LOCUS       NM_022622               5289 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus BRCA1 associated RING domain 1 (Bard1), mRNA.
ACCESSION   NM_022622
VERSION     NM_022622.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5289)
  AUTHORS   Shen,H., Yao,Z., Zhao,W., Zhang,Y., Yao,C. and Tong,C.
  TITLE     miR-21 enhances the protective effect of loperamide on rat
            cardiomyocytes against hypoxia/reoxygenation, reactive oxygen
            species production and apoptosis via regulating Akap8 and Bard1
            expression
  JOURNAL   Exp Ther Med 17 (2), 1312-1320 (2019)
   PUBMED   30680008
REFERENCE   2  (bases 1 to 5289)
  AUTHORS   Ono,A., Hirooka,K., Nakano,Y., Nitta,E., Nishiyama,A. and
            Tsujikawa,A.
  TITLE     Gene expression changes in the retina after systemic administration
            of aldosterone
  JOURNAL   Jpn J Ophthalmol 62 (4), 499-507 (2018)
   PUBMED   29713904
REFERENCE   3  (bases 1 to 5289)
  AUTHORS   Sakka,L., Deletage,N., Chalus,M., Aissouni,Y., Sylvain-Vidal,V.,
            Gobron,S. and Coll,G.
  TITLE     Assessment of citalopram and escitalopram on neuroblastoma cell
            lines. Cell toxicity and gene modulation
  JOURNAL   Oncotarget 8 (26), 42789-42807 (2017)
   PUBMED   28467792
REFERENCE   4  (bases 1 to 5289)
  AUTHORS   Zhang,Y.Q., Bianco,A., Malkinson,A.M., Leoni,V.P., Frau,G., De
            Rosa,N., Andre,P.A., Versace,R., Boulvain,M., Laurent,G.J.,
            Atzori,L. and Irminger-Finger,I.
  TITLE     BARD1: an independent predictor of survival in non-small cell lung
            cancer
  JOURNAL   Int J Cancer 131 (1), 83-94 (2012)
   PUBMED   21815143
REFERENCE   5  (bases 1 to 5289)
  AUTHORS   Kim,Y.J., Lim,H.J. and Choi,S.U.
  TITLE     Effect of propofol on cardiac function and gene expression after
            ischemic-reperfusion in isolated rat heart
  JOURNAL   Korean J Anesthesiol 58 (2), 153-161 (2010)
   PUBMED   20498794
REFERENCE   6  (bases 1 to 5289)
  AUTHORS   Wu-Baer,F., Lagrazon,K., Yuan,W. and Baer,R.
  TITLE     The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through
            an unconventional linkage involving lysine residue K6 of ubiquitin
  JOURNAL   J Biol Chem 278 (37), 34743-34746 (2003)
   PUBMED   12890688
REFERENCE   7  (bases 1 to 5289)
  AUTHORS   Ganesan,S., Silver,D.P., Greenberg,R.A., Avni,D., Drapkin,R.,
            Miron,A., Mok,S.C., Randrianarison,V., Brodie,S., Salstrom,J.,
            Rasmussen,T.P., Klimke,A., Marrese,C., Marahrens,Y., Deng,C.X.,
            Feunteun,J. and Livingston,D.M.
  TITLE     BRCA1 supports XIST RNA concentration on the inactive X chromosome
  JOURNAL   Cell 111 (3), 393-405 (2002)
   PUBMED   12419249
REFERENCE   8  (bases 1 to 5289)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   9  (bases 1 to 5289)
  AUTHORS   Gratas,C., Meflah,K., Harb,J., Van Vooren,P., Szpirer,J. and
            Szpirer,C.
  TITLE     Assignment of the BRCA1-associated RING domain gene (Bard1) to rat
            chromosome 9q34 by in situ hybridization and radiation hybrid
            mapping
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 250-251 (2001)
   PUBMED   11856892
  REMARK    GeneRIF: Assignment of the BRCA1-associated RING domain gene
            (Bard1) to rat chromosome 9q34 by in situ hybridization and
            radiation hybrid mapping
REFERENCE   10 (bases 1 to 5289)
  AUTHORS   Gautier,F., Irminger-Finger,I., Gregoire,M., Meflah,K. and Harb,J.
  TITLE     Identification of an apoptotic cleavage product of BARD1 as an
            autoantigen: a potential factor in the antitumoral response
            mediated by apoptotic bodies
  JOURNAL   Cancer Res 60 (24), 6895-6900 (2000)
   PUBMED   11156388
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 30, 2020 this sequence version replaced NM_022622.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF182946.1, SRR26643292.37897.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000009.1  80143450-80143755   c
            307-363             JAXUCZ010000009.1  80123817-80123873   c
            364-512             JAXUCZ010000009.1  80122512-80122660   c
            513-1450            JAXUCZ010000009.1  80115997-80116934   c
            1451-1531           JAXUCZ010000009.1  80108844-80108924   c
            1532-1704           JAXUCZ010000009.1  80107307-80107479   c
            1705-1813           JAXUCZ010000009.1  80096410-80096518   c
            1814-1949           JAXUCZ010000009.1  80090596-80090731   c
            1950-2042           JAXUCZ010000009.1  80089837-80089929   c
            2043-2140           JAXUCZ010000009.1  80074479-80074576   c
            2141-5289           JAXUCZ010000009.1  80069960-80073108   c
FEATURES             Location/Qualifiers
     source          1..5289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q33"
     gene            1..5289
                     /gene="Bard1"
                     /note="BRCA1 associated RING domain 1"
                     /db_xref="GeneID:64557"
                     /db_xref="RGD:621072"
     exon            1..306
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..2473
                     /gene="Bard1"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase BARD1"
                     /codon_start=1
                     /product="BRCA1-associated RING domain protein 1"
                     /protein_id="NP_072144.2"
                     /db_xref="GeneID:64557"
                     /db_xref="RGD:621072"
                     /translation="MPHRPPRVRSGNKPPPVPAMEPATDGLWAHSRAALARLEKLLRC
                     SRCANILREPVCLGGCEHIFCSGCISDCVGSGCPVCHTPAWILDLKINRQLDSMIQLY
                     SKLQNLLHDNKGSDSKDDTSRASLLGDAERKKNSVKMWFSPRSKKIRCVVNKVSVQTQ
                     PQKAKDDKAQEASVFEFVSATPPVVVSTRAKTASRTSAKKHPKKSVAKINREGNFRPE
                     TRDSRFDSKEKLKEEKVVSFSQTLVMENSRVNGEIDLLASGSVVESECSGSFAEVSLP
                     LAEHIVSPDTVSKSEEAPEKKVCVEDRCPVGSDGNPKGCHRPPTSTSKKCGSNVPSTS
                     GEIREPTLLAENVVLVDCSSLPSGRLQVDVTLRRQSNASDDSLSLSPGTPPSLLNNST
                     HRQMMSKPSTVKLSSGIPARKRNHRGETLLHIASIKGDISSVEYLLQNGNDPNVKDHA
                     GWTPLHEACSHGHLKIVELLLQHNALVNTTGYHNDSPLHDAAKNGHIDIVKVLLSHGA
                     SRNAVNIFGERPVDYTDAENIRSLLLLPEKTDSFSTSQCSVQVNTGQRKSGPLVLIGS
                     GLSSQQQKLLSKLETVLKAKKCAEFDNTVTHVIVPDEEAQSTLKCMLGILNGCWVLKF
                     DWVKACLDSQEREQEEKYEVPGGPQRSRLNREQLLPKLFDGCYFFLGGNFKHHPKEDL
                     LKLIAAAGGRILSRKPKPDSDVTQTINTVAYHAKPDSDQRFCTQYIVYEDLFNCHPER
                     VRQGKVWMAPSTWLISCVMAFELLPLDS"
     exon            307..363
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..512
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..1450
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1531
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1704
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1813
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1949
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2042
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2140
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..5289
                     /gene="Bard1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggcgtggc ttcaagccgc gtccctccat ctctgggaat tttaccgcat ttgcgctgcc
       61 cagccctagg tgacccaagg attctgaaac tccgcgctca gcgggattcg gcggtgacca
      121 gcggggtgcg gcgctcaagc agacctgacc tccccaccta cgcgggatgc cgcaccggcc
      181 gccgagggtc cgctccggga acaagcctcc tcccgtgccc gccatggaac cagctaccga
      241 cgggctttgg gcccacagcc gtgcggcgct tgcccgtctg gagaagttgt tgcgctgctc
      301 ccgctgtgct aatattctga gggagcccgt gtgcctagga ggatgcgagc acatcttctg
      361 tagtggttgt ataagcgact gtgttggatc aggatgccca gtgtgtcata ccccagcctg
      421 gatcctagac ctcaagataa acagacagtt ggacagcatg atccagcttt atagtaagct
      481 tcaaaatttg ctacatgaca ataaaggttc agattcaaaa gacgacacat ctagggcaag
      541 tttacttggt gatgcagaaa ggaagaagaa ttcagtaaaa atgtggttta gtcctcgaag
      601 taagaaaatt agatgtgttg tgaataaagt ttcagtacaa acccagcctc aaaaggcaaa
      661 ggatgacaaa gcccaggaag cctcagtgtt tgaatttgtt tccgcaactc cccctgtagt
      721 tgtttctacg agggctaaaa cagcttcaag aacatctgca aaaaagcatc ccaagaaatc
      781 tgtagctaag atcaaccggg agggaaattt caggccagaa acaagggata gtagatttga
      841 ttccaaagaa aagctgaagg aagagaaggt tgtctccttt agccaaacac tagttatgga
      901 gaattcacgg gtaaatggcg aaatagactt attagcgagt ggctctgtgg tagaatccga
      961 atgttctgga agctttgctg aagtctcttt accattggct gagcatatag tgtctccaga
     1021 tactgtgagc aagagtgaag aggctcctga gaagaaggtc tgtgtagaag atcgttgtcc
     1081 agtagggagt gatggaaatc ccaaaggctg ccacaggcct cccacttcta cttctaagaa
     1141 atgtgggagc aacgttccaa gcaccagcgg agaaatccgt gagccaacat tgcttgcaga
     1201 aaatgtagtg ttggttgact gttcttcact gccttcaggc cgacttcagg ttgatgtcac
     1261 cctcaggaga cagagtaacg catcagatga ctctcttagc ctttcaccag gcacaccccc
     1321 atctctgctg aacaattcca ctcacagaca aatgatgtca aagccctcca cagtgaagct
     1381 gtcttctggt attccagcca ggaaaagaaa tcacagagga gagacgttac tgcacattgc
     1441 ctctataaag ggtgatatat cttctgttga atacctcttg caaaatggaa acgacccaaa
     1501 tgttaaggac catgctggat ggacaccgtt gcatgaagcc tgcagtcatg ggcacctgaa
     1561 gatagtggag ctgctgctcc agcacaatgc cttggtgaac accaccggct atcacaatga
     1621 ctcgccactg cacgatgccg ccaagaatgg ccacatcgat atagtcaagg tgttactgtc
     1681 ccacggagct tccaggaacg ctgttaacat atttggtgag cggccagtgg attacacaga
     1741 cgctgagaat ataaggtcat tattgctgct gccagagaag acggattcat tctcaactag
     1801 ccagtgctct gtccaggtga acaccgggca gcggaagagt gggccgctgg tactaatagg
     1861 cagtgggctt tcttcacagc agcagaaact gctcagcaaa cttgagacag tgctaaaggc
     1921 taagaagtgt gctgagtttg acaacacagt aactcatgtc attgttcctg atgaggaagc
     1981 tcagagtacc ttgaagtgta tgcttgggat tctcaatgga tgctgggtcc tgaagtttga
     2041 ttgggtgaaa gcctgtctgg acagccaaga acgtgagcag gaagaaaagt atgaagttcc
     2101 tggaggtccg cagaggagca ggctcaacag agagcagctg ctgcccaaac tgttcgatgg
     2161 atgctacttc tttctggggg ggaacttcaa acatcatcca aaagaagacc tcctgaagct
     2221 cattgctgca gcaggaggca gaatcctcag cagaaagccc aagccagaca gtgacgtgac
     2281 tcagaccatc aacacggttg cataccatgc caagcctgac tctgatcagc gcttctgtac
     2341 gcagtacatt gtctatgagg atctgtttaa ctgtcaccca gagagggttc ggcagggcaa
     2401 agtctggatg gctccttcca cctggctaat cagctgtgta atggcctttg agttgcttcc
     2461 tcttgacagc tgaatgtcgt accaggtgaa cattttaagt tgaaggcgcg tggtttgtga
     2521 gaacacggcc attgtgatgt ttgatcactc tcgcttttat ggataggtag aaccattcat
     2581 atcccccctc cctttgaatt gcaaaataaa ataattgata atagattagg aattcattta
     2641 gatgcctaaa ccacttttaa gattttcttg ttgttgctct ctttcgaggg tgggggctat
     2701 aactcaagtc ttagagtctt catcaactct ggctgaggca cagtttccac actaggaatt
     2761 tactttacac gtggcctgtg gttttgattg atcatgtttt tcagttttat caacatctgt
     2821 caaggattaa taagtgagat agcatcaaac tatttgataa atctatacgt ggcctgccac
     2881 taatttagca tcctttagta aacagagcat caccagatga ttttcttctg tcccttttat
     2941 gatataaatg tgccagtgtg ggtgaaaagc tctatctgga gttatctttt ttatgttata
     3001 ttttaatttc ttgtattttc ttggctttcc tttgtgtttg ttcatttaaa aaaaaatctt
     3061 gtgtatgtat taggaaatca tgattccaag cgctagatgt tagtggcaaa atcagcagtg
     3121 tgcttgtgtg catgctttca gtatgcacac ttactgtctg tctactgtgc atttgtgcac
     3181 acctattttc tgtaacttat tatagtgcca ctacttctta gaaggtcttg ccagtttaga
     3241 acactgttaa atgtcaattc cttacattag aagcaatctg tttttggtaa atctttctgg
     3301 gaattactaa aatagtccct gaaggcttta atcccttctc tattcccttc ctccttcctc
     3361 cttcctccct ctccctcctt ctctccttcc ctttatttgt gatagtgagt atagaaggga
     3421 ggatcttatg catgctaggc agttacctcc ttcagaacta tatctgcagc ccacttttct
     3481 ctctctctgg tgagcaaatg ggggccttgc acataccagg gaactgagct ccactccaaa
     3541 ccttcattta tttggagaca tcttgctaag ttagagaggt tgcccttgat ctcactgagc
     3601 tgtaagtttt tatacagcct ttaagttggt gggtaggcaa aagttggaga ttgcttgact
     3661 tataacattt ttgacatatt ctacacaaac tccctagcag gaaataagga agtgggagtg
     3721 agaagagctg cttgatagag aagcagccac agcagggaag tagagagggc cctccctgag
     3781 catgcgcaca ctggaagctt accctgcctc ttctgaaggt tctcattgtg aatggacagg
     3841 ctctatactt taaatggtct taaagaagag gattctttcg tgcatctttg cataagctag
     3901 tgttgacagc actatgatgt acagaaggag gtgctaagag aaccatctgt tttgttttta
     3961 ggagaacagg gcagcttgat aagcacgggg cagggggatg gtcatggatg gtgggaatct
     4021 tcccagctcg gaactgggaa agccagtcat ttcaagatcc acttaccagg aaaggttgag
     4081 attctgctaa tcttatgaaa gtataccttg cataaatcct tctttagcat actatttttc
     4141 atgccaacag gtatgttaat gtgaacacaa tgttctcccc atgctggctt cccagtgtct
     4201 tgtctgtgtt tgacacaatt ctttttaaat ctggggagtg gtggaagggt aatgtggatt
     4261 aagctgttta ggtgtgggtt tggggtatag ggcttgtttt ctcttcgctc gctgagctcc
     4321 ttcctcttgc tcctggtatc tcacccctgc tcagggttct gttctctttg ctgtgaactc
     4381 ctgtgtctga aatgcctttg gggttcctct tcatgtttcc tctcttgcct tacccccttt
     4441 ctcgttttcc cctttactgt tagtattact acttttgagt gctctaaatg ctgattttta
     4501 aaaaacttgt ctgaaacaga aatgtattct cagaataatg cataaaagca caggtcgagc
     4561 tatgcagaaa cttccctccc ttctcctacc ttttcccttc tctgaatgcc agggagaagg
     4621 acgcagttga aggaaatatg caatcaaaac agtgaccaac tctaaggaca aaggcgtggt
     4681 ccaaaagaac ttaccattat ccaattatgt gaacagcttc actgaccagg gttaagatgc
     4741 tgcagatgtc ttgtttctgt agggcggctt ctcagggctg cttcagggag gtaaggatgc
     4801 agtgcacgtg ggagacatct gtggcctgct ccctgggctt agggtaaagt cgcacagctg
     4861 tgcacccact ttgggacact cattagtgtc ctcacaatgg ctgtgctgcc cggccgtttg
     4921 cctccgcttt ctgtactgct cactgtctca cgcacgcacc acctcccagc tccttggttg
     4981 ctttccacgc tgcttcttgc caccaagaat tggcatcaag tgcttccagg cgctgtttgc
     5041 tcttctctcc atttatggag actcagtctc tgatcgcggc ggatccactt ttgagatagc
     5101 ggcataactg ttggcccttt actctccgct cgcatttgcc gcttccctcc catcagcagt
     5161 gtcgggactt ggtttaggtt accttctagc actcgaggct gtacgttcat ctacagaaat
     5221 gtttgtaatt ttttttccta atggatttaa acttataaat cattaaaacc atttgagctt
     5281 gtatctgta
//
