LOCUS       NM_022698               1001 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus BCL2-associated agonist of cell death (Bad),
            mRNA.
ACCESSION   NM_022698
VERSION     NM_022698.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1001)
  AUTHORS   Bernhem,K., Fontana,J.M., Svensson,D., Zhang,L., Nilsson,L.M.,
            Scott,L., Blom,H., Brismar,H. and Aperia,A.
  TITLE     Super-resolution microscopy reveals that Na+/K+-ATPase signaling
            protects against glucose-induced apoptosis by deactivating Bad
  JOURNAL   Cell Death Dis 12 (8), 739 (2021)
   PUBMED   34315852
  REMARK    GeneRIF: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase
            signaling protects against glucose-induced apoptosis by
            deactivating Bad.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1001)
  AUTHORS   Michurina,S.V., Kolesnikov,S.I., Bochkareva,A.L., Ishchenko,I.Y.
            and Arkhipov,S.A.
  TITLE     Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat
            Ovarian Follicular Apparatus during Recovery after Extreme
            Hypothermia
  JOURNAL   Bull Exp Biol Med 168 (2), 205-209 (2019)
   PUBMED   31784847
  REMARK    GeneRIF: On day 14 after hyperthermia changes in synthesis led to a
            decrease in Bcl-2/Bad index, which attested to weakening of the
            antiapoptotic defense and activation of oocyte apoptosis by the
            mitochondrial pathway.
REFERENCE   3  (bases 1 to 1001)
  AUTHORS   Yuan,F., Xu,X., Wu,Y., Duan,S. and Wu,H.
  TITLE     Gastrodin Ameliorates Acute Rejection via IRE1alpha/TRAF2/NF-kappaB
            in Rats Receiving Liver Allografts
  JOURNAL   Biomed Res Int 2019, 9276831 (2019)
   PUBMED   31828147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1001)
  AUTHORS   Wang,Q., Chen,R., Zhang,C., Inam-U-Llah, Piao,F. and Shi,X.
  TITLE     NGF protects bone marrow mesenchymal stem cells against
            2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal
            pathway
  JOURNAL   Mol Cell Biochem 457 (1-2), 133-143 (2019)
   PUBMED   30911955
  REMARK    GeneRIF: it was found that NGF promoted phosphorylation of Akt and
            Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and
            Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF,
            indicating the protective effect of NGF on BMSCs apoptosis via a
            novel Akt/Bad pathway.
REFERENCE   5  (bases 1 to 1001)
  AUTHORS   Thangarajan,S., Ramachandran,S. and Krishnamurthy,P.
  TITLE     Chrysin exerts neuroprotective effects against 3-Nitropropionic
            acid induced behavioral despair-Mitochondrial dysfunction and
            striatal apoptosis via upregulating Bcl-2 gene and downregulating
            Bax-Bad genes in male wistar rats
  JOURNAL   Biomed Pharmacother 84, 514-525 (2016)
   PUBMED   27690136
  REMARK    GeneRIF: Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA
            expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in
            3-nitropropionic acid induced behavioral despair/mitochondrial
            dysfunction/striatal apoptosis.
REFERENCE   6  (bases 1 to 1001)
  AUTHORS   Ottilie,S., Diaz,J.L., Horne,W., Chang,J., Wang,Y., Wilson,G.,
            Chang,S., Weeks,S., Fritz,L.C. and Oltersdorf,T.
  TITLE     Dimerization properties of human BAD. Identification of a BH-3
            domain and analysis of its binding to mutant BCL-2 and BCL-XL
            proteins
  JOURNAL   J Biol Chem 272 (49), 30866-30872 (1997)
   PUBMED   9388232
REFERENCE   7  (bases 1 to 1001)
  AUTHORS   Kaipia,A., Hsu,S.Y. and Hsueh,A.J.
  TITLE     Expression and function of a proapoptotic Bcl-2 family member
            Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary
  JOURNAL   Endocrinology 138 (12), 5497-5504 (1997)
   PUBMED   9389536
REFERENCE   8  (bases 1 to 1001)
  AUTHORS   Hsu,S.Y., Kaipia,A., Zhu,L. and Hsueh,A.J.
  TITLE     Interference of BAD (Bcl-xL/Bcl-2-associated death
            promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms
            and P11
  JOURNAL   Mol Endocrinol 11 (12), 1858-1867 (1997)
   PUBMED   9369453
REFERENCE   9  (bases 1 to 1001)
  AUTHORS   Tzung,S.P., Fausto,N. and Hockenbery,D.M.
  TITLE     Expression of Bcl-2 family during liver regeneration and
            identification of Bcl-x as a delayed early response gene
  JOURNAL   Am J Pathol 150 (6), 1985-1995 (1997)
   PUBMED   9176392
REFERENCE   10 (bases 1 to 1001)
  AUTHORS   Yang,E., Zha,J., Jockel,J., Boise,L.H., Thompson,C.B. and
            Korsmeyer,S.J.
  TITLE     Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax
            and promotes cell death
  JOURNAL   Cell 80 (2), 285-291 (1995)
   PUBMED   7834748
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022698.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF279910.1, AF003523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               JAXUCZ010000001.1  213563114-213563231
            119-301             JAXUCZ010000001.1  213563668-213563850
            302-492             JAXUCZ010000001.1  213570794-213570984
            493-1001            JAXUCZ010000001.1  213571525-213572033
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1001
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="BCL2-associated agonist of cell death"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
     CDS             1..618
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /note="bcl2 antagonist of cell death; bcl-2-binding
                     component 6; bcl-xL/Bcl-2-associated death promoter;
                     Bcl2-antagonist of cell death; bcl-2 associated death
                     agonist; bcl2-associated death promoter"
                     /codon_start=1
                     /product="bcl2-associated agonist of cell death"
                     /protein_id="NP_073189.1"
                     /db_xref="GeneID:64639"
                     /db_xref="RGD:620103"
                     /translation="MGTPKQPSLAPAHALGLRKSDPGIRSLGSDAGGRRWRPAAQSMF
                     QIPEFEPSEQEDASTTDRGLGPSLTEDQPGPYLAPGLLGSIVQQQPGQAANNSHHGGA
                     GTMETRSRHSSYPAGTEEDEGMEEELSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFE
                     GSFKGLPRPKSAGTATQMRQSASWTRIIQSWWDRNLGKGGSTPSQ"
     exon            1..118
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            119..301
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            302..492
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1001
                     /gene="Bad"
                     /gene_synonym="Bad_v1; Bad_v2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggaaccc caaagcagcc ctcgctggct cctgcacacg ccctaggctt gaggaagtcc
       61 gatcccggaa tccggagcct ggggagcgac gcgggaggaa ggcggtggag accagcagcc
      121 cagagtatgt tccagatccc agagtttgag ccgagtgagc aggaagacgc tagtactaca
      181 gataggggcc tgggccctag cctcactgag gaccagccag gtccctacct ggccccaggt
      241 ctcctgggga gcatcgttca gcagcagccg ggacaggcag ccaataacag tcatcatgga
      301 ggcgctggga ctatggagac ccggagtcgc cacagttcgt acccagcggg gactgaggaa
      361 gatgaaggga tggaggagga gcttagccct tttcgaggac gctcgcgctc ggctcccccc
      421 aatctctggg cagcgcagcg ctatggccgt gagctccgaa gaatgagcga tgaatttgag
      481 ggttccttca agggacttcc tcgcccaaag agcgcaggca ctgcaacaca gatgcgacaa
      541 agcgccagtt ggacgcgcat tatccagtcc tggtgggatc gaaatttggg gaaaggaggc
      601 tccactccct cccagtgatc tgctccacat tcccggaatt ctacccgctc ccatcgcccg
      661 ccatattggg tgtgggcgga agtctttcga ggccttagga aaaaaggatc gctgtgtccc
      721 tttaacaggg agaagagctg acgtacagcg ttgagttcct tccggtgcgt gcaatagcca
      781 tggaggggtg gcccttgctt tggagttttc aaagttttcc acacacccta ccccctacgc
      841 ctccggaagt ggctatgttc cctctccgtt actggacagc cctcaggcgc ctgtgctaag
      901 ttgcgagtcc tggtaaaccg agactgggtg ctgtcctatc atcctagctg gaggccccag
      961 gtcgggagaa acgtgcttta taataaagcc cgcgcatgtg t
//
