LOCUS       NM_001108608            1831 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus beta-1,4-galactosyltransferase 5 (B4galt5), mRNA.
ACCESSION   NM_001108608 XM_001073367 XM_342584
VERSION     NM_001108608.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1831)
  AUTHORS   Yoshihara T, Satake H, Nishie T, Okino N, Hatta T, Otani H, Naruse
            C, Suzuki H, Sugihara K, Kamimura E, Tokuda N, Furukawa K,
            Fururkawa K, Ito M and Asano M.
  TITLE     Lactosylceramide synthases encoded by B4galt5 and 6 genes are
            pivotal for neuronal generation and myelin formation in mice
  JOURNAL   PLoS Genet 14 (8), e1007545 (2018)
   PUBMED   30114188
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1831)
  AUTHORS   Zhang L, Ren J, Shi P, Lu D, Zhao C, Su Y, Zhang L and Huang J.
  TITLE     The Immunological Regulation Roles of Porcine beta-1, 4
            Galactosyltransferase V (B4GALT5) in PRRSV Infection
  JOURNAL   Front Cell Infect Microbiol 8, 48 (2018)
   PUBMED   29546034
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1831)
  AUTHORS   Li SF, Zhu CS, Wang YM, Xie XX, Xiao LL, Zhang ZC, Tang QQ and Li
            X.
  TITLE     Downregulation of beta1,4-galactosyltransferase 5 improves insulin
            resistance by promoting adipocyte commitment and reducing
            inflammation
  JOURNAL   Cell Death Dis 9 (2), 196 (2018)
   PUBMED   29415997
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1831)
  AUTHORS   Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI,
            Mascanfroni ID, Yeste A, Kivisakk P, Kallas K, Ellezam B, Bakshi R,
            Prat A, Antel JP, Weiner HL and Quintana FJ.
  TITLE     Regulation of astrocyte activation by glycolipids drives chronic
            CNS inflammation
  JOURNAL   Nat Med 20 (10), 1147-1156 (2014)
   PUBMED   25216636
REFERENCE   5  (bases 1 to 1831)
  AUTHORS   Yamaji T and Hanada K.
  TITLE     Establishment of HeLa cell mutants deficient in
            sphingolipid-related genes using TALENs
  JOURNAL   PLoS One 9 (2), e88124 (2014)
   PUBMED   24498430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1831)
  AUTHORS   Nishie T, Hikimochi Y, Zama K, Fukusumi Y, Ito M, Yokoyama H,
            Naruse C, Ito M and Asano M.
  TITLE     Beta4-galactosyltransferase-5 is a lactosylceramide synthase
            essential for mouse extra-embryonic development
  JOURNAL   Glycobiology 20 (10), 1311-1322 (2010)
   PUBMED   20574042
REFERENCE   7  (bases 1 to 1831)
  AUTHORS   Wei Y, Zhou F, Ge Y, Chen H, Cui C, Li Q, Liu D, Yang Z, Wu G, Sun
            S, Gu J and Jiang J.
  TITLE     Beta1,4-galactosyltransferase V regulates self-renewal of
            glioma-initiating cell
  JOURNAL   Biochem Biophys Res Commun 396 (3), 602-607 (2010)
   PUBMED   20417617
REFERENCE   8  (bases 1 to 1831)
  AUTHORS   Yan M, Cheng C, Ding F, Jiang J, Gao L, Xia C and Shen A.
  TITLE     The expression patterns of beta1,4 galactosyltransferase I and V
            mRNAs, and Galbeta1-4GlcNAc group in rat gastrocnemius muscles post
            sciatic nerve injury
  JOURNAL   Glycoconj J 25 (7), 685-701 (2008)
   PUBMED   18512149
  REMARK    GeneRIF: These results indicated that the expressions of
            beta1,4-GalT I, V mRNAs and Galbeta1-4GlcNAc group were involved in
            the process of denervation and reinnervation.
REFERENCE   9  (bases 1 to 1831)
  AUTHORS   Yan M, Cheng C, Shao X, Qian J, Shen A and Xia C.
  TITLE     Expression change of beta-1,4 galactosyltransferase I, V mRNAs and
            Galbeta1,4GlcNAc group in rat sciatic nerve after crush
  JOURNAL   J Mol Histol 39 (3), 317-328 (2008)
   PUBMED   18320333
  REMARK    GeneRIF: beta1,4-GalT I and V might play important roles in the
            regeneration of the injured sciatic nerve.
            Erratum:[J Mol Histol. 2008 Aug;39(4):469. Xia, Chun [corrected to
            Xia, Chunlin]]
REFERENCE   10 (bases 1 to 1831)
  AUTHORS   Yan M, Xia C, Niu S, Shao X, Cheng C, Zhao J and Shen A.
  TITLE     The role of TNF-alpha and its receptors in the production of
            beta-1,4 galactosyltransferase I and V mRNAs by rat primary
            astrocytes
  JOURNAL   J Mol Neurosci 33 (2), 155-162 (2007)
   PUBMED   17917074
  REMARK    GeneRIF: These results suggest that an autocrine loop involving
            TNF-alpha, TNFR1 and TNFR2 contributes to the production of
            beta-1,4-GalT I and V mRNA in response to inflammation.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474005.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342584.3, XM_001073367.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1831
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1831
                     /gene="B4galt5"
                     /note="beta-1,4-galactosyltransferase 5"
                     /db_xref="GeneID:362275"
                     /db_xref="RGD:1310062"
     exon            1..140
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..454
                     /gene="B4galt5"
                     /EC_number="2.4.1.38"
                     /note="UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase,
                     polypeptide 5"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 5"
                     /protein_id="NP_001102078.1"
                     /db_xref="GeneID:362275"
                     /db_xref="RGD:1310062"
                     /translation="MVQAQGILLRDNVRTIGAQVYEQVVRSAYAKRNSSLNDSDYPLD
                     LNHSEAFPPTTTFLPEDFTYFANHPCPERLPSMKGPIDINMSEIRMDDIHELFSRDPA
                     IRLGGHWKPADCMPRWKVAILIPFRNRHDSFLCLPPCSLCP"
     exon            141..254
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            255..379
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            380..414
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
     exon            415..1831
                     /gene="B4galt5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagtgaac acctacctct tcatggtgca ggctcaaggc atcctgcttc gggacaacgt
       61 gaggaccatc ggtgcccagg tgtatgagca ggtggtccgc agcgcctacg ccaagaggaa
      121 cagcagcctg aatgactcag attatcctct ggacttgaac cacagtgaag cctttccccc
      181 aaccacaaca tttcttcctg aagatttcac ctattttgcc aaccaccctt gcccggagag
      241 gctcccttcc atgaagggcc cgatagacat aaacatgagt gagatcagaa tggacgatat
      301 tcatgagctc ttctccagag acccggccat caggcttgga ggacactgga agcctgcaga
      361 ctgcatgcct cggtggaagg tggccatcct catccctttc cggaaccgcc acgactcctt
      421 cctgtgtctg cctccctgca gcctctgtcc ctgaagcagg gatctgtgtg tggcgaggag
      481 cgttctcctc tggcctctgc tcttcgcctt tttgccttca gcacccttga tgttcatggt
      541 ttacatgggt gggggtgggg tgtagataca cggggatggg gtttacatca cacagttggt
      601 tctgaggaca gatgatcccc acagactgtg ggagtgattg gccaggcctt tttttttgtt
      661 ctttttgtag agtagagtgg tatctaggga acagatggcg ctgcagagcg cttcccgctc
      721 gtatgagaga gcaggtgcct gcccttgaga gcgctggtga accacgtcat ctgtttgcac
      781 tgggcaagga gctgcacgag gcgctgcgtt gacttgcctt tgtcttacgg tacacacagc
      841 aataaagatt gggttccgcc tgcccggctc aaccctctgc cccctgtgtt agttttacag
      901 tgcggggaag gaaacccatg gctgatgtgc taggcaagag ctctgccact gagtcacggg
      961 tccagccccc tctcccctca tccttctgtt tccactctga aggtcaggga tgctgtcgct
     1021 gtggtagagc cttggtgtcc ttggagggac agtggtgtgt gtagcatgtg tcctggctga
     1081 agccctgcat cctcacaata gccacagggc acctttttaa gccaaaggct gatacttgat
     1141 ttaagaagga aaatgcagat ttggggacaa agaaaggtct ttttactgct caagtcgggt
     1201 cacttatgtt cccttgcaat catgtccaag tttgttatta gtgtggactc ttgtgggcac
     1261 tgtcagtcat tgtccgccca gtcacatacc gagtgggaaa tgtcacagtc agagccacac
     1321 cactggacca cacattaggt cattgcttaa agaaaatgac attgagaatc aagtgtgacc
     1381 ttggtgtact ttggcagctg aaattactcc atgctacaga cgagtgaccc ttaagccgac
     1441 ctgcccttga ctgactgccc tgtgtgtgca aggtctctct ccgcacaggc tttctttggg
     1501 gaggggggat ttgcaaaact ttaattttgc taaaatgggg actcctgtca tcgagttcct
     1561 tcctcagagc ggcagagcac acactgactg tgcctaccat cgacgaggca ctgacgccac
     1621 tggcttagcc accattactg tctttgttct gagcttgctc tttgttttaa aggtgccagg
     1681 gggacatttt tgcactgaag cctaaagatg ttttaaaaac acttttcaca gaaatagtcc
     1741 ttgtcattac attgttcact catgtgtttg tacatttttg tatgttaatt tatgaatgat
     1801 tttttcagta aaaaatacat attcaataac c
//
