LOCUS       NM_022609               1996 bp    mRNA    linear   ROD 03-DEC-2024
DEFINITION  Rattus norvegicus beta-1,3-glucuronyltransferase 2 (B3gat2), mRNA.
ACCESSION   NM_022609
VERSION     NM_022609.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Ruhle,F., Witten,A., Barysenka,A., Huge,A., Arning,A., Heller,C.,
            Krumpel,A., Mesters,R., Franke,A., Lieb,W., Riemenschneider,M.,
            Hiersche,M., Limperger,V., Nowak-Gottl,U. and Stoll,M.
  TITLE     Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to
            pediatric venous thromboembolism
  JOURNAL   Blood 129 (6), 783-790 (2017)
   PUBMED   28011674
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Yu,M., O'Leary,R.M., Kaz,A.M., Morris,S.M., Carter,K.T., Chak,A.,
            Chandar,A., Willis,J.E., Moinova,H.R., Markowitz,S.D.,
            Brenner,D.E., Anandabapasathy,S., Westerhoff,M., Wong,C.J.,
            Shaheen,N.J., Chen,Y., Barnholtz-Sloan,J.S. and Grady,W.M.
  TITLE     Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for
            Barrett's Esophagus
  JOURNAL   Cancer Epidemiol Biomarkers Prev 24 (12), 1890-1897 (2015)
   PUBMED   26545406
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Kahler,A.K., Djurovic,S., Rimol,L.M., Brown,A.A., Athanasiu,L.,
            Jonsson,E.G., Hansen,T., Gustafsson,O., Hall,H., Giegling,I.,
            Muglia,P., Cichon,S., Rietschel,M., Pietilainen,O.P., Peltonen,L.,
            Bramon,E., Collier,D., St Clair,D., Sigurdsson,E., Petursson,H.,
            Rujescu,D., Melle,I., Werge,T., Steen,V.M., Dale,A.M.,
            Matthews,R.T., Agartz,I. and Andreassen,O.A.
  TITLE     Candidate gene analysis of the human natural killer-1 carbohydrate
            pathway and perineuronal nets in schizophrenia: B3GAT2 is
            associated with disease risk and cortical surface area
  JOURNAL   Biol Psychiatry 69 (1), 90-96 (2011)
   PUBMED   20950796
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Shimoda,Y., Tajima,Y., Nagase,T., Harii,K., Osumi,N. and Sanai,Y.
  TITLE     Cloning and expression of a novel galactoside beta1,
            3-glucuronyltransferase involved in the biosynthesis of HNK-1
            epitope
  JOURNAL   J Biol Chem 274 (24), 17115-17122 (1999)
   PUBMED   10358066
  REMARK    Erratum:[J Biol Chem 1999 Jul 23;274(30):21490]
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Seiki,T., Oka,S., Terayama,K., Imiya,K. and Kawasaki,T.
  TITLE     Molecular cloning and expression of a second glucuronyltransferase
            involved in the biosynthesis of the HNK-1 carbohydrate epitope
  JOURNAL   Biochem Biophys Res Commun 255 (1), 182-187 (1999)
   PUBMED   10082676
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB010441.1.
            
            On Feb 21, 2013 this sequence version replaced NM_022609.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB010441.1, AF106624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1996              AB010441.1         1-1996
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..1996
                     /gene="B3gat2"
                     /note="beta-1,3-glucuronyltransferase 2"
                     /db_xref="GeneID:64544"
                     /db_xref="RGD:620903"
     exon            1..1233
                     /gene="B3gat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..1614
                     /gene="B3gat2"
                     /EC_number="2.4.1.135"
                     /note="galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 2; glcAT-D; glcAT-S;
                     glucuronosyltransferase S; UDP-glucuronosyltransferase S;
                     galactoside beta-1,3-glucuronyltransferase"
                     /codon_start=1
                     /product="galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 2 precursor"
                     /protein_id="NP_072131.1"
                     /db_xref="GeneID:64544"
                     /db_xref="RGD:620903"
                     /translation="MKSALCNRFFILLPWILIVIIMLDVDPRRPAPQLTSRPYFSPHT
                     VGCGGSRVPLRRSSPGRDAAEKRNESRPQLQPEPRLPTIYAITPTYSRPVQKAELTRL
                     ANTFRQVAQLHWILVEDRATRSELVSSFLARAGLPNTHLHVPTPRRYKRPWLPRATEQ
                     RNAGLAWLRQRHQHQSAQPGVLFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRY
                     ERPLVKNGKVVGWYTGWREDRPFAIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESD
                     FLKQITTVDELEPKANNCTKVLVWHTRTEKVNLANEPKYHMDTVNIEV"
     exon            1234..1378
                     /gene="B3gat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1527
                     /gene="B3gat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1996
                     /gene="B3gat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcttgctgt ctggagccag gagaggttcc gaggaggaga gagcggcggg agcgcaggtt
       61 tctgccgcgg cgctcgaatg agagcttagg ggcgcagcat cctcggtgtc cacccgggat
      121 cgcagctgca ccggccgaca tgtgacagag aaaagccctc agcatcatca gcggccgcct
      181 tcaaaaggga cccagagctc tcgccgaggc cggcagccgg atcctcttag cccgcagaaa
      241 cgcgggactg gagcggcgag gcacaacggc tggtgggttc caggctcgca ctcaggaaaa
      301 gagcgcagcg gcgaccgccg cctggctcgc actcggcaca actccgggac cagcggagcg
      361 cggctggacc gcgtccagat tcccgccgac ttcatccaga gtgacccacg cccccagcct
      421 gtccgcctgc accccctgga gttctagctt gccctgcatc tcgccgaccc cgcaacgccc
      481 aggtccccgc aacgccccgg gccgtatggg gagcgcggtg ccgctgctcc ctgattgctg
      541 acaacgccgc cgtccgaact gcacaccgag gtcccccgtc ccccatccgg agcctagtcc
      601 ttgccgaggg tggtgtccga gacgctggga gcgcgcacca tgaagtccgc gctgtgcaac
      661 cgcttcttca tcctcctgcc ctggatcctg atcgtcatca tcatgttgga cgtggacccc
      721 cgcaggcccg cgccccaact cacttcccga ccctacttct ctccgcatac agtgggctgc
      781 gggggttccc gagtcccgct ccgacggagc agccccgggc gtgacgctgc ggagaagcgg
      841 aacgagtctc ggcctcagct gcagccggag ccgcgcttgc ccaccatcta tgccatcaca
      901 cccacctaca gtcgcccggt gcagaaagcc gagctcaccc gcctggccaa caccttccgc
      961 caggtggcgc agttgcactg gatcctggtg gaggaccggg cgacgcgcag cgagctggtg
     1021 agcagcttcc tagctcgggc cgggctgccc aacacgcacc tgcatgtgcc cacgccgcgg
     1081 cgctacaagc gaccgtggct gccgcgcgcc accgaacagc gcaacgcggg cctcgcctgg
     1141 ctgcgccaga ggcaccagca tcagagcgcg caacccggcg tgctcttctt cgccgacgac
     1201 gacaacacgt acagtctgga gctcttccag gagatgagaa ccacccgcaa ggtttctgtc
     1261 tggcccgtgg gcctagttgg tgggcgacgc tatgaacgtc cattggtgaa aaatggcaaa
     1321 gttgttggct ggtacaccgg atggagagaa gacaggcctt ttgccatcga catggctgga
     1381 tttgctgtga gtctgcaagt catcttgtcc aatccgaaag ctgtatttaa gcgccgcgga
     1441 tcccagccag ggatgcagga atctgacttt ctaaagcaga tcacaacagt tgacgaactg
     1501 gaaccaaaag ctaacaactg caccaaggtt ctcgtgtggc acactcggac agagaaggtc
     1561 aatctagcca atgagccaaa gtaccacatg gacacagtga acatcgaggt gtagccacca
     1621 ggagcagccg ctgaggagag aaggagtctg gagcgtaggc tgcgctcact caggtacggt
     1681 ccctttgccg tcagcctttc ccgtcaaccg aaggacgtct gtatcgacag ctacctggac
     1741 actacaaaat gtgctatctt cctttgttct gcatgtgttc tcctaactgg gaagattctg
     1801 tacagtgaag ctacacgaca ctgaaataga acacgggagt atctcacgca ctactccctc
     1861 cctctcgcca agacatgtca tgactggtag aatgaaatag gttttagaag ctgctgatga
     1921 gtactttgtc aattaaagtt ttggcttcac aacatgaaat atttggaaag ctggtggcag
     1981 tgtacactgt aggaaa
//
