LOCUS       NM_173837               1823 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus Bcl-2 binding component 3 (Bbc3), mRNA.
ACCESSION   NM_173837
VERSION     NM_173837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1823)
  AUTHORS   Das,A.K. and Biswas,S.C.
  TITLE     Cdc25A phosphatase is activated and mediates neuronal cell death by
            PUMA via pRb/E2F1 pathway in a model of Parkinson's disease
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119848 (2024)
   PUBMED   39305937
  REMARK    GeneRIF: Cdc25A phosphatase is activated and mediates neuronal cell
            death by PUMA via pRb/E2F1 pathway in a model of Parkinson's
            disease.
REFERENCE   2  (bases 1 to 1823)
  AUTHORS   Guo,J., Li,Z.D., Xiao,C.S. and Bian,Y.F.
  TITLE     [Effects of PUMA knockout on the apoptosis of H9C2 cardiomyocytes
            induced by high glucose]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 38 (5), 504-509 (2022)
   PUBMED   37088760
  REMARK    GeneRIF: [Effects of PUMA knockout on the apoptosis of H9C2
            cardiomyocytes induced by high glucose].
REFERENCE   3  (bases 1 to 1823)
  AUTHORS   Zhou,X.B., Lai,L.F., Xie,G.B., Ding,C., Xu,X. and Wang,Y.
  TITLE     LncRNAGAS5 sponges miRNA-221 to promote neurons apoptosis by
            up-regulated PUMA under hypoxia condition
  JOURNAL   Neurol Res 42 (1), 8-16 (2020)
   PUBMED   31878844
  REMARK    GeneRIF: LncRNAGAS5 sponges miRNA-221 to promote neurons apoptosis
            by up-regulated PUMA under hypoxia condition.
REFERENCE   4  (bases 1 to 1823)
  AUTHORS   Shi,S.Y., Luk,C.T., Schroer,S.A., Kim,M.J., Dodington,D.W.,
            Sivasubramaniyam,T., Lin,L., Cai,E.P., Lu,S.Y., Wagner,K.U.,
            Bazinet,R.P. and Woo,M.
  TITLE     Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from
            Hepatocellular Carcinoma in Mice
  JOURNAL   J Biol Chem 292 (9), 3789-3799 (2017)
   PUBMED   28100771
REFERENCE   5  (bases 1 to 1823)
  AUTHORS   Omori,K., Kobayashi,E., Komatsu,H., Rawson,J., Agrawal,G.,
            Parimi,M., Oancea,A.R., Valiente,L., Ferreri,K., Al-Abdullah,I.H.,
            Kandeel,F., Takahashi,M. and Mullen,Y.
  TITLE     Involvement of a proapoptotic gene (BBC3) in islet injury mediated
            by cold preservation and rewarming
  JOURNAL   Am J Physiol Endocrinol Metab 310 (11), E1016-E1026 (2016)
   PUBMED   27117005
  REMARK    GeneRIF: These results demonstrated the involvement of BBC3/Bbc3 in
            cold preservation/rewarming-mediated islet injury, possibly through
            modulating HMGB1- and oxidative stress-mediated injury to islets.
REFERENCE   6  (bases 1 to 1823)
  AUTHORS   Villunger,A., Michalak,E.M., Coultas,L., Mullauer,F., Bock,G.,
            Ausserlechner,M.J., Adams,J.M. and Strasser,A.
  TITLE     p53- and drug-induced apoptotic responses mediated by BH3-only
            proteins puma and noxa
  JOURNAL   Science 302 (5647), 1036-1038 (2003)
   PUBMED   14500851
REFERENCE   7  (bases 1 to 1823)
  AUTHORS   Reimertz,C., Kogel,D., Rami,A., Chittenden,T. and Prehn,J.H.
  TITLE     Gene expression during ER stress-induced apoptosis in neurons:
            induction of the BH3-only protein Bbc3/PUMA and activation of the
            mitochondrial apoptosis pathway
  JOURNAL   J Cell Biol 162 (4), 587-597 (2003)
   PUBMED   12913114
REFERENCE   8  (bases 1 to 1823)
  AUTHORS   Itoh,T., Itoh,A. and Pleasure,D.
  TITLE     Bcl-2-related protein family gene expression during
            oligodendroglial differentiation
  JOURNAL   J Neurochem 85 (6), 1500-1512 (2003)
   PUBMED   12787069
REFERENCE   9  (bases 1 to 1823)
  AUTHORS   Nakano,K. and Vousden,K.H.
  TITLE     PUMA, a novel proapoptotic gene, is induced by p53
  JOURNAL   Mol Cell 7 (3), 683-694 (2001)
   PUBMED   11463392
REFERENCE   10 (bases 1 to 1823)
  AUTHORS   Yu,J., Zhang,L., Hwang,P.M., Kinzler,K.W. and Vogelstein,B.
  TITLE     PUMA induces the rapid apoptosis of colorectal cancer cells
  JOURNAL   Mol Cell 7 (3), 673-682 (2001)
   PUBMED   11463391
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY157758.1.
            
            On Jun 3, 2003 this sequence version replaced NM_173837.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY157758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1823
                     /gene="Bbc3"
                     /gene_synonym="Puma"
                     /note="Bcl-2 binding component 3"
                     /db_xref="GeneID:317673"
                     /db_xref="RGD:631434"
     exon            1..263
                     /gene="Bbc3"
                     /gene_synonym="Puma"
                     /inference="alignment:Splign:2.1.0"
     exon            264..552
                     /gene="Bbc3"
                     /gene_synonym="Puma"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..860
                     /gene="Bbc3"
                     /gene_synonym="Puma"
                     /note="p53 up-regulated modulator of apoptosis"
                     /codon_start=1
                     /product="bcl-2-binding component 3"
                     /protein_id="NP_776209.1"
                     /db_xref="GeneID:317673"
                     /db_xref="RGD:631434"
                     /translation="MARARQEGSSPEPVEGLARDSPRPFPLGRLMPSAVSCGLCEPGL
                     PAAPAAPALLPAAYLCAPTAPPAVTAALGGPRWPGGHRSRPRGPRPDGPQPSLSPAQQ
                     HLESPVPSAPEALAGGPTQAAPGVRVEEEEWAREIGAQLRRMADDLNAQYERRRQEEQ
                     HRHRPSPWRVMYNLFMGLLPLPRDPGAPEMEPN"
     exon            553..743
                     /gene="Bbc3"
                     /gene_synonym="Puma"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1823
                     /gene="Bbc3"
                     /gene_synonym="Puma"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgccggg aggcctgaga cgaggctcgg agccacatgc gagcggggcg cccaggagac
       61 ggcggcgaca ccagcgagca atctgcagcg gtgatccgga cgcagacacg aacgcaccag
      121 aagcagcagc agcagccact gcagtcagag cagcaacaac agcaaggagc ctcggtagca
      181 agccagtcgg cgggcgagcc ctccagaagg cagccgcccg ccaccccatc gcctccttcc
      241 tccggcgtgt tcatgccccc ggggctccag ggagcgccat ggcccgcgca cgccaggagg
      301 gcagctctcc ggagcccgta gagggcctag cccgcgacag cccgcgtcct ttcccgctcg
      361 gccgcctgat gccctccgct gtatcctgcg gcctctgcga gcccggcctg cccgctgccc
      421 ctgctgcccc tgccttgctg ccggccgcct acctctgcgc ccccaccgcc ccgcctgccg
      481 tcaccgccgc cctggggggc ccccgctggc ctgggggtca ccgcagccgg ccccgaggcc
      541 cgcgcccgga cggtcctcag ccctcgctgt caccagccca gcagcaccta gagtcgcccg
      601 tgcccagcgc cccggaggcc ctggcgggag gccccaccca agctgccccg ggagtgcgtg
      661 tggaggagga ggagtgggcc cgggagatcg gggcccagct gcggaggatg gcggacgacc
      721 tcaacgcgca gtacgagcgg cggagacaag aagagcaaca tcgacaccga ccctcgccct
      781 ggagggtcat gtataatctc ttcatgggac tcctcccctt acccagggat cctggagccc
      841 cagaaatgga gcccaactag gtgcctacac ccgtcccggg ggacgtcgga gacttgaggg
      901 gcaggacccc ctccgccttc tgacaccctg gccagcgcgg gggacttttt ctgcaccatg
      961 tagcatactg gactgccagc cttgcttgtc ccaggggcag gcaagggaag ccactcgagc
     1021 cccggcagcc tgggtgcact gatggagata cggacttggg ggaccctggc ctcccaaaag
     1081 ccagggaagg gagggctgaa ggactcatgg tgaccgaggg ggtggggacc gagccgcccg
     1141 cctctgccgc ccaccaccat ctcaggaaag gctgctggtg ctggctgccc gttccagctg
     1201 cagggggggc tctgggggtg tccccagtgc gccttcactt tgggcctggc ctcaggcccc
     1261 tggtgcttcc ccccctcctc ctgaggaggg ggcctgtgaa gagcatatga gccaaacctg
     1321 accactagcc tcctggagcc agagaatggg gggcatgtga aagccttctc aacccagtgc
     1381 ccagccatct tccctgagcc gccggcgggc ggtgagcaat gcctgcctca ccttcatctg
     1441 ggggtgtcca ggaggggtcc agactgtgaa tcctgtgctc tggccgggac cactccccca
     1501 gtccccatcc atcccattgc ataggtttag agagagcacg tgtgaccact ggcattcatt
     1561 tggggggtgg gagatattgg cggaagccac cccagcctta gtccccaggg caaagcgctg
     1621 gggaggaaga tggggagtca gggagggggg aagtctcaga agagggagga gtctgggagc
     1681 ggggagggac ggcccagcct gtaaaatact gtacatgcac tgctgtagat atactggaat
     1741 gaattttctg tacatgtttg gttaattttt tttgtacatg atttttgtat gtttcctttt
     1801 caataaaatc agattgaaca gtg
//
