LOCUS       NM_001011936            2355 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus BAG cochaperone 3 (Bag3), mRNA.
ACCESSION   NM_001011936 XM_215054
VERSION     NM_001011936.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Martin,T.G., Sherer,L.A. and Kirk,J.A.
  TITLE     BAG3 localizes to mitochondria in cardiac fibroblasts and regulates
            mitophagy
  JOURNAL   Am J Physiol Heart Circ Physiol 326 (5), H1124-H1130 (2024)
   PUBMED   38488519
  REMARK    GeneRIF: BAG3 localizes to mitochondria in cardiac fibroblasts and
            regulates mitophagy.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Lin,H., Sandkuhler,S., Dunlea,C., Rodwell-Bullock,J., King,D.H. and
            Johnson,G.V.W.
  TITLE     BAG3 regulates the specificity of the recognition of specific MAPT
            species by NBR1 and SQSTM1
  JOURNAL   Autophagy 20 (3), 577-589 (2024)
   PUBMED   37899687
  REMARK    GeneRIF: BAG3 regulates the specificity of the recognition of
            specific MAPT species by NBR1 and SQSTM1.
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Lu,X., Zhang,J., Xue,P., Wang,Q., Wang,X., Sun,Y. and Cui,Z.
  TITLE     BAG3 protects chondrocytes against lumbar facet joint
            osteoarthritis by regulating autophagy and apoptosis
  JOURNAL   J Physiol Biochem 78 (2), 427-437 (2022)
   PUBMED   35253089
  REMARK    GeneRIF: BAG3 protects chondrocytes against lumbar facet joint
            osteoarthritis by regulating autophagy and apoptosis.
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Lovenich,L., Dreissen,G., Hoffmann,C., Konrad,J., Springer,R.,
            Hohfeld,J., Merkel,R. and Hoffmann,B.
  TITLE     Strain-induced mechanoresponse depends on cell contractility and
            BAG3-mediated autophagy
  JOURNAL   Mol Biol Cell 32 (20), ar9 (2021)
   PUBMED   34379447
  REMARK    GeneRIF: Strain-induced mechanoresponse depends on cell
            contractility and BAG3-mediated autophagy.
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Zhao,L.L., Gu,J.N., Zhu,X.F., Hu,Y., Cao,H., Yao,N., Sang,H.,
            Guo,B.B., Wang,Y.H., Qian,H.Y. and Zhu,W.Z.
  TITLE     HSC70-JNK-BAG3 complex is critical for cardiomyocyte protection of
            BAG3 through its PXXP and BAG structural domains
  JOURNAL   Front Biosci (Landmark Ed) 26 (6), 102-113 (2021)
   PUBMED   34162039
  REMARK    GeneRIF: HSC70-JNK-BAG3 complex is critical for cardiomyocyte
            protection of BAG3 through its PXXP and BAG structural domains.
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Lee,M.Y., Kim,S.Y., Shin,S.L., Choi,Y.S., Lee,J.H., Tsujimoto,Y.
            and Lee,J.H.
  TITLE     Reactive astrocytes express bis, a bcl-2-binding protein, after
            transient forebrain ischemia
  JOURNAL   Exp Neurol 175 (2), 338-346 (2002)
   PUBMED   12061864
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Lee,M.Y., Kim,S.Y., Choi,J.S., Choi,Y.S., Jeon,M.H., Lee,J.H.,
            Kim,I.K. and Lee,J.H.
  TITLE     Induction of Bis, a Bcl-2-binding protein, in reactive astrocytes
            of the rat hippocampus following kainic acid-induced seizure
  JOURNAL   Exp Mol Med 34 (2), 167-171 (2002)
   PUBMED   12085992
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Antoku,K., Maser,R.S., Scully,W.J. Jr., Delach,S.M. and
            Johnson,D.E.
  TITLE     Isolation of Bcl-2 binding proteins that exhibit homology with
            BAG-1 and suppressor of death domains protein
  JOURNAL   Biochem Biophys Res Commun 286 (5), 1003-1010 (2001)
   PUBMED   11527400
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Liao,Q., Ozawa,F., Friess,H., Zimmermann,A., Takayama,S.,
            Reed,J.C., Kleeff,J. and Buchler,M.W.
  TITLE     The anti-apoptotic protein BAG-3 is overexpressed in pancreatic
            cancer and induced by heat stress in pancreatic cancer cell lines
  JOURNAL   FEBS Lett 503 (2-3), 151-157 (2001)
   PUBMED   11513873
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Lee,J.H., Takahashi,T., Yasuhara,N., Inazawa,J., Kamada,S. and
            Tsujimoto,Y.
  TITLE     Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in
            preventing cell death
  JOURNAL   Oncogene 18 (46), 6183-6190 (1999)
   PUBMED   10597216
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085857.1.
            
            On Feb 11, 2005 this sequence version replaced XM_215054.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085857.1, DQ631552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2355
                     /gene="Bag3"
                     /note="BAG cochaperone 3"
                     /db_xref="GeneID:293524"
                     /db_xref="RGD:1307794"
     exon            1..287
                     /gene="Bag3"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1826
                     /gene="Bag3"
                     /note="Bcl2-associated athanogene 3"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 3"
                     /protein_id="NP_001011936.1"
                     /db_xref="GeneID:293524"
                     /db_xref="RGD:1307794"
                     /translation="MSAATQSPVMQMASGNGASDRDPLPPGWEIKIDPQTGWPFFVDH
                     NSRTTTWNDPRVPPEGPKETASSANGPSRDGSRLLPAREGHPIYPQLRPGYIPIPVHH
                     EGSENRQPHLFHAYSQPGVQRFRTEAAAAAPQRSQSPLRGGVTETTQTDKQCGQVPAA
                     ATAQPPTAHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYIPIPVIHEQN
                     ITRPAAQPSFHQAQKTHYPAQQGEYQPQQPVYHKIQGDDWEPRPLRATSPFRSPVRGA
                     SSREGSPARSGTPVHCPSPIRVHTVVDRPQPMTHREPPPVTQPENKPESKPGLAGPDL
                     PPGHIPIQVIRREADSKPVSQKPPPPAEKVEVKVSSAPIPCPSPGPAPSAVPSSPKNV
                     AAEPKAAPSPAPAEAASLKSGDAEAPHKHPGVLKVEAILEKVQGLEQAVDNFEGKKTD
                     KKYLMIEEYLTKELLALDSVDPEGRADVRQARRDGVRKVQTILEKLEQKAIDVPGQVQ
                     VYELQPSNLEPEQPLQEIMGAVAADKDKKGPENEDPQTESQQLEAKAATPPNPSSTAD
                     SAGNPVAP"
     exon            288..617
                     /gene="Bag3"
                     /inference="alignment:Splign:2.1.0"
     exon            618..1019
                     /gene="Bag3"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..2328
                     /gene="Bag3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaccggctt cccggacaca tcggctacac agaggtgccc gcactccacg acctcgtgac
       61 ccgcgcccta gctctgcgcc ccgggcggac cccaactaag catgagcgcc gccacccagt
      121 cgccggtgat gcagatggcg tccggcaacg gagccagcga ccgagacccc ctgcccccgg
      181 gctgggagat caagatcgac ccgcagaccg gctggccctt cttcgtggac cacaacagcc
      241 gcaccacgac gtggaacgac ccgcgtgtgc cccccgaggg ccctaaggaa actgcatcat
      301 ctgccaacgg cccttcccgt gatggctcca ggctgctgcc cgctagggaa ggccacccca
      361 tataccccca gctccgacca ggttacattc ccattcccgt ccaccatgaa ggctcggaaa
      421 accggcagcc gcaccttttc catgcctact cccagcctgg ggtgcagcga tttcgaaccg
      481 aggcagcagc cgccgccccg cagaggtccc agtctccttt gcgtgggggc gtgacagaaa
      541 ccactcagac agataaacag tgtggacagg tgccggcagc tgcaacagcc cagcccccga
      601 ctgcccacgg acctgagcga tctcagtctc cagctgcctc tgactgctca tcctcgtcct
      661 cctcggccag cctgccgtcc tctggcagga gcagtctggg tagccatcag ctccccaggg
      721 gttacatacc catccccgtg atacatgagc agaacatcac ccggccagca gcccagccct
      781 ccttccacca agcccagaag acccactacc cagctcagca gggtgaatac cagccccagc
      841 agcctgtgta ccacaagatc cagggggacg actgggagcc ccggcctctt cgggccacat
      901 ctccattcag gtcacctgtc agaggtgcat ccagccggga gggctctcca gccagaagcg
      961 gcacaccggt tcactgccca tcacccatcc gtgtgcacac ggtggttgac aggcctcagc
     1021 ccatgaccca tcgagagcct ccccctgtca cccaacccga aaacaaacca gaaagcaagc
     1081 caggcctagc tggaccagat ctccctcctg gacacatccc cattcaagtg atccgcaggg
     1141 aggccgactc taagcctgtt tctcagaaac cacctcctcc tgctgagaaa gtggaagtga
     1201 aggtctcctc tgccccaatt ccttgtcctt ctcccggccc cgccccttcg gctgtccctt
     1261 cttccccgaa gaatgtggct gcagaaccga aggcagcccc cagccctgcc cctgcagagg
     1321 ctgcatccct caagtcagga gacgccgaag cgccccataa gcatccaggc gtgctgaaag
     1381 tggaagccat cttggagaag gtgcaggggc tggagcaggc cgtcgacaac tttgaaggca
     1441 agaagactga taaaaaatac ctgatgatcg aagagtattt gaccaaagag ctgctggccc
     1501 tggattccgt agaccccgaa ggacgagctg atgtccgtca ggccaggaga gatggcgtca
     1561 ggaaggttca gaccatcttg gaaaaactgg agcagaaagc aatcgatgtc ccgggtcagg
     1621 tccaagtcta tgaactccag cccagcaacc ttgagcccga gcagccactg caggaaatca
     1681 tgggcgccgt ggcagccgac aaggataaga aaggtcctga aaacgaagat ccacaaactg
     1741 aaagccaaca gctagaagcc aaagccgcca cgcctccaaa ccccagcagc acagcagact
     1801 cggctggcaa cccggtggct ccctagggtc cgcgttgtag agacttttta agatgcatgc
     1861 actgcgggac ttgcagtcag ctggttgtct ttattcatag ccgcttggta tgcagtaact
     1921 tggggtggag gcaaagcgct aaccaagggg gcttctcttc cctattctta cccgtataaa
     1981 taaacaagtt gcccgttcca gaagtctaac ccctctgctt gtttgggagc cctttctgtg
     2041 catgggtatg gtgatttagc cttggctgtg ggctgtcttc ctgttagctc tggaccgtag
     2101 ggggttttag gttttgaggg ataggcagag agttacagga acaagaaacc cgtctttgag
     2161 atgtgccacc attttgatga gataaccttc atttcgttac tgaaacatct aacttcagct
     2221 acaatgagat atgcaaggag ccgtagaaat agatctacgt tggaatggct ttaatgttgt
     2281 tacatttcgg ggagggggac agaaaataaa gcgattgtat aagtctcaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaa
//
