LOCUS       NM_012826               1212 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus alpha-2-glycoprotein 1, zinc-binding (Azgp1),
            mRNA.
ACCESSION   NM_012826
VERSION     NM_012826.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Kim,S.H., Oh,J.M., Roh,H., Lee,K.W., Lee,J.H. and Lee,W.J.
  TITLE     Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and III
            Collagen Expression via Suppression of TGF-beta and p-Smad 2/3
            Pathway in Keloid Fibroblasts and Rat Incisional Model
  JOURNAL   Tissue Eng Regen Med 21 (7), 1079-1092 (2024)
   PUBMED   39105875
  REMARK    GeneRIF: Zinc-Alpha-2-Glycoprotein Peptide Downregulates Type I and
            III Collagen Expression via Suppression of TGF-beta and p-Smad 2/3
            Pathway in Keloid Fibroblasts and Rat Incisional Model.
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Jain,A., Kotimoole,C.N., Ghoshal,S., Bakshi,J., Chatterjee,A.,
            Prasad,T.S.K. and Pal,A.
  TITLE     Identification of potential salivary biomarker panels for oral
            squamous cell carcinoma
  JOURNAL   Sci Rep 11 (1), 3365 (2021)
   PUBMED   33564003
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1212)
  AUTHORS   Tan,C., Liu,X., Peng,W., Wang,H., Zhou,W., Jiang,J., Wei,X., Mo,L.,
            Chen,Y. and Chen,L.
  TITLE     Seizure-induced impairment in neuronal ketogenesis: Role of
            zinc-alpha2-glycoprotein in mitochondria
  JOURNAL   J Cell Mol Med 24 (12), 6833-6845 (2020)
   PUBMED   32340079
  REMARK    GeneRIF: Seizure-induced impairment in neuronal ketogenesis: Role
            of zinc-alpha2-glycoprotein in mitochondria.
REFERENCE   4  (bases 1 to 1212)
  AUTHORS   Yu,W., Ling,J., Yu,H., Du,J. and Liu,T.
  TITLE     AZGP1 suppresses the process of colorectal cancer after
            upregulating FASN expression via mTOR signal pathway
  JOURNAL   Gen Physiol Biophys 39 (3), 239-248 (2020)
   PUBMED   32525817
REFERENCE   5  (bases 1 to 1212)
  AUTHORS   Wei,X., Liu,X., Tan,C., Mo,L., Wang,H., Peng,W., Zhou,W., Jiang,J.,
            Deng,F. and Chen,L.
  TITLE     Insulin attenuates epileptiform discharge-induced oxidative stress
            by increasing zinc-alpha2-glycoprotein in primary cultured cortical
            neurons
  JOURNAL   Neuroreport 30 (8), 580-585 (2019)
   PUBMED   30950934
  REMARK    GeneRIF: Insulin attenuates epileptiform discharge-induced
            oxidative stress by increasing zinc-alpha2-glycoprotein in primary
            cultured cortical neurons.
REFERENCE   6  (bases 1 to 1212)
  AUTHORS   Hale,L.P., Price,D.T., Sanchez,L.M., Demark-Wahnefried,W. and
            Madden,J.F.
  TITLE     Zinc alpha-2-glycoprotein is expressed by malignant prostatic
            epithelium and may serve as a potential serum marker for prostate
            cancer
  JOURNAL   Clin Cancer Res 7 (4), 846-853 (2001)
   PUBMED   11309332
REFERENCE   7  (bases 1 to 1212)
  AUTHORS   Ogikubo,O., Maeda,T., Yamane,T., Ohtsuka,T., Ohkubo,I.,
            Takahashi,S., Ohnishi,S. and Matsui,N.
  TITLE     Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by
            kininogens and their derivatives
  JOURNAL   Biochem Biophys Res Commun 252 (1), 257-262 (1998)
   PUBMED   9813179
REFERENCE   8  (bases 1 to 1212)
  AUTHORS   Uria,J.A., Fueyo,A., Balbin,M., Velasco,G., Pendas,A.M. and
            Lopez-Otin,C.
  TITLE     Alternative splicing gives rise to two novel long isoforms of
            Zn-alpha 2-glycoprotein, a member of the immunoglobulin superfamily
  JOURNAL   Gene 169 (2), 233-236 (1996)
   PUBMED   8647453
REFERENCE   9  (bases 1 to 1212)
  AUTHORS   Ueyama,H., Naitoh,H. and Ohkubo,I.
  TITLE     Structure and expression of rat and mouse mRNAs for Zn-alpha
            2-glycoprotein
  JOURNAL   J Biochem 116 (3), 677-681 (1994)
   PUBMED   7852290
REFERENCE   10 (bases 1 to 1212)
  AUTHORS   Fueyo,A., Uria,J.A., Freije,J.M. and Lopez-Otin,C.
  TITLE     Cloning and expression analysis of the cDNA encoding rat Zn-alpha
            2-glycoprotein
  JOURNAL   Gene 145 (2), 245-249 (1994)
   PUBMED   8056339
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105822.1.
            
            On Aug 18, 2012 this sequence version replaced NM_012826.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105822.1, FQ219362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q11"
     gene            1..1212
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="alpha-2-glycoprotein 1, zinc-binding"
                     /db_xref="GeneID:25294"
                     /db_xref="RGD:2187"
     exon            1..79
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..909
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /note="zinc-alpha-2-glycoprotein; zn-alpha-2-GP;
                     zn-alpha-2-glycoprotein; alpha-2 - glycoprotein 1, zinc;
                     Zn - alpha2 - glycoprotein; alpha-2-glycoprotein 1, zinc"
                     /codon_start=1
                     /product="zinc-alpha-2-glycoprotein precursor"
                     /protein_id="NP_036958.2"
                     /db_xref="GeneID:25294"
                     /db_xref="RGD:2187"
                     /translation="MVPVLLSLPLLLGPAVLQETGSYSLIFLYTGLSRPSKGLLRFQA
                     TAFLNDQAFFHYNSNSGKAEPVEPWSHVEGMEDWEKESQLQRAREEIFLVTLKDIMDY
                     YEDSTGSHTFQGMFGCEITNNRSSGAVWRYAYDGEDFIEFNKEIPAWIPLDPAAANTK
                     LKWEAEKVYVQRAKAYLEEECPTMLKKYLTYSRSHLDRTDPPTVKITSRVAPGRNRIF
                     RCLAYDFYPQRISLHWNQASKKLASEPERGVFPNGNGTYLSWMEVEVPPQNRDPFVCH
                     IEHKGLSQSLSVQWDEKSKV"
     exon            80..340
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
     exon            341..616
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1185
                     /gene="Azgp1"
                     /gene_synonym="ZA2GA; Zna2gp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggcacta cagtagcaat ggtgcctgtc ctgttgtccc tgcctctcct tctgggtcct
       61 gcagtccttc aggagactgg gtcttattct ctgatcttcc tctacaccgg gttgtccagg
      121 cccagcaaag gccttctgag gtttcaagcc accgcatttc tcaacgatca ggccttcttc
      181 cactacaaca gcaacagtgg gaaggcagag cccgtggaac cctggagcca tgtggaagga
      241 atggaggact gggagaagga aagccagctt cagagagcca gggaggagat cttcctcgtg
      301 accctgaaag acatcatgga ctattacgag gacagtacag ggtctcacac ctttcaggga
      361 atgtttggtt gtgagatcac aaataacaga agtagtggag cagtctggag gtatgcctac
      421 gatggagaag atttcatcga attcaacaag gaaatcccag cctggatccc cttagaccca
      481 gcagccgcaa acaccaagct gaagtgggag gcagaaaagg tctatgtgca gcgagccaag
      541 gcatacctag aggaggagtg tcctacaatg ctgaagaagt acctgaccta cagtagatct
      601 cacctggacc gaacagatcc tcccactgtg aaaatcacca gccgtgtggc cccaggaaga
      661 aacagaatat tcagatgtct ggcctatgac ttctacccac aaagaattag tctgcactgg
      721 aaccaggcca gcaagaagct ggcatctgaa ccagaaagag gtgtttttcc caatggaaat
      781 ggcacttacc tctcctggat ggaggtggaa gtccccccac agaacagaga cccctttgtc
      841 tgccacatag aacacaaggg gctatcccaa tctctctcag tgcagtggga tgagaaaagt
      901 aaagtctgaa aacagtgctg tatctcagcc tcagaaaggt taccctctct gccggatatg
      961 agagagttga acttcagaag tcactgtcac cagcaagccc gcaagtctcc aaggaatggg
     1021 tgtgggccca gaagatttga ataccaagca ccgagttcac tctcaaagtc aaatcaatca
     1081 ccttgccttg taaaactcct cctcaattaa tctgtaagcc cttgcaatta ccttcacgcc
     1141 cagcacagca cagaaaggca ttttaaactc tgagatgcta cagaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aa
//
