LOCUS       NM_001135754            3764 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus BTB domain and CNC homolog 2 (Bach2), mRNA.
ACCESSION   NM_001135754 XM_232858
VERSION     NM_001135754.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3764)
  AUTHORS   Afzali,B., Gronholm,J., Vandrovcova,J., O'Brien,C., Sun,H.W.,
            Vanderleyden,I., Davis,F.P., Khoder,A., Zhang,Y., Hegazy,A.N.,
            Villarino,A.V., Palmer,I.W., Kaufman,J., Watts,N.R., Kazemian,M.,
            Kamenyeva,O., Keith,J., Sayed,A., Kasperaviciute,D., Mueller,M.,
            Hughes,J.D., Fuss,I.J., Sadiyah,M.F., Montgomery-Recht,K.,
            McElwee,J., Restifo,N.P., Strober,W., Linterman,M.A.,
            Wingfield,P.T., Uhlig,H.H., Roychoudhuri,R., Aitman,T.J.,
            Kelleher,P., Lenardo,M.J., O'Shea,J.J., Cooper,N. and
            Laurence,A.D.J.
  TITLE     BACH2 immunodeficiency illustrates an association between
            super-enhancers and haploinsufficiency
  JOURNAL   Nat Immunol 18 (7), 813-823 (2017)
   PUBMED   28530713
REFERENCE   2  (bases 1 to 3764)
  AUTHORS   Dopie,J., Rajakyla,E.K., Joensuu,M.S., Huet,G., Ferrantelli,E.,
            Xie,T., Jaalinoja,H., Jokitalo,E. and Vartiainen,M.K.
  TITLE     Genome-wide RNAi screen for nuclear actin reveals a network of
            cofilin regulators
  JOURNAL   J Cell Sci 128 (13), 2388-2400 (2015)
   PUBMED   26021350
REFERENCE   3  (bases 1 to 3764)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Mar 20, 2025 this sequence was replaced by
            NM_001135754.2.
            
            On Oct 10, 2008 this sequence version replaced XM_232858.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643284.7045.1,
                                           SRR26643292.21152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000005.1  51513405-51513499
            96-244              JAXUCZ010000005.1  51617261-51617409
            245-499             JAXUCZ010000005.1  51691041-51691295
            500-2089            JAXUCZ010000005.1  51755070-51756659
            2090-2296           JAXUCZ010000005.1  51768580-51768786
            2297-3764           JAXUCZ010000005.1  51772777-51774244
FEATURES             Location/Qualifiers
     source          1..3764
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..3764
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /note="BTB domain and CNC homolog 2"
                     /db_xref="GeneID:313125"
                     /db_xref="RGD:1562865"
     exon            1..95
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /inference="alignment:Splign:2.1.0"
     exon            96..244
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /inference="alignment:Splign:2.1.0"
     exon            245..499
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..2776
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /note="BTB and CNC homology 2; BTB and CNC homology 1,
                     basic leucine zipper transcription factor 2"
                     /codon_start=1
                     /product="transcription regulator protein BACH2"
                     /protein_id="NP_001129226.1"
                     /db_xref="GeneID:313125"
                     /db_xref="RGD:1562865"
                     /translation="MSVDEKPDSPMYVYESTVHCANILLGLNDQRKKDILCDVTLIVE
                     RKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAKLLLS
                     RENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNREDGLFVCRKDSACQRPQEDHGNSA
                     GEEEEEEETMDSETARMACATDQMLPDPISFEATAIPVAEKEEALLPESEVPTDTKEN
                     SEKGALTQYPRYKKYQLACTKNVYSAASHGTSGFAGTFSEESPGNSLKPGLSVGQIKS
                     EPPNEETEEESITLCLSGDETDIKDRPGDVEMDRKQPSPAPPPGTPTGATSLDRSRSV
                     SSPSCLRSLFSIAKGVESTGLPSTSQQHFVRSSACPFNKGISQGDLKTDYTPLAGNYG
                     QPHVGQKDVSNFAMGSPLRGPGPETLCKQEGELDRRSVIFSASTCDQPNTPVHSYSSV
                     SSLDKDLSEPVPKSLWVGAGQSLPSSQAYSHGGLMADHLPGRIRPNTSCPVPIKVCPR
                     SPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLM
                     GDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDL
                     PRNDFQMMIKMHKLTSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVC
                     EKEKLLSERNQLKVCMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLIPMDLPGA
                     SVNPPPLGVEQSLAPSQCAVGGSVPCCLEPGAAPPGLPWVPSNTSENCTSGRRLEGSD
                     PGTFSERGPPLEARSQSVTVDFCQEMTEKCTTDEQPRKDYA"
     exon            500..2089
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2296
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..3764
                     /gene="Bach2"
                     /gene_synonym="RGD1562865"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaagtgagg gttccgaaac aagaaggacc ttcaggagct tcttcacact gtgacatgtc
       61 tgatcccttg tgcccgtccc tgcagcatga acaaggtgga cactcactga tctaccacaa
      121 gattgcctcg ccgagttttg gggtccatgt ctgaatggat tgctgcagcc ttcttatctc
      181 ttcctctgcc cagttcccgg catcctaaga ctcaaagcca ggacaggacc tggggaaatt
      241 atatggtttg aacggcatgt ctgtggatga gaagcctgac tcccccatgt atgtgtatga
      301 gtccacagtc cactgtgcca acatcctcct gggcctcaat gaccaacgga agaaggacat
      361 tctctgtgac gtgacgctga ttgtggagag gaaggagttt cgagcccacc gggctgtgct
      421 ggctgcatgc agtgaatact tctggcaagc tctggttgga caaacaaaag atgacttggt
      481 ggtcagcttg cctgaggagg tcacggccag gggctttggg ccgctgctac agtttgccta
      541 cactgccaag ctgttactca gcagagagaa catccgcgag gtcatccgct gtgccgagtt
      601 cctgcgcatg cacaatctgg aggactcctg cttcagcttc ctgcagaccc agctcctgaa
      661 cagggaggat ggtctgttcg tatgtcggaa ggacagtgcg tgccagcgcc cccaggagga
      721 ccatgggaac tctgcaggag aagaggagga ggaggaagag acgatggact cagagacagc
      781 caggatggct tgcgccacag accagatgct cccagacccc atcagcttcg aggccactgc
      841 catcccagta gcagagaaag aagaagcctt gcttcctgag tctgaggtac ccacagatac
      901 caaggaaaac tcagaaaagg gtgcactgac ccagtaccct cgatataaga agtaccagct
      961 cgcgtgtacc aagaatgtct acagcgcagc ctcacacggt acctcagggt ttgcaggcac
     1021 attcagtgaa gagagtcctg gcaatagcct caaaccaggg ctctccgtgg gacagattaa
     1081 aagtgagcca cccaacgagg agacggagga ggagagcatc acactctgcc tgtcaggaga
     1141 tgaaactgac atcaaagaca gaccaggaga tgtcgagatg gaccggaaac aaccgagccc
     1201 tgcccctcct cccggtaccc ctactggagc caccagcctg gacagatcca ggagtgtgtc
     1261 ctcaccttcc tgtctgcggt ctctgttcag tatagcaaaa ggcgtggagt cgactggcct
     1321 acctagtaca tctcagcaac actttgtcag gagttcagca tgccctttca acaaggggat
     1381 ctctcagggt gaccttaaaa ctgattacac ccctttggca gggaactacg gacagcccca
     1441 cgtgggccag aaggatgtgt ccaacttcgc aatggggtcg ccactcaggg ggcccgggcc
     1501 ggagactctt tgtaaacagg agggagagct ggaccgcagg agcgtcatct tctccgcaag
     1561 cacgtgtgac caaccgaaca ctccggtgca ttcatattct tcggtgagca gtttggacaa
     1621 agacctttct gagccggtgc caaaaagtct atgggtggga gctggccagt ccctccccag
     1681 ctcccaggcc tactcccacg gcggactgat ggctgaccac ttgccaggaa ggataaggcc
     1741 caacaccagc tgcccggtgc caatcaaagt ctgtcctcgc tcacctccac tagagaccag
     1801 aaccaggacc tccagctcct gctcctccta ttcctacgca gaggatggga gtgggggctc
     1861 cccctgcagc ctccctctct gcgagttttc ctcttcaccc tgttcccagg gagccagatt
     1921 ccttgccacg gaacatcagg aaccaggcct gatgggagat ggaatgtaca accaagtccg
     1981 accccaaatt aaatgtgagc agtcttacgg aaccaattcc agtgacgaat ctggatcatt
     2041 ctcggaagca gacagtgagt cgtgtcctgt gcaggacagg ggccaggagg ttaaacttcc
     2101 ttttcctgtc gatcagatca cagaccttcc caggaacgac ttccagatga tgattaaaat
     2161 gcacaagcta acctcagaac agttggagtt cattcacgac atccggaggc gtagtaagaa
     2221 ccgcattgcg gctcagcgct gtcggaagag gaaactggac tgcattcaga acctggaatg
     2281 cgagatacga aaactggtgt gcgagaaaga gaagctgttg tccgagagga atcaattgaa
     2341 agtgtgcatg ggggagctac tggacaactt ctcctgcctc tcacaggagg tctgtcgaga
     2401 catccagagt ccagagcaga tccaggccct gcaccggtac tgccctgttc tcatacccat
     2461 ggaccttcct ggagccagtg ttaacccccc tcccttgggg gttgagcaga gccttgcgcc
     2521 ctcccagtgt gcagtaggag gaagtgtacc ctgctgcctg gagccagggg cagctccccc
     2581 tgggctcccc tgggtgccca gcaacacctc tgagaattgt acgtctggga ggaggttgga
     2641 aggcagtgac cctggaacct tctctgaaag aggacctcct ctggaagcca ggagccagtc
     2701 agtgacggtg gacttctgtc aggaaatgac tgagaagtgt acaacagacg aacagcccag
     2761 gaaagattat gcctagccgc gatcagctct gccccccgac ccccggtctt cacacctctc
     2821 tcatctgaga gtgcctctgc cagccagggg cactgttcat ctgtgtcttg aagaaccgag
     2881 aacgacgaat ttggtgcaca ctacagcagt cttagcagca atactgttcc gaagtattcc
     2941 ctcctctctt gtaagcagga gtgctagtta ccttcctaat ggtgctaccc cttgccctgg
     3001 caaggtagac aacagtgccg acactgtctg tctgtgggtt aattgcaaac ttcacaggga
     3061 ttagactaca cctctaggac ccaaccacgg attttttttc tcagtggccc atgtcacaaa
     3121 ccctatctca ggaatttctt ctgaatgttc aatttttttc attgaagaca gcttctatac
     3181 acatcaaagt tttatagcta tactgtgtac atagtatata taatatatat gaaatatata
     3241 tccatatgca aaagtcctgc atgcctcgat tttctcaatt tcctgaaact ggaaacttca
     3301 cttatcattt acaaacatgt cccaacattc ctctttctgt gtctgatgcc agaactggtt
     3361 ttgtagctgt taacatggtt gcttttcttg ctgcacaatt cggtttctaa tctgtactta
     3421 tttacagacc aaattcagca tcggaagttt cttctcaagg ttcagtctca gacctttcac
     3481 tttcgttggt ttggtttcgg cgcccccgaa tggcattggg tgagcatcgt gggtctgtcc
     3541 tttcctcctc gtgtttcccc ctcgtccttg cagatactgc acagcaatgg tcaacttcgc
     3601 cacttgcact gagttttgag tcaaacctat tttcttaaat gaagttgtaa cttcggtata
     3661 actcaagtat attgtatatt ctttgctttc agttaaagag gtaaaaaaaa acattttagc
     3721 taattaaaaa gcactcaggt gataattatg taggaaaaaa aaaa
//
