LOCUS       NM_001107113            3232 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Rattus norvegicus BTB domain and CNC homolog 1 (Bach1), mRNA.
ACCESSION   NM_001107113 XM_001067103 XM_001067152 XM_221712
VERSION     NM_001107113.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3232)
  AUTHORS   Shen,Z., Zhang,Y., Bu,G. and Fang,L.
  TITLE     Renal denervation improves mitochondrial oxidative stress and
            cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling
  JOURNAL   Int Immunopharmacol 141, 112778 (2024)
   PUBMED   39173402
  REMARK    GeneRIF: Renal denervation improves mitochondrial oxidative stress
            and cardiac hypertrophy through inactivating SP1/BACH1-PACS2
            signaling.
REFERENCE   2  (bases 1 to 3232)
  AUTHORS   Hu,Y., Li,J., Hu,L., Liu,F., Chen,R., Xu,L., Tang,Z., Lu,B. and
            Yu,J.
  TITLE     BACH1 impairs hepatocyte regeneration after hepatectomy with
            repeated ischemia/reperfusion by reprogramming energy metabolism
            and exacerbating oxidative stress
  JOURNAL   Biochem Pharmacol 226, 116377 (2024)
   PUBMED   38906228
  REMARK    GeneRIF: BACH1 impairs hepatocyte regeneration after hepatectomy
            with repeated ischemia/reperfusion by reprogramming energy
            metabolism and exacerbating oxidative stress.
REFERENCE   3  (bases 1 to 3232)
  AUTHORS   Tong,Y., Wang,D.D., Zhang,Y.L., He,S., Chen,D., Wu,Y.X. and
            Pang,Q.F.
  TITLE     MiR-196a-5p hinders vascular smooth muscle cell proliferation and
            vascular remodeling via repressing BACH1 expression
  JOURNAL   Sci Rep 14 (1), 16904 (2024)
   PUBMED   39043832
  REMARK    GeneRIF: MiR-196a-5p hinders vascular smooth muscle cell
            proliferation and vascular remodeling via repressing BACH1
            expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3232)
  AUTHORS   Wang,Y., Qiu,J., Yan,H., Zhang,N., Gao,S., Xu,N., Wang,C. and
            Lou,H.
  TITLE     The Bach1/HO-1 pathway regulates oxidative stress and contributes
            to ferroptosis in doxorubicin-induced cardiomyopathy in H9c2 cells
            and mice
  JOURNAL   Arch Toxicol 98 (6), 1781-1794 (2024)
   PUBMED   38573338
  REMARK    GeneRIF: The Bach1/HO-1 pathway regulates oxidative stress and
            contributes to ferroptosis in doxorubicin-induced cardiomyopathy in
            H9c2 cells and mice.
REFERENCE   5  (bases 1 to 3232)
  AUTHORS   Yao,B., Cai,Y., Wan,L., Deng,J., Zhao,L., Wang,W. and Han,Z.
  TITLE     BACH1 promotes intervertebral disc degeneration by regulating
            HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid
            metabolism in nucleus pulposus cells
  JOURNAL   J Gene Med 25 (6), e3488 (2023)
   PUBMED   36813742
  REMARK    GeneRIF: BACH1 promotes intervertebral disc degeneration by
            regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and
            lipid metabolism in nucleus pulposus cells.
REFERENCE   6  (bases 1 to 3232)
  AUTHORS   Sigal,A., Milo,R., Cohen,A., Geva-Zatorsky,N., Klein,Y., Alaluf,I.,
            Swerdlin,N., Perzov,N., Danon,T., Liron,Y., Raveh,T.,
            Carpenter,A.E., Lahav,G. and Alon,U.
  TITLE     Dynamic proteomics in individual human cells uncovers widespread
            cell-cycle dependence of nuclear proteins
  JOURNAL   Nat Methods 3 (7), 525-531 (2006)
   PUBMED   16791210
REFERENCE   7  (bases 1 to 3232)
  AUTHORS   Hu,Y.H., Warnatz,H.J., Vanhecke,D., Wagner,F., Fiebitz,A.,
            Thamm,S., Kahlem,P., Lehrach,H., Yaspo,M.L. and Janitz,M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3232)
  AUTHORS   Kitamuro,T., Takahashi,K., Ogawa,K., Udono-Fujimori,R., Takeda,K.,
            Furuyama,K., Nakayama,M., Sun,J., Fujita,H., Hida,W., Hattori,T.,
            Shirato,K., Igarashi,K. and Shibahara,S.
  TITLE     Bach1 functions as a hypoxia-inducible repressor for the heme
            oxygenase-1 gene in human cells
  JOURNAL   J Biol Chem 278 (11), 9125-9133 (2003)
   PUBMED   12511571
REFERENCE   9  (bases 1 to 3232)
  AUTHORS   Cantor,S.B., Bell,D.W., Ganesan,S., Kass,E.M., Drapkin,R.,
            Grossman,S., Wahrer,D.C., Sgroi,D.C., Lane,W.S., Haber,D.A. and
            Livingston,D.M.
  TITLE     BACH1, a novel helicase-like protein, interacts directly with BRCA1
            and contributes to its DNA repair function
  JOURNAL   Cell 105 (1), 149-160 (2001)
   PUBMED   11301010
REFERENCE   10 (bases 1 to 3232)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473989.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_221712.4, XM_001067103.1, XM_001067152.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132266,
                              SAMD00132270 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3232
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3232
                     /gene="Bach1"
                     /note="BTB domain and CNC homolog 1"
                     /db_xref="GeneID:304127"
                     /db_xref="RGD:1306693"
     exon            1..87
                     /gene="Bach1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..381
                     /gene="Bach1"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2367
                     /gene="Bach1"
                     /note="BTB and CNC homology 1 transcription factor;
                     transcription regulator protein BACH1-like; BTB and CNC
                     homology 1, basic leucine zipper transcription factor 1"
                     /codon_start=1
                     /product="transcription regulator protein BACH1"
                     /protein_id="NP_001100583.1"
                     /db_xref="GeneID:304127"
                     /db_xref="RGD:1306693"
                     /translation="MSVSESAVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQQ
                     FRAHRSVLAACSSYFHSRIVGQTDAELTITLPQEVTVKGFEPLIQFAYTAKLILSKDN
                     VDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTSEQQGCARKKCFSSHCQKADFKFSFS
                     EQKDLEIDEADEFFEKKSAQTSHCDSQRCQGNVRASPHLQDSVGPTCQSMCVDKDGAL
                     ALPSLCPKYRKFQKAFGTDKIRTLESGVRDVHAASVHPKETSELECLGGAQGCADLQV
                     ILKCEGMKPAMEREDTKCKDPAPQCPAEQAEVTALSQDSAGPHGLYSLSVLHTYEQSG
                     DVGFPGLQSKTVKTEKPLLGPDAQDEKPLENQELYLKSNMGPKEDSSSLASEDRSSVE
                     REVAEHLAKGFWSDICSTDSPCQMQLSSAVAKDGSEQGYSQRRSECPWLGIRISESPE
                     PGQRTFTTLSSVNCPFISTLSSEGCSSNLEIGNYDYVAEPQQEPCPYACVISLGDDSE
                     TDTEGDSESCSAREQDCEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRR
                     RSKNRIAAQRCRKRKLDCIQNLESEIEKLQNEKESLLKERDHILSTLGETKQNLTGLC
                     QQVCKEAALSPEQIQILAKYSASDCPLSFLISEKGKSTPDGELPFTSVFSVSDMPPTA
                     PPPCGRGSTAARQELVQESQPTTTATPEQATLLEPCRQSAGISDFCQQMSDKCTTDE"
     exon            382..1725
                     /gene="Bach1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1932
                     /gene="Bach1"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..3232
                     /gene="Bach1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagacgggcg gccgtccgcg cggagggagt gagtcacctg accgccgctt gccgcctgca
       61 gtcgggccgt gccgcgcctc ggctccggtc gatgacagtg agaagcatgc tttccactgc
      121 tctccctgat cccgtttgcc acccaggatg tctgtgagtg agagtgcagt gtttgcctac
      181 gagtcctctg tgcacagcac caacgtcttg ctcagcctca atgaccagcg gaagaaggat
      241 gtgctgtgcg atgtcactgt cctggtggag ggccagcagt tccgagccca ccgctcggtg
      301 ctggctgcat gcagcagcta cttccactcg cgaatcgtag gccaaactga tgccgagctc
      361 accatcacac tgccgcaaga ggtaacagtt aaaggatttg aacctttaat tcagtttgcc
      421 tacactgcca aactcatttt aagtaaagac aatgttgacg aagtctgcaa gtgtgtggag
      481 tttctaagcg tacacaatat cgaggaatcc tgctttcagt ttctcaagtt taagtttttg
      541 gactccacct cagagcagca gggatgtgca agaaaaaagt gcttctcctc acactgtcag
      601 aaagcagatt ttaaattttc attttcagaa cagaaagatc tagaaattga tgaagcagat
      661 gaattctttg aaaagaaaag tgctcagact tctcattgtg actcccaaag atgtcagggc
      721 aatgtaagag catcccccca tctccaagac agtgtcggtc cgacgtgcca gtccatgtgc
      781 gtggacaagg acggagccct ggcactgcca tctttatgcc ccaaatatag aaagttccag
      841 aaagcatttg gaaccgacaa gatccgaact cttgaatccg gcgtcagaga tgttcatgct
      901 gcctctgtcc atccaaagga gacatctgaa cttgagtgtt tagggggagc gcagggctgt
      961 gcagatttac aagtgatctt aaaatgtgaa gggatgaagc cagccatgga gagggaagac
     1021 acaaagtgca aagaccccgc ccctcagtgt cctgcagagc aggctgaagt gactgctttg
     1081 tcccaggatt ctgctggacc tcacgggctc tattccctgt cggtcctaca cacatacgag
     1141 cagtcaggcg atgtgggctt tcctgggctg cagagtaaaa cagtgaaaac agaaaagcct
     1201 ctgttgggtc cagatgccca ggacgagaag ccattggaaa atcaggaatt atacctgaag
     1261 tctaacatgg gacccaaaga agacagcagc agccttgcgt ccgaggatcg gagtagtgtg
     1321 gagcgagagg tggcagagca cctggccaaa ggcttctgga gtgacatttg cagcacggac
     1381 tcgccttgcc aaatgcagtt gtcatccgct gtggccaaag atggctcaga acagggctac
     1441 tctcaaaggc gatctgagtg tccctggttg ggtatcagga tcagcgagag cccggagcca
     1501 ggccagcgga ctttcacaac tctcagttcc gtcaactgcc cttttattag tactctgagt
     1561 tctgaaggct gctcaagcaa cttggaaatt ggaaactatg attacgtcgc agagcctcag
     1621 caggagcctt gcccgtatgc ttgtgtgatc agtttgggag atgactcgga gaccgacacg
     1681 gaaggcgaca gcgagtcctg ttctgccagg gagcaggact gtgaggtgaa actgcctttc
     1741 aatgctcaac gaataatttc gctctcacga aatgatttcc agtccttgtt gaaaatgcac
     1801 aaactgaccc cagagcagct ggactgtatc catgacatcc gcaggaggag caagaacagg
     1861 atcgctgccc agcgctgtcg caagaggaag ctcgactgca tccagaacct tgagtcagaa
     1921 attgagaagc tgcaaaatga aaaggagagc ttgctgaagg agcgagatca cattttgtca
     1981 acgctcgggg agacaaagca gaaccttacc ggactttgtc aacaagtgtg caaggaagcc
     2041 gcactgagtc cagagcagat tcagatcctc gccaagtact cagcctcaga ctgtccgctt
     2101 tcttttttaa tttctgagaa aggaaaaagt actcctgacg gcgagcttcc ttttacttca
     2161 gttttcagtg tgtctgacat gcctccaact gcaccacctc cctgtgggcg agggagcacc
     2221 gcggcccgcc aggagcttgt gcaggagtct cagccaacca ccacagccac cccggagcag
     2281 gccacgctgt tggaaccctg tcggcagagt gctgggatct cagacttctg tcagcagatg
     2341 tctgacaagt gtactactga tgagtaagcc gcaggagtgt ccttcagctc acggattccc
     2401 ctctgacgct ctggcattgt cttgagagcc tagtgtggct gtgtcttagc agccctgctt
     2461 cctcctggta gctttctatt gagggaattt ctctttaagg tgaccctgag ttctccttgg
     2521 ttttcatagg agacatgaca tgctctatct cttgaatgat gggaaattgt gtgtgaccag
     2581 gtaataattt cctagtgttc aaagtaacta cagcaataga agccacagtg tccatctcaa
     2641 cagctcaaag catctgcatg cagtcctcct gctcagaaaa aagagtcccc ctaagccata
     2701 cagtggggat ctccccagca gtgcagagct gtaatgtgga aaagaaatca cctttgaact
     2761 ccaacactct gctcctcagc tcctaccaaa gtccagcatg ggctggacct ggtgactcag
     2821 gctgccctgg ccggacctag tcaaaggccg cagctggcct gagctggagg cctctgctgt
     2881 cctcagtatt gactaggagt tttggttgca caaactagaa agtgtaacgt tccctgctct
     2941 cgcttctgtt cctctcttta gtctccacct tgtctaggct gttagaaact ttctgttccc
     3001 tgacttttct cgtcccctgg aggaagaagt tgggatttag gctgaagcag ccctagtgtg
     3061 catgatctgg ccagaaccgt cactgcctct ccctggagag agctgcatga ggatgtcggt
     3121 catctcattg caggtcactg atgaccacga gggcactggg gtcaaggaga gggaaatgtc
     3181 cacattgacc ggaagagcgg cttattggca tcctgtgaag actgtggtgt gt
//
