LOCUS       NM_001301702            4186 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus antizyme inhibitor 1 (Azin1), transcript variant
            2, mRNA.
ACCESSION   NM_001301702 XM_006241567
VERSION     NM_001301702.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4186)
  AUTHORS   Okugawa,Y., Toiyama,Y., Shigeyasu,K., Yamamoto,A., Shigemori,T.,
            Yin,C., Ichikawa,T., Yasuda,H., Fujikawa,H., Yoshiyama,S., Hiro,J.,
            Ohi,M., Araki,T., Kusunoki,M. and Goel,A.
  TITLE     Enhanced AZIN1 RNA editing and overexpression of its regulatory
            enzyme ADAR1 are important prognostic biomarkers in gastric cancer
  JOURNAL   J Transl Med 16 (1), 366 (2018)
   PUBMED   30563560
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4186)
  AUTHORS   Shigeyasu,K., Okugawa,Y., Toden,S., Miyoshi,J., Toiyama,Y.,
            Nagasaka,T., Takahashi,N., Kusunoki,M., Takayama,T., Yamada,Y.,
            Fujiwara,T., Chen,L. and Goel,A.
  TITLE     AZIN1 RNA editing confers cancer stemness and enhances oncogenic
            potential in colorectal cancer
  JOURNAL   JCI Insight 3 (12), 99976 (2018)
   PUBMED   29925690
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4186)
  AUTHORS   Fernandes,J.R.D., Jain,S. and Banerjee,A.
  TITLE     Expression of ODC1, SPD, SPM and AZIN1 in the hypothalamus, ovary
            and uterus during rat estrous cycle
  JOURNAL   Gen Comp Endocrinol 246, 9-22 (2017)
   PUBMED   28315656
REFERENCE   4  (bases 1 to 4186)
  AUTHORS   Zhu,D., Zhang,L., Cheng,L., Ren,L., Tang,J. and Sun,D.
  TITLE     Pancreatic Kininogenase Ameliorates Renal Fibrosis in
            Streptozotocin Induced-Diabetic Nephropathy Rat
  JOURNAL   Kidney Blood Press Res 41 (1), 9-17 (2016)
   PUBMED   26751697
REFERENCE   5  (bases 1 to 4186)
  AUTHORS   Greenwood,M.P., Greenwood,M., Paton,J.F. and Murphy,D.
  TITLE     Control of Polyamine Biosynthesis by Antizyme Inhibitor 1 Is
            Important for Transcriptional Regulation of Arginine Vasopressin in
            the Male Rat Hypothalamus
  JOURNAL   Endocrinology 156 (8), 2905-2917 (2015)
   PUBMED   25961839
  REMARK    GeneRIF: Identification of AZIN1, and hence by inference,
            polyamines as novel regulators of the expression of the Arginine
            vasopressin gene.
REFERENCE   6  (bases 1 to 4186)
  AUTHORS   Mangold,U., Hayakawa,H., Coughlin,M., Munger,K. and Zetter,B.R.
  TITLE     Antizyme, a mediator of ubiquitin-independent proteasomal
            degradation and its inhibitor localize to centrosomes and modulate
            centriole amplification
  JOURNAL   Oncogene 27 (5), 604-613 (2008)
   PUBMED   17667942
REFERENCE   7  (bases 1 to 4186)
  AUTHORS   Lopez-Contreras,A.J., Lopez-Garcia,C., Jimenez-Cervantes,C.,
            Cremades,A. and Penafiel,R.
  TITLE     Mouse ornithine decarboxylase-like gene encodes an antizyme
            inhibitor devoid of ornithine and arginine decarboxylating activity
  JOURNAL   J Biol Chem 281 (41), 30896-30906 (2006)
   PUBMED   16916800
REFERENCE   8  (bases 1 to 4186)
  AUTHORS   Kim,S.W., Mangold,U., Waghorne,C., Mobascher,A., Shantz,L.,
            Banyard,J. and Zetter,B.R.
  TITLE     Regulation of cell proliferation by the antizyme inhibitor:
            evidence for an antizyme-independent mechanism
  JOURNAL   J Cell Sci 119 (Pt 12), 2583-2591 (2006)
   PUBMED   16735445
  REMARK    GeneRIF: Wild-type antizyme inhibitor and the AZI(DeltaY) mutant
            are capable of direct interaction with cyclin D1 suggesting a
            potential mechanism for the antizyme-independent effects, and a
            novel function for antizyme inhibitor in cellular growth control.
REFERENCE   9  (bases 1 to 4186)
  AUTHORS   Murakami,Y., Ichiba,T., Matsufuji,S. and Hayashi,S.
  TITLE     Cloning of antizyme inhibitor, a highly homologous protein to
            ornithine decarboxylase
  JOURNAL   J Biol Chem 271 (7), 3340-3342 (1996)
   PUBMED   8631929
REFERENCE   10 (bases 1 to 4186)
  AUTHORS   Kitani,T. and Fujisawa,H.
  TITLE     Purification and characterization of antizyme inhibitor of
            ornithine decarboxylase from rat liver
  JOURNAL   Biochim Biophys Acta 991 (1), 44-49 (1989)
   PUBMED   2713421
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000007.1.
            
            On Sep 5, 2014 this sequence version replaced XM_006241567.2.
            
            Summary: The protein encoded by this gene belongs to the antizyme
            inhibitor family, which plays a role in cell growth and
            proliferation by maintaining polyamine homeostasis within the cell.
            Antizyme inhibitors are homologs of ornithine decarboxylase (ODC,
            the key enzyme in polyamine biosynthesis) that have lost the
            ability to decarboxylase ornithine; however, retain the ability to
            bind to antizymes. Antizymes negatively regulate intracellular
            polyamine levels by binding to ODC and targeting it for
            degradation, as well as by inhibiting polyamine uptake. Antizyme
            inhibitors function as positive regulators of polyamine levels by
            sequestering antizymes and neutralizing their effect. This gene
            encodes antizyme inhibitor 1, the first member of this gene family
            that is ubiquitously expressed, and is localized in the nucleus and
            cytoplasm. Overexpression of antizyme inhibitor 1 gene has been
            associated with increased proliferation, cellular transformation
            and tumorigenesis. Gene knockout studies showed that homozygous
            mutant mice lacking functional antizyme inhibitor 1 gene died at
            birth with abnormal liver morphology. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (2) lacks an internal 5'
            non-coding exon, thus has a shorter 5' UTR compared to variant 1.
            Variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.40949.1, D50734.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-391               JAXUCZ010000007.1  71566125-71566515   c
            392-529             JAXUCZ010000007.1  71562056-71562193   c
            530-726             JAXUCZ010000007.1  71551709-71551905   c
            727-900             JAXUCZ010000007.1  71550715-71550888   c
            901-1073            JAXUCZ010000007.1  71549362-71549534   c
            1074-1208           JAXUCZ010000007.1  71548122-71548256   c
            1209-1290           JAXUCZ010000007.1  71546210-71546291   c
            1291-1365           JAXUCZ010000007.1  71545350-71545424   c
            1366-1528           JAXUCZ010000007.1  71544443-71544605   c
            1529-1644           JAXUCZ010000007.1  71543686-71543801   c
            1645-1859           JAXUCZ010000007.1  71542991-71543205   c
            1860-4186           JAXUCZ010000007.1  71539711-71542037   c
FEATURES             Location/Qualifiers
     source          1..4186
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4186
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /note="antizyme inhibitor 1"
                     /db_xref="GeneID:58961"
                     /db_xref="RGD:61934"
     exon            1..391
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            392..529
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            530..726
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     CDS             625..1971
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /note="ornithine decarboxylase antizyme inhibitor; AZI"
                     /codon_start=1
                     /product="antizyme inhibitor 1"
                     /protein_id="NP_001288631.1"
                     /db_xref="GeneID:58961"
                     /db_xref="RGD:61934"
                     /translation="MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGD
                     LGKIVKKHSQWQNVVAQIKPFYMVKCNSTPAVLEILAALGTGFACSSKNEMALVQELG
                     VSPENIIYTSPCKQASQIKYAAKVGVNIMTCDNEVELKKIARNHPNAKVLLHIATEDN
                     IGGEDGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHISSACKEYQVYVHALSDARCV
                     FDMAGEFGFTMNMLDIGGGFTGTEIQLEEVNHVISPLLDIYFPEGSGIQIISEPGSYY
                     VSSAFTLAVNIIAKKVVENDKLSSGVEKNGSDEPAFVYYMNDGVYGSFASKLSEDLNT
                     VPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELSVGDWLIFDNMGADSLHGP
                     SAFSDTQRPAIYFMMSLSDWYEMQDAGITSDAMMKNFFFAPSCIQLSQEDNFSTEA"
     exon            727..900
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1073
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1208
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1290
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1365
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1528
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1644
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1859
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..4186
                     /gene="Azin1"
                     /gene_synonym="Oazi; Oazin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aatataaata ctggcgtctc cggcgccgcc ttcccacact ctctggctca actctcggcc
       61 gcggtgtttc cgtttctctc cctggttgtc gcctgctctg ctcttctcat ccttctcgct
      121 ctgctgctct gcggagtgac gaggctgaat cttctcccca cccagttcgc gcttttcttc
      181 tttttctcgc gccgctccat ttctccagtc cggctgccgc cgccactgct gctcagctgg
      241 tgtcggtgcc gcgcgtttcc cccacgtcgt ccccgcagcc tatggcccag gccgccttgg
      301 gtatttctgc tcaaggtaac cacatccctc tttaaaaatt ccgccgaaaa agagaagacg
      361 ctttacccga ctctttgggc cgttatctca cggcgaactt tctgaccgag tatacaacta
      421 cccagaaggc ctaggagaag tgctgtatag agagcagttc gattttaacg ctgagccacc
      481 ttgggaacct agctgatgat aggggggttc catctcctaa cttgtccatt ttgttgcata
      541 ttctaaggac ccagacatag gcttggtggc ccgtctcttg tttttcctgg tttatgactt
      601 tcggctttgt ggaatacggc tgagatgaaa ggatttattg acgatgcaaa ctactccgtt
      661 ggcctgttgg atgaaggaac aaaccttgga aatgttattg ataactatgt ttatgaacat
      721 accctgacag gaaaaaatgc attttttgtg ggggatcttg ggaagatcgt gaagaagcac
      781 agtcagtggc agaacgtggt ggctcagata aagccatttt acatggtgaa gtgcaactcc
      841 actccagccg tactggagat cttggcagct cttggaactg gatttgcttg ttccagcaaa
      901 aatgaaatgg ctttagtgca agaattaggc gtatctccag aaaacatcat ttatacaagt
      961 ccttgtaagc aagcatctca gataaagtac gcagcaaaag ttggagtaaa tattatgaca
     1021 tgtgacaatg aagttgaatt aaagaaaatt gcgaggaatc acccaaatgc caaggtctta
     1081 ctacatattg caacagaaga taatattgga ggtgaagatg gtaatatgaa gtttggcact
     1141 acactgaaga actgtaggca tcttttggaa tgtgccaagg aacttgatgt ccaaataatt
     1201 ggggttaaat ttcatatttc aagtgcttgc aaagaatatc aagtctatgt ccatgccctg
     1261 tctgatgctc gatgtgtgtt tgacatggct ggggagtttg gctttacaat gaacatgtta
     1321 gacatcggtg gaggcttcac aggaactgaa attcagttgg aagaggttaa tcatgttatc
     1381 agtcctctgt tggatattta cttccctgaa ggatctggca ttcagatcat ttccgaacct
     1441 ggaagctact atgtatcttc tgcatttacg cttgcagtca atattattgc taagaaagtt
     1501 gttgaaaatg ataaattatc ctctggagta gaaaaaaatg ggagtgacga gccagccttc
     1561 gtgtactaca tgaatgacgg tgtttatggt tcttttgcaa gtaagctttc tgaggactta
     1621 aatactgttc cagaggttca caagaaatac aaggaagatg agcctctgtt tacaagcagc
     1681 ctttggggtc catcctgtga cgagcttgat caaattgtgg aaagttgtct tcttcctgag
     1741 ctgagcgtgg gagattggct tatctttgat aacatgggag cagattcttt gcacggaccg
     1801 tctgctttta gtgacactca gaggccagct atttatttca tgatgtcact cagtgattgg
     1861 tatgagatgc aagatgctgg aattacttca gatgcaatga tgaaaaactt cttctttgca
     1921 ccctcttgca ttcagctgag ccaagaagac aacttctcca ctgaagctta aacaggcatt
     1981 aacgcttctt tagatctgaa gtcgcaggtt aagcttgtct ggtctacatt ccagtgtggg
     2041 gaaaaattca atcaatcttt attctgttaa ttttcttgga aacaaattca tagtaatagc
     2101 tgtttgggac cagacaaaat cagctttcat ctataattca ttgggggtaa taggggattt
     2161 atttagataa tgtatccaga tttaaacata ccagtttgac ccacccctta agcgtttaaa
     2221 ataaaatatg caacaaaatg gatgacttag tggagatgga agcccattaa ttgggttccc
     2281 catcaaatcg tttacataca agtacacagt ttttataata aggattcctg ttaaaagtct
     2341 tgtaaagttg atgtctttca cccagatcta tcacatgtga gtggaagacc agtgtgactt
     2401 cattagatac gtttagtgta tttagagtgt gtaaatttgt gctttggact gtagtttaat
     2461 aaatgtaaaa ttgcatcata gtatttgttg tatttgacct aatgtaacct tgtatgattg
     2521 caataaaact ttgtgtagat tttaccattt tttcaggcta aaaatttggg aatggggcta
     2581 gctagcaaag gtagttttga actagttgtg tgtatggtct gttttgagag ttttctttat
     2641 agtccatttg tttggtttgg ctcaatatac tttttagtta tttaattagt aatttaagta
     2701 aaaagtgttt ggtaatcatt gtgaagttca gattcattat ggagagtcga tgtgcagtaa
     2761 gcatgatgtt taacaatttt aacaccagaa aatgttaatc ttgcataaac caattgtaat
     2821 aataataggt gtttctgtat agataggatg catagagtac cttagtaaat ctttgaatca
     2881 caaatctttt ggctgataga aaagatttta ttaaacactg aaaacttggt cggggatggg
     2941 gagagagact gcagaagact gcagaaccct aaccttaaag aagggctatg tctatttcca
     3001 gcatcctgat gccccttcgc acagacattt aaatcgagag ggctttgggg tggtgaagca
     3061 cactcttcaa tttctcactt gtaatggtat caaattgcaa tttttttgtt gttgctgatc
     3121 ttggtttgaa cctagtccct tagtttcttg ttaattccca tttgttcaag cttagtaatt
     3181 cttccttcgt actaaagctt ggtggggggt ggggggagga gttagcttca ctaacctgac
     3241 actgttgcca ggaattttgg ctttgttcac tgctagtgtg ttagtcctaa gtctcagaat
     3301 cacagaagta atgagacaac ttacaggggt cacttttcct accttactct atgttcacaa
     3361 gtggaattcc tgacctccaa gaggaaatgt gacttcactt tggtgccaat ggacaggaaa
     3421 ttctacctgt gctacatagg agaagtgtgg gatacacttg aatagctgga ttttacacct
     3481 tgatttcaag gtggaaagaa attgatcatg aatctctaat ttcaaatcaa accagtaggt
     3541 gcttaatatt tttgatttga atattgccca cttgaatatc atgggttcta ttaattataa
     3601 gaacaactaa ggaccccagt ccactgtcat ctagttgccc ttggactttt ttccaaggta
     3661 tactatgggg tttatgcaaa atttgaagct accatatgca ttgttgtggt ccaggaatgc
     3721 caaaacttaa agcgtggtac aacctgagtc cttggcctga ctgtacaggc gtggtctctg
     3781 tggcatcagt tttgccttct gcataggaga aaggttgtat gtaacacagc ccggaattgc
     3841 tatctcacat gtgaatgata ggtaaacata agaatgtctg tattgttttt gaagactgtt
     3901 tgccataaat ctaaagtcaa acctatgtat ttcaatttgg tatgcttaag aataattaat
     3961 gtaaaatctt tttatatgat attgtaatct cagttcaaat ttaattgcaa atataaaacc
     4021 caaatgattt ctatatatag taaattgaac tgtcaaggta acttgtgtgt gattctgaat
     4081 acacagatac aatgttttta ttcctcatgc tttactttga tggcttctat catgaaatag
     4141 atgtgaaatt ttatgaatta attctgtgta tactgcccac attctt
//
