LOCUS       NM_001107292            3751 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Rattus norvegicus BRCA1 associated deubiquitinase 1 (Bap1), mRNA.
ACCESSION   NM_001107292 XM_001058224 XM_224614
VERSION     NM_001107292.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Qin,T., Lv,Y., Xi,X. and Wu,Z.
  TITLE     PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy
  JOURNAL   Biochem Pharmacol 226, 116374 (2024)
   PUBMED   38906226
  REMARK    GeneRIF: PLK-3-mediated phosphorylation of BAP1 prevents diabetic
            retinopathy.
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Liu,Y., Hu,N., Ai,B., Xia,H. and Li,W.
  TITLE     MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to
            inhibit SLC7A11 deubiquitination and ferroptosis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 286 (2024)
   PUBMED   38816686
  REMARK    GeneRIF: MiR-31-5p alleviates septic cardiomyopathy by targeting
            BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Misumi,K., Hayashi,A., Shibahara,J., Arita,J., Sakamoto,Y.,
            Hasegawa,K., Kokudo,N. and Fukayama,M.
  TITLE     Intrahepatic cholangiocarcinoma frequently shows loss of BAP1 and
            PBRM1 expression, and demonstrates specific clinicopathological and
            genetic characteristics with BAP1 loss
  JOURNAL   Histopathology 70 (5), 766-774 (2017)
   PUBMED   27864835
REFERENCE   4  (bases 1 to 3751)
  AUTHORS   Righi,L., Duregon,E., Vatrano,S., Izzo,S., Giorcelli,J.,
            Rondon-Lagos,M., Ascoli,V., Ruffini,E., Ventura,L., Volante,M.,
            Papotti,M. and Scagliotti,G.V.
  TITLE     BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as
            a Diagnostic Tool in Malignant Pleural Mesothelioma Classification:
            A Large Retrospective Study
  JOURNAL   J Thorac Oncol 11 (11), 2006-2017 (2016)
   PUBMED   27422796
REFERENCE   5  (bases 1 to 3751)
  AUTHORS   Napolitano,A., Pellegrini,L., Dey,A., Larson,D., Tanji,M.,
            Flores,E.G., Kendrick,B., Lapid,D., Powers,A., Kanodia,S.,
            Pastorino,S., Pass,H.I., Dixit,V., Yang,H. and Carbone,M.
  TITLE     Minimal asbestos exposure in germline BAP1 heterozygous mice is
            associated with deregulated inflammatory response and increased
            risk of mesothelioma
  JOURNAL   Oncogene 35 (15), 1996-2002 (2016)
   PUBMED   26119930
REFERENCE   6  (bases 1 to 3751)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   7  (bases 1 to 3751)
  AUTHORS   Scheuermann,J.C., de Ayala Alonso,A.G., Oktaba,K., Ly-Hartig,N.,
            McGinty,R.K., Fraterman,S., Wilm,M., Muir,T.W. and Muller,J.
  TITLE     Histone H2A deubiquitinase activity of the Polycomb repressive
            complex PR-DUB
  JOURNAL   Nature 465 (7295), 243-247 (2010)
   PUBMED   20436459
REFERENCE   8  (bases 1 to 3751)
  AUTHORS   Machida,Y.J., Machida,Y., Vashisht,A.A., Wohlschlegel,J.A. and
            Dutta,A.
  TITLE     The deubiquitinating enzyme BAP1 regulates cell growth via
            interaction with HCF-1
  JOURNAL   J Biol Chem 284 (49), 34179-34188 (2009)
   PUBMED   19815555
REFERENCE   9  (bases 1 to 3751)
  AUTHORS   Misaghi,S., Ottosen,S., Izrael-Tomasevic,A., Arnott,D.,
            Lamkanfi,M., Lee,J., Liu,J., O'Rourke,K., Dixit,V.M. and
            Wilson,A.C.
  TITLE     Association of C-terminal ubiquitin hydrolase BRCA1-associated
            protein 1 with cell cycle regulator host cell factor 1
  JOURNAL   Mol Cell Biol 29 (8), 2181-2192 (2009)
   PUBMED   19188440
REFERENCE   10 (bases 1 to 3751)
  AUTHORS   Ventii,K.H., Devi,N.S., Friedrich,K.L., Chernova,T.A.,
            Tighiouart,M., Van Meir,E.G. and Wilkinson,K.D.
  TITLE     BRCA1-associated protein-1 is a tumor suppressor that requires
            deubiquitinating activity and nuclear localization
  JOURNAL   Cancer Res 68 (17), 6953-6962 (2008)
   PUBMED   18757409
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474046.1.
            
            [WARNING] On Mar 19, 2025 this sequence was replaced by
            NM_001107292.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001058224.1, XM_224614.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132296,
                              SAMD00132299 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..3751
                     /gene="Bap1"
                     /note="BRCA1 associated deubiquitinase 1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
     exon            1..441
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..2627
                     /gene="Bap1"
                     /EC_number="3.4.19.12"
                     /note="BRCA1-associated protein 1; BRCA1 associated
                     protein-1 (ubiquitin carboxy-terminal hydrolase); Brca1
                     associated protein 1"
                     /codon_start=1
                     /product="ubiquitin carboxyl-terminal hydrolase BAP1"
                     /protein_id="NP_001100762.1"
                     /db_xref="GeneID:306257"
                     /db_xref="RGD:1311938"
                     /translation="MNKGWLELESDPGLFTLLVEDFGKNPFTPDRRALAGVKGVQVEE
                     IYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNSMFFAHQLIPN
                     SCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARP
                     EPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDK
                     ARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRVKYEARLHVLKGNRQTVLEALQQLI
                     RVTQPELIQTHKSQESQLPEESKPASSKSPFGLEAGRTPAASECTHTDGAEEVAGSCP
                     QTTTHSPPSKSKLVVKPSGSSLNGVPPTPTPIVQRLPAFLDNHNYAKSPMQEEEDLAA
                     GVGRSRVPVRPQQYSDDEEDYEDEEEDVQNTSSAIRYKRKGTGKPGSLSNSSDGQLSV
                     LQPNTINVLTEKLQESQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTAS
                     EIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGP
                     VISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSSQGSQGSSSLEEKEVVEVTDSRDKS
                     GLNRSSEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNY
                     DEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
                     "
     exon            442..510
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..565
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            566..698
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..818
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..880
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1023
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1102
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1226
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1374
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1559
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1687
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..2166
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2327
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2420
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2493
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..3751
                     /gene="Bap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgccc cgcgcggtga ctgcgccgtc gaaggaggcg agcgcgctaa cgggggatgg
       61 gtcacgcgga ctgtggcccg cgggcacctc agcgttgcag acagttgtca aaacggggac
      121 cgctaacggc cgcgcgctaa cagtcgcgcg cccgacccat cttccgcgcg tgcgcatcct
      181 cgcctctgcg cgcgcgcatc cggcctccgc gcaggcggaa ggccagcccc ggattaggct
      241 cgtcgtgtgt gatgacgttg tactcccggc gcgggtgagt gacgcggcgc ggcccgttgt
      301 ctgtgtgggg ctgagaagcc ccgagggcgg tgggcgctcc cggtgggggc ggcgcggggt
      361 tagcagggcc tggacatggc gctgagagac cgctccgcgg gaagatgaat aagggctggc
      421 tggagctgga gagtgacccg ggcctcttca ccctcctggt ggaagatttc ggtaagaacc
      481 cctttacccc cgatcgtcgg gccctggctg gtgtcaaagg ggtgcaagtg gaggagatct
      541 atgaccttca gagtaaatgc caggggcctg tatatggatt tatcttcctg ttcaaatgga
      601 tcgaagagcg caggtcccgc cgcaaggttt ctacgttggt ggatgataca tctgtgattg
      661 atgatgacat cgtgaatagc atgttctttg ctcaccagct gattcccaac tcttgtgcca
      721 ctcacgcctt gctgagcgtg cttctgaact gcagcaatgt ggatttgggg cccacgctga
      781 gtcgaatgaa ggatttcacc aaaggcttca gccctgagag caaaggatat gcgattggca
      841 atgcccctga actggccaag gcacataata gccatgccag gccagaacca cgtcaccttc
      901 ctgagaaaca gaatggcctc agtgcagtgc ggaccatgga ggcgtttcac tttgtcagct
      961 atgtgcctat cacaggacgg ctctttgaat tggatgggtt gaaagtctac cctattgatc
     1021 atgggccctg gggagaggat gaggagtgga cagataaagc ccgaagggtc atcatggagc
     1081 gaatcggcct tgctactgca ggggagccct accatgacat tcgcttcaac ctgatggcag
     1141 tggtgcctga ccgcagggtt aagtatgagg ccaggctgca tgtgctgaag gggaaccgac
     1201 aaacagtcct ggaggccctg cagcagctga ttagagtaac acagccagag ctgattcaga
     1261 cccacaaatc tcaagagtca caactgcctg aggagagcaa gccagccagc agcaagtctc
     1321 cctttgggct agaggcgggc agaaccccgg cggcctctga gtgcactcac acagatggtg
     1381 cagaggaggt ggctggttcg tgcccacaaa ctacaaccca tagtcctccc agcaaatcta
     1441 agctggtggt gaagccttca gggagcagcc tcaatggggt tcccccaacc cctaccccta
     1501 ttgtccagcg gctgccagcc tttctagata atcacaatta tgccaaatcc cctatgcagg
     1561 aggaggaaga cctggcggca ggtgtgggcc gcagccgagt tccagtccga ccccagcagt
     1621 actctgatga tgaggaggac tatgaggatg aggaggagga tgtgcagaat accagttctg
     1681 ccatcagata caagcggaag gggacaggga agccaggatc gttgagcaat tcttcagatg
     1741 ggcagctgtc agtgctgcag cccaacacca tcaatgtctt aactgagaag cttcaagagt
     1801 ctcagaaaga cctttcaatt cctctgtcca tcaagactag cagtggggct gggagtccag
     1861 ccgtggctgt gcccacacac tcgcagcctt cacccacccc tagcaatgag agcacggaca
     1921 cagcctctga gattggcagt gctttcaact cacccttgcg ctcacccatc cgctcagcca
     1981 acccaacacg gccctctagc cctgtcacct ctcacatctc caaggtgctc tttggagaag
     2041 atgacagcct acttcgtgtt gactgcatac gctacaaccg tgctgtccgt gacctgggtc
     2101 ctgtcattag cacgggcctg ctgcaccttg ctgaggatgg tgtactgagt cccctggcac
     2161 tcacagaggg tgggaagggt tcctcacctt ctaccagatc aagccaaggc agccaggggt
     2221 ccagcagcct agaggagaag gaggtggtgg aagtcacaga tagcagagac aagtctgggc
     2281 tgaacaggtc cagtgagccc ttgagtggag agaagtactc gcccaaggag ctgttagcac
     2341 tgttaaagtg tgtagaggcc gagattgcaa actatgaggc ctgtctcaag gaggaggtgg
     2401 agaaaaggaa gaagttcaag attgatgacc agcgaaggac ccacaactat gatgagttca
     2461 tctgcacctt catatccatg ctggctcagg aaggaatgct ggccaacctg gtggagcaga
     2521 acatctcagt gcggcgccgc caaggggtca gcattggtcg gcttcacaag cagcggaagc
     2581 ctgataggcg gaaacgctct cgcccctaca aggccaaacg ccagtgagga cctctagccc
     2641 tgactctgca gcctctcttg ccgcaaggcc ctcaccaggg cccttcactg ttcgactttt
     2701 ccaagtatta ctgaatagtt cagctagagc tcaggccctg ggagtaggaa tgggatgtgt
     2761 attctgcatt atgctctggg gtctggcagg gacaaggcag ctccataatg ctcaggaagc
     2821 agcagctgga attggagggt gctgtggcct ccacggccat ctgaggagca gcaggatata
     2881 tattctacct gttggagatg tctatttttt tgacttttgg ccatcttgcc actgtattaa
     2941 catggccagc ttcctgactc tgctttctct cccagcagct gtcattctgc tgggcccagg
     3001 tctcttataa ccacagtacc agctgggaaa cccagaaggc attggtcctg gtgctctagc
     3061 accagccacc agcctgtcct tgttgtgaag aagcttggcc tactactctt gattccttct
     3121 gggagagcgc caaactcagg gacctggctg ctgagctgga atgggcatgg ggtatcctag
     3181 taggatgtac agcctatcag ggtcccacag ctatcgtgga gacaagtgtt tgaactgtcc
     3241 tcgtaccacc cagacttgtt agtgagtcag agcagggctc tggggctctt tgccttcagt
     3301 gttgtggccc tggccgtggg cctaccttag gctcctaatc tccgtctctg gggtccagag
     3361 gagccactac ttagcccctc agtattacca tgtctcctct taggaatgtc agaggcaggg
     3421 ctgctcgaat gaggctggca ctattcaatt ctcccgaccg tgccagcttc cttggcctca
     3481 tgcaggtact cagggtaggg gacagggtca agaggagtta gaacttctgt gttcccatag
     3541 ggcttgatgc cagtggggta gtaagcacag cactgcttca agctccaggc ccagatagcc
     3601 ctgtgccctc tgctagatac aggtgatcca agcaggcccc ttacctgtac atagcaactg
     3661 tcggggggat ggtacagcag tccgacccgc tatagtgtct gtaaatactg aatcagtgag
     3721 tgaagaataa aagtgtgcta ataagtgatc t
//
