LOCUS       NM_054003               2090 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus beta-1,3-glucuronyltransferase 1 (B3gat1), mRNA.
ACCESSION   NM_054003
VERSION     NM_054003.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Tomazelli,K.B., Modolo,F., Trentin,A.G., Garcez,R.C. and Biz,M.T.
  TITLE     Temporo-spatial analysis of Osterix, HNK1 and Sox10 during
            odontogenesis and maxillaries osteogenesis
  JOURNAL   Tissue Cell 47 (5), 465-470 (2015)
   PUBMED   26253417
  REMARK    GeneRIF: positive expression for Osterix and HNK1 in
            undifferentiated ectomesenchymal cells in early and late stages
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Venkatesan,N., Tsuchiya,K., Kolb,M., Farkas,L., Bourhim,M.,
            Ouzzine,M. and Ludwig,M.S.
  TITLE     Glycosyltransferases and glycosaminoglycans in bleomycin and
            transforming growth factor-beta1-induced pulmonary fibrosis
  JOURNAL   Am J Respir Cell Mol Biol 50 (3), 583-594 (2014)
   PUBMED   24127863
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Gogate,S.S., Nasser,R., Shapiro,I.M. and Risbud,M.V.
  TITLE     Hypoxic regulation of beta-1,3-glucuronyltransferase 1 expression
            in nucleus pulposus cells of the rat intervertebral disc: role of
            hypoxia-inducible factor proteins
  JOURNAL   Arthritis Rheum 63 (7), 1950-1960 (2011)
   PUBMED   21400481
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Venkatesan,N., Ouzzine,M., Kolb,M., Netter,P. and Ludwig,M.S.
  TITLE     Increased deposition of chondroitin/dermatan sulfate
            glycosaminoglycan and upregulation of
            beta1,3-glucuronosyltransferase I in pulmonary fibrosis
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 300 (2), L191-L203 (2011)
   PUBMED   21056957
  REMARK    GeneRIF: increased expression of CS-GAGs and GlcAT-I in fibrotic
            lungs and fibrotic lung fibroblasts
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Hiyama,A., Gogate,S.S., Gajghate,S., Mochida,J., Shapiro,I.M. and
            Risbud,M.V.
  TITLE     BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl
            transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1,
            TonEBP, and Sp1: role of MAPKs
  JOURNAL   J Bone Miner Res 25 (5), 1179-1190 (2010)
   PUBMED   19961337
  REMARK    GeneRIF: Results of these studies demonstrate that BMP-2 and
            TGF-beta regulate GlcAT-1 expression in nucleus pulposus cells
            through a signaling network comprising MAPK, AP1, Sp1, and TonEBP
REFERENCE   6  (bases 1 to 2090)
  AUTHORS   Saghir,S.A., Charles,G.D., Bartels,M.J., Kan,L.H., Dryzga,M.D.,
            Brzak,K.A. and Clark,A.J.
  TITLE     Mechanism of trifluralin-induced thyroid tumors in rats
  JOURNAL   Toxicol Lett 180 (1), 38-45 (2008)
   PUBMED   18582544
  REMARK    GeneRIF: Trifluralin-induced total hepatic UGT enzymes (2.4-fold)
            and mRNA expression of selected hepatic UGT isozymes (UGT1A1,
            1.4-fold; UGT1A6, 6.4-fold; UGT2B1, 3.7-fold).
REFERENCE   7  (bases 1 to 2090)
  AUTHORS   Isawa,M., Takumi,Y., Hashimoto,S., Nakayama,J. and Usami,S.
  TITLE     Polysialic acid and HNK-1 are expressed in the adult rat vestibular
            endorgans
  JOURNAL   Neuroreport 15 (10), 1575-1578 (2004)
   PUBMED   15232286
  REMARK    GeneRIF: These results combined suggest that both PSA and HNK-1
            carbohydrate epitopes are synthesized and may have an important
            role in the adult peripheral vestibular endorgans.
REFERENCE   8  (bases 1 to 2090)
  AUTHORS   Malissard,M., Dinter,A., Berger,E.G. and Hennet,T.
  TITLE     Functional assignment of motifs conserved in beta
            1,3-glycosyltransferases
  JOURNAL   Eur J Biochem 269 (1), 233-239 (2002)
   PUBMED   11784317
REFERENCE   9  (bases 1 to 2090)
  AUTHORS   Terayama,K., Seiki,T., Nakamura,A., Matsumori,K., Ohta,S., Oka,S.,
            Sugita,M. and Kawasaki,T.
  TITLE     Purification and characterization of a glucuronyltransferase
            involved in the biosynthesis of the HNK-1 epitope on glycoproteins
            from rat brain
  JOURNAL   J Biol Chem 273 (46), 30295-30300 (1998)
   PUBMED   9804790
REFERENCE   10 (bases 1 to 2090)
  AUTHORS   Terayama,K., Oka,S., Seiki,T., Miki,Y., Nakamura,A., Kozutsumi,Y.,
            Takio,K. and Kawasaki,T.
  TITLE     Cloning and functional expression of a novel glucuronyltransferase
            involved in the biosynthesis of the carbohydrate epitope HNK-1
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6093-6098 (1997)
   PUBMED   9177175
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D88035.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2090
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /note="beta-1,3-glucuronyltransferase 1"
                     /db_xref="GeneID:117108"
                     /db_xref="RGD:70880"
     exon            1..103
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..198
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1238
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /EC_number="2.4.1.135"
                     /note="glcAT-P; glcUAT-P; UDP-GlcUA:glycoprotein
                     beta-1,3-glucuronyltransferase; glucuronosyltransferase P"
                     /codon_start=1
                     /product="galactosylgalactosylxylosylprotein
                     3-beta-glucuronosyltransferase 1"
                     /protein_id="NP_446455.1"
                     /db_xref="GeneID:117108"
                     /db_xref="RGD:70880"
                     /translation="MGNEELWAQPALEMPKRRDILAIVLIVLPWTLLITVWHQSSLAP
                     LLAVHKDEGSDPRHEAPPGADPREYCMSDRDIVEVVRTEYVYTRPPPWSDTLPTIHVV
                     TPTYSRPVQKAELTRMANTLLHVPNLHWLVVEDAPRRTPLTARLLRDTGLNYTHLHVE
                     TPRNYKLRGDARDPRIPRGTMQRNLALRWLRETFPRNSTQPGVVYFADDDNTYSLELF
                     EEMRSTRRVSVWPVAFVGGLRYEAPRVNGAGKVVGWKTVFDPHRPFAIDMAGFAVNLR
                     LILQRSQAYFKLRGVKGGYQESSLLRELVTLNDLEPKAANCTKILVWHTRTEKPVLVN
                     EGKKGFTDPSVEI"
     exon            199..345
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..854
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1151
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1252
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..2090
                     /gene="B3gat1"
                     /gene_synonym="Hnk-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgcgcat cgcagggcag cagccctggg tctctggggc cagggcatag gactgccacc
       61 cgctatggac cgcgccaggg acgatatgga ctcgctgccg caggtatcaa cctccgaagg
      121 ttcctgaccc tgcgctggac tacttcccct tcgcagactc ccatcaggcc ggactctgca
      181 aacctgctgc cacaatgggt aatgaggagc tgtgggcgca gccagccttg gagatgccga
      241 agagaaggga catcctcgcg attgtcctca ttgtgcttcc ctggacactg ctcatcaccg
      301 tctggcacca gagcagcctc gcacctctgc ttgctgtgca caaggatgag ggaagtgacc
      361 cccgccatga ggcaccaccc ggtgcggacc ctagggagta ctgcatgtcc gaccgtgaca
      421 tcgtggaggt ggtgcgcaca gagtacgtgt acacgaggcc gccaccgtgg tccgacacgc
      481 tgcccaccat ccatgtggtg acgcccacct acagtagacc ggtgcagaag gcagagctga
      541 cgcgaatggc caacacgcta ttgcatgtgc ccaaccttca ctggctggtg gtggaggatg
      601 ctccacgtag gacgcccctc acagcgcgcc tgctgcgcga cactggcctc aactatacac
      661 acctgcacgt agagacacca cgcaactaca agctgcgagg tgacgcccga gaccctcgca
      721 tcccacgtgg caccatgcag cgcaatctgg ccctgcgctg gttgcgggag accttcccac
      781 ggaactccac tcagccgggt gtagtgtact tcgcagatga cgacaacacg tacagtctgg
      841 agctctttga agagatgcgc agcacaagaa gggtgtccgt gtggcctgtg gcctttgttg
      901 gcggccttcg gtatgaggcc ccccgggtga atggggcagg gaaagtggtt ggctggaaga
      961 cagtcttcga cccccaccgg ccatttgcaa tagacatggc tggatttgct gtcaacctcc
     1021 ggctcatctt gcaacgaagc caggcctact ttaagctacg tggggtaaaa ggaggctacc
     1081 aggaaagcag tctccttcga gaacttgtca ccctcaatga tctagagccc aaggcagcaa
     1141 actgtaccaa gatcctggtc tggcatacgc gaacagagaa gccagtgctg gtgaatgagg
     1201 ggaagaaggg cttcactgac ccctcggtgg agatctgaaa ctacacatgc aggaatcacc
     1261 ttctcagacc ctgatcttgg cttccatcct ctcccatgac tgacagtgac tctgaggcag
     1321 actcctgagg aatacctatt atgtatactg aaggcttcca agagagccca gcttgacgcc
     1381 aggacaaaag acagagaatt taagcacaga atcccagacc tgtggttctc tacatcaaca
     1441 aggccagggg cttgaaagac ccaagttctg gggattcccg ttgccagcaa agcctgtgct
     1501 cagcacacct ccttggaagc ttcctgcatt gatggggctg tgtaagcaag gggaccctgc
     1561 cttcgagtga tgctggggtg agggaggtca gaaaacgcca ctattgagtg cagcatggct
     1621 gtccatggct ccctgctctt gggcccagca tgactacaca gcatgtgccc agccaggaca
     1681 tcctgaagac cagagagcag cctggggcat gaagatgccc caacacttgt ctttcacacc
     1741 tgctcttcct cagagctgct cccaaatcag aaatacctct ggctctcctc tggttcgtgt
     1801 ttacagggca taaggctgtc ttggatccca cctggcaccc agccctgcat tgggggagcc
     1861 tgggcctacc tacagctccc cttgtacctc aggctgtaga agaaccaagc ccttccccgt
     1921 gtccttcaag cctcctgtgc cagaatcagt caggtggtgg gcctagagcc agcacaggtc
     1981 atggattgac ctggattgag aaccaagtca ccccacagtc cacactgcct ctccaatacc
     2041 cctgggctgc aatgcccctt gctgggtttg gactggggag gcaattgccc
//
