LOCUS       NM_139082                842 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus BMP and activin membrane-bound inhibitor (Bambi),
            mRNA.
ACCESSION   NM_139082
VERSION     NM_139082.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 842)
  AUTHORS   Zhu,K., Hu,X., Chen,H., Li,F., Yin,N., Liu,A.L., Shan,K., Qin,Y.W.,
            Huang,X., Chang,Q., Xu,G.Z. and Wang,Z.
  TITLE     Downregulation of circRNA DMNT3B contributes to diabetic retinal
            vascular dysfunction through targeting miR-20b-5p and BAMBI
  JOURNAL   EBioMedicine 49, 341-353 (2019)
   PUBMED   31636010
  REMARK    GeneRIF: Downregulation of circDNMT3B contributes to vascular
            dysfunction in diabetic retinas through regulating miR-20b-5p and
            BAMBI, providing a potential treatment strategy for diabetic
            retinopathy
REFERENCE   2  (bases 1 to 842)
  AUTHORS   Sun,L., Xiu,M., Wang,S., Brigstock,D.R., Li,H., Qu,L. and Gao,R.
  TITLE     Lipopolysaccharide enhances TGF-beta1 signalling pathway and rat
            pancreatic fibrosis
  JOURNAL   J Cell Mol Med 22 (4), 2346-2356 (2018)
   PUBMED   29424488
  REMARK    GeneRIF: These findings indicate that LPS increases TGF-beta1
            production through paracrine and autocrine mechanisms and that LPS
            enhances TGF-beta1 signalling in PSCs by repressing BAMBI via
            TLR4/MyD88/NF-kB activation.
REFERENCE   3  (bases 1 to 842)
  AUTHORS   Yang,Y., Guo,C., Liao,B., Cao,J., Liang,C. and He,X.
  TITLE     BAMBI inhibits inflammation through the activation of autophagy in
            experimental spinal cord injury
  JOURNAL   Int J Mol Med 39 (2), 423-429 (2017)
   PUBMED   28035406
  REMARK    GeneRIF: BAMBI plays a neuroprotective role by decreasing
            inflammation and activating autophagy in rats with SCI.
REFERENCE   4  (bases 1 to 842)
  AUTHORS   Zhang,J.C., Chen,G., Chen,L., Meng,Z.J., Xiong,X.Z., Liu,H.J.,
            Jin,Y., Tao,X.N., Wu,J.H. and Sun,S.W.
  TITLE     TGF-beta/BAMBI pathway dysfunction contributes to peripheral
            Th17/Treg imbalance in chronic obstructive pulmonary disease
  JOURNAL   Sci Rep 6, 31911 (2016)
   PUBMED   27549738
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 842)
  AUTHORS   He,Y., Ou,Z., Chen,X., Zu,X., Liu,L., Li,Y., Cao,Z., Chen,M.,
            Chen,Z., Chen,H., Qi,L. and Wang,L.
  TITLE     LPS/TLR4 Signaling Enhances TGF-beta Response Through
            Downregulating BAMBI During Prostatic Hyperplasia
  JOURNAL   Sci Rep 6, 27051 (2016)
   PUBMED   27243216
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 842)
  AUTHORS   Lin,Z., Gao,C., Ning,Y., He,X., Wu,W. and Chen,Y.G.
  TITLE     The pseudoreceptor BMP and activin membrane-bound inhibitor
            positively modulates Wnt/beta-catenin signaling
  JOURNAL   J Biol Chem 283 (48), 33053-33058 (2008)
   PUBMED   18838381
REFERENCE   7  (bases 1 to 842)
  AUTHORS   Togo,N., Ohwada,S., Sakurai,S., Toya,H., Sakamoto,I., Yamada,T.,
            Nakano,T., Muroya,K., Takeyoshi,I., Nakajima,T., Sekiya,T.,
            Yamazumi,Y., Nakamura,T. and Akiyama,T.
  TITLE     Prognostic significance of BMP and activin membrane-bound inhibitor
            in colorectal cancer
  JOURNAL   World J Gastroenterol 14 (31), 4880-4888 (2008)
   PUBMED   18756595
REFERENCE   8  (bases 1 to 842)
  AUTHORS   Sekiya,T., Adachi,S., Kohu,K., Yamada,T., Higuchi,O., Furukawa,Y.,
            Nakamura,Y., Nakamura,T., Tashiro,K., Kuhara,S., Ohwada,S. and
            Akiyama,T.
  TITLE     Identification of BMP and activin membrane-bound inhibitor (BAMBI),
            an inhibitor of transforming growth factor-beta signaling, as a
            target of the beta-catenin pathway in colorectal tumor cells
  JOURNAL   J Biol Chem 279 (8), 6840-6846 (2004)
   PUBMED   14660579
REFERENCE   9  (bases 1 to 842)
  AUTHORS   Loveland,K.L., Bakker,M., Meehan,T., Christy,E., von Schonfeldt,V.,
            Drummond,A. and de Kretser,D.
  TITLE     Expression of Bambi is widespread in juvenile and adult rat tissues
            and is regulated in male germ cells
  JOURNAL   Endocrinology 144 (9), 4180-4186 (2003)
   PUBMED   12933693
  REMARK    GeneRIF: Regulated Bambi mRNA synthesis may contribute to TGF beta
            superfamily signaling modulation in several organs, as suggested by
            its discrete expression switch in male germ cells.
REFERENCE   10 (bases 1 to 842)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF387513.1.
            
            On Jun 10, 2007 this sequence version replaced NM_139082.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF387513.1, BC070516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..842
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.1"
     gene            1..842
                     /gene="Bambi"
                     /note="BMP and activin membrane-bound inhibitor"
                     /db_xref="GeneID:83837"
                     /db_xref="RGD:621831"
     exon            1..87
                     /gene="Bambi"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..794
                     /gene="Bambi"
                     /note="kinase-deficient TGFbeta superfamily receptor
                     subunit; BMP and activin membrane-bound inhibitor,
                     homolog"
                     /codon_start=1
                     /product="BMP and activin membrane-bound inhibitor homolog
                     precursor"
                     /protein_id="NP_620782.1"
                     /db_xref="GeneID:83837"
                     /db_xref="RGD:621831"
                     /translation="MDRHSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMC
                     KSELSACFSRLLDPQNTNSPLTHGCLDSLASTADICRAKQAQNHSGPTMPTLECCHED
                     MCNYRGLHDVLSPPKSEASGQGNRYQHDSSRNLITKVQELTSSKELWFRAAVIAVPIA
                     GGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHHSKKGQVAKLDLECMVP
                     VSGQENCCLTCDKMRQADLSNEKILSLVHWGMYSGHGKLEFV"
     exon            88..375
                     /gene="Bambi"
                     /inference="alignment:Splign:2.1.0"
     exon            376..842
                     /gene="Bambi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggcgtc aatggatcgc cactccagct acatcttcat ctggctgcag ttggagctct
       61 gcgccatggc tgtgctgctc accaaaggcg agatcagatg ctactgtgat gccgctcact
      121 gtgtggcaac tggttacatg tgtaagtccg agcttagtgc ctgcttctcc agactccttg
      181 atcctcagaa caccaattcc ccactaaccc acggctgcct ggactcactc gcaagcacag
      241 cagacatctg ccgagccaaa caggcccaaa accactctgg tcccaccatg cccactttgg
      301 aatgctgtca tgaagacatg tgcaattacc gaggactgca tgatgtcctc tctcctccca
      361 agagtgaagc ctcaggacaa ggaaacagat accagcatga cagcagcaga aacctcatca
      421 ctaaggtgca ggagctgact tcctccaaag aactgtggtt ccgtgcagcc gtgatcgcgg
      481 ttcccattgc tggcggactg atcttggtgc tgctcattat gttggccttg cgaatgctgc
      541 gaagtgagaa caagaggctg caggatcagc ggcagcagat gctctctcgt ttgcactaca
      601 gcttccatgg acaccactcc aagaagggac aggttgcaaa gttggactta gagtgcatgg
      661 tgcccgtcag tgggcaggag aactgctgtc tgacctgcga caaaatgagg caagcagatc
      721 tcagcaacga gaagatcctc tcccttgtgc actggggcat gtacagtggt catgggaagc
      781 tggaattcgt atgacagtcg tgtctgaact gtaaatggaa cccttgaagg ccttctgagt
      841 tc
//
