LOCUS       NM_017059                865 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Rattus norvegicus BCL2 associated X, apoptosis regulator (Bax),
            mRNA.
ACCESSION   NM_017059
VERSION     NM_017059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 865)
  AUTHORS   Tan,W., Li,Y., Ma,L., Fu,X., Long,Q., Yan,F., Li,W., Liu,X.,
            Ding,H., Wang,Y. and Zhang,W.
  TITLE     Exosomes of endothelial progenitor cells repair injured vascular
            endothelial cells through the Bcl2/Bax/Caspase-3 pathway
  JOURNAL   Sci Rep 14 (1), 4465 (2024)
   PUBMED   38396011
  REMARK    GeneRIF: Exosomes of endothelial progenitor cells repair injured
            vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 865)
  AUTHORS   Nakamura,K., Seno,M., Yoshimura,Y. and Suzuki,O.
  TITLE     Long-term culture induces Bax-dependent apoptosis in rat
            preimplantation embryos
  JOURNAL   Mol Reprod Dev 91 (1), e23711 (2024)
   PUBMED   37831754
  REMARK    GeneRIF: Long-term culture induces Bax-dependent apoptosis in rat
            preimplantation embryos.
REFERENCE   3  (bases 1 to 865)
  AUTHORS   Wang,Y., Wu,Y., Wang,P., Luo,J. and Rui,Y.
  TITLE     Exploration of the Protective Mechanism of Bax Removal against
            Ischemia Reperfusion Injury of Skin Flap through the p38
            Mitogen-Activated Protein Kinase Pathway
  JOURNAL   Oxid Med Cell Longev 2022, 1175078 (2022)
   PUBMED   36299606
  REMARK    GeneRIF: Exploration of the Protective Mechanism of Bax Removal
            against Ischemia Reperfusion Injury of Skin Flap through the p38
            Mitogen-Activated Protein Kinase Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 865)
  AUTHORS   Wang,S., Duan,J., Liao,J., Wang,Y., Xiao,X., Li,L., Liu,Y., Gu,H.,
            Yang,P., Fu,D., Du,J., Li,X. and Shao,M.
  TITLE     LncRNA H19 inhibits ER stress induced apoptosis and improves
            diabetic cardiomyopathy by regulating PI3K/AKT/mTOR axis
  JOURNAL   Aging (Albany NY) 14 (16), 6809-6828 (2022)
   PUBMED   36044268
REFERENCE   5  (bases 1 to 865)
  AUTHORS   Zhai,Y., Liu,B.G., Mo,X.N., Zou,M., Mei,X.P., Chen,W., Huang,G.D.
            and Wu,L.
  TITLE     Gingerol ameliorates neuronal damage induced by
            hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic
            factor axis
  JOURNAL   Kaohsiung J Med Sci 38 (4), 367-377 (2022)
   PUBMED   34962339
REFERENCE   6  (bases 1 to 865)
  AUTHORS   Knudson,C.M., Tung,K.S., Tourtellotte,W.G., Brown,G.A. and
            Korsmeyer,S.J.
  TITLE     Bax-deficient mice with lymphoid hyperplasia and male germ cell
            death
  JOURNAL   Science 270 (5233), 96-99 (1995)
   PUBMED   7569956
REFERENCE   7  (bases 1 to 865)
  AUTHORS   Chao,D.T., Linette,G.P., Boise,L.H., White,L.S., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bcl-XL and Bcl-2 repress a common pathway of cell death
  JOURNAL   J Exp Med 182 (3), 821-828 (1995)
   PUBMED   7650488
REFERENCE   8  (bases 1 to 865)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
REFERENCE   9  (bases 1 to 865)
  AUTHORS   Tilly,J.L., Tilly,K.I., Kenton,M.L. and Johnson,A.L.
  TITLE     Expression of members of the bcl-2 gene family in the immature rat
            ovary: equine chorionic gonadotropin-mediated inhibition of
            granulosa cell apoptosis is associated with decreased bax and
            constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels
  JOURNAL   Endocrinology 136 (1), 232-241 (1995)
   PUBMED   7828536
REFERENCE   10 (bases 1 to 865)
  AUTHORS   Krieger,N.S., Sessler,N.E. and Bushinsky,D.A.
  TITLE     Acidosis inhibits osteoblastic and stimulates osteoclastic activity
            in vitro
  JOURNAL   Am J Physiol 262 (3 Pt 2), F442-F448 (1992)
   PUBMED   1558161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB586216.1 and AF235993.1.
            
            On May 10, 2012 this sequence version replaced NM_017059.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229844.1, U49729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132279, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               CB586216.1         1-584
            585-865             AF235993.1         950-1230
FEATURES             Location/Qualifiers
     source          1..865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..865
                     /gene="Bax"
                     /note="BCL2 associated X, apoptosis regulator"
                     /db_xref="GeneID:24887"
                     /db_xref="RGD:2192"
     exon            1..123
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..668
                     /gene="Bax"
                     /note="Bcl2-associated X protein"
                     /codon_start=1
                     /product="apoptosis regulator BAX"
                     /protein_id="NP_058755.2"
                     /db_xref="GeneID:24887"
                     /db_xref="RGD:2192"
                     /translation="MDGSGDHLGGGGPTSSEQIMKTGAFLLQGFIQDRAERMAGETPE
                     LTLEQPPQDASTKKLSECLRRIGDELDNNMELQRMIADVDTDSPREVFFRVAADMFAD
                     GNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLVWIQDQGGWDG
                     LLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG"
     exon            124..175
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            176..322
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            323..458
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            459..563
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
     exon            564..832
                     /gene="Bax"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccgtgagg gccgcacgtc tgcggggagt cacgtgaccg gggcgcgccg cagccgccgg
       61 ggcgcacccg gcgagaggca gcggcagtga tggacgggtc cggggatcat ctcggaggcg
      121 gcgggcccac cagctctgaa cagatcatga agacaggggc ctttttgcta cagggtttca
      181 tccaggatcg agcagagagg atggctgggg agacacctga gctgaccttg gagcagccgc
      241 cccaggacgc atccaccaag aagctgagcg agtgtctcag gcgaattggc gatgaactgg
      301 acaacaacat ggagctgcag aggatgattg ctgatgtgga tacagactcc ccccgagagg
      361 tcttcttccg tgtggcagct gacatgtttg cagacggcaa cttcaactgg ggccgggtgg
      421 ttgccctttt ctactttgct agcaaactgg tgctcaaggc cctgtgcact aaagtgcccg
      481 agctgatcag aaccatcatg ggctggacac tggacttcct ccgggagcgg ctgcttgtct
      541 ggatccaaga ccagggtggc tgggatggcc tcctttccta cttcgggacc cccacatggc
      601 agacagtgac catctttgtg gctggagtcc tcactgcctc actcaccatc tggaagaaga
      661 tgggctgagg cttcctgctg ccttggactg tgtcttttct tcataaatta tgacattttt
      721 cctgggatga atggggaacg gggaaaggca tttttcttac ttttgtaatt attgggaggg
      781 gtgggaatgg tggcctgggg gaggtgccaa taaacctcag gtccactttg gaaaaaaaaa
      841 aaaaaaaaaa aaaaaaaaaa aaaaa
//
