LOCUS       NM_001106647            1308 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus BAG cochaperone 1 (Bag1), transcript variant 1,
            mRNA.
ACCESSION   NM_001106647 XM_001059235 XM_216377
VERSION     NM_001106647.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Luo,S., Hou,Y., Zhang,Y., Feng,L., Hunter,R.G., Yuan,P., Jia,Y.,
            Li,H., Wang,G., K Manji,H., S McEwen,B., Xiao,C., Bao,H. and Du,J.
  TITLE     Bag-1 mediates glucocorticoid receptor trafficking to mitochondria
            after corticosterone stimulation: Potential role in regulating
            affective resilience
  JOURNAL   J Neurochem 158 (2), 358-372 (2021)
   PUBMED   33025573
  REMARK    GeneRIF: Bag-1 mediates glucocorticoid receptor trafficking to
            mitochondria after corticosterone stimulation: Potential role in
            regulating affective resilience.
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Xilouri,M. and Stefanis,L.
  TITLE     Chaperone mediated autophagy to the rescue: A new-fangled target
            for the treatment of neurodegenerative diseases
  JOURNAL   Mol Cell Neurosci 66 (Pt A), 29-36 (2015)
   PUBMED   25724482
  REMARK    Review article
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Rauch,J.N. and Gestwicki,J.E.
  TITLE     Binding of human nucleotide exchange factors to heat shock protein
            70 (Hsp70) generates functionally distinct complexes in vitro
  JOURNAL   J Biol Chem 289 (3), 1402-1414 (2014)
   PUBMED   24318877
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Wu,H., Liu,Y., Zhou,Y., Long,L., Cheng,X., Ji,L., Weng,H., Ding,T.,
            Yang,J., Wei,H., Li,M., Huan,W., Deng,X. and Wang,Y.
  TITLE     Changes in the BAG1 expression of Schwann cells after sciatic nerve
            crush
  JOURNAL   J Mol Neurosci 49 (3), 512-522 (2013)
   PUBMED   23108487
  REMARK    GeneRIF: BAG1 expression increased progressively after sciatic
            nerve crush, reached a peak 2 weeks post-injury. It returned to the
            normal level 4 weeks post-injury. Spatially, BAG1 was mainly
            expressed in Schwann cells.
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Yang,L., McBurney,D., Tang,S.C., Carlson,S.G. and Horton,W.E. Jr.
  TITLE     A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in
            regulation of the endoplasmic reticulum stress response in
            mammalian chondrocytes
  JOURNAL   J Cell Biochem 102 (3), 786-800 (2007)
   PUBMED   17546604
  REMARK    GeneRIF: BAG-1 has a role in supporting viability and matrix
            expression of chondrocytes
REFERENCE   6  (bases 1 to 1308)
  AUTHORS   Yamada,K., Ishiguro,H., Ichino,N., Nishii,K., Sawada,H., Hida,T.
            and Nagatsu,T.
  TITLE     Expression levels of Rab2, a G protein, and Bag-1, a Bcl-2 binding
            protein are controlled by withdrawal of nicotine from cultured
            pheochromocytoma PC12 cells
  JOURNAL   J Neural Transm (Vienna) 112 (5), 633-639 (2005)
   PUBMED   15785859
REFERENCE   7  (bases 1 to 1308)
  AUTHORS   Hayashi,T., Sakai,K., Sasaki,C., Itoyama,Y. and Abe,K.
  TITLE     Loss of bag-1 immunoreactivity in rat brain after transient middle
            cerebral artery occlusion
  JOURNAL   Brain Res 852 (2), 496-500 (2000)
   PUBMED   10678782
REFERENCE   8  (bases 1 to 1308)
  AUTHORS   Takayama,S., Krajewski,S., Krajewska,M., Kitada,S., Zapata,J.M.,
            Kochel,K., Knee,D., Scudiero,D., Tudor,G., Miller,G.J.,
            Miyashita,T., Yamada,M. and Reed,J.C.
  TITLE     Expression and location of Hsp70/Hsc-binding anti-apoptotic protein
            BAG-1 and its variants in normal tissues and tumor cell lines
  JOURNAL   Cancer Res 58 (14), 3116-3131 (1998)
   PUBMED   9679980
REFERENCE   9  (bases 1 to 1308)
  AUTHORS   Packham,G., Brimmell,M. and Cleveland,J.L.
  TITLE     Mammalian cells express two differently localized Bag-1 isoforms
            generated by alternative translation initiation
  JOURNAL   Biochem J 328 (Pt 3) (Pt 3), 807-813 (1997)
   PUBMED   9396724
  REMARK    GeneRIF: Shows that the human and mouse orthologs use alternative
            translation initiation codons, including a non-AUG(CUG) codon.
REFERENCE   10 (bases 1 to 1308)
  AUTHORS   Takayama,S., Sato,T., Krajewski,S., Kochel,K., Irie,S., Millan,J.A.
            and Reed,J.C.
  TITLE     Cloning and functional analysis of BAG-1: a novel Bcl-2-binding
            protein with anti-cell death activity
  JOURNAL   Cell 80 (2), 279-284 (1995)
   PUBMED   7834747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC159418.1 and
            JAXUCZ010000005.1.
            
            On Jan 4, 2012 this sequence version replaced NM_001106647.2.
            
            Summary: The oncogene Bcl2 encodes a membrane protein that blocks a
            step in a pathway leading to apoptosis or programmed cell death.
            Studies in human and mouse suggest that the protein encoded by this
            gene (referred to as Bcl2-associated athanogene) binds to Bcl2
            protein. It enhances the anti-apoptotic effects of Bcl2 and
            represents a link between growth factor receptors and
            anti-apoptotic mechanisms. At least two protein isoforms are
            encoded by this mRNA through the use of a non-AUG (CUG) start site
            and an alternative, downstream, AUG translation initiation site.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes multiple isoforms due
            to the use of alternative translation initiation codons. The longer
            isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG)
            start codon, while the shorter isoform (BAG-1S or p32) is derived
            from a downstream AUG start codon. The longer isoform (1L) is
            represented in this RefSeq.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159418.1, FQ224976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676789, SAMN16676810
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1303              BC159418.1         1-1303
            1304-1308           JAXUCZ010000005.1  60864476-60864480   c
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1308
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /note="BAG cochaperone 1"
                     /db_xref="GeneID:297994"
                     /db_xref="RGD:1305203"
     exon            1..541
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1128
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /note="isoform 1L is encoded by transcript variant 1;
                     non-AUG (CUG) translation initiation codon;
                     bcl-2-associated athanogene 1; BAG family molecular
                     chaperone regulator 1; BCL2-associated athanogene; Bcl2
                     associated athanogene 1"
                     /codon_start=1
                     /product="BAG family molecular chaperone regulator 1
                     isoform 1L"
                     /protein_id="NP_001100117.2"
                     /db_xref="GeneID:297994"
                     /db_xref="RGD:1305203"
                     /translation="MADRGGARRPRGDQEPLGPRLRAPRSARETRQSESRAERGLPPS
                     QRSSVRSAASGHDRSTRGAASGACKPRVKKKVRPRSSQSEKVAHSKELTRSKKLTRSK
                     KVTGTQEATQVEEVTTIEEATQTEEITVAEEVTQTENMAQTEEMVQTEEMEPPTLSVV
                     VTHSNERYDLLVTPQQGNSEPIVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLS
                     ALGMQNGCRVMLIGEKSNPEEEAELKKLKDLEVSVEKTANHLEELNKELSDIQQGFLA
                     KELQAEALCRLDRKIKATIEQFMKILEEIDTMVLPENFKDSRLKRKNLVKKVQVFLAE
                     CDTVEQYICQETERLQSTNLALPE"
     exon            542..670
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /inference="alignment:Splign:2.1.0"
     exon            671..753
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..867
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /inference="alignment:Splign:2.1.0"
     exon            868..975
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1038
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1308
                     /gene="Bag1"
                     /gene_synonym="Bag-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcaagactg cgcgccccgt tgcctccgct gctccgtgaa caaacgcggg cctggcggat
       61 cgcggcggcg cgcggcgacc gcgaggcgac caggagccgc tgggaccccg gctgcgcgcc
      121 cctcggtcgg cccgggagac gcgccagtcg gagtcccggg ccgagcgtgg cttgcctccc
      181 tctcagcgtt catctgtccg cagtgcagcc agcgggcatg accgatccac caggggcgcc
      241 gcctccggcg cttgcaagcc gcgggtgaag aagaaagtcc ggccccgctc ttctcagagc
      301 gagaaggtag ctcacagcaa ggagttgact agaagtaaga agttgacccg cagcaagaaa
      361 gtgaccggga cccaggaggc gacccaagta gaggaggtga ccacgatcga ggaggcgacc
      421 cagaccgagg agattacggt agcggaagag gtgacccaga ccgagaacat ggcccagacc
      481 gaggagatgg tccagacgga ggaaatggaa ccacccacac tcagcgtggt cgtcacccac
      541 agcaatgaga ggtatgacct tcttgttacc ccacagcaag gtaacagtga gccaattgtc
      601 caagacctgg ctcagcttgt tgaagaggcc acaggagttc cactaccttt tcagaagctc
      661 atatttaagg gcaaatctct gaaagaaatg gaaacaccct tgtcagcact tggaatgcaa
      721 aatggttgcc gagtcatgtt aattggtgaa aagagcaatc cagaagaaga ggctgagttg
      781 aaaaagctga aggacttgga ggtatctgtg gagaagacag ctaaccacct ggaagagttg
      841 aataaagagc tttctgacat ccagcagggt tttctggcta aggaattaca agcggaggct
      901 ctctgcagac ttgataggaa aataaaggcc acaattgagc aattcatgaa gatcttggag
      961 gagattgaca caatggtcct accagaaaac tttaaagaca gcaggctaaa aaggaagaat
     1021 ttggtgaaaa aggttcaggt gttcctagca gagtgtgata cagtggagca gtacatctgc
     1081 caagagacag agcggctgca gtctacaaac ttggccctgc ctgaatgaag tgtagtagag
     1141 aggggctgta ctggcctgaa gagcagcttc atagccctgc cctccctaga acagaagctg
     1201 cttgtttctc catggctgtc aggggcaact agccaaatgt aaatttccct tccctactcc
     1261 tccgtcggtt ctcaatgaaa aagtactgtc tttgcaacct gaactaga
//
