LOCUS       NM_001128195            1572 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus BAG cochaperone 2 (Bag2), mRNA.
ACCESSION   NM_001128195 XM_001054708 XM_001073000
VERSION     NM_001128195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1572)
  AUTHORS   Xing X, Zhang C, Zhou J, Jin Q and Zheng Q.
  TITLE     BAG2-activated cell autophagy and mir-27b dynamic regulation
            mechanism during Mycobacterium tuberculosis infection
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 67 (5), 38-44 (2022)
   PUBMED   35818274
  REMARK    GeneRIF: BAG2-activated cell autophagy and mir-27b dynamic
            regulation mechanism during Mycobacterium tuberculosis infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1572)
  AUTHORS   de Oliveira AS, Santiago FE, Balioni LF, Ferrari Mde F, Almeida MC
            and Carrettiero DC.
  TITLE     BAG2 expression dictates a functional intracellular switch between
            the p38-dependent effects of nicotine on tau phosphorylation levels
            via the alpha7 nicotinic receptor
  JOURNAL   Exp Neurol 275 Pt 1, 69-77 (2016)
   PUBMED   26496817
  REMARK    GeneRIF: found a role for BAG2 as an important regulator of
            p38-dependent tau kinase activity and phospho-tau degradation in
            response to nicotinic receptor stimulation
REFERENCE   3  (bases 1 to 1572)
  AUTHORS   Che XQ, Tang BS, Wang HF, Yan XX, Jiang H, Shen L, Xu Q, Wang GH,
            Zhang HN, Wang CY and Guo JF.
  TITLE     The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic
            ataxin3-80Q
  JOURNAL   Int J Neurosci 125 (5), 390-394 (2015)
   PUBMED   25006867
REFERENCE   4  (bases 1 to 1572)
  AUTHORS   Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H,
            Berger B, Gingras AC and Lindquist S.
  TITLE     A quantitative chaperone interaction network reveals the
            architecture of cellular protein homeostasis pathways
  JOURNAL   Cell 158 (2), 434-448 (2014)
   PUBMED   25036637
REFERENCE   5  (bases 1 to 1572)
  AUTHORS   Rauch JN and Gestwicki JE.
  TITLE     Binding of human nucleotide exchange factors to heat shock protein
            70 (Hsp70) generates functionally distinct complexes in vitro
  JOURNAL   J Biol Chem 289 (3), 1402-1414 (2014)
   PUBMED   24318877
REFERENCE   6  (bases 1 to 1572)
  AUTHORS   Che,X., Tang,B., Wang,X., Chen,D., Yan,X., Jiang,H., Shen,L.,
            Xu,Q., Wang,G. and Guo,J.
  TITLE     The BAG2 protein stabilises PINK1 by decreasing its ubiquitination
  JOURNAL   Biochem Biophys Res Commun 441 (2), 488-492 (2013)
   PUBMED   24383081
REFERENCE   7  (bases 1 to 1572)
  AUTHORS   Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M,
            Will CL, Pena V, Luhrmann R and Stelzl U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   8  (bases 1 to 1572)
  AUTHORS   Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T and
            Kosik KS.
  TITLE     The cochaperone BAG2 sweeps paired helical filament- insoluble tau
            from the microtubule
  JOURNAL   J Neurosci 29 (7), 2151-2161 (2009)
   PUBMED   19228967
  REMARK    GeneRIF: BAG2 levels in cells are under the physiological control
            of the microRNA miR-128a, which can tune paired helical filament
            Tau levels in neurons.
REFERENCE   9  (bases 1 to 1572)
  AUTHORS   Arndt V, Daniel C, Nastainczyk W, Alberti S and Hohfeld J.
  TITLE     BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin
            ligase CHIP
  JOURNAL   Mol Biol Cell 16 (12), 5891-5900 (2005)
   PUBMED   16207813
REFERENCE   10 (bases 1 to 1572)
  AUTHORS   Halse R, Rochford JJ, McCormack JG, Vandenheede JR, Hemmings BA and
            Yeaman SJ.
  TITLE     Control of glycogen synthesis in cultured human muscle cells
  JOURNAL   J Biol Chem 274 (2), 776-780 (1999)
   PUBMED   9873015
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158711.1.
            
            On or before Jun 10, 2008 this sequence version replaced
            XM_001054708.1, XM_001073000.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158711.1, FQ228417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1572
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..1572
                     /gene="Bag2"
                     /note="BAG cochaperone 2"
                     /db_xref="GeneID:690038"
                     /db_xref="RGD:1585173"
     exon            1..133
                     /gene="Bag2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..653
                     /gene="Bag2"
                     /note="Bcl2-associated athanogene 2"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 2"
                     /protein_id="NP_001121667.1"
                     /db_xref="GeneID:690038"
                     /db_xref="RGD:1585173"
                     /translation="MAQAKISAKAHEGRFCRSSSMADRSSRLLESLDQLELRVEALRD
                     AATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIR
                     NPQQEESLKHATKIIDEVVSKFLDDLGNAKSHLMSLYSACSSEVPPGPVDQKFQSIVI
                     GCALEDQKKIKRRLETLLRNIDNSDKAIKLLEHTKGSGSKNLQNTDNKFN"
     exon            134..243
                     /gene="Bag2"
                     /inference="alignment:Splign:2.1.0"
     exon            244..1549
                     /gene="Bag2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgaggacc cccggagctc atggcccagg cgaagatcag cgccaaggcc cacgagggcc
       61 gcttctgccg ctcgtcctcc atggccgacc gctccagccg cctgctggag agcctggacc
      121 agctggagct cagggtcgaa gccttgagag acgcagctac tgctgttgaa caagaaaagg
      181 aaatcctctt ggagatgatc cacagcatcc agaacagcca ggacatgagg cagatcagcg
      241 atggagaaag agaggaatta aacctgactg ccaaccgtct gatgggccgg accctcactg
      301 tggaggtctc agtggaaacg atccgaaacc cccagcagga ggaatcctta aagcatgcca
      361 cgaagattat cgatgaggtg gtcagtaagt tcctggacga cctggggaat gccaagagcc
      421 acttaatgtc actttacagt gcatgctcat ctgaggtgcc gcctgggccg gttgatcaga
      481 aattccaatc gatagtcatc ggttgcgctc ttgaggatca gaagaaaatc aagaggcgat
      541 tggagactct gctgaggaac attgacaact ccgacaaagc cattaaactc ttagagcaca
      601 ctaaagggtc cggttccaaa aacctgcaga acactgacaa caaatttaat tagtcacatc
      661 ctcaggccct tccaaaagat gtagaagaga aaactactat tttaaatagc tatgtcttta
      721 tgttaggcac aaccactata tggtttcaga tggggaagta ttccagtgtc ggcagacaca
      781 caaataacta ggaatatttc agtcacctac tttgaggttt tggacagtgt tcctgtcttg
      841 aattggactc tatcactaca tatttaattc tgaagatgca catgtagtat gtgggggggg
      901 gtagaaaagg ggagggggca aaaataccac tgctctttct ttgacttcag cacagagcac
      961 ccaacgctgg agcactgcac tcacaccagt gcgaacagag cacccagtcc ctggggcagt
     1021 gcactcaccc cacagtgtga ggacagcacc cagcccctgg aggggtgcag ttacgccaca
     1081 cagtgtgcct agaaggataa acgcatcaga acttcaccct gcatgttctc cacgttttgg
     1141 gcatctgttt ctctatgcat cttgtaacat gtatttctag ctgtgtgtgg aagcatgaca
     1201 acatgcgagg agcccgcctt cgttttacca ctgtgaagct ccgcccccac cctgtaccct
     1261 gcccggcatc cctccagtgc tgactgcctt gagcccacat gtgtggcagg agcactcacc
     1321 cgaccacttc tctggacagc tggtggtttc gatctgtcgc tatgactaca acatacctat
     1381 gtcggttgag ctttactgtt cttggtcttc tttgtttaaa attccatgaa tgggttcatc
     1441 gggccaaagg atatagacat tttcatggcc tagaaacata tttctaaatt tttataagtt
     1501 gtatcagttt gtactgtctt cagtgattaa aagaatccat ttcgctgaaa aaaaaaaaaa
     1561 aaaaaaaaaa aa
//
