LOCUS       NM_001413175            2654 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gamma-butyrobetaine hydroxylase 1 (Bbox1),
            transcript variant 2, mRNA.
ACCESSION   NM_001413175 XM_039105803
VERSION     NM_001413175.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2654)
  AUTHORS   Rigault,C., Le Borgne,F., Tazir,B., Benani,A. and Demarquoy,J.
  TITLE     A high-fat diet increases L-carnitine synthesis through a
            differential maturation of the Bbox1 mRNAs
  JOURNAL   Biochim Biophys Acta 1831 (2), 370-377 (2013)
   PUBMED   23127966
REFERENCE   2  (bases 1 to 2654)
  AUTHORS   Broderick,T.L., El Midaoui,A., Chiasson,J.L., Wang,D., Jankowski,M.
            and Gutkowska,J.
  TITLE     The effects of exercise training on gamma-butyrobetaine hydroxylase
            and novel organic cation transporter-2 gene expression in the rat
  JOURNAL   Appl Physiol Nutr Metab 36 (6), 781-789 (2011)
   PUBMED   22014179
  REMARK    GeneRIF: Data suggest that expression of BBH mRNA and protein is
            up-regulated in liver with training in physical activity; in
            kidney, only BBH mRNA expression is up-regulated.
REFERENCE   3  (bases 1 to 2654)
  AUTHORS   Tars,K., Rumnieks,J., Zeltins,A., Kazaks,A., Kotelovica,S.,
            Leonciks,A., Sharipo,J., Viksna,A., Kuka,J., Liepinsh,E. and
            Dambrova,M.
  TITLE     Crystal structure of human gamma-butyrobetaine hydroxylase
  JOURNAL   Biochem Biophys Res Commun 398 (4), 634-639 (2010)
   PUBMED   20599753
REFERENCE   4  (bases 1 to 2654)
  AUTHORS   Garcia-Delgado,M., Peral,M.J., Duran,J.M., Garcia-Miranda,P.,
            Calonge,M.L. and Ilundain,A.A.
  TITLE     Ontogeny of Na(+)/L-carnitine transporter and of
            gamma-trimethylaminobutyraldehyde dehydrogenase and
            gamma-butyrobetaine hydroxylase genes expression in rat kidney
  JOURNAL   Mech Ageing Dev 130 (4), 227-233 (2009)
   PUBMED   19150623
  REMARK    GeneRIF: BBH mRNA, however, was detected during the suckling period
            onwards and its abundance was not changed significantly by
            maturation
REFERENCE   5  (bases 1 to 2654)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2654)
  AUTHORS   Davis,A.T. and Monroe,T.J.
  TITLE     Carnitine deficiency and supplementation do not affect the gene
            expression of carnitine biosynthetic enzymes in rats
  JOURNAL   J Nutr 135 (4), 761-764 (2005)
   PUBMED   15795431
  REMARK    GeneRIF: Alterations in enzyme activities in the pivalate-treated
            rats are not regulated at the transcriptional level, and are
            apparently related to post-transcriptional effects on the enzymes
            themselves.
REFERENCE   7  (bases 1 to 2654)
  AUTHORS   Galland,S., Georges,B., Le Borgne,F., Conductier,G., Dias,J.V. and
            Demarquoy,J.
  TITLE     Thyroid hormone controls carnitine status through modifications of
            gamma-butyrobetaine hydroxylase activity and gene expression
  JOURNAL   Cell Mol Life Sci 59 (3), 540-545 (2002)
   PUBMED   11964131
  REMARK    GeneRIF: Thyroid hormone controls carnitine status through
            modifications of gamma-butyrobetaine hydroxylase activity and gene
            expression
REFERENCE   8  (bases 1 to 2654)
  AUTHORS   Galland,S., Le Borgne,F., Bouchard,F., Georges,B., Clouet,P.,
            Grand-Jean,F. and Demarquoy,J.
  TITLE     Molecular cloning and characterization of the cDNA encoding the rat
            liver gamma-butyrobetaine hydroxylase
  JOURNAL   Biochim Biophys Acta 1441 (1), 85-92 (1999)
   PUBMED   10526231
REFERENCE   9  (bases 1 to 2654)
  AUTHORS   Vaz,F.M., van Gool,S., Ofman,R., Ijlst,L. and Wanders,R.J.
  TITLE     Carnitine biosynthesis: identification of the cDNA encoding human
            gamma-butyrobetaine hydroxylase
  JOURNAL   Biochem Biophys Res Commun 250 (2), 506-510 (1998)
   PUBMED   9753662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_001413175.2.
            
            On Oct 27, 2022 this sequence version replaced XM_039105803.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210746.1, SRR26643286.11021.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                JAXUCZ010000003.1  117325977-117326064 c
            89-345              JAXUCZ010000003.1  117317301-117317557 c
            346-460             JAXUCZ010000003.1  117316142-117316256 c
            461-659             JAXUCZ010000003.1  117303495-117303693 c
            660-765             JAXUCZ010000003.1  117290598-117290703 c
            766-962             JAXUCZ010000003.1  117283514-117283710 c
            963-1129            JAXUCZ010000003.1  117281603-117281769 c
            1130-2654           JAXUCZ010000003.1  117277226-117278750 c
FEATURES             Location/Qualifiers
     source          1..2654
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q34"
     gene            1..2654
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /note="gamma-butyrobetaine hydroxylase 1"
                     /db_xref="GeneID:64564"
                     /db_xref="RGD:619756"
     exon            1..88
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
     exon            89..345
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1290
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /EC_number="1.14.11.1"
                     /note="gamma butyrobetaine hydroxylase; butyrobetaine
                     (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine
                     hydroxylase); gamma-butyrobetaine,2-oxoglutarate
                     dioxygenase; gamma-BBH; butyrobetaine (gamma),
                     2-oxoglutarate dioxygenase (gamma-butyrobetaine
                     hydroxylase) 1"
                     /codon_start=1
                     /product="gamma-butyrobetaine dioxygenase"
                     /protein_id="NP_001400104.1"
                     /db_xref="GeneID:64564"
                     /db_xref="RGD:619756"
                     /translation="MHCAILKAEAVDGARLMQIFWHDGAESLYPAVWLRDNCQCSDCY
                     LHSAKARKLLLEALDVNIRMDDLTFDQKKVYITWPNGHYSEFEANWLKKRCFSQEARA
                     GLQGELFLPECQYWGSELQLPTLNFEDVLNDDDHAYKWLSSLKKVGIVRLTGAADKRG
                     EIIKLGKRIGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLH
                     CIKQTVTGGDSEIVDGFNVCQKLKEKNPQAFSILSSTFVDFTDIGVDYCDFSVQSKHK
                     IIELDDKGQVVRINFNNATRDTVFDVPIERVQPFYAALKEFVDLMNSKEYKYTFKMNP
                     GDVITFDNWRLLHGRRSYEAGTEISRHLEGAYADWDVVMSRLRILRQRVMNGN"
     exon            346..460
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
     exon            461..659
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
     exon            660..765
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
     exon            766..962
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1129
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..2654
                     /gene="Bbox1"
                     /gene_synonym="Bbh; Bbox"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagtgtga gcaggtggaa gtgaagtaaa agctcttgtc tgcttgttcc tgttgcagca
       61 gctggctctg gcacaggaga caagacagca ggtagctggt agaatttgtc accaaagacc
      121 agaaacatgc actgtgccat cttaaaggcg gaagcagtgg atggggctcg cctgatgcag
      181 atcttttggc acgatggggc agagtccctc tacccagcag tatggctcag agacaactgt
      241 cagtgttcgg actgctatct acattctgca aaagctcgga aacttctcct ggaagctctc
      301 gatgtgaaca ttagaatgga tgacttgaca tttgaccaga aaaaggttta tatcacttgg
      361 cccaatggcc attacagcga atttgaagct aattggctga agaaaagatg cttttctcag
      421 gaggccagag caggactcca aggagaatta tttttaccag aatgtcagta ctggggctca
      481 gagctccagc tgccaactct gaactttgaa gatgtgttaa atgatgatga ccatgcatac
      541 aaatggcttt ctagtctcaa gaaagtaggc attgtgagac tcactggagc agctgacaaa
      601 cgtggcgaga tcataaaact tgggaaaaga attggctttc tgtacctcac attttatgga
      661 cacacttggc aagtgcagga caagattgat gccaacaatg tggcttatac aactgggaag
      721 ctcagcttcc acacagatta cccagccctc caccatccac ctggggttca gcttctgcac
      781 tgtatcaagc aaacagtcac aggaggtgac tctgaaatcg tagatgggtt taatgtgtgc
      841 caaaaactca aggagaagaa cccccaggct ttttctattc tctcctccac ctttgtggat
      901 tttacagaca ttggagtgga ttactgtgat ttctctgtgc agtctaaaca caagattata
      961 gagctggatg ataaaggcca agtggttcgc atcaacttca acaacgcaac cagagataca
     1021 gtcttcgatg tccccattga aagagttcag cctttctacg ctgctctgaa ggagtttgtt
     1081 gacctgatga acagcaaaga atacaagtac accttcaaga tgaatccagg tgatgtgatt
     1141 acctttgaca actggcgctt gcttcatgga cgtcgcagct atgaagcagg aactgagata
     1201 tcccgccatc tggaaggcgc ttatgctgac tgggatgtag tgatgtcaag gcttcgtatt
     1261 ctgagacaga gagtcatgaa tgggaactga ctatcctggc cttaaactgt actgcacgtc
     1321 caacgacgga atgttgttat ctatagcctg gctattccaa tatcatgatc aatagcattc
     1381 acataataat ttctttaaaa ctgaacatgc agcttctctc atcagagtct tcttccttgt
     1441 aatctcattc gatatcactt attaaacgtc atggtaagga gcagtctcaa agcatccctt
     1501 ctgccgcatg tgttctctga ctttgcatta gtgagtatta tctaacaaac gtttctggca
     1561 aataaaactt ttttatgcat gaataaagct tatgtttcaa gtagaagatc ttaaaatacg
     1621 ctcctcctca gttgcctacc cggtctcatt gttcatgact gcatatcatt agcgcgcttc
     1681 aaaggtgttc atattttcga agatctgggg ggtttttttc tatatcgcag gatatttttg
     1741 tacatgctta gagacctcat tcagttgata atcccaacat tgtttgtcat ccttaaatca
     1801 tgagagtaaa cccaagtatg acaaattaaa agaaaactct agtctttcta aatttgtctt
     1861 gtctaaaaaa tatgttccca tagactgcca gcattgctct cacctaagga cgaaccactc
     1921 ctcctcattc cttgtcttca actcatgcat ttgtaaatga tgctggcaac ctacatgaac
     1981 agacaacatt gtctccttgc ctctggacag ccttaccagc tggtctcatc ttcctgcatg
     2041 gccacacccc tagtgatgga actcaggtat catagcacaa cgtgaagttg tagtctgttg
     2101 agcctcccat accaatgaga aaagaagctt tggaattcca gtttgctgag attctggtag
     2161 taccttcata tttcatgttg tagacatttg aaactgtgta aactttattt ttctagaaat
     2221 ccttaacttc agttagcatg caaaggaggg gctttcactg tggtaacatc atcttaatac
     2281 atggttatcc ttacctgctt tcctcaatgt cttgtctcat ctctatcctg atgtttaagg
     2341 ttcttagcac tacactaaga atggcaagag tgatcacaca cctcatttct gactttagag
     2401 gaaaatctct gtctttcttc attaagtatg atgtcatttc caggttcatc atatctagcc
     2461 tttaatatgt aaagacattt ttcttctcct aattcttcca acattttatc ctgaggggaa
     2521 acatgggctt tttctaacta tattaagatg accatgtaat ttctgccata actcatatgt
     2581 gtgctgtgtt aacatttatc aattgtatat gttgtagcat cgtggtatcc cacaataaaa
     2641 ccaatttgtc ctca
//
