LOCUS       NP_445739                399 aa            linear   ROD 03-APR-2024
DEFINITION  beta-1,4-galactosyltransferase 1 [Rattus norvegicus].
ACCESSION   NP_445739 XP_001058948 XP_342821
VERSION     NP_445739.1
DBSOURCE    REFSEQ: accession NM_053287.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 399)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (residues 1 to 399)
  AUTHORS   Zhao,J., Gao,Y., Cheng,C., Yan,M. and Wang,J.
  TITLE     Upregulation of beta-1,4-galactosyltransferase I in rat spinal cord
            with experimental autoimmune encephalomyelitis
  JOURNAL   J Mol Neurosci 49 (3), 437-445 (2013)
   PUBMED   22706684
  REMARK    GeneRIF: beta-1,4-GalT-I may be an inflammatory mediator regulating
            adhesion & migration of inflammatory cells in EAE by modifying
            galactosylated carbohydrate chains to modulate selectin-ligand
            biosynthesis & interaction with E-selectin.
REFERENCE   3  (residues 1 to 399)
  AUTHORS   Liu,X., Cheng,C., Shao,B., Wu,X., Ji,Y., Lu,X. and Shen,A.
  TITLE     The functional interaction between CDK11p58 and
            beta-1,4-galactosyltransferase I involved in astrocyte activation
            caused by lipopolysaccharide
  JOURNAL   Inflammation 35 (4), 1365-1377 (2012)
   PUBMED   22527143
  REMARK    GeneRIF: These findings indicated that the functional interaction
            between CDK11(p58) and beta-1,4-GalT-I may play an important role
            during astrocyte activation after LPS administration.
REFERENCE   4  (residues 1 to 399)
  AUTHORS   Yuan,Q., Yang,H., Cheng,C., Li,C., Wu,X., Huan,W., Sun,H., Zhou,Z.,
            Wang,Y., Zhao,Y., Lu,X. and Shen,A.
  TITLE     beta-1,4-Galactosyltransferase I involved in Schwann cells
            proliferation and apoptosis induced by tumor necrosis factor-alpha
            via the activation of MAP kinases signal pathways
  JOURNAL   Mol Cell Biochem 365 (1-2), 149-158 (2012)
   PUBMED   22359038
  REMARK    GeneRIF: B4galt1 may play an important role in Schwann cell
            proliferation and apoptosis induced by tumor necrosis factor-alpha
            via different signal pathways and tumor necrosis factor receptors.
REFERENCE   5  (residues 1 to 399)
  AUTHORS   Sato,T. and Furukawa,K.
  TITLE     [Regulation of human beta-1,4-galactosyltransferase V gene
            expression in cancer cells]
  JOURNAL   Yakugaku Zasshi 132 (6), 691-697 (2012)
   PUBMED   22687727
  REMARK    GeneRIF: The expression of the beta-1,4-GalT V gene has been shown
            to be regulated by transcription factors Sp1 and Ets-1 in cancer
            cells.(review)
            Review article
REFERENCE   6  (residues 1 to 399)
  AUTHORS   Yamada,K.A. and Rothman,S.M.
  TITLE     Diazoxide blocks glutamate desensitization and prolongs excitatory
            postsynaptic currents in rat hippocampal neurons
  JOURNAL   J Physiol 458, 409-423 (1992)
   PUBMED   1302270
REFERENCE   7  (residues 1 to 399)
  AUTHORS   Aoki,D., Appert,H.E., Johnson,D., Wong,S.S. and Fukuda,M.N.
  TITLE     Analysis of the substrate binding sites of human
            galactosyltransferase by protein engineering
  JOURNAL   EMBO J 9 (10), 3171-3178 (1990)
   PUBMED   2120039
REFERENCE   8  (residues 1 to 399)
  AUTHORS   Lopez,L.C., Maillet,C.M., Oleszkowicz,K. and Shur,B.D.
  TITLE     Cell surface and Golgi pools of beta-1,4-galactosyltransferase are
            differentially regulated during embryonal carcinoma cell
            differentiation
  JOURNAL   Mol Cell Biol 9 (6), 2370-2377 (1989)
   PUBMED   2503706
REFERENCE   9  (residues 1 to 399)
  AUTHORS   Roth,J., Lentze,M.J. and Berger,E.G.
  TITLE     Immunocytochemical demonstration of ecto-galactosyltransferase in
            absorptive intestinal cells
  JOURNAL   J Cell Biol 100 (1), 118-125 (1985)
   PUBMED   3917437
REFERENCE   10 (residues 1 to 399)
  AUTHORS   Gerber,A.C., Kozdrowski,I., Wyss,S.R. and Berger,E.G.
  TITLE     The charge heterogeneity of soluble human galactosyltransferases
            isolated from milk, amniotic fluid and malignant ascites
  JOURNAL   Eur J Biochem 93 (3), 453-460 (1979)
   PUBMED   33805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA818683.1, AA956551.1, AI709691.1, CB741712.1, CB736416.1 and
            CK364907.1.
            
            On or before Oct 11, 2007 this sequence version replaced
            XP_342821.1, XP_001058948.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN16676811
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..399
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     Protein         1..399
                     /product="beta-1,4-galactosyltransferase 1"
                     /EC_number="2.4.1.22"
                     /EC_number="2.4.1.90"
                     /EC_number="2.4.1.38"
                     /EC_number="2.4.1.275"
                     /note="b4Gal-T1; beta4Gal-T1; beta-1,4-GalTase 1;
                     UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1;
                     UDP-galactose:beta-N-acetylglucosamine
                     beta-1,4-galactosyltransferase 1;
                     Glycoprotein-4-beta-galactosyltransferase 2;
                     UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase,
                     polypeptide 1; nal synthase; lactose synthase A protein;
                     N-acetyllactosamine synthase;
                     beta-N-acetylglucosaminyl-glycolipid
                     beta-1,4-galactosyltransferase;
                     beta-N-acetylglucosaminylglycopeptide
                     beta-1,4-galactosyltransferase; neolactotriaosylceramide
                     beta-1,4-galactosyltransferase"
                     /calculated_mol_wt=44353
     Region          176..394
                     /region_name="b4GalT"
                     /note="Beta-4-Galactosyltransferase is involved in the
                     formation of the poly-N-acetyllactosamine core structures
                     present in glycoproteins and glycosphingolipids; cd00899"
                     /db_xref="CDD:132999"
     Site            order(184,186,188,223,249..251)
                     /site_type="active"
                     /note="ligand binding site [active]"
                     /db_xref="CDD:132999"
     Site            order(249,251,344)
                     /site_type="active"
                     /note="metal binding site [active]"
                     /db_xref="CDD:132999"
     CDS             1..399
                     /gene="B4galt1"
                     /gene_synonym="Ggtb2"
                     /coded_by="NM_053287.1:219..1418"
                     /db_xref="GeneID:24390"
                     /db_xref="RGD:620900"
ORIGIN      
        1 mrfrepflgg saampgatlq racrllvavc alhlgvtlvy ylsgrdlsrl pqlvgvsssl
       61 qggtngaaas kqpsgelrpr garpppplgv spkprpgsds spdaasgpgl ksnltsvpmp
      121 tstglltlpa cpeespllvg pmvidfnipv dlellakknp eikmggryfp kdcisphkva
      181 iiipfrnrqe hlkywlyylh pvlqrqqldy giyvinqagd tmfnraklln vgfqealkdy
      241 dyncfvfsdv dlipmddhna yrcfsqprhi svamdkfgfs lpyvqyfggv salskqqflt
      301 ingfpnnywg wggedddifn rlvhkgmsis rpnavvgrcr mirhsrdkkn epnpqrfdri
      361 ahtketmrld glnsltyqvl diqryplytk itvdigtpr
//
