LOCUS       NM_001109286            2667 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus Bardet-Biedl syndrome 10 (Bbs10), mRNA.
ACCESSION   NM_001109286 XM_001080833 XM_576222
VERSION     NM_001109286.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2667)
  AUTHORS   Lindstrand A, Davis EE, Carvalho CM, Pehlivan D, Willer JR, Tsai
            IC, Ramanathan S, Zuppan C, Sabo A, Muzny D, Gibbs R, Liu P, Lewis
            RA, Banin E, Lupski JR, Clark R and Katsanis N.
  TITLE     Recurrent CNVs and SNVs at the NPHP1 locus contribute pathogenic
            alleles to Bardet-Biedl syndrome
  JOURNAL   Am J Hum Genet 94 (5), 745-754 (2014)
   PUBMED   24746959
REFERENCE   2  (bases 1 to 2667)
  AUTHORS   Zhang Q, Yu D, Seo S, Stone EM and Sheffield VC.
  TITLE     Intrinsic protein-protein interaction-mediated and
            chaperonin-assisted sequential assembly of stable bardet-biedl
            syndrome protein complex, the BBSome
  JOURNAL   J Biol Chem 287 (24), 20625-20635 (2012)
   PUBMED   22500027
REFERENCE   3  (bases 1 to 2667)
  AUTHORS   Gascue C, Tan PL, Cardenas-Rodriguez M, Libisch G, Fernandez-Calero
            T, Liu YP, Astrada S, Robello C, Naya H, Katsanis N and Badano JL.
  TITLE     Direct role of Bardet-Biedl syndrome proteins in transcriptional
            regulation
  JOURNAL   J Cell Sci 125 (Pt 2), 362-375 (2012)
   PUBMED   22302990
REFERENCE   4  (bases 1 to 2667)
  AUTHORS   Mukherjee K, Conway de Macario E, Macario AJ and Brocchieri L.
  TITLE     Chaperonin genes on the rise: new divergent classes and intense
            duplication in human and other vertebrate genomes
  JOURNAL   BMC Evol Biol 10, 64 (2010)
   PUBMED   20193073
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2667)
  AUTHORS   Seo S, Baye LM, Schulz NP, Beck JS, Zhang Q, Slusarski DC and
            Sheffield VC.
  TITLE     BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family
            chaperonins and mediate BBSome assembly
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1488-1493 (2010)
   PUBMED   20080638
REFERENCE   6  (bases 1 to 2667)
  AUTHORS   Gerth C, Zawadzki RJ, Werner JS and Heon E.
  TITLE     Retinal morphology in patients with BBS1 and BBS10 related
            Bardet-Biedl Syndrome evaluated by Fourier-domain optical coherence
            tomography
  JOURNAL   Vision Res 48 (3), 392-399 (2008)
   PUBMED   17980398
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473960.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_576222.2, XM_001080833.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC160915.1, FQ211675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2667
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..2667
                     /gene="Bbs10"
                     /gene_synonym="RGD1560748"
                     /note="Bardet-Biedl syndrome 10"
                     /db_xref="GeneID:500832"
                     /db_xref="RGD:1560748"
     exon            1..233
                     /gene="Bbs10"
                     /gene_synonym="RGD1560748"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2190
                     /gene="Bbs10"
                     /gene_synonym="RGD1560748"
                     /codon_start=1
                     /product="Bardet-Biedl syndrome 10 protein"
                     /protein_id="NP_001102756.1"
                     /db_xref="GeneID:500832"
                     /db_xref="RGD:1560748"
                     /translation="MASQGSVTAALRVAEVLETIANRCVGPEGGLVLCTKPTGEVLLS
                     RDGGCLLEALHLEHPLARMIVACVSSHLKKTGDGAKTFIIFLCHLLRGLHAIGEKEKD
                     SFTSEDIQSHERHWKNCCQWKSISRALLRFQTQTLGCIVDQHLSRHYLSAFSSSAEGR
                     TLCRRSLELLLEPYFCGRVGRNNHRFISQLMCDYVFKCMACESGIEVFEFLDNCFVEL
                     NVGVTGLPVSESRIVDGLVLPRDFSVYCPADGGIRMVIVTEILQPLFSSSSSEFVLDS
                     ETQFQASQSWIMDRTKTVMNHLRSHNVKLLLSSVKQPDLVTYCARLNSISVVECLSSE
                     EVSLVQRITGLSPCVLPELASQCHIADSALVRFCKPLIVRSGRYAHLGLVSTCAFVPH
                     CVVLCGPVLGLVQQHESAFHGAFKMLRQLFTDLDLNCMIQTKERRNPSPLADSSNRES
                     SHSPKTGKYQDVVAKNKDKLETQTRLEVYPRLGASDTELITCKLWSAHKETSIDPSQT
                     NEIPKRLSPEKSRIVDNCEVFLENNPTGNPTAEDTRTEMSFKHLQVADNPGEGYTLPV
                     TYKSPDTCPSQAHCSSAVPAGCVLPVGGHFEILMHFYLLNYAKQCRQSDDAVISMLIA
                     NALLGVPKILYKPKKGKDSFPHIYTRALRALQTRQPIVSGQSGFESVAGKYQLLTSVL
                     QCLMKILTIDLIINVKRQPQKTGDQESEDEL"
     exon            234..2667
                     /gene="Bbs10"
                     /gene_synonym="RGD1560748"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catcggtcct gaccttctaa agaagtattt acccacagct ccgtttccat ggcgtcccag
       61 gggtctgtga cagcggcact gcgggtggct gaggtgctgg aaaccatcgc gaaccgctgc
      121 gtggggcccg agggcggcct ggtgttgtgt acgaagccca ccggcgaggt gctgcttagc
      181 agggatggag gttgcctcct ggaggcgctg cacttagagc atcccttagc caggatgata
      241 gtggcgtgtg tttccagtca ccttaaaaaa acaggagatg gtgctaaaac atttattatt
      301 tttctttgcc atttactcag aggacttcat gcaatcggag aaaaagaaaa agactcattc
      361 acttctgaag atattcagag ccatgaaagg cattggaaaa actgctgcca gtggaaatct
      421 atttcccggg ctctgctaag gtttcagaca caaacgttag gttgtattgt agaccaacat
      481 ttaagcaggc actacctctc tgccttttct tcatctgctg aaggaagaac actgtgcagg
      541 cgctctctgg agttgctcct ggaaccatac ttttgtggaa gagtgggaag aaacaaccac
      601 agattcattt cacagttgat gtgtgactac gttttcaagt gtatggcttg tgaaagtggg
      661 attgaagtat ttgagttttt ggacaactgt tttgtggagt tgaatgttgg cgtgacaggc
      721 cttcctgttt cagagtctag aattgtggat ggccttgtgc ttcccagaga cttttctgtg
      781 tactgcccag cagatggtgg cattaggatg gtgatagtaa ccgaaatcct ccagcctctg
      841 ttttcatcgt ctagctcgga atttgttctc gactcagaaa cacagtttca ggcatctcag
      901 agttggatca tggacaggac aaaaaccgta atgaaccacc tgcgtagtca taatgtaaaa
      961 ctgctcctgt ccagtgtgaa gcaaccagac ctagttactt attgtgcaag actaaatagc
     1021 atctcagtgg tggagtgttt atcatctgag gaagtttctc tcgtccagag gatcaccggt
     1081 ctttctcctt gtgtcctacc agagctcgct tcacagtgtc acattgctga cagtgctttg
     1141 gtgaggtttt gtaaacccct catcgttagg tccggaaggt atgctcatct cggcttggtt
     1201 agcacgtgtg cattcgtacc tcactgtgta gtcctttgtg gaccagttct gggtcttgtt
     1261 caacagcatg agagtgcttt ccatggagcc tttaagatgc ttcggcagct gttcactgac
     1321 ctcgatctaa attgcatgat acagaccaaa gagcgacgta acccgagccc tcttgctgac
     1381 agcagtaaca gagagagcag tcactcaccc aaaactggta agtatcagga cgtagtagca
     1441 aagaacaaag ataaactgga aactcaaaca cgtttagaag tatatccacg tctgggggct
     1501 tcggatacag aattgataac atgtaagctg tggtcagcac acaaggagac atcaatagat
     1561 ccatcccaaa caaatgaaat accgaagcgc ttatctccag aaaaaagtag gatagttgat
     1621 aactgtgaag tgttccttga aaataatccc actggaaatc ctacagcaga agacactagg
     1681 acagaaatgt ctttcaaaca tttacaggtc gcagataatc ctggagaagg gtacacattg
     1741 ccagtgacat acaagtcccc agatacctgt ccttcccagg ctcactgttc atcagctgta
     1801 ccagcaggct gtgttctgcc cgtgggtgga cattttgaga ttttgatgca tttctacctt
     1861 ctcaactacg ccaagcaatg ccggcaatca gacgacgctg tcatcagcat gttaatagct
     1921 aatgctcttc taggtgtccc taaaatcctt tataagccca agaagggaaa agacagtttc
     1981 ccacacatat acactcgggc tctccgtgca ctgcaaacca ggcaacccat agtaagtggt
     2041 cagtcaggct tcgagtcagt agctggtaag taccaattac taacttcagt tcttcagtgt
     2101 ttgatgaaaa tattaaccat tgatttaata atcaacgtca agagacagcc tcagaaaact
     2161 ggtgaccaag aatcagaaga cgaactttaa cactcaggtt ttttttgttg ttgttttttg
     2221 ttgttgttgt tgttgttgtt gatgttgttg ctcgaacttt cagtctatgg ccagggagat
     2281 ggcccagtga gcaaaagcat ttaatgccaa acctgactac ctggggtcaa cacccagggt
     2341 ggaaggagag gatgaaggaa aaatgtattc atctcaaggt aaatattaaa acaggcttct
     2401 ggctggcttt ggagccaatc ctgtccttaa atacattgag tccagcagac cattcagaca
     2461 cagagatcag ctctgtggaa caaaacctgg ctaaatatct ctccttcctg tctcgggtct
     2521 ctgctagtct ctgtgtaagg aaggttgtgt ctatatttcc cctttctgta tctttttttc
     2581 cacttcattt ccttgaactt tctgtctgtc atagagccag gtaatctcct gactatgtaa
     2641 agcagtaaat aaaagtcaaa tttccct
//
