2004)
   PUBMED   15107855
REFERENCE   10 (bases 1 to 2510)
  AUTHORS   Ansley,S.J., Badano,J.L., Blacque,O.E., Hill,J., Hoskins,B.E.,
            Leitch,C.C., Kim,J.C., Ross,A.J., Eichers,E.R., Teslovich,T.M.,
            Mah,A.K., Johnsen,R.C., Cavender,J.C., Lewis,R.A., Leroux,M.R.,
            Beales,P.L. and Katsanis,N.
  TITLE     Basal body dysfunction is a likely cause of pleiotropic
            Bardet-Biedl syndrome
  JOURNAL   Nature 425 (6958), 628-633 (2003)
   PUBMED   14520415
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001074984.1, XM_217154.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2510
                     /gene="Bbs4"
                     /note="Bardet-Biedl syndrome 4"
                     /db_xref="GeneID:300754"
                     /db_xref="RGD:1309134"
     exon            1..53
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1592
                     /gene="Bbs4"
                     /note="Bardet-Biedl syndrome 4 homolog"
                     /codon_start=1
                     /product="Bardet-Biedl syndrome 4 protein"
                     /protein_id="NP_001100296.1"
                     /db_xref="GeneID:300754"
                     /db_xref="RGD:1309134"
                     /translation="MAEEKLGMKTQVPASIESQKPRPKKAPEFPIVEKLNWLIHLYYI
                     RKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQCAD
                     NLKQVARSLFLLGKHKAATEVYNEAAKLNQKDWEICHNLGVCYTYLKQFSKAQDQLHS
                     ALQLNKHDLTYIMLGKIHLLQGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGVY
                     QKAFEHLGNALTYDPANYKAILAAGSMMQTHGDFDVALTKYRVVACAIPESPPLWNNI
                     GMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQ
                     PKMGELYMLLAVALTNLEDIENAKRAYVEAVRLDKCNPLVNLNYAVLLYNQGEKKGAL
                     AQYQEMEKKVHFLKDNNPLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKHRTN
                     SGSKSATLQQPLGSFQALGQAMSSAAAHRKIPSGAVGAQLTKPPSLPLEPEPEPTVEA
                     SPTEASEQNKEK"
     exon            54..105
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            106..185
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            186..249
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            250..361
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            362..434
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            435..488
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            489..616
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..671
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            672..740
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            741..893
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1065
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1135
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1277
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1479
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..2510
                     /gene="Bbs4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggtttcga ggcggtgggc ggagccaaga tggctgagga gaagcttggg atgaaaactc
       61 aggttcctgc atctattgaa tctcaaaaac ccaggccaaa aaaagctcca gagtttccta
      121 ttgtggagaa gctgaactgg ctgatccatc tctactatat ccggaaggat tatgaggcgt
      181 gcaaggctgt gatcaaagaa cagcttcagg agactcaagg gctgtgtgaa tatgctattt
      241 atgtccaagc actgattttc cgcctggaag gaaatatcca agaatcccta gaactctttc
      301 agacgtgtgc tgttctcagc ccacagtgtg ctgataatct caagcaggtg gccagatctt
      361 tatttcttct gggaaaacat aaagccgcca cagaagtata taatgaagca gctaagctca
      421 accagaaaga ctgggagatc tgccataacc tgggagtgtg ctacacttac ctaaagcagt
      481 tcagcaaggc gcaagaccaa ttgcacagtg ccctccagct taacaagcat gacctgactt
      541 acattatgct ggggaagatc catttactgc agggagactt ggataaagcc attgagatct
      601 acaagaaagc agtggagttc tctccagaaa atacagaact tctcacaact ttaggattac
      661 tctacctaca gcttggtgtt taccagaagg catttgaaca ccttgggaat gcactgactt
      721 acgaccctgc caactacaag gccatcttgg cagcaggcag catgatgcag actcatgggg
      781 actttgatgt tgcccttacc aaatacagag ttgtagcttg tgctattcca gaaagtcctc
      841 cactttggaa taacattgga atgtgtttct ttggcaagaa gaaatacgtg gcagctatca
      901 gctgcctaaa acgagccaat tacttggcac ccttcgactg gaagattctg tacaatctgg
      961 gccttgtcca tttgaccatg cagcagtatg catcggcatt ccactttctc agcgcagcca
     1021 tcaacttcca gccaaagatg ggggaactct acatgctctt ggctgtggct ctgaccaacc
     1081 tggaagacat agaaaatgcc aaaagagctt atgtagaagc tgtccgcctg gataagtgca
     1141 accctttagt aaacctgaac tacgctgtgc tgctgtacaa ccagggtgag aagaagggtg
     1201 ccttggctca gtaccaggag atggagaaga aggtccattt tctcaaggac aacaatcctc
     1261 tggaatttga ttctgagatg gtagagatgg ctcagaagtt gggagctgcc ctccaggttg
     1321 gagaggcact ggtctggacc aagccagtca aagatcccaa gtcaaagcac cggaccaatt
     1381 caggcagcaa atctgctact ctccagcagc ctctgggctc ctttcaagct cttggacagg
     1441 cgatgtcttc ggcagctgca cacaggaaga tcccttcagg tgctgtagga gcccagctca
     1501 caaagccgcc atcacttcca ctggagccag agccagagcc cactgtggag gcgagtccaa
     1561 cagaagcatc agaacaaaac aaagaaaaat agcaacaaac atgaaaatcc aggatgaccc
     1621 tggagtaggg ggtgtctctt aagtgagacc atatagaagg tggtcacatg accaagcaga
     1681 tggaggccaa cacttcctcc ctgggtgggc agtgcagaat aaaacagaac ccagggtgtg
     1741 ttgtgatgat caggaggagc ccaagcagct cttggctggc cccatcatag gaacaaggga
     1801 gaagacatgc tacatagact tgaggtcctg catgtatact ccaagactca gcaaggcaaa
     1861 tgatgaaaga ccattactca gtgaaggact ttatcttgat aacgggaaaa gtactctact
     1921 cagtaggctg tggtgatgaa gcttcttcat tctaactgga ctgtgggaag acgtaagtct
     1981 ccactggaaa caaaccttgg attaagaacc tagttaaata cggcttcccc aaccaccacc
     2041 accaccacca caaccaccac caccaccacc acccctttta gattaagttg agatccaaac
     2101 tggaatgaat ccagctatat ctgcccaaag acaatctaaa acaagtcctt atctccattc
     2161 ttcagagagg tcagagtcta gagccagatc atgtcagttt aagtagagtc aaggactggt
     2221 caggaattgg cgccaagaat ttaaagaaaa aagtgggtag ggtgactgag gacatagctc
     2281 agtatcagag cacttgctta gcatacacaa ggccctgggt ttaatcccca gtactgatga
     2341 aaaagaacag agcttttcga taaggaattt taaccaagac aatcaatgat gaatgctgac
     2401 agatgctctc atggcccatt agcagccttt gtgaaagatt atggatctcc aagaggtcac
     2461 attaaaatat ttttaaaaaa ataaaactat gatcactgtc tgtttttacc
//
