LOCUS       NM_053287               2298 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus beta-1,4-galactosyltransferase 1 (B4galt1), mRNA.
ACCESSION   NM_053287 XM_001058948 XM_342820
VERSION     NM_053287.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2298)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2298)
  AUTHORS   Zhao,J., Gao,Y., Cheng,C., Yan,M. and Wang,J.
  TITLE     Upregulation of beta-1,4-galactosyltransferase I in rat spinal cord
            with experimental autoimmune encephalomyelitis
  JOURNAL   J Mol Neurosci 49 (3), 437-445 (2013)
   PUBMED   22706684
  REMARK    GeneRIF: beta-1,4-GalT-I may be an inflammatory mediator regulating
            adhesion & migration of inflammatory cells in EAE by modifying
            galactosylated carbohydrate chains to modulate selectin-ligand
            biosynthesis & interaction with E-selectin.
REFERENCE   3  (bases 1 to 2298)
  AUTHORS   Liu,X., Cheng,C., Shao,B., Wu,X., Ji,Y., Lu,X. and Shen,A.
  TITLE     The functional interaction between CDK11p58 and
            beta-1,4-galactosyltransferase I involved in astrocyte activation
            caused by lipopolysaccharide
  JOURNAL   Inflammation 35 (4), 1365-1377 (2012)
   PUBMED   22527143
  REMARK    GeneRIF: These findings indicated that the functional interaction
            between CDK11(p58) and beta-1,4-GalT-I may play an important role
            during astrocyte activation after LPS administration.
REFERENCE   4  (bases 1 to 2298)
  AUTHORS   Yuan,Q., Yang,H., Cheng,C., Li,C., Wu,X., Huan,W., Sun,H., Zhou,Z.,
            Wang,Y., Zhao,Y., Lu,X. and Shen,A.
  TITLE     beta-1,4-Galactosyltransferase I involved in Schwann cells
            proliferation and apoptosis induced by tumor necrosis factor-alpha
            via the activation of MAP kinases signal pathways
  JOURNAL   Mol Cell Biochem 365 (1-2), 149-158 (2012)
   PUBMED   22359038
  REMARK    GeneRIF: B4galt1 may play an important role in Schwann cell
            proliferation and apoptosis induced by tumor necrosis factor-alpha
            via different signal pathways and tumor necrosis factor receptors.
REFERENCE   5  (bases 1 to 2298)
  AUTHORS   Sato,T. and Furukawa,K.
  TITLE     [Regulation of human beta-1,4-galactosyltransferase V gene
            expression in cancer cells]
  JOURNAL   Yakugaku Zasshi 132 (6), 691-697 (2012)
   PUBMED   22687727
  REMARK    GeneRIF: The expression of the beta-1,4-GalT V gene has been shown
            to be regulated by transcription factors Sp1 and Ets-1 in cancer
            cells.(review)
            Review article
REFERENCE   6  (bases 1 to 2298)
  AUTHORS   Yamada,K.A. and Rothman,S.M.
  TITLE     Diazoxide blocks glutamate desensitization and prolongs excitatory
            postsynaptic currents in rat hippocampal neurons
  JOURNAL   J Physiol 458, 409-423 (1992)
   PUBMED   1302270
REFERENCE   7  (bases 1 to 2298)
  AUTHORS   Aoki,D., Appert,H.E., Johnson,D., Wong,S.S. and Fukuda,M.N.
  TITLE     Analysis of the substrate binding sites of human
            galactosyltransferase by protein engineering
  JOURNAL   EMBO J 9 (10), 3171-3178 (1990)
   PUBMED   2120039
REFERENCE   8  (bases 1 to 2298)
  AUTHORS   Lopez,L.C., Maillet,C.M., Oleszkowicz,K. and Shur,B.D.
  TITLE     Cell surface and Golgi pools of beta-1,4-galactosyltransferase are
            differentially regulated during embryonal carcinoma cell
            differentiation
  JOURNAL   Mol Cell Biol 9 (6), 2370-2377 (1989)
   PUBMED   2503706
REFERENCE   9  (bases 1 to 2298)
  AUTHORS   Roth,J., Lentze,M.J. and Berger,E.G.
  TITLE     Immunocytochemical demonstration of ecto-galactosyltransferase in
            absorptive intestinal cells
  JOURNAL   J Cell Biol 100 (1), 118-125 (1985)
   PUBMED   3917437
REFERENCE   10 (bases 1 to 2298)
  AUTHORS   Gerber,A.C., Kozdrowski,I., Wyss,S.R. and Berger,E.G.
  TITLE     The charge heterogeneity of soluble human galactosyltransferases
            isolated from milk, amniotic fluid and malignant ascites
  JOURNAL   Eur J Biochem 93 (3), 453-460 (1979)
   PUBMED   33805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA818683.1, AA956551.1, AI709691.1, CB741712.1, CB736416.1 and
            CK364907.1.
            
            On or before Oct 11, 2007 this sequence version replaced
            XM_342820.3, XM_001058948.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676811
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               AA818683.1         7-470               c
            465-915             AA956551.1         1-451
            916-1176            AI709691.1         216-476
            1177-1533           CB741712.1         18-374              c
            1534-1941           CB736416.1         6-413               c
            1942-2298           CK364907.1         1-357               c
FEATURES             Location/Qualifiers
     source          1..2298
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..2298
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /note="beta-1,4-galactosyltransferase 1"
                     /db_xref="GeneID:24390"
                     /db_xref="RGD:620900"
     exon            1..633
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1418
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /EC_number="2.4.1.22"
                     /EC_number="2.4.1.90"
                     /EC_number="2.4.1.38"
                     /EC_number="2.4.1.275"
                     /note="b4Gal-T1; beta4Gal-T1; beta-1,4-GalTase 1;
                     UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 1;
                     Glycoprotein-4-beta-galactosyltransferase 2;
                     UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase,
                     polypeptide 1; nal synthase; lactose synthase A protein;
                     N-acetyllactosamine synthase;
                     beta-N-acetylglucosaminyl-glycolipid
                     beta-1,4-galactosyltransferase;
                     beta-N-acetylglucosaminylglycopeptide
                     beta-1,4-galactosyltransferase; neolactotriaosylceramide
                     beta-1,4-galactosyltransferase"
                     /codon_start=1
                     /product="beta-1,4-galactosyltransferase 1"
                     /protein_id="NP_445739.1"
                     /db_xref="GeneID:24390"
                     /db_xref="RGD:620900"
                     /translation="MRFREPFLGGSAAMPGATLQRACRLLVAVCALHLGVTLVYYLSG
                     RDLSRLPQLVGVSSSLQGGTNGAAASKQPSGELRPRGARPPPPLGVSPKPRPGSDSSP
                     DAASGPGLKSNLTSVPMPTSTGLLTLPACPEESPLLVGPMVIDFNIPVDLELLAKKNP
                     EIKMGGRYFPKDCISPHKVAIIIPFRNRQEHLKYWLYYLHPVLQRQQLDYGIYVINQA
                     GDTMFNRAKLLNVGFQEALKDYDYNCFVFSDVDLIPMDDHNAYRCFSQPRHISVAMDK
                     FGFSLPYVQYFGGVSALSKQQFLTINGFPNNYWGWGGEDDDIFNRLVHKGMSISRPNA
                     VVGRCRMIRHSRDKKNEPNPQRFDRIAHTKETMRLDGLNSLTYQVLDIQRYPLYTKIT
                     VDIGTPR"
     exon            634..869
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1057
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1180
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1285
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..2292
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctctcgtgc cccgctgatc tctccagagt cccgcggctg ggggtgtcga ctttccgcca
       61 caggcggccg gtgctgcgct aggtcctagc cctccccccg gcccccaccc cccggcccct
      121 ccttccatcg ctgtggtcgg gtagcgcctg gcgggcggcc tgcgggcggg ccgtcctctc
      181 agccgtagcc caccccctct taaagccgcg gcgggaagat gaggtttcgt gagccgttcc
      241 tgggcggcag cgccgcgatg ccgggcgcga ccctgcagcg ggcctgccgc ctgctcgtgg
      301 cggtctgcgc gctgcacctt ggcgtcaccc tggtctatta cctctccggt cgcgatctga
      361 gccgcctgcc ccaactggtc ggagtctcct cttcactgca aggcggcacg aacggcgccg
      421 ccgccagcaa gcagccctcg ggagagctcc ggccccgggg cgcgcggccg ccgcctcctt
      481 taggcgtctc cccgaagcct cgcccgggtt ctgactccag ccctgatgcg gcttctggcc
      541 ccggcctgaa gagcaacttg acttcggtgc caatgcccac cagcactgga ttgttgactc
      601 tgcctgcttg ccctgaggag tccccgctgc tcgttggccc catggtgatt gactttaata
      661 ttcctgtgga tctggagctt ttggcaaaga agaacccaga gataaagatg ggcggccgtt
      721 acttccccaa ggactgtatc tcccctcaca aggtggccat cattatccca ttccgtaacc
      781 ggcaggagca cctcaaatac tggctgtatt atttgcatcc agtccttcag cgccagcaac
      841 tcgactatgg catctacgtc atcaatcagg ctggagacac catgtttaat cgagctaagc
      901 tgctcaacgt tggctttcaa gaggccttga aagactatga ctacaactgc tttgtgttca
      961 gtgatgtgga cctcattcca atggatgacc ataatgccta caggtgcttt tcacagccac
     1021 ggcatatttc tgtcgcaatg gacaagttcg ggtttagcct gccttacgtt cagtattttg
     1081 gaggtgtctc cgctctcagt aaacaacagt tccttaccat caatggattt cctaataatt
     1141 actggggctg gggaggagaa gatgatgaca tttttaacag attagttcat aaaggcatgt
     1201 ctatatcacg cccaaatgct gtggtaggca ggtgtcgcat gatccggcac tcaagagaca
     1261 agaaaaatga gcccaaccct cagaggtttg accggatcgc acatacaaag gaaacgatgc
     1321 gccttgatgg tttgaactca cttacctacc aggtgttgga catacagaga tacccgttat
     1381 ataccaaaat cacagtggac atcgggacac caagatagca ttttggtaca aataagagac
     1441 ccgaggatgg ccagagacct cagatgtgtg tctctgccag tcgactgggc tggtccctct
     1501 catttgttca gtctgaatga tagttctcct tccttaccat tcagacatct ttccagatgc
     1561 ccagggtgaa tgtcacgttt acccacaacc tggctcggca ctgggtgaaa ttctacaagg
     1621 tgtttatcag tgtaaaaacg gtcagccttt ggagaggttt cttggacacg tcacccccaa
     1681 agagtcggaa ctgtgcccag ctccaacctt agtgactgtg ggtcatagtc ccagtgctga
     1741 aactgctgaa gtgtgacatg ggtaagagct ttgctttagt cggcgatgtc cacacttcat
     1801 gaccaatgga ggctgctgct ggattcggat tcacaagata ttcttgcata tttttttata
     1861 caaaaaatca aaatttcaat cagtctcgtg ttctgtccct ttcctatgtc ctctcaccgg
     1921 tatgcaacta ttacaatcac tgcgtgtgcg tcttttctta gcaaaagagt tttaaaactt
     1981 gagcctggag cttggtgtcc tgtgagtgtg gctgccgagg ccttgccctc agagcagggg
     2041 ccgggacact cacttccgtg acccgtctcc agatccctgt ctgatttctg aatgtaaaga
     2101 ggttttttgt ggttgttgtt ttgttttgtt tttgttttta gaagcagttt gtagtatttt
     2161 aaagaataaa tcaagttttg attatgctat aggttgattt ttgtgttgat ccaaattgga
     2221 atagctattg agtgttttaa gtcgtgactt tatttttctg ggcatgctat ataaacttga
     2281 atttcctatg taaaaaaa
//
