LOCUS       NM_001107569            3750 bp    mRNA    linear   ROD 25-APR-2023
DEFINITION  Rattus norvegicus Bardet-Biedl syndrome 1 (Bbs1), mRNA.
ACCESSION   NM_001107569 XM_001069507 XM_219691
VERSION     NM_001107569.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3750)
  AUTHORS   Rouabhi M, Guo DF, Morgan DA, Zhu Z, Lopez M, Zingman L, Grobe JL
            and Rahmouni K.
  TITLE     BBSome ablation in SF1 neurons causes obesity without comorbidities
  JOURNAL   Mol Metab 48, 101211 (2021)
   PUBMED   33722691
REFERENCE   2  (bases 1 to 3750)
  AUTHORS   Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, Ren H, Cheng SY,
            Jiang Q and Zhang C.
  TITLE     DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like
            Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of
            the BBSome Protein during the Cell Cycle
  JOURNAL   J Biol Chem 292 (4), 1351-1360 (2017)
   PUBMED   27979967
REFERENCE   3  (bases 1 to 3750)
  AUTHORS   Chamling X, Seo S, Searby CC, Kim G, Slusarski DC and Sheffield VC.
  TITLE     The centriolar satellite protein AZI1 interacts with BBS4 and
            regulates ciliary trafficking of the BBSome
  JOURNAL   PLoS Genet 10 (2), e1004083 (2014)
   PUBMED   24550735
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3750)
  AUTHORS   Zhang Y, Seo S, Bhattarai S, Bugge K, Searby CC, Zhang Q, Drack AV,
            Stone EM and Sheffield VC.
  TITLE     BBS mutations modify phenotypic expression of CEP290-related
            ciliopathies
  JOURNAL   Hum Mol Genet 23 (1), 40-51 (2014)
   PUBMED   23943788
REFERENCE   5  (bases 1 to 3750)
  AUTHORS   Carter CS, Vogel TW, Zhang Q, Seo S, Swiderski RE, Moninger TO,
            Cassell MD, Thedens DR, Keppler-Noreuil KM, Nopoulos P, Nishimura
            DY, Searby CC, Bugge K and Sheffield VC.
  TITLE     Abnormal development of NG2+PDGFR-alpha+ neural progenitor cells
            leads to neonatal hydrocephalus in a ciliopathy mouse model
  JOURNAL   Nat Med 18 (12), 1797-1804 (2012)
   PUBMED   23160237
REFERENCE   6  (bases 1 to 3750)
  AUTHORS   Forti E, Aksanov O and Birk RZ.
  TITLE     Temporal expression pattern of Bardet-Biedl syndrome genes in
            adipogenesis
  JOURNAL   Int J Biochem Cell Biol 39 (5), 1055-1062 (2007)
   PUBMED   17379567
REFERENCE   7  (bases 1 to 3750)
  AUTHORS   Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch
            CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR,
            Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT,
            Dollfus H, Tada M, Katsanis N, Forge A and Beales PL.
  TITLE     Disruption of Bardet-Biedl syndrome ciliary proteins perturbs
            planar cell polarity in vertebrates
  JOURNAL   Nat Genet 37 (10), 1135-1140 (2005)
   PUBMED   16170314
  REMARK    Erratum:[Nat Genet. 2005 Dec;37(12):1381]
REFERENCE   8  (bases 1 to 3750)
  AUTHORS   Kulaga HM, Leitch CC, Eichers ER, Badano JL, Lesemann A, Hoskins
            BE, Lupski JR, Beales PL, Reed RR and Katsanis N.
  TITLE     Loss of BBS proteins causes anosmia in humans and defects in
            olfactory cilia structure and function in the mouse
  JOURNAL   Nat Genet 36 (9), 994-998 (2004)
   PUBMED   15322545
REFERENCE   9  (bases 1 to 3750)
  AUTHORS   Fan Y, Rahman P, Peddle L, Hefferton D, Gladney N, Moore SJ, Green
            JS, Parfrey PS and Davidson WS.
  TITLE     Bardet-Biedl syndrome 1 genotype and obesity in the Newfoundland
            population
  JOURNAL   Int J Obes Relat Metab Disord 28 (5), 680-684 (2004)
   PUBMED   14993910
REFERENCE   10 (bases 1 to 3750)
  AUTHORS   Mykytyn K, Nishimura DY, Searby CC, Beck G, Bugge K, Haines HL,
            Cornier AS, Cox GF, Fulton AB, Carmi R, Iannaccone A, Jacobson SG,
            Weleber RG, Wright AF, Riise R, Hennekam RC, Luleci G,
            Berker-Karauzum S, Biesecker LG, Stone EM and Sheffield VC.
  TITLE     Evaluation of complex inheritance involving the most common
            Bardet-Biedl syndrome locus (BBS1)
  JOURNAL   Am J Hum Genet 72 (2), 429-437 (2003)
   PUBMED   12524598
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473953.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_219691.4, XM_001069507.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3750
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3750
                     /gene="Bbs1"
                     /note="Bardet-Biedl syndrome 1"
                     /db_xref="GeneID:309156"
                     /db_xref="RGD:1307581"
     exon            1..90
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1825
                     /gene="Bbs1"
                     /note="Bardet-Biedl syndrome 1 homolog"
                     /codon_start=1
                     /product="Bardet-Biedl syndrome 1 protein"
                     /protein_id="NP_001101039.1"
                     /db_xref="GeneID:309156"
                     /db_xref="RGD:1307581"
                     /translation="MAATTSSPDSDSGRAESNEANSKWLDAHYDPMANIHTFSSCLAL
                     ADLHGDGEYKLVVGDLGPGGQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRT
                     PALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLEDI
                     REKAEVPLSVQSLRFLQLELNEMEAFVNQHKSKVIKRQTVITTMTTLKKNLADEDAVS
                     CLVLGTENKELLVLDPEAFTILTKMSLPSVPVFLEVSGQFDVEFRLTAACRDGSIYIL
                     RRDSKHPKYCIELSAQPVGLVRVHKILVVGSTQESLHGFTHKGKKLWTVQMPAAILTM
                     NLLEQRSRGLQAVMAALANGEVRIYRDKALLNVVRAPDAVTSLCFGRYGREDNTLIMT
                     TRGGGLIIKILKRTAVFVEGTGEVGPPLAQTTKLSVPRKTRLYVDQTLREREAGTVMH
                     RTFQTDLYLLRLRAARAYVQALESSLSPMSATAREPLKLHAVVQGLGPTFKLTLHLQN
                     TSTARPVLGLQVCFLYNEAFYALPRAFFKVPLLVPGLSYPLETFVESLSSKGISDIIK
                     VLVLREGQSAPLLSAHINMPVSEGLAAA"
     exon            91..167
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..202
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..475
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..522
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..561
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..634
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..766
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..873
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..994
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1153
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1223
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1382
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1516
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1651
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1738
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..3750
                     /gene="Bbs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggctggct gagctggttg ccaagacgac gcctgggaag atggctgcga cgacgtcttc
       61 accggattct gacagcgggc gagctgagag caacgaagcc aattcgaaat ggctggatgc
      121 acactacgac cccatggcca acatccatac cttctcctcc tgcctggcac tggcagattt
      181 gcatggcgac ggggagtaca agctggtggt gggagacctt ggcccaggtg ggcagcagcc
      241 ccgcctgaag gtgctcaaag gacccacagt gctgacagaa agcccactgc ctgccctgcc
      301 agcctcggct gccaccttcc tcatggacca acatgagccc aggacacctg ccttagcact
      361 cgcttcagga ccttgtgtct atgtttataa gaaccttcga ccctacttca agttcagcct
      421 gccccagtta cctccaaacc ctttggaaca agacctttgg aaccaagcca aagaggaccg
      481 gattgacccc ttaaccctga aggagatgct ggaggacatc agggaaaagg cagaggtgcc
      541 tttgtctgtg cagtcactca ggtttctgca gctggagctg aatgaaatgg aggcgtttgt
      601 gaaccagcac aagtccaagg ttatcaagcg tcagacagtc atcaccacca tgaccaccct
      661 gaagaagaac ctggcagatg aggatgcagt gtcctgtctg gtgctaggca ctgagaacaa
      721 ggagctccta gtgctggacc ctgaagcttt caccattttg accaagatga gcctgcccag
      781 tgtccctgtc ttcctggagg tttctggcca gtttgatgtg gagttccgat tgactgctgc
      841 ctgccgagat gggagcatct atatcctgag aagagactcc aaacacccca agtactgcat
      901 cgagttgagt gcccagcctg tggggctggt ccgggtacac aagatcctgg tggtgggcag
      961 cacccaagag agtctgcatg gcttcaccca caagggtaag aagctgtgga cggtgcagat
     1021 gcctgcagcc atcctgacca tgaaccttct ggagcagcga tcccgaggcc tgcaagctgt
     1081 catggccgct ttggccaatg gggaagtccg gatttaccgt gacaaggccc tgctcaatgt
     1141 cgtccgggcc cctgatgcag taaccagcct gtgctttggc cgatatggac gagaagataa
     1201 caccctcatc atgactacta gaggtggggg cctgatcatc aagatcctga agcgcacagc
     1261 agtgtttgtg gaagggacag gcgaggtggg cccaccgcta gcacagacaa caaaactcag
     1321 tgtgccccga aagacccggc tgtatgtgga tcagacccta cgggagcgag aagctggcac
     1381 agtcatgcac cggaccttcc agactgacct ctacctgctg cgtctacgag ctgccagagc
     1441 ctatgttcag gccctggagt ccagcctgag ccccatgtca gccacagctc gggagccact
     1501 caagctgcac gctgtggttc aaggcctggg ccccaccttt aagctcacac ttcacctgca
     1561 gaatacctca acggctcggc cagtactggg gctacaggtc tgcttcctgt acaacgaggc
     1621 attttatgcc ctgcctcggg ccttctttaa ggttcccttg ctggtgccag gactcagtta
     1681 cccactggag acctttgtag agagtctcag cagcaagggc atctcagaca taatcaaggt
     1741 gctcgtgctc cgggaaggcc agagtgcacc cctgctgagt gcccacatca acatgcctgt
     1801 gagtgaaggt ctggcagctg cctgagccct gggccagcat tcaagcctcc acaagatgaa
     1861 gccagtcaga tccagtgact tccagtgtca ccagactact tccccccaac agcagtgtag
     1921 tgagacatca gctccctgtt cctgtcagac agtcccttgc tccccacctc ggcaagtggg
     1981 cctgagcaac aagacatgga gtgttcagtc aggtcctccc ccctcagaac ccacccaatt
     2041 actgtccctt agttcctgat gcctaccact ctccccagct cttgaaagac acctccccag
     2101 gtcccaggac gagatctgag atggtcagtg taagcaaagc gccagtccat ccttcctccc
     2161 ctccttcctt cctccttcct tccttccttc cacttaccta tttcagatca aggccacagt
     2221 tgatcaaggg ctccagacgt cagctggtac caatccctct gctgcccttt gaagtttcag
     2281 ggacacggat gctgccagcc taatttacag gcacatgtgc taagcctcct cagctgaaga
     2341 gaggctccac tttctaccct gaagcccagc agtcacgggg ctctgtctta gagtagccac
     2401 agagattgcc tgaggaggtg atgtggaaga agggatctat gtgaggagct aggttcacac
     2461 agcagctgct cctgatgtgg atgctcctgt ccagagatag tgttctgaaa tggaatgcca
     2521 agcaagatag cacagctagg gctggtggca ccgggagagg tgtttctggg acctgggaag
     2581 tgacccaaga ggcagatgct gacaagtgcc tatcagaatg cacttaggtc caggagttca
     2641 agatggtcct gagggtggca tgtttactgt gcagtggcca gaatatgcct gagaccactg
     2701 aaaaggtaca cagcaggggt atggaataaa gctgaagact aaaggaagat gtgtttagat
     2761 ctcaagtgct gggacccctg gccctccaga ctattctgaa tcacttggga accaggagcc
     2821 ctgctccatg gagagcacat ttttctagtc gaatcaggtt cacctgctgt gtggcagcca
     2881 gctcagtctt gcaggcttcc acctcctctc cagtaaagac agacgttggc ccgcattaat
     2941 tctaaaccgt tgtcagctct aacaccatta gagcttggca gctcctcagg aggaaggaaa
     3001 gaattggtcc aagaaggtga tacgtcacta cacagctttt gtccacaaaa ccaatgtctc
     3061 caagctggcc accactgccc agtaacaacc tttgtgccca cccagggacc agggtgacac
     3121 tgcctacctt gtcccttcca agggtacttc aggagccaga ctaagagaca ctgagtctgg
     3181 accaaagaaa cagcccaagc cctcgagaca ggcactgtgt gagcaaggat agccaggggg
     3241 cacagcagga ctaagtggga ggtctgactg gagatgggag atgagaggtg ggaggagtgt
     3301 tgctgtgagt cagagacccc agcctaacct gcaacactaa acagggaagg aaggtctgcc
     3361 cgaggtgttg agccccttgt cactgtgccc cgtgtcactg gtgaatgggg ctatcacagg
     3421 gccaggtcgt gtgttggatc atgacactcc actttcaccc aagtcaagct gtgaaatcag
     3481 aacaaaaata tttgatgtgt gctctctcca taactatctg tgatgatcca aattggtgag
     3541 acatatgccc aggccctacc atgaaacaca gtgttgtatt actcttgcct agtaagaaat
     3601 gtgtgacatg taccttatgc acataaaaga accatcaaca gtgcagagca tccaatactc
     3661 agagtgagag ctctaagaaa ttgtgaacct taaggatgag atgagtctat gaaacacata
     3721 cctatgtagt catctggaat agactattta
//
