LOCUS       NM_017300               1734 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus bile acid CoA:amino acid N-acyltransferase
            (Baat), mRNA.
ACCESSION   NM_017300
VERSION     NM_017300.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1734)
  AUTHORS   Ghosh,D. and Berg,J.M.
  TITLE     A proteome-wide perspective on peroxisome targeting signal
            1(PTS1)-Pex5p affinities
  JOURNAL   J Am Chem Soc 132 (11), 3973-3979 (2010)
   PUBMED   20178365
REFERENCE   2  (bases 1 to 1734)
  AUTHORS   Chen,B.C., Kuo,K.K., Chen,K.Y., Liu,C.H., Tsai,L.Y., Hsu,H.K. and
            Hsu,C.
  TITLE     Retinoid X receptor alpha participation in dexamethasone-induced
            rat bile acid coenzyme A-amino acid N-acyltransferase expression in
            septic liver
  JOURNAL   Shock 32 (2), 164-171 (2009)
   PUBMED   19008781
  REMARK    GeneRIF: Dex restored the expression of rBAT in septic rats by
            enhancing RXR[alpha], a process that might explain the mechanism
            underlying Dex's anticholestatic effect.
REFERENCE   3  (bases 1 to 1734)
  AUTHORS   Chen,Y.H., Hong,I.C., Kuo,K.K., Hsu,H.K. and Hsu,C.
  TITLE     Role of retinoid-X receptor-alpha in the suppression of rat bile
            acid coenzyme A-amino acid N-acyltransferase in liver during sepsis
  JOURNAL   Shock 28 (1), 65-70 (2007)
   PUBMED   17483744
  REMARK    GeneRIF: mechanisms of RXR-alpha-mediated BAAT regulation during
            polymicrobial sepsis
REFERENCE   4  (bases 1 to 1734)
  AUTHORS   Pellicoro,A., van den Heuvel,F.A., Geuken,M., Moshage,H.,
            Jansen,P.L. and Faber,K.N.
  TITLE     Human and rat bile acid-CoA:amino acid N-acyltransferase are
            liver-specific peroxisomal enzymes: implications for intracellular
            bile salt transport
  JOURNAL   Hepatology 45 (2), 340-348 (2007)
   PUBMED   17256745
  REMARK    GeneRIF: hBAAT and rBaat are peroxisomal enzymes present in
            undetectable amounts in the cytosol. Unconjugated or deconjugated
            bile salts returning to the liver need to shuttle through the
            peroxisome before reentering the enterohepatic circulation.
REFERENCE   5  (bases 1 to 1734)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   6  (bases 1 to 1734)
  AUTHORS   Falany,C.N., Fortinberry,H., Leiter,E.H. and Barnes,S.
  TITLE     Cloning, expression, and chromosomal localization of mouse liver
            bile acid CoA:amino acid N-acyltransferase
  JOURNAL   J Lipid Res 38 (6), 1139-1148 (1997)
   PUBMED   9215542
REFERENCE   7  (bases 1 to 1734)
  AUTHORS   Furutani,M., Arii,S., Higashitsuji,H., Mise,M., Fukumoto,M.,
            Takano,S., Nakayama,H., Imamura,M. and Fujita,J.
  TITLE     Reduced expression of kan-1 (encoding putative bile acid-CoA-amino
            acid N-acyltransferase) mRNA in livers of rats after partial
            hepatectomy and during sepsis
  JOURNAL   Biochem J 311 (Pt 1) (Pt 1), 203-208 (1995)
   PUBMED   7575455
REFERENCE   8  (bases 1 to 1734)
  AUTHORS   Falany,C.N., Johnson,M.R., Barnes,S. and Diasio,R.B.
  TITLE     Glycine and taurine conjugation of bile acids by a single enzyme.
            Molecular cloning and expression of human liver bile acid CoA:amino
            acid N-acyltransferase
  JOURNAL   J Biol Chem 269 (30), 19375-19379 (1994)
   PUBMED   8034703
REFERENCE   9  (bases 1 to 1734)
  AUTHORS   Johnson,M.R., Barnes,S., Kwakye,J.B. and Diasio,R.B.
  TITLE     Purification and characterization of bile acid-CoA:amino acid
            N-acyltransferase from human liver
  JOURNAL   J Biol Chem 266 (16), 10227-10233 (1991)
   PUBMED   2037576
REFERENCE   10 (bases 1 to 1734)
  AUTHORS   Killenberg,P.G. and Jordan,J.T.
  TITLE     Purification and characterization of bile acid-CoA:amino acid
            N-acyltransferase from rat liver
  JOURNAL   J Biol Chem 253 (4), 1005-1010 (1978)
   PUBMED   624713
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088153.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017300.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088153.1, D43964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1734
                     /gene="Baat"
                     /gene_synonym="kan-1"
                     /note="bile acid CoA:amino acid N-acyltransferase"
                     /db_xref="GeneID:29725"
                     /db_xref="RGD:2190"
     exon            1..147
                     /gene="Baat"
                     /gene_synonym="kan-1"
                     /inference="alignment:Splign:2.1.0"
     exon            148..663
                     /gene="Baat"
                     /gene_synonym="kan-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1460
                     /gene="Baat"
                     /gene_synonym="kan-1"
                     /EC_number="2.3.1.65"
                     /EC_number="3.1.2.2"
                     /EC_number="3.1.2.27"
                     /note="BAT; BACAT; glycine N-choloyltransferase;
                     long-chain fatty-acyl-CoA hydrolase; bile acid-Coenzyme A
                     dehydrogenase: amino acid n-acyltransferase; choloyl-CoA
                     hydrolase; bile acid-Coenzyme A: amino acid
                     N-acyltransferase; bile acid Coenzyme A: amino acid
                     N-acyltransferase (glycine N-choloyltransferase); bile
                     acid-CoA thioesterase"
                     /codon_start=1
                     /product="bile acid-CoA:amino acid N-acyltransferase"
                     /protein_id="NP_058996.2"
                     /db_xref="GeneID:29725"
                     /db_xref="RGD:2190"
                     /translation="MAKLTAVPLSALVDEPVHIRVTGLTPFQVVCLQASLKDDKGNLF
                     NSQAFYRASEVGEVDLERDSSLGGDYMGVHPMGLFWSMKPEKLLTRLVKRDVMNRPHK
                     VHIKLCHPYFPVEGKVISSSLDSLILERWYVAPGVTRIHVKEGRIRGALFLPPGEGPF
                     PGVIDLFGGAGGLFEFRASLLASHGFATLALAYWGYDDLPSRLEKVDLEYFEEGVEFL
                     LRHPKVLGPGVGILSVCIGAEIGLSMAINLKQITATVLINGPNFVSSNPHVYRGKVFQ
                     PTPCSEEFVTTNALGLVEFYRTFEETADKDSKYCFPIEKAHGHFLFVVGEDDKNLNSK
                     VHAKQAIAQLMKSGKKNWTLLSYPGAGHLIEPPYSPLCSASRMPFVIPSINWGGEVIP
                     HAAAQEHSWKEIQKFLKQHLNPGFNSQL"
     exon            664..866
                     /gene="Baat"
                     /gene_synonym="kan-1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1707
                     /gene="Baat"
                     /gene_synonym="kan-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccttaactg gatagtctga agttttcaaa actcttatcc acaaagttgt cagaaccttg
       61 attgggaagt cctgtgcatc tgtgctaacc tacagggcct ccttatccag agcactctgc
      121 atttcagagg gttgctgtcg aactacggtt ttggcgaaga cattcctgaa gaattgtctg
      181 aggtttcctc tgcaaaaatg gccaagctga cagctgttcc tctcagtgca cttgttgatg
      241 agcctgtgca tatccgggtc acaggcctga cccccttcca ggtggtgtgc cttcaggcat
      301 cactgaaaga tgataaggga aacctgttta attctcaggc cttctacagg gccagtgaag
      361 tgggtgaggt agatctggaa cgtgattcct ctcttggagg agactacatg ggggtccacc
      421 ccatgggtct tttctggtcc atgaaacctg aaaagctatt gactagattg gtaaaaagag
      481 atgtgatgaa taggccccac aaagtccaca taaaactttg ccatccatac tttccagtag
      541 aaggcaaagt tatcagttcc tccttggata gtctgattct ggaaaggtgg tatgtggcac
      601 ctggtgtcac taggatccat gtaaaggaag gccgaatccg gggagccctg tttctgcctc
      661 caggagaagg tcctttccca ggggtcattg acttgtttgg aggagctggt ggactgtttg
      721 agttccgggc cagcctcctg gccagtcatg gctttgccac tttagctctg gcttactggg
      781 gctatgatga cctgccctct cgactggaga aggtagatct agagtatttt gaagaaggtg
      841 tagagtttct cctgagacat cctaaggtcc tgggcccagg ggttggcatc ctttctgtgt
      901 gcattggagc agagattgga ctttctatgg ctattaacct aaaacagata acagccactg
      961 tacttataaa tgggcctaat tttgtttcta gcaatccaca tgtatatcgt ggtaaggtct
     1021 tccagcctac accctgcagt gaagaatttg taaccaccaa tgctttggga cttgtagagt
     1081 tctatcgaac ctttgaggaa actgcagata aggatagcaa atactgtttt cccattgaaa
     1141 aagctcacgg acattttctt ttcgtggtgg gagaagatga taagaatctc aacagcaaag
     1201 tgcatgctaa gcaagccata gcccagctga tgaaaagtgg aaagaagaac tggactctgc
     1261 tgtcttaccc tggggcaggt cacctgattg agcctcccta ctccccactg tgctcagcct
     1321 caaggatgcc ctttgtaatc ccaagcatca actggggagg agaggttatc ccacacgcag
     1381 ctgcgcagga acattcttgg aaggagatac agaaatttct caagcagcat cttaatccag
     1441 gtttcaacag tcagctgtga gtggacttga ttatattact ggaaagagga gctgggcatc
     1501 tcctggccag ctccactcct cacttccata gaggaatgtc tttaatctct tatcacgtga
     1561 ggaagaagag taccaccaga aaatgccgaa ggacagagag tgataacctc atgactttgg
     1621 aaggggagac atgttttcca tggaataaaa tgtccctcag tgagagtcct atatctgtat
     1681 aaataaaatc ttagggtttt cctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
