LOCUS       NM_001414741            3882 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus BAG cochaperone 6 (Bag6), transcript variant 3,
            mRNA.
ACCESSION   NM_001414741 XM_006256086
VERSION     NM_001414741.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3882)
  AUTHORS   Mock,J.Y., Xu,Y., Ye,Y. and Clemons,W.M. Jr.
  TITLE     Structural basis for regulation of the nucleo-cytoplasmic
            distribution of Bag6 by TRC35
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), 11679-11684 (2017)
   PUBMED   29042515
REFERENCE   2  (bases 1 to 3882)
  AUTHORS   Topalidou,I., Cattin-Ortola,J., Pappas,A.L., Cooper,K.,
            Merrihew,G.E., MacCoss,M.J. and Ailion,M.
  TITLE     The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo
            Sorting to Dense-Core Vesicles
  JOURNAL   PLoS Genet 12 (5), e1006074 (2016)
   PUBMED   27191843
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3882)
  AUTHORS   Rusakiewicz,S., Perier,A., Semeraro,M., Pitt,J.M., Pogge von
            Strandmann,E., Reiners,K.S., Aspeslagh,S., Piperoglou,C., Vely,F.,
            Ivagnes,A., Jegou,S., Halama,N., Chaigneau,L., Validire,P.,
            Christidis,C., Perniceni,T., Landi,B., Berger,A., Isambert,N.,
            Domont,J., Bonvalot,S., Terrier,P., Adam,J., Coindre,J.M.,
            Emile,J.F., Poirier-Colame,V., Chaba,K., Rocha,B., Caignard,A.,
            Toubert,A., Enot,D., Koch,J., Marabelle,A., Lambert,M.,
            Caillat-Zucman,S., Leyvraz,S., Auclair,C., Vivier,E., Eggermont,A.,
            Borg,C., Blay,J.Y., Le Cesne,A., Mir,O. and Zitvogel,L.
  TITLE     NKp30 isoforms and NKp30 ligands are predictive biomarkers of
            response to imatinib mesylate in metastatic GIST patients
  JOURNAL   Oncoimmunology 6 (1), e1137418 (2016)
   PUBMED   28197361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3882)
  AUTHORS   Osorio,F.G., Soria-Valles,C., Santiago-Fernandez,O., Bernal,T.,
            Mittelbrunn,M., Colado,E., Rodriguez,F., Bonzon-Kulichenko,E.,
            Vazquez,J., Porta-de-la-Riva,M., Ceron,J., Fueyo,A., Li,J.,
            Green,A.R., Freije,J.M. and Lopez-Otin,C.
  TITLE     Loss of the proteostasis factor AIRAPL causes myeloid
            transformation by deregulating IGF-1 signaling
  JOURNAL   Nat Med 22 (1), 91-96 (2016)
   PUBMED   26692333
REFERENCE   5  (bases 1 to 3882)
  AUTHORS   Kadowaki,H., Nagai,A., Maruyama,T., Takami,Y., Satrimafitrah,P.,
            Kato,H., Honda,A., Hatta,T., Natsume,T., Sato,T., Kai,H., Ichijo,H.
            and Nishitoh,H.
  TITLE     Pre-emptive Quality Control Protects the ER from Protein Overload
            via the Proximity of ERAD Components and SRP
  JOURNAL   Cell Rep 13 (5), 944-956 (2015)
   PUBMED   26565908
REFERENCE   6  (bases 1 to 3882)
  AUTHORS   Desmots,F., Russell,H.R., Lee,Y., Boyd,K. and McKinnon,P.J.
  TITLE     The reaper-binding protein scythe modulates apoptosis and
            proliferation during mammalian development
  JOURNAL   Mol Cell Biol 25 (23), 10329-10337 (2005)
   PUBMED   16287848
REFERENCE   7  (bases 1 to 3882)
  AUTHORS   Wu,Y.H., Shih,S.F. and Lin,J.Y.
  TITLE     Ricin triggers apoptotic morphological changes through caspase-3
            cleavage of BAT3
  JOURNAL   J Biol Chem 279 (18), 19264-19275 (2004)
   PUBMED   14960581
REFERENCE   8  (bases 1 to 3882)
  AUTHORS   Hurt,P., Walter,L., Sudbrak,R., Klages,S., Muller,I., Shiina,T.,
            Inoko,H., Lehrach,H., Gunther,E., Reinhardt,R. and Himmelbauer,H.
  TITLE     The genomic sequence and comparative analysis of the rat major
            histocompatibility complex
  JOURNAL   Genome Res 14 (4), 631-639 (2004)
   PUBMED   15060004
REFERENCE   9  (bases 1 to 3882)
  AUTHORS   Fernandez-Chacon,R., Achiriloaie,M., Janz,R., Albanesi,J.P. and
            Sudhof,T.C.
  TITLE     SCAMP1 function in endocytosis
  JOURNAL   J Biol Chem 275 (17), 12752-12756 (2000)
   PUBMED   10777571
REFERENCE   10 (bases 1 to 3882)
  AUTHORS   Ozaki,T., Hanaoka,E., Naka,M., Nakagawara,A. and Sakiyama,S.
  TITLE     Cloning and characterization of rat BAT3 cDNA
  JOURNAL   DNA Cell Biol 18 (6), 503-512 (1999)
   PUBMED   10390159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 12, 2022 this sequence version replaced XM_006256086.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.62971.1,
                                           SRR26360190.487878.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000020.1  3693081-3693329     c
            250-370             JAXUCZ010000020.1  3692308-3692428     c
            371-488             JAXUCZ010000020.1  3690102-3690219     c
            489-685             JAXUCZ010000020.1  3689462-3689658     c
            686-739             JAXUCZ010000020.1  3689169-3689222     c
            740-814             JAXUCZ010000020.1  3688933-3689007     c
            815-1053            JAXUCZ010000020.1  3687799-3688037     c
            1054-1183           JAXUCZ010000020.1  3687283-3687412     c
            1184-1381           JAXUCZ010000020.1  3686369-3686566     c
            1382-1634           JAXUCZ010000020.1  3685891-3686143     c
            1635-1712           JAXUCZ010000020.1  3685573-3685650     c
            1713-1820           JAXUCZ010000020.1  3685352-3685459     c
            1821-1933           JAXUCZ010000020.1  3685118-3685230     c
            1934-2021           JAXUCZ010000020.1  3684947-3685034     c
            2022-2365           JAXUCZ010000020.1  3684269-3684612     c
            2366-2657           JAXUCZ010000020.1  3683472-3683763     c
            2658-2827           JAXUCZ010000020.1  3683158-3683327     c
            2828-2881           JAXUCZ010000020.1  3682934-3682987     c
            2882-2984           JAXUCZ010000020.1  3682711-3682813     c
            2985-3109           JAXUCZ010000020.1  3682499-3682623     c
            3110-3256           JAXUCZ010000020.1  3682200-3682346     c
            3257-3316           JAXUCZ010000020.1  3682034-3682093     c
            3317-3460           JAXUCZ010000020.1  3681787-3681930     c
            3461-3568           JAXUCZ010000020.1  3681603-3681710     c
            3569-3715           JAXUCZ010000020.1  3681051-3681197     c
            3716-3882           JAXUCZ010000020.1  3680607-3680773     c
FEATURES             Location/Qualifiers
     source          1..3882
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..3882
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /note="BAG cochaperone 6"
                     /db_xref="GeneID:94342"
                     /db_xref="RGD:71064"
     exon            1..249
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            250..370
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..3811
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /note="isoform 3 is encoded by transcript variant 3; large
                     proline-rich protein BAT3; large proline-rich protein
                     BAG6; HLA-B-associated transcript 3; BCL2-associated
                     athanogene 6"
                     /codon_start=1
                     /product="large proline-rich protein BAG6 isoform 3"
                     /protein_id="NP_001401670.1"
                     /db_xref="GeneID:94342"
                     /db_xref="RGD:71064"
                     /translation="MEPSDSTSTAMEEPDSLEVLVKTLDSQTRTFIVGAQMNVKEFKE
                     HIAASVSIPSEKQRLIYQGRVLQDDKKLQDYNVGGKVIHLVERAPPQTQLPSGASSGT
                     GSASATHGGGPLPGTRGPGASGHDRNANSYVMVGTFNLPSDGSAVDVHINMEQAPIQS
                     EPRVRLVMAQHMIRDIQTLLSRMECRGGTQAQASQPPPQTPTVASETVALNSQTSEPV
                     ESEAPPREPMESEEMEERPPTQTPELPPSGPAPAGPAPAPETNAPNHPSPAEHVEVLQ
                     ELQRLQRRLQPFLQRYCEVLGAAATTDYNNNHEGREEDQRLINLVGESLRLLGNTFVA
                     LSDLRCNLACAPPRHLHVVRPMSHYTTPMVLQQAAIPIQINVGTTVTMTGNGARPPPA
                     PGAEAASPGSGQASSLPPSSATVDSSTEGAPPPGPAPPPATSHPRVIRISHQSVEPVV
                     MMHMNIQDSGAQPGGVPSAPTGPLGPPGHGQSLGSTLIQLPSLPPEFMHAVAHQITHQ
                     AMVAAVASAAAGQQVPGFPTAPTRVVIARPTPPQARPSHPGGPPVSGALQGAGLGTNT
                     SLAQMVSGLVGQLLMQPVLVAQGTPGMAPASASAPATAQAQAPAPAPAPAPAPATASA
                     SAGTTNTATTAGPAPGGPAQPPPPQPSAADLQFSQLLGNLLGPAGPGAGGPSLASPTI
                     TVAVPGVPAFLQGMTEFLQASQAAPPPPPPPPPPPPAPEQQTTPPPGSPSGGTASPGG
                     LGPESLPPEFFTSVVQGVLSSLLGSLGARAGSSESIAAFIQRLSGSSNIFEPGADGAL
                     GFFGALLSLLCQNFSMVDVVMLLHGHFQPLQRLQPQLRSFFHQHYLGGQEPTSSNIRM
                     ATHTLITGLEEYVRESFSLVQVQPGVDIIRTNLEFLQEQFNSIAAHVLHCTDSGFGAR
                     LLELCNQGLFECLALNLHCLGGQQMELAAVINGRIRRMSRGVNPSLVSWLTTMMGLRL
                     QVVLEHMPVGPDAILRYVRRIGDPPQALPEEPMEVQGAERTSPEPQREDASPAPGTTA
                     EEAMSRGPPPAPEGGSRDEQDGASADAEPWAAAVPPEWVPIIQQDIQSQRKVKPQPPL
                     SDAYLSGMPAKRRKTMQGEGPQLLLSEAVSRAAKAAGARPLTSPESLSRDLEAPEVQE
                     SYRQQLRSDIQKRLQEDPNYSPQRFPNAHRAFADDP"
     exon            371..488
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            489..685
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..739
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..814
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1053
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1183
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1381
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1634
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1712
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1820
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1933
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2021
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2365
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2657
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2827
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2881
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2984
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..3109
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3256
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3316
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3460
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3568
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3715
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
     exon            3716..3882
                     /gene="Bag6"
                     /gene_synonym="Bat3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtccccc gggcgacggc ggcggcggcg gctcctccgg gtggtcggct ccctcccatc
       61 taggccggcc ccggcccgtc tcgcccccca gaaactcact gctcggggct gtggactttc
      121 tcatcgtgcc ccacgaaagt aaatcggggg agactggggg agccggaagt accgcctcga
      181 gatccccaaa tactatcggg gaaacggaag tggcccttgg tgccaggttg ggggagaccg
      241 gaagtgacga gagctgtcgg ccatggagcc gagtgatagt accagtaccg ctatggagga
      301 gcctgacagc ctggaggtac tggtgaagac cctggactct cagactcgga cttttattgt
      361 gggggcccag atgaatgtaa aggagtttaa ggaacacata gctgcctctg tcagcatccc
      421 ttccgagaaa cagcggctca tctaccaggg ccgggttcta caagatgaca agaagctcca
      481 ggactacaat gttgggggaa aggttatcca cctggtggaa cgggctcctc ctcagactca
      541 gctaccttct ggagcatctt ctgggacagg ctctgcctca gctactcatg gtgggggccc
      601 cctgcctggc actcggggcc ctggggcctc tggtcatgac cggaatgcca acagttatgt
      661 catggttgga accttcaatc ttcctagtga cggctctgct gtggacgttc acatcaacat
      721 ggaacaggcc ccaattcaga gtgagccccg ggtacggctg gtgatggctc agcacatgat
      781 tagggatata cagaccttac tgtcccggat ggagtgtcga gggggaaccc aagcacaggc
      841 cagtcagcca cccccgcaga ctccgactgt ggcctcagag acagtagctt tgaactcaca
      901 aacatcagag ccagttgaaa gtgaagctcc tcctcgagag cccatggagt cagaagaaat
      961 ggaggaacgt cccccaaccc agactccaga gcttccaccc tctggcccag ctccagcagg
     1021 cccagcaccc gcaccagaga caaatgcacc caaccaccct tcccctgcag agcacgtgga
     1081 ggtgctccag gagcttcagc gcttgcaacg ccgtcttcag cccttcctgc agcgctactg
     1141 tgaggtcctg ggtgctgctg ccactacaga ctacaataac aatcatgagg gccgagaaga
     1201 ggaccagagg ttgattaact tggtggggga gagcctgcgg ctactgggca acactttcgt
     1261 ggcattgtct gatctgcgct gtaatctagc ctgtgcaccc ccacggcacc tgcatgtggt
     1321 acggcctatg tctcactaca cgactcccat ggtgctccag caggcagcca ttcccattca
     1381 gatcaatgtg gggactactg tgaccatgac aggcaatggg gctcggcctc caccagctcc
     1441 cggtgcagag gcagcatccc caggttctgg ccaggcctca tcccttcctc catcttctgc
     1501 cactgttgat tcatcaacgg aaggagctcc cccaccaggg ccagcaccac caccagccac
     1561 cagccatcca cgggtcatcc ggatttccca ccagagtgtg gaacctgtgg tcatgatgca
     1621 catgaacatt caagactccg gagcacagcc tggaggtgtg cccagtgctc ccactggccc
     1681 cctgggacct cctggtcatg gacagagcct gggctccacc ctcatccagc tgccctccct
     1741 gccccctgag ttcatgcacg ccgtcgccca ccagatcact catcaggcca tggtggcagc
     1801 tgttgcctcc gcggccgcag gacagcaggt gcccggcttc ccaacagcac caactcgggt
     1861 ggtgattgcc cgacccactc ctccacaggc tcggccttcc catcctgggg gccctccagt
     1921 ctctggagct ctacagggtg ctgggctggg tacaaacact tcattggccc agatggtgag
     1981 cggccttgtg gggcaacttc tcatgcagcc tgttcttgtg gctcagggga ctccaggaat
     2041 ggctccggct tctgcttcag ctccggctac ggcccaggca caggccccgg ccccagcccc
     2101 agctccggcc ccagctccgg ccactgcttc agctagtgct ggcactacca acacagccac
     2161 cacagccggc cctgctcctg ggggtcccgc ccagcctcca cctcctcagc cctctgcggc
     2221 tgatcttcag ttctctcagc tcctgggaaa tctgctgggg cctgcagggc caggggctgg
     2281 gggcccaagc ctggcttctc ccaccatcac tgtggcagtg cctggagttc ctgcttttct
     2341 ccagggcatg actgagtttt tgcaggcatc acaggctgcc cctccacccc ctccacctcc
     2401 tccaccccca cctcctgctc cagagcagca gaccacaccg cctccaggat ccccttctgg
     2461 tgggacagcg agtcctgggg gcttaggtcc tgagagcctg ccaccagagt ttttcacctc
     2521 agtggtgcag ggcgtgttga gctctctcct gggctccttg ggggctcgtg ctggcagcag
     2581 cgagagtatt gctgccttca tccaacgcct cagtggatcc agcaacatct ttgagcctgg
     2641 ggctgatggc gcccttggat tctttggagc tctgctctct cttctgtgcc agaatttctc
     2701 catggtggat gtggtgatgc ttctccatgg ccatttccag ccactacagc ggctccagcc
     2761 acagctacga tctttcttcc accagcacta cctgggtggc caggagccca cgtccagcaa
     2821 catccggatg gcaacccaca cgttgatcac ggggctggaa gagtatgtac gggagagttt
     2881 ctctttggtg caggttcagc caggtgtgga tatcatccgg acaaatttag aatttctcca
     2941 ggagcaattt aacagcattg ctgctcacgt gctgcactgt acagacagtg gatttggagc
     3001 ccggctgctg gagctatgta accagggcct gtttgaatgc ttggccctga acctgcactg
     3061 cttggggggc cagcaaatgg agcttgctgc tgtcatcaat ggccgaattc gccgcatgtc
     3121 tcgtggggtg aatccatcct tggtgagctg gctgacaact atgatgggac tcaggcttca
     3181 ggtggtctta gagcacatgc ccgtgggtcc cgacgccatc ctcagatatg tgcgcaggat
     3241 tggtgatcct cctcaggcac ttcctgaaga gccaatggaa gttcagggag cagaaagaac
     3301 ttcccctgag cctcagagag aggatgcttc cccagccccc ggaacaacag cagaagaagc
     3361 catgtcccga ggtccacccc ctgctcctga aggaggttcc cgagacgaac aggatggagc
     3421 ttcagccgat gcagagccct gggcagctgc agtcccccct gaatgggtac ctattatcca
     3481 gcaggacatt cagagccagc ggaaggtgaa acctcagccg cccctgagtg atgcctacct
     3541 cagtggcatg cctgccaaga gacgaaagac aatgcagggt gagggccccc agctgctact
     3601 ctcagaggca gtgagccggg cagctaaggc agccggagct cggcccctga caagccccga
     3661 gagcctgagc cgggacctgg aggcaccaga ggttcaggag agctacaggc agcagctccg
     3721 gtctgatatt caaaaacgac tgcaggaaga tcccaactac agcccccagc gcttccctaa
     3781 tgcccaccgg gcatttgctg atgaccccta gctttctcac caggggacca tttcccccct
     3841 tccttcacag tatttaagaa ataaaagtcg gattttcctg gc
//
