LOCUS       NM_031794               4325 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus Axl receptor tyrosine kinase (Axl), transcript
            variant 1, mRNA.
ACCESSION   NM_031794 XM_001081882
VERSION     NM_031794.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4325)
  AUTHORS   Huang,M., Liu,M., Huang,D., Ma,Y., Ye,G., Wen,Q., Li,Y., Deng,L.,
            Qi,Q., Liu,T., Liu,X., Chen,M., Ye,W. and Zhang,D.
  TITLE     Tumor perivascular cell-derived extracellular vesicles promote
            angiogenesis via the Gas6/Axl pathway
  JOURNAL   Cancer Lett 524, 131-143 (2022)
   PUBMED   34678434
  REMARK    GeneRIF: Tumor perivascular cell-derived extracellular vesicles
            promote angiogenesis via the Gas6/Axl pathway.
REFERENCE   2  (bases 1 to 4325)
  AUTHORS   Liang,L., Zhang,J., Tian,L., Wang,S., Xu,L., Wang,Y., Guo-Shuai,Q.,
            Dong,Y., Chen,Y., Jia,H., Yang,X. and Yuan,C.
  TITLE     AXL signaling in primary sensory neurons contributes to chronic
            compression of dorsal root ganglion-induced neuropathic pain in
            rats
  JOURNAL   Mol Pain 16, 1744806919900814 (2020)
   PUBMED   31884887
  REMARK    GeneRIF: AXL signaling in primary sensory neurons contributes to
            chronic compression of dorsal root ganglion-induced neuropathic
            pain in rats.
REFERENCE   3  (bases 1 to 4325)
  AUTHORS   Batlle,M., Castillo,N., Alcarraz,A., Sarvari,S., Sanguesa,G.,
            Cristobal,H., Garcia de Frutos,P., Sitges,M., Mont,L. and Guasch,E.
  TITLE     Axl expression is increased in early stages of left ventricular
            remodeling in an animal model with pressure-overload
  JOURNAL   PLoS One 14 (6), e0217926 (2019)
   PUBMED   31181097
  REMARK    GeneRIF: Axl expression pattern suggests a role in the early
            progression of LV remodeling in HF but not in the later systolic
            dysfunction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4325)
  AUTHORS   Wu,G., McBride,D.W. and Zhang,J.H.
  TITLE     Axl activation attenuates neuroinflammation by inhibiting the
            TLR/TRAF/NF-kappaB pathway after MCAO in rats
  JOURNAL   Neurobiol Dis 110, 59-67 (2018)
   PUBMED   29196212
  REMARK    GeneRIF: activation of Axl by recombinant Growth-arrest-specific
            protein 6 (rGas6) attenuates neuroinflammation by inhibiting the
            TLR/TRAF/NF-kappaB pathway after middle cerebral artery occlusion
            (MCAO) in rats
REFERENCE   5  (bases 1 to 4325)
  AUTHORS   Qiu,C., Zheng,H., Tao,H., Yu,W., Jiang,X., Li,A., Jin,H., Lv,A. and
            Li,H.
  TITLE     Vitamin K2 inhibits rat vascular smooth muscle cell calcification
            by restoring the Gas6/Axl/Akt anti-apoptotic pathway
  JOURNAL   Mol Cell Biochem 433 (1-2), 149-159 (2017)
   PUBMED   28386842
  REMARK    GeneRIF: the Gas6/Axl interaction was inhibited by R428, which
            abolished the preventive effect of VK2 on CaCl2- and
            beta-GP-induced apoptosis and calcification. These results suggest
            that Gas6 is critical in VK2-mediated functions that attenuate
            CaCl2- and beta-GP-induced VSMC calcification by blocking
            apoptosis.
REFERENCE   6  (bases 1 to 4325)
  AUTHORS   Augustine,K.A., Rossi,R.M., Van,G., Housman,J., Stark,K.,
            Danilenko,D., Varnum,B. and Medlock,E.
  TITLE     Noninsulin-dependent diabetes mellitus occurs in mice ectopically
            expressing the human Axl tyrosine kinase receptor
  JOURNAL   J Cell Physiol 181 (3), 433-447 (1999)
   PUBMED   10528229
REFERENCE   7  (bases 1 to 4325)
  AUTHORS   Lu,Q., Gore,M., Zhang,Q., Camenisch,T., Boast,S., Casagranda,F.,
            Lai,C., Skinner,M.K., Klein,R., Matsushima,G.K., Earp,H.S.,
            Goff,S.P. and Lemke,G.
  TITLE     Tyro-3 family receptors are essential regulators of mammalian
            spermatogenesis
  JOURNAL   Nature 398 (6729), 723-728 (1999)
   PUBMED   10227296
REFERENCE   8  (bases 1 to 4325)
  AUTHORS   Leimeister,C., Bach,A., Woolf,A.S. and Gessler,M.
  TITLE     Screen for genes regulated during early kidney morphogenesis
  JOURNAL   Dev Genet 24 (3-4), 273-283 (1999)
   PUBMED   10322635
REFERENCE   9  (bases 1 to 4325)
  AUTHORS   Melaragno,M.G., Wuthrich,D.A., Poppa,V., Gill,D., Lindner,V.,
            Berk,B.C. and Corson,M.A.
  TITLE     Increased expression of Axl tyrosine kinase after vascular injury
            and regulation by G protein-coupled receptor agonists in rats
  JOURNAL   Circ Res 83 (7), 697-704 (1998)
   PUBMED   9758639
REFERENCE   10 (bases 1 to 4325)
  AUTHORS   Bellosta,P., Zhang,Q., Goff,S.P. and Basilico,C.
  TITLE     Signaling through the ARK tyrosine kinase receptor protects from
            apoptosis in the absence of growth stimulation
  JOURNAL   Oncogene 15 (20), 2387-2397 (1997)
   PUBMED   9395235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 5, 2022 this sequence version replaced NM_031794.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.1498.1,
                                           SRR26643429.1301.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               JAXUCZ010000001.1  90423751-90424009   c
            260-485             JAXUCZ010000001.1  90422639-90422864   c
            486-586             JAXUCZ010000001.1  90422226-90422326   c
            587-763             JAXUCZ010000001.1  90421140-90421316   c
            764-844             JAXUCZ010000001.1  90414926-90415006   c
            845-960             JAXUCZ010000001.1  90414672-90414787   c
            961-1171            JAXUCZ010000001.1  90411126-90411336   c
            1172-1311           JAXUCZ010000001.1  90410695-90410834   c
            1312-1462           JAXUCZ010000001.1  90409940-90410090   c
            1463-1489           JAXUCZ010000001.1  90409703-90409729   c
            1490-1622           JAXUCZ010000001.1  90406902-90407034   c
            1623-1714           JAXUCZ010000001.1  90406466-90406557   c
            1715-1810           JAXUCZ010000001.1  90402057-90402152   c
            1811-1888           JAXUCZ010000001.1  90401660-90401737   c
            1889-1981           JAXUCZ010000001.1  90400001-90400093   c
            1982-2103           JAXUCZ010000001.1  90399529-90399650   c
            2104-2213           JAXUCZ010000001.1  90398861-90398970   c
            2214-2373           JAXUCZ010000001.1  90397035-90397194   c
            2374-2510           JAXUCZ010000001.1  90396337-90396473   c
            2511-4325           JAXUCZ010000001.1  90392864-90394678   c
FEATURES             Location/Qualifiers
     source          1..4325
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4325
                     /gene="Axl"
                     /note="Axl receptor tyrosine kinase"
                     /db_xref="GeneID:308444"
                     /db_xref="RGD:620028"
     exon            1..259
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2862
                     /gene="Axl"
                     /EC_number="2.7.10.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tyrosine-protein kinase receptor UFO"
                     /codon_start=1
                     /product="tyrosine-protein kinase receptor UFO isoform 1
                     precursor"
                     /protein_id="NP_113982.2"
                     /db_xref="GeneID:308444"
                     /db_xref="RGD:620028"
                     /translation="MGRVPLAWCVALCCWGCAAPKDTQTEADSPFVGNPGNITGARGL
                     TGTLRCELQVQGEPPEVMWLRDGQILELADNTQTQVPLGEDWQDEWKVVSQLRISALQ
                     LSDAGEYQCMVHLEGRTFVSQPGFVGLEGLPYFLEEPEDKAVPANTPFNLSCQAQGPP
                     EPVTLLWLQDAVPLAPVAGYSFQHSLQAPGLNKTSSFSCEAHNAKGVTTSRTATITVL
                     PQRPHNLHVVSRHPTELEVAWIPSLSGIYPLTHCTLQAVLSDDGVGVWLGESDPPEEP
                     LTVQVSVPPHQLRLEKLLPHTPYHIRVSCTSSQGPSPWTHWLPVETTEGVPLGPPENV
                     SAMRNGSQALVRWQEPREPLQGTLLGYRLAYRGQDTPEVLMDIGLTREVTLELRGDRP
                     VANLTVSVAAYTSAGDGPWSLPVPLEPWRPGQGQPLHHLVSEPPPPAFSWPWWYVLLG
                     ALVAAACVLILTLFLVHRRKKETRYGEVFEPTVERGELVVRYRARKSYSRRTTEATLN
                     SLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIA
                     ICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSDREGFPEPVVILPFMKHGDLHS
                     FLLYSRLGDQPVFLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCV
                     ADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRG
                     QTPYPGVENSEIYDYLRQGNRLKQPLDCLDGLYALMSRCWELNPRDRPSFAELREDLE
                     NTLKALPPAQEPDEILYVNMDEGGSHLEPRGAAGGADPPTQPDPKDSCSCLTEADVHS
                     AGRYVLCPSTAPGPTLSADRGCPAPPGQEDGA"
     exon            260..485
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            486..586
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            587..763
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            764..844
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            845..960
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1171
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1311
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1462
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1489
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1622
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1714
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1810
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1888
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..1981
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            1982..2103
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2213
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2373
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2510
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..4325
                     /gene="Axl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggcggcta gctagctgcg gaggagttga gccagccgag gggctcccgc tgtgccaggc
       61 gggcagtgcc aaatcccagg agcccagagg tggggggagg gccggggaca acccggccct
      121 gcccccttcc ctagtaaggt gcccatcaac ttcggaagaa agtttggcat caatctcagc
      181 cgttgtgact tgaggatggg cagggtcccg ctggcctggt gcgtggcgct gtgctgctgg
      241 gggtgtgcag ctcctaagga cacacagacc gaggctgaca gcccattcgt ggggaaccca
      301 gggaatatca cgggtgccag aggactcaca gggacccttc ggtgtgagct ccaggttcag
      361 ggggagcccc ctgaggtgat gtggcttcga gatggacaga tcctagaact ggctgataac
      421 acccagaccc aggtgcctct gggcgaagac tggcaagatg aatggaaagt cgtcagtcag
      481 ctcagaatct cagccctgca actttcagat gcaggagagt accagtgtat ggtgcacctg
      541 gaaggacgga cctttgtgtc tcagcctggc tttgtaggac tggaaggtct cccatacttc
      601 ctggaggaac ctgaagacaa agctgtgcct gccaacaccc ccttcaacct aagctgccag
      661 gcccagggac ccccggaacc cgtgaccctg ctctggcttc aagatgctgt ccctctggcc
      721 ccagtcgcag gatacagctt tcagcacagt ttgcaagctc caggcctgaa caagacatct
      781 tctttctcat gtgaagccca caatgccaag ggagtcacca cctcccgcac agctaccatc
      841 acagtgctcc cacagagacc tcacaatctc cacgtggttt ccagacatcc cacggagcta
      901 gaggtagctt ggatccctag cctgagtggc atctacccgc tcacccactg caccctgcag
      961 gctgtgctgt cagacgatgg ggtgggcgtc tggctgggag agtcagatcc tccagaagag
     1021 cccctcacgg tgcaagtatc agtgcccccc caccagcttc ggctggaaaa gctccttcct
     1081 cacaccccat atcacatccg ggtatcctgc actagcagcc agggcccctc accttggacc
     1141 cactggcttc ctgtggagac cacggaggga gtgcccttgg gtccccctga gaacgttagc
     1201 gccatgcgga atgggagcca ggccctcgtg cgttggcagg agccaaggga gcccttgcag
     1261 ggcaccctgt tagggtaccg gctggcatat cgaggccagg acacccccga ggtacttatg
     1321 gatatagggc taactcgaga ggtgaccttg gaacttcggg gggacaggcc tgtggctaac
     1381 ctgactgtgt ctgtggcagc ctatacctca gctggggatg ggccctggag ccttcctgtg
     1441 cccctagagc cctggcgccc agggcaagga cagccactcc accatctggt gagtgaaccc
     1501 ccacctcccg ccttctcgtg gccttggtgg tatgtactgc tgggagcact tgtggccgcc
     1561 gcctgtgtcc ttatcttgac cctgttcctt gtccatcgga ggaagaagga gacgagatat
     1621 ggggaggtgt tcgagccaac tgtggaaagg ggtgaactgg tagtcaggta ccgtgcccga
     1681 aagtcctaca gtcgccggac cacggaagcc accttgaaca gtctgggcat cagcgaagag
     1741 ctgaaggaga aactacgaga cgtcatggta gatcggcata aggtggcctt ggggaagacc
     1801 ctgggagaag gagaatttgg tgctgtgatg gagggccagc tcaaccagga tgactccatc
     1861 ctcaaggtcg ctgtgaagac catgaaaatt gccatctgca caagatcaga gctggaggat
     1921 ttcctgagtg aagctgtctg catgaaggaa tttgaccacc ccaacgtcat gaggctcatt
     1981 ggcgtctgtt tccagggttc tgaccgagag ggtttcccag aaccggtggt catcttgcct
     2041 ttcatgaaac atggagacct ccacagtttc ctcctgtact cgcggctcgg ggaccagcca
     2101 gtgttcctgc ccactcagat gctagtgaag tttatggccg acattgccag tggcatggag
     2161 tacctcagta ccaagagatt catacaccgg gacctagctg ccaggaactg catgctgaat
     2221 gagaacatgt ccgtgtgcgt ggcagacttc gggctctcca agaagatcta caatggggat
     2281 tactaccgcc aagggcgcat tgccaagatg ccagtcaagt ggattgctat cgagagtctg
     2341 gcagatcgag tctacaccag caagagtgac gtgtggtcct tcggtgtgac aatgtgggag
     2401 atcgccaccc gaggccaaac tccctatcct ggggtggaga acagtgagat ttacgactac
     2461 ctacgtcaag gaaatcgcct gaaacagcct ctggactgtc tggatggcct ctatgccctg
     2521 atgtcccggt gctgggagct gaaccctcga gaccggccaa gttttgcaga gctccgggaa
     2581 gacttggaga acacattgaa ggctctaccc cctgctcagg agcctgatga aatcctctac
     2641 gtcaacatgg atgagggcgg aagtcacctt gaaccccgtg gtgctgctgg aggagctgac
     2701 cccccaactc aacccgatcc taaggattcc tgtagctgtc tcactgaagc tgacgtccat
     2761 tcggctggac gctatgtcct ctgtccttct acagccccag gacccactct gtctgctgac
     2821 agaggctgcc cagcacctcc agggcaggag gacggagcct gagacaatct tgcacctggg
     2881 acaccctctc aggacccaag ctaggcactg ccactggggg aaagctcgcc cccactctgc
     2941 cactccaggc cttctcccca gctgcagaat gacccttccc tcccttgtca aattcagtcc
     3001 agaaagatgt gtcctgcttt ctatgccctg aacaccctat tcataacaag aagggctgga
     3061 ctgcagtctc agagcgtcat ctcagatctt ccagcccagc attgtagatt ttaaggtttg
     3121 agtttagact tcagagttct caaagatggt gagtctttga ggaaccgaga tgcctgtgtc
     3181 taggtctgaa gtgctattgc catagacaag gcctgctgtt cgaagactct gagattctgt
     3241 ggctctggat tttctggttc tataatcttg gtagtgcccc catggtttta ggttgcatgg
     3301 ctctgagatt ccaggatcta aggctcaatg attctagact ttatctttct ggagcccggg
     3361 gttctatcag tggaagactg tagattttta agttctaaag attctaggca tgaaggtttt
     3421 aaggcatact gttctccaat ttaacagttt aaggctcatg ttggaatatt ccagatcata
     3481 aaatttcaaa cctttatttt tttttaattt ctaagatttt agtgatggtc aaccacagtt
     3541 tctgaggcct tatgattata gattatttta tataaaattc tgcctcctaa ggaaatgtga
     3601 ttgtagactc tgaaattcaa aagctttaag agtccccaga tggagtttct aagctgtgat
     3661 gtgatgataa tctaaaattt ggtccaaagt tctagattct taagcttcca tatcatatgt
     3721 tcccaagatt ccagattatt aaactctaaa actctaatgt tggcctgatc ttcatcttag
     3781 gcacagtaag atgctttggg tccaagaaga tgggtcctca gcatctgagt cataagaggc
     3841 tcacagttaa ttatgactaa ccaaatacca aagttctaac catttctaat gatgggcacc
     3901 tctaggtcta tgctgctttc tgcctttcta gcacataatt aaatatccaa gaatacatat
     3961 gtctaaaaat cttaaatctc taagcactct aacttaagaa tccaatgttc tgagtgtctc
     4021 aaattctaaa ggtccacaga tctacagtat taggtacgat tccaaggatg ggagcttgta
     4081 gcatttgcca ctaagccctt ttccctcctt aggcacttat gcttcctcct ctcctcgtgt
     4141 ggggtgtgcc ccaccttaag cctgtgcaat gcattgggaa tgcctccttt cctctaaggg
     4201 atgggtcatc tcccttcctt ttgggccacg ttgccccttg agccagtccc ttgttcctgt
     4261 tctgaagtgt ggactctggt gcctccagag aggctcagat cacataaaac ttttgtcaat
     4321 cacta
//
