LOCUS       NM_022956               1577 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus BarH-like homeobox 2 (Barhl2), mRNA.
ACCESSION   NM_022956
VERSION     NM_022956.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1577)
  AUTHORS   Lin,S.C., Kao,S.Y., Chang,J.C., Liu,Y.C., Yu,E.H., Tseng,S.H.,
            Liu,C.J. and Chang,K.W.
  TITLE     Up-regulation of miR-187 modulates the advances of oral carcinoma
            by targeting BARX2 tumor suppressor
  JOURNAL   Oncotarget 7 (38), 61355-61365 (2016)
   PUBMED   27542258
REFERENCE   2  (bases 1 to 1577)
  AUTHORS   Mi,Y., Zhao,S., Zhang,W., Zhang,D., Weng,J., Huang,K., Sun,H.,
            Tang,H., Zhang,X., Sun,X., Peng,Z. and Wen,Y.
  TITLE     Down-regulation of Barx2 predicts poor survival in colorectal
            cancer
  JOURNAL   Biochem Biophys Res Commun 478 (1), 67-73 (2016)
   PUBMED   27453340
REFERENCE   3  (bases 1 to 1577)
  AUTHORS   Yamamoto,H., Watanabe,Y., Oikawa,R., Morita,R., Yoshida,Y.,
            Maehata,T., Yasuda,H. and Itoh,F.
  TITLE     BARHL2 Methylation Using Gastric Wash DNA or Gastric Juice Exosomal
            DNA is a Useful Marker For Early Detection of Gastric Cancer in an
            H. pylori-Independent Manner
  JOURNAL   Clin Transl Gastroenterol 7 (7), e184 (2016)
   PUBMED   27441821
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1577)
  AUTHORS   Chellappa,R., Li,S., Pauley,S., Jahan,I., Jin,K. and Xiang,M.
  TITLE     Barhl1 regulatory sequences required for cell-specific gene
            expression and autoregulation in the inner ear and central nervous
            system
  JOURNAL   Mol Cell Biol 28 (6), 1905-1914 (2008)
   PUBMED   18212062
REFERENCE   5  (bases 1 to 1577)
  AUTHORS   Mo,Z., Li,S., Yang,X. and Xiang,M.
  TITLE     Role of the Barhl2 homeobox gene in the specification of
            glycinergic amacrine cells
  JOURNAL   Development 131 (7), 1607-1618 (2004)
   PUBMED   14998930
REFERENCE   6  (bases 1 to 1577)
  AUTHORS   Saba,R., Nakatsuji,N. and Saito,T.
  TITLE     Mammalian BarH1 confers commissural neuron identity on dorsal cells
            in the spinal cord
  JOURNAL   J Neurosci 23 (6), 1987-1991 (2003)
   PUBMED   12657654
REFERENCE   7  (bases 1 to 1577)
  AUTHORS   Saito,T., Sawamoto,K., Okano,H., Anderson,D.J. and Mikoshiba,K.
  TITLE     Mammalian BarH homologue is a potential regulator of neural bHLH
            genes
  JOURNAL   Dev Biol 199 (2), 216-225 (1998)
   PUBMED   9698441
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB004056.1.
            
            On Aug 31, 2012 this sequence version replaced NM_022956.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB004056.1, BF409413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1577              AB004056.1         5-1581
FEATURES             Location/Qualifiers
     source          1..1577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1577
                     /gene="Barhl2"
                     /gene_synonym="Barh; MBH1"
                     /note="BarH-like homeobox 2"
                     /db_xref="GeneID:65050"
                     /db_xref="RGD:620726"
     exon            1..685
                     /gene="Barhl2"
                     /gene_synonym="Barh; MBH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1224
                     /gene="Barhl2"
                     /gene_synonym="Barh; MBH1"
                     /note="homeobox protein B-H1; bar-class homeodomain
                     protein MBH1; BarH-class homeodomain transcription factor"
                     /codon_start=1
                     /product="barH-like 2 homeobox protein"
                     /protein_id="NP_075245.1"
                     /db_xref="GeneID:65050"
                     /db_xref="RGD:620726"
                     /translation="MTAMEGASGSSFGIDTILSGAGSGSPGMMNGDFRSLGEARTTDF
                     RSQATPSPCSEIDTVGTAPSSPISVTLEPPEPHLVTDGPQHHHHLHHGQQPPPPSAPP
                     AQSLQPSPQQQPPPQPQSAAQQLGSAAAAPRTSTSSFLIKDILGDSKPLAACAPYSTS
                     VSSPHHTPKQECNAAHESFRPKLEQEDSKTKLDKREDSQSDIKCHGTKEEGDREITSS
                     RESPPVRAKKPRKARTAFSDHQLNQLERSFERQKYLSVQDRMDLAAALNLTDTQVKTW
                     YQNRRTKWKRQTAVGLELLAEAGNYSALQRMFPSPYFYHPSLLGSMDSTTAAAAAAAM
                     YSSMYRTPPAPHPQLQRPLVPRVLIHGLGPGGQPALNPLSNPIPGTPHPR"
     exon            686..911
                     /gene="Barhl2"
                     /gene_synonym="Barh; MBH1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1574
                     /gene="Barhl2"
                     /gene_synonym="Barh; MBH1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatcgatagt ttcccttgtt tggtcccgga ggcggctgat ccgcggagtg gcgtggacct
       61 catgtagaaa tgacagcaat ggaaggggcc agcgggtcga gttttggaat agacacgatt
      121 ttgtccggtg ccggttccgg cagtccgggc atgatgaacg gagatttccg atcgctcggt
      181 gaagcgagga ccacggattt taggagccag gccaccccgt caccctgttc ggagattgat
      241 accgtgggaa cggcgccctc ttcaccgatc tcggtcaccc tggagccccc ggagccgcat
      301 cttgtgacag acggacccca gcatcaccat cacctccacc acggccaaca gccaccgcca
      361 ccgtccgcgc cccccgcgca aagtttgcag ccttctcccc aacagcaacc gccgccgcag
      421 ccgcagtctg cagcccagca actgggctcg gccgccgcgg cccccaggac ttccacctct
      481 tcctttttaa ttaaggacat cttgggagac agcaaacccc tggcggcttg tgcaccctac
      541 agcaccagcg tttcttctcc tcatcacacc ccgaagcagg agtgcaacgc ggcgcacgag
      601 agcttcaggc caaagctgga gcaggaggac agcaaaacca agctggacaa gagggaagac
      661 tctcagagcg acatcaaatg ccacggaaca aaggaggaag gagaccggga gattacaagt
      721 agccgagaga gtccccctgt gagagccaag aaacctcgaa aggccaggac agctttctcg
      781 gaccaccagc tcaatcaact ggaacgtagc tttgagcggc agaagtacct cagtgtacag
      841 gaccgcatgg acctggcagc tgcactcaac ctcactgata cccaagtcaa gacctggtac
      901 cagaaccgca gaaccaagtg gaagcggcag actgcagtgg gcctggagtt gcttgccgag
      961 gcggggaact actccgcgct gcagaggatg tttccgtcgc cttatttcta ccacccaagc
     1021 ctgctgggga gcatggacag cacgacggcg gccgcggcgg ccgcggcaat gtacagcagc
     1081 atgtaccgaa ctcctcctgc accccatccg cagctgcagc ggccactggt gccccgcgtg
     1141 ctcatccacg gcctggggcc tgggggacag ccggccctca accctttgtc caaccccatc
     1201 ccaggcaccc cgcatccccg gtgaggaagg agggacagtg cagcccgagc agccctccag
     1261 gtttccaccc ggccgccgac agctgcccca cctctccccg caccaaacca acaggaatag
     1321 aggcagacga gtaaaggggg ggagctcacc ggtgggctgg gtccccaagg accggccagc
     1381 cctctgttct ccatctgccc cctcagaggc agggccgcaa agctccccaa cagtgtgact
     1441 ggagaaaata ctgaccccac tgaaagtgca accagtaagt gaaaacaccc acccacccac
     1501 ccacccacac acacacacaa aatgaaccct cgagttcttt ctttctttct tttttttttt
     1561 ttttgaaaaa aaaaaaa
//
