LOCUS       NM_012512               1845 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus beta-2 microglobulin (B2m), mRNA.
ACCESSION   NM_012512
VERSION     NM_012512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1845)
  AUTHORS   Wu,Z., Yan,M., Zhang,M., Wu,N., Ma,G., Wang,B., Fan,Y., Du,X.,
            Ding,C. and Liu,Y.
  TITLE     beta2-microglobulin as a biomarker of pulmonary fibrosis
            development in COPD patients
  JOURNAL   Aging (Albany NY) 13 (1), 1251-1263 (2020)
   PUBMED   33472168
  REMARK    GeneRIF: beta2-microglobulin as a biomarker of pulmonary fibrosis
            development in COPD patients.
REFERENCE   2  (bases 1 to 1845)
  AUTHORS   Kohsari,M., Khadem Ansari,M.H. and Rasmi,Y.
  TITLE     Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in
            Stage I of Multiple Myeloma
  JOURNAL   Asian Pac J Cancer Prev 21 (8), 2237-2242 (2020)
   PUBMED   32856850
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1845)
  AUTHORS   Shimbo,A., Kosaki,Y., Ito,I. and Watanabe,S.
  TITLE     Mice lacking hippocampal left-right asymmetry show non-spatial
            learning deficits
  JOURNAL   Behav Brain Res 336, 156-165 (2018)
   PUBMED   28864206
REFERENCE   4  (bases 1 to 1845)
  AUTHORS   Marcinko,T.M., Dong,J., LeBlanc,R., Daborowski,K.V. and Vachet,R.W.
  TITLE     Small molecule-mediated inhibition of beta-2-microglobulin-based
            amyloid fibril formation
  JOURNAL   J Biol Chem 292 (25), 10630-10638 (2017)
   PUBMED   28468825
REFERENCE   5  (bases 1 to 1845)
  AUTHORS   Gao,N., Wang,Y., Zheng,C.M., Gao,Y.L., Li,H., Li,Y., Fu,T.T.,
            Xu,L.L., Wang,W., Ying,S. and Huang,K.
  TITLE     beta2-Microglobulin participates in development of lung emphysema
            by inducing lung epithelial cell senescence
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 312 (5), L669-L677 (2017)
   PUBMED   28213472
REFERENCE   6  (bases 1 to 1845)
  AUTHORS   Griffin,D.E., Ward,B.J., Juaregui,E., Johnson,R.T. and Vaisberg,A.
  TITLE     Immune activation during measles: beta 2-microglobulin in plasma
            and cerebrospinal fluid in complicated and uncomplicated disease
  JOURNAL   J Infect Dis 166 (5), 1170-1173 (1992)
   PUBMED   1402029
REFERENCE   7  (bases 1 to 1845)
  AUTHORS   Attaya,M., Jameson,S., Martinez,C.K., Hermel,E., Aldrich,C.,
            Forman,J., Lindahl,K.F., Bevan,M.J. and Monaco,J.J.
  TITLE     Ham-2 corrects the class I antigen-processing defect in RMA-S cells
  JOURNAL   Nature 355 (6361), 647-649 (1992)
   PUBMED   1538753
REFERENCE   8  (bases 1 to 1845)
  AUTHORS   Koller,B.H., Marrack,P., Kappler,J.W. and Smithies,O.
  TITLE     Normal development of mice deficient in beta 2M, MHC class I
            proteins, and CD8+ T cells
  JOURNAL   Science 248 (4960), 1227-1230 (1990)
   PUBMED   2112266
REFERENCE   9  (bases 1 to 1845)
  AUTHORS   Cole,T., Dickson,P.W., Esnard,F., Averill,S., Risbridger,G.P.,
            Gauthier,F. and Schreiber,G.
  TITLE     The cDNA structure and expression analysis of the genes for the
            cysteine proteinase inhibitor cystatin C and for beta
            2-microglobulin in rat brain
  JOURNAL   Eur J Biochem 186 (1-2), 35-42 (1989)
   PUBMED   2689174
REFERENCE   10 (bases 1 to 1845)
  AUTHORS   Simister,N.E. and Mostov,K.E.
  TITLE     An Fc receptor structurally related to MHC class I antigens
  JOURNAL   Nature 337 (6203), 184-187 (1989)
   PUBMED   2911353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM032790.1, FM042487.1, FM080788.1 and CB714511.1.
            
            On May 13, 2011 this sequence version replaced NM_012512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM032790.1, FQ227468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               FM032790.1         1-528
            529-984             FM042487.1         202-657
            985-1557            FM080788.1         78-650
            1558-1845           CB714511.1         20-307              c
FEATURES             Location/Qualifiers
     source          1..1845
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1845
                     /gene="B2m"
                     /note="beta-2 microglobulin"
                     /db_xref="GeneID:24223"
                     /db_xref="RGD:2189"
     exon            1..87
                     /gene="B2m"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..380
                     /gene="B2m"
                     /note="beta-2-microglobulin C-terminal fragment (55 AA)"
                     /codon_start=1
                     /product="beta-2-microglobulin precursor"
                     /protein_id="NP_036644.1"
                     /db_xref="GeneID:24223"
                     /db_xref="RGD:2189"
                     /translation="MARSVTVIFLVLVSLAVVLAIQKTPQIQVYSRHPPENGKPNFLN
                     CYVSQFHPPQIEIELLKNGKKIPNIEMSDLSFSKDWSFYILAHTEFTPTETDVYACRV
                     KHVTLKEPKTVTWDRDM"
     exon            88..366
                     /gene="B2m"
                     /inference="alignment:Splign:2.1.0"
     exon            367..395
                     /gene="B2m"
                     /inference="alignment:Splign:2.1.0"
     exon            396..1829
                     /gene="B2m"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgaccg gaccggcacg atggctcgct cggtgaccgt gatctttctg gtgcttgtct
       61 ctctggccgt cgtgcttgcc attcagaaaa ctccccaaat tcaagtgtac tctcgccatc
      121 caccggagaa tgggaagccc aacttcctca actgctacgt gtctcagttc cacccacctc
      181 aaatagaaat tgagctactg aagaatggaa agaagatacc aaatatcgag atgtcagatc
      241 tgtccttcag caaggactgg tctttctaca tcctggctca cactgaattc acacccaccg
      301 agaccgatgt atatgcttgc agagttaaac acgtcactct gaaggagccc aaaaccgtca
      361 cctgggaccg agacatgtaa tcaagctcta tggagctctg aatcatctgg accagtttaa
      421 ctccagatcc ggtttctaat atgctataca atttatccac aaagtaaaga atagcaatga
      481 gcacaccatc ttcttcatat cttaccttaa atattttatg catgttttaa aaaaaattgg
      541 agactaatat cctagatttc cggaataata aagcttcaat gagtgttttg atcagaataa
      601 taaatatggt taagaacaag agttgatcat atgtcaaacc ctctgtactt ttattagttg
      661 gatgcagtta ctcatctttg gtttatcaca gcataagtga tttgtttaaa aaacttaaga
      721 aacttgagat attttctttt tggtaaggtg aagaggccta gctgaagtct gtcactgtgc
      781 ttagcagcct agcagttcaa tcccccaccc tcatggctac ttctgctttg ttatttttac
      841 taaaaataaa aaactaaaaa aaaccaaaaa accaaaaacc taaaaacatt tgtgccagag
      901 tgaagtgaag tggtttctag gtagccttaa atgtctgcaa gcctgtgtgc ggttttcatc
      961 acccaaagag acagtgggtg tcttagaagg ttcttgtaga agcaggttcc tcaaacaagg
     1021 gtccagagga aagggactaa gaaaggactc caaggcagaa cagtaggagg tgctcgatga
     1081 agggcagggg aggaaactga ggggagtagg gatttcagac gtgctggccc cacagggagc
     1141 tctagagcaa agatcacatc ttaacgtttg tcttggtgat gtgcacagcc tgttgctggc
     1201 tctacaggag cttatgttag gatgaaagcc caggtatttt ggggtatgat tatggttatc
     1261 tgtggcaaat tgtgtaaagg ctggggtctg gttcttactg cagggcgtgg gaggagcatc
     1321 agggactact gtgtttcctg gtaaattctg ttgggcctac agcacacgca gtctgaaaac
     1381 cccactcctc ctcattcagc gtttcagcta atgttaaaga gggaatgcta atttgaaact
     1441 aagtttgaat cctaatctaa caaaagttac tataacattt ctgacttgag cttctaattt
     1501 tgatagttta attgtgtccc caaagctcct tttgtggctg gaggtttagt ccccggggtg
     1561 gtgatgagaa gttgtgggac ccataagagg gagtctagtg ggaagtcctg tcaagggaca
     1621 aggagccttc tgagttctga gagggttggt ataaaggcag caaacctggc gtcttctgcc
     1681 cttctgttgc tccagcatgt aaagtactca ctcctgatgc agtcctccat cgctgttggg
     1741 aaagaggaat ctatggcata gagcctgtgc ttatcactaa cattttgaaa tttccaaacc
     1801 ctttagttaa ataaatctct tcttcctaaa aaaaaaaaaa aaaaa
//
