LOCUS       NM_057196               1798 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus BAR/IMD domain containing adaptor protein 2
            (Baiap2), mRNA.
ACCESSION   NM_057196
VERSION     NM_057196.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Liu,F., Chen,Y., Zhao,S., Li,M., Luo,F. and Tang,C.E.
  TITLE     Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced
            Activation of NF-kappaB and Impaired Mobility of HUVECs
  JOURNAL   Biomed Res Int 2021, 3210586 (2021)
   PUBMED   33506012
  REMARK    GeneRIF: Insulin Receptor Substrate p53 Ameliorates
            High-Glucose-Induced Activation of NF-kappaB and Impaired Mobility
            of HUVECs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Dosemeci,A., Burch,A., Loo,H., Toy,D. and Tao-Cheng,J.H.
  TITLE     IRSp53 accumulates at the postsynaptic density under excitatory
            conditions
  JOURNAL   PLoS One 12 (12), e0190250 (2017)
   PUBMED   29284046
  REMARK    GeneRIF: IRSp53 molecules may have a structural role organizing the
            Shank scaffold and/or linking the PSD to the actin cytoskeleton
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1798)
  AUTHORS   Chuang,H.C., Huang,T.N. and Hsueh,Y.P.
  TITLE     T-Brain-1--A Potential Master Regulator in Autism Spectrum
            Disorders
  JOURNAL   Autism Res 8 (4), 412-426 (2015)
   PUBMED   25600067
REFERENCE   4  (bases 1 to 1798)
  AUTHORS   Chen,C.J., Shih,C.H., Chang,Y.J., Hong,S.J., Li,T.N., Wang,L.H. and
            Chen,L.
  TITLE     SH2B1 and IRSp53 proteins promote the formation of dendrites and
            dendritic branches
  JOURNAL   J Biol Chem 290 (10), 6010-6021 (2015)
   PUBMED   25586189
  REMARK    GeneRIF: These findings suggest that SH2B1-IRSp53 complexes promote
            the formation of filopodia, neurite initiation, and neuronal
            branching.
REFERENCE   5  (bases 1 to 1798)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1798)
  AUTHORS   Bockmann,J., Kreutz,M.R., Gundelfinger,E.D. and Bockers,T.M.
  TITLE     ProSAP/Shank postsynaptic density proteins interact with insulin
            receptor tyrosine kinase substrate IRSp53
  JOURNAL   J Neurochem 83 (4), 1013-1017 (2002)
   PUBMED   12421375
REFERENCE   7  (bases 1 to 1798)
  AUTHORS   Okamura-Oho,Y., Miyashita,T. and Yamada,M.
  TITLE     Distinctive tissue distribution and phosphorylation of IRSp53
            isoforms
  JOURNAL   Biochem Biophys Res Commun 289 (5), 957-960 (2001)
   PUBMED   11741283
REFERENCE   8  (bases 1 to 1798)
  AUTHORS   Krugmann,S., Jordens,I., Gevaert,K., Driessens,M.,
            Vandekerckhove,J. and Hall,A.
  TITLE     Cdc42 induces filopodia by promoting the formation of an
            IRSp53:Mena complex
  JOURNAL   Curr Biol 11 (21), 1645-1655 (2001)
   PUBMED   11696321
REFERENCE   9  (bases 1 to 1798)
  AUTHORS   Thomas,E.A., Foye,P.E., Alvarez,C.E., Usui,H. and Sutcliffe,J.G.
  TITLE     Insulin receptor substrate protein p53 localization in rats
            suggests mechanism for specific polyglutamine neurodegeneration
  JOURNAL   Neurosci Lett 309 (3), 145-148 (2001)
   PUBMED   11514062
REFERENCE   10 (bases 1 to 1798)
  AUTHORS   Okamura-Oho,Y., Miyashita,T., Ohmi,K. and Yamada,M.
  TITLE     Dentatorubral-pallidoluysian atrophy protein interacts through a
            proline-rich region near polyglutamine with the SH3 domain of an
            insulin receptor tyrosine kinase substrate
  JOURNAL   Hum Mol Genet 8 (6), 947-957 (1999)
   PUBMED   10332026
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY037934.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY037934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1798
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /note="BAR/IMD domain containing adaptor protein 2"
                     /db_xref="GeneID:117542"
                     /db_xref="RGD:619814"
     exon            1..115
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1630
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /note="insulin receptor substrate 53; BAI-associated
                     protein 2; insulin receptor substrate p53; insulin
                     receptor substrate protein of 53 kDa; insulin receptor
                     tyrosine kinase substrate protein p53; brain-specific
                     angiogenesis inhibitor 1-associated protein 2;
                     BAI1-associated protein 2; brain-specific angiogenesis
                     inhibitor 1-associated protein 2-like"
                     /codon_start=1
                     /product="BAR/IMD domain-containing adapter protein 2"
                     /protein_id="NP_476544.1"
                     /db_xref="GeneID:117542"
                     /db_xref="RGD:619814"
                     /translation="MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAG
                     VTFAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKAFHNELL
                     TQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDK
                     ELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKEL
                     LAQKLPLWQQACADPNKIPDRAAQLMQQMANSNGSILPSALSASKSNLVISDPIPGAK
                     PLPVPPELAPFVGRMSAQENVPVMNGVAGADSEDYNPWADRKAAQPKSLSPPQSQSKL
                     SDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNS
                     TLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQ
                     GKSSSTGNLLDKDDLALPPPDYGTSSRAFPSQTAGTFKQRPYSVAVPAFSQGLDDYGA
                     RSVSSGSGTLVSTV"
     exon            116..191
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            192..278
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            279..340
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            341..412
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            413..550
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            551..703
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            704..928
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1130
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1332
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1401
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1564
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1599
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1798
                     /gene="Baiap2"
                     /gene_synonym="Irsp53"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctttctca ccgacacccg tgcccctgct ctggtctgtg gtgtagccgg gacccaggac
       61 catgtcgctt tcacgctcgg aggagatgca ccggctcacg gaaaatgtct acaagaccat
      121 catggagcag ttcaacccca gcctccgcaa cttcatcgcc atggggaaga actatgagaa
      181 agcactggca ggtgtcacct tcgctgccaa aggctatttc gatgctctgg taaagatggg
      241 ggagctggcc agcgagagcc agggctctaa ggaacttggg gacgtcctct tccagatggc
      301 cgaagtccac cggcagatcc agaaccagct ggaagagatg ctgaaggcct ttcacaatga
      361 gctgctcaca cagctggagc agaaagtaga actggattcc aggtatctga gtgctgcgct
      421 gaagaaatac caaacagaac agaggagcaa aggggacgcc ctggacaagt gtcaggctga
      481 gctaaagaag ctccgtaaga agagccaagg gagtaagaac cctcagaagt actcagacaa
      541 ggagctgcag tacatcgatg ccatcagcaa caagcagggc gagctggaga actacgtgtc
      601 tgacggctac aagacagcac tcactgagga gcgcaggagg ttctgcttcc tggtggaaaa
      661 gcaatgtgca gtggccaaga actccgctgc ctaccactcc aagggcaagg agttactagc
      721 ccagaagctg cctttgtggc agcaagcctg tgctgacccc aacaagatcc cagaccgtgc
      781 tgcccagctg atgcagcaga tggccaacag caatggctcc atccttccaa gtgccctgtc
      841 agcctccaag tccaacctgg tcatctcaga ccccattccc ggggccaagc ccttgccagt
      901 gccgccggaa ctggccccgt tcgtggggcg gatgtctgct caggagaatg tacctgtcat
      961 gaatggcgtc gcaggcgcgg acagcgagga ctacaacccc tgggccgacc gaaaggctgc
     1021 ccagcccaaa tccctgtctc ccccgcagtc tcaaagcaag ctgagcgact cgtactccaa
     1081 cacactcccc gtgcgcaaga gcgtgacccc gaagaacagc tatgccacca ctgagaacaa
     1141 gacgctgcca cggtcaagct ccatggcagc cggcctagaa cgtaacggcc gcatgcgggt
     1201 caaggccatt ttctcccacg cggccggcga caatagcact ctgctgagct tcaaggaggg
     1261 cgacctcatc acgctgctag tgcccgaggc ccgagacggc tggcactatg gcgagagcga
     1321 gaagaccaag atgcggggct ggttcccctt ctcctacact cgggtcctgg acagcgacgg
     1381 aagtgacagg ttgcacatga gcctgcagca gggtaagagc agcagcacag gcaacctcct
     1441 ggacaaggat gacctggccc tccctcctcc tgactatggc acgtcctccc gggcattccc
     1501 cagtcagaca gctgggactt tcaagcaaag accctacagt gtggcagttc ctgccttctc
     1561 tcagggtctg gatgactacg gggcacggtc tgtgagcagt ggcagtggca cgctggtgtc
     1621 cacagtgtga ggacgctgac cccaggcagc tgctctgaag agcgcccccc agtctccatc
     1681 ggtttccctc ctcagctctc gttggtttgt tcttgggttg ttttctttcc cacccgctcc
     1741 tgccttttgg ttggtgatcc cagactctga aatcccccag ggtccatggt gctgctcc
//
