LOCUS       NM_024355               3216 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus axin 2 (Axin2), mRNA.
ACCESSION   NM_024355 XM_001081593
VERSION     NM_024355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Qiu,Z., Chen,W., Liu,Y., Jiang,B., Yin,L. and Chen,X.
  TITLE     LncRNA AC061961.2 overexpression inhibited endoplasmic reticulum
            stress induced apoptosis in dilated cardiomyopathy rats and
            cardiomyocytes via activating wnt/beta-catenin pathway
  JOURNAL   J Recept Signal Transduct Res 41 (5), 494-503 (2021)
   PUBMED   33092439
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   An,Y.Z., Cho,E., Ling,J. and Zhang,X.
  TITLE     The Axin2-snail axis promotes bone invasion by activating
            cancer-associated fibroblasts in oral squamous cell carcinoma
  JOURNAL   BMC Cancer 20 (1), 987 (2020)
   PUBMED   33046030
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Wu,Z., Liang,Y. and Yu,S.
  TITLE     Downregulation of microRNA-103a reduces microvascular endothelial
            cell injury in a rat model of cerebral ischemia by targeting AXIN2
  JOURNAL   J Cell Physiol 235 (5), 4720-4733 (2020)
   PUBMED   31650542
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Otero,L., Lacunza,E., Vasquez,V., Arbelaez,V., Cardier,F. and
            Gonzalez,F.
  TITLE     Variations in AXIN2 predict risk and prognosis of colorectal cancer
  JOURNAL   BDJ Open 5, 13 (2019)
   PUBMED   31632692
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3216)
  AUTHORS   Mishra,A., Singh,S., Tiwari,V., Chaturvedi,S., Wahajuddin,M. and
            Shukla,S.
  TITLE     Dopamine receptor activation mitigates mitochondrial dysfunction
            and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA
            lesioned rats: A role of Wnt signalling
  JOURNAL   Neurochem Int 129, 104463 (2019)
   PUBMED   31078578
REFERENCE   6  (bases 1 to 3216)
  AUTHORS   Leung,J.Y., Kolligs,F.T., Wu,R., Zhai,Y., Kuick,R., Hanash,S.,
            Cho,K.R. and Fearon,E.R.
  TITLE     Activation of AXIN2 expression by beta-catenin-T cell factor. A
            feedback repressor pathway regulating Wnt signaling
  JOURNAL   J Biol Chem 277 (24), 21657-21665 (2002)
   PUBMED   11940574
REFERENCE   7  (bases 1 to 3216)
  AUTHORS   Lustig,B., Jerchow,B., Sachs,M., Weiler,S., Pietsch,T., Karsten,U.,
            van de Wetering,M., Clevers,H., Schlag,P.M., Birchmeier,W. and
            Behrens,J.
  TITLE     Negative feedback loop of Wnt signaling through upregulation of
            conductin/axin2 in colorectal and liver tumors
  JOURNAL   Mol Cell Biol 22 (4), 1184-1193 (2002)
   PUBMED   11809809
REFERENCE   8  (bases 1 to 3216)
  AUTHORS   Liu,W., Dong,X., Mai,M., Seelan,R.S., Taniguchi,K.,
            Krishnadath,K.K., Halling,K.C., Cunningham,J.M., Boardman,L.A.,
            Qian,C., Christensen,E., Schmidt,S.S., Roche,P.C., Smith,D.I. and
            Thibodeau,S.N.
  TITLE     Mutations in AXIN2 cause colorectal cancer with defective mismatch
            repair by activating beta-catenin/TCF signalling
  JOURNAL   Nat Genet 26 (2), 146-147 (2000)
   PUBMED   11017067
  REMARK    Erratum:[Nat Genet 2000 Dec;26(4):501]
REFERENCE   9  (bases 1 to 3216)
  AUTHORS   Yamamoto,H., Kishida,S., Uochi,T., Ikeda,S., Koyama,S., Asashima,M.
            and Kikuchi,A.
  TITLE     Axil, a member of the Axin family, interacts with both glycogen
            synthase kinase 3beta and beta-catenin and inhibits axis formation
            of Xenopus embryos
  JOURNAL   Mol Cell Biol 18 (5), 2867-2875 (1998)
   PUBMED   9566905
REFERENCE   10 (bases 1 to 3216)
  AUTHORS   Behrens,J., Jerchow,B.A., Wurtele,M., Grimm,J., Asbrand,C.,
            Wirtz,R., Kuhl,M., Wedlich,D. and Birchmeier,W.
  TITLE     Functional interaction of an axin homolog, conductin, with
            beta-catenin, APC, and GSK3beta
  JOURNAL   Science 280 (5363), 596-599 (1998)
   PUBMED   9554852
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF017757.1.
            
            On Jun 25, 2006 this sequence version replaced XM_001081593.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3216
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="axin 2"
                     /db_xref="GeneID:29134"
                     /db_xref="RGD:69259"
     exon            1..899
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2601
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /note="conductin; axin-like protein; axis inhibition
                     protein 2"
                     /codon_start=1
                     /product="axin-2"
                     /protein_id="NP_077331.1"
                     /db_xref="GeneID:29134"
                     /db_xref="RGD:69259"
                     /translation="MSSAVLVTLLPDPSSSFREDAPRPPVPGEEGETPPCQPSVGKVQ
                     STKPMPVSSNARRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLERE
                     KCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDG
                     IKKQQIGSVMFDQAQTEIQAVMEENAYQVFLTSDIYLEYVRSGGENTAYMSNGGLGSL
                     KVLCGYLPTLNEEEEWTCADLKCKLSPTVVGLSSKTLRATASVRSTETAENGFRSFKR
                     SEPVNPYHVGSGYVFAPATSANDSELSSDALTDDSMSMTDSSVDGIPPYRMGSKKQLQ
                     REMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPAAFAAELISRLEKLKLELESRHSLE
                     ERLQQIREDEEKEGSEQALSSRDGAPVQHPLALLPSGSYEEDPQTILDDHLSRVLKTP
                     GCQSPGVGRYSPRSRSPDHHHHHHQQCHALLPTGGKLPPEAACPLLGGKSFLTKQTTK
                     HVHHHYIHHHAVPKTKEEIEAEATQRVRCLCPGGTDYYCYSKCKSHSKPPEPLPGEQF
                     CGSRGGTLPKRNTKGTEPGLALPAREGGMSSAAGAPQLPGEEGDRSQDVWQWMLESER
                     QSKSKPHSTQSIRKSYPLESARAPPGERVSRHHLLGASGHPRSAARAHPFTQDPAMPP
                     LTPPNTLAQLEEACRRLAEVSKPQKQRCCVASQQRDRNHPATGQAGPTSFSNPSLASE
                     DHKEPKRLASVHALQASELIVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRY
                     YFKKASDEFACGAVFEEIWDDETVLPMYEGRILGKVERID"
     exon            900..1040
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1143
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1284
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1784
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1979
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2210
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2306
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2474
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..3197
                     /gene="Axin2"
                     /gene_synonym="axil; axin-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgagaggaac tggaagaaga aaaaggaaga ggaaaaaaaa aaagcaaaac aaaacccaaa
       61 ctcagtgaga cgctctccct caccatgagt agcgctgtgt tagtgactct ccttccagat
      121 ccaagcagca gcttccgcga ggatgctccg cggcccccgg ttcccggaga agaaggggag
      181 accccaccgt gtcagcctag cgtgggcaag gtccagtcca ccaaacctat gcctgtctcc
      241 tctaacgcta ggcggaatga agatgggctg ggggagcccg aggggcgggc ctccccagat
      301 tcccctctga ccaggtggac caagtctttg cactccttgt tgggggacca agatggtgca
      361 tacctcttcc ggactttcct ggagagggag aaatgtgtgg ataccctgga cttctggttt
      421 gcctgcaatg ggttcaggca gatgaacttg aaggatacca aaactttgcg agtggccaaa
      481 gcaatctaca agaggtacat tgagaacaac agtgttgtct ccaaacagct gaaacccgcc
      541 accaagacct acataagaga tggcatcaag aagcagcaga tcggctcggt catgtttgac
      601 caggcgcaga cggagattca ggcggtgatg gaggaaaatg cctatcaggt gttcttgact
      661 tctgacatat acctcgaata tgtgaggagt gggggagaaa acacagctta catgagcaat
      721 gggggactgg ggagcctaaa ggtcttatgt ggctacctcc ccaccctgaa tgaggaagag
      781 gagtggacat gtgccgacct gaagtgcaaa ctttcaccca ccgtggttgg cctatccagc
      841 aaaactctcc gggccacagc gagcgtgaga tccacagaaa cggctgaaaa cggattcaga
      901 tccttcaaga gaagcgaacc ggttaatcct tatcacgtag gttctggcta tgtctttgca
      961 ccagccacca gcgccaacga cagcgagtta tccagcgacg cgctgaccga cgattccatg
     1021 tccatgacag acagtagcgt agatggaatc cctccttacc gcatggggag taagaaacaa
     1081 ctccagagag agatgcaccg cagtgtgaag gccaatggcc aagtgtctct acctcacttc
     1141 ccgagaaccc accgcctgcc caaggagatg acgcccgtgg aacctgctgc cttcgccgca
     1201 gagctcatct ccaggctgga gaagctgaaa ctggagctgg agagccgcca cagcctggag
     1261 gaacggctgc agcagatccg ggaggatgaa gaaaaggagg ggtctgagca ggccctgagc
     1321 tcacgggatg gagcaccggt ccaacacccc ctggccctct taccctctgg cagctatgaa
     1381 gaggacccac aaaccatctt ggacgaccac ctgtccaggg tcctcaagac ccccggctgc
     1441 cagtcccctg gtgtgggccg ctacagccca cgctcccgct cccccgacca ccaccaccac
     1501 caccatcagc agtgtcacgc ccttcttcca actgggggca agctgccccc cgaggctgct
     1561 tgcccgctcc ttggaggcaa gagcttcctg accaaacaga cgacgaagca cgtccaccac
     1621 cactacatcc accaccacgc cgtccctaag accaaggagg agatcgaggc agaagccaca
     1681 cagagagtac gctgcctctg ccctggaggc acagattatt actgctactc caagtgcaag
     1741 agccactcga agcctccaga gcccctccct ggggagcagt tttgtggcag cagaggtggc
     1801 accttgccaa aacggaatac gaaaggcaca gaaccgggtc tggcactgcc ggccagggaa
     1861 ggagggatgt ccagtgcagc aggggcccct cagcttcctg gggaagaagg agaccggtca
     1921 caggatgtct ggcagtggat gttggagagt gagcgtcaga gcaagtccaa gccccatagt
     1981 acccaaagca taagaaagag ctacccgttg gagtctgccc gcgcgccccc aggcgaacga
     2041 gtcagccggc accatctgct gggggccagt ggacaccccc gctcagcggc ccgggctcac
     2101 ccatttaccc aggaccctgc catgcctccc ctaaccccac ccaacacctt ggcgcagcta
     2161 gaggaagcct gccgcaggct ggccgaggtg tcaaagcccc agaaacagag gtgctgcgtg
     2221 gccagtcagc agagggacag gaaccaccca gccacaggtc aggcaggacc cacatccttc
     2281 tccaacccga gcctggcttc agaagatcac aaagagccaa agagactggc tagtgtccac
     2341 gcactccaag ccagcgagct gattgttacc tactttttct gtggagaaga aattccatac
     2401 aggaggatgc tgaaggcgca gagcttgact ctgggccact tcaaggagca gctcagcaaa
     2461 aagggaaatt acaggtatta cttcaagaag gcgagtgacg aatttgcctg tggagcagtc
     2521 tttgaggaga tctgggatga tgagacagtg ctccccatgt acgaaggcag gatcctgggc
     2581 aaagtggaga ggatcgactg agcctcggcc tccgccgcgt gcacctccgc gtgcacctcc
     2641 gcgtgcacca cggagccgga gcccagagag acctgtctca ggcctacaca acagccatga
     2701 aatattttga aggaaaatga aaccaattaa gaagacaaag cctagggagg gactggcccc
     2761 tgggccttca ggagggcggg ggtggttggt tttcaatatc cacgagctgg gtactgagat
     2821 cagaaaagcc cgaactattt attcaaaaca tgaccactct gggctataga agatgctgag
     2881 tgctcgagag actgccatac ataatagatg gcttcctagg gatctgaaat ccatagacta
     2941 agagaaaact gtgtatagct tgcccgaaca ggagtcctta ctgatattta ttgaacagtc
     3001 gattccccta ccccactccc acccccaacc cccaaccccc agtttatgct gctttaaacc
     3061 tggaaatgag agagagaagt ttggtttgct gtctatgctt aagagccaag ccgggaacgc
     3121 attaatcatt tcttcgttaa cagaggaatc cgctctgcat ggcatctctc caagtgaaga
     3181 caggcttctt tacaaaaaaa aaaaaaaaaa aaaaaa
//
