LOCUS       NM_024405               3599 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus axin 1 (Axin1), mRNA.
ACCESSION   NM_024405
VERSION     NM_024405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3599)
  AUTHORS   Wang,Y., Zhong,Y., Xu,X., Li,X., Li,H., Shen,H., Wang,W. and
            Fang,Q.
  TITLE     Axin1 participates in blood-brain barrier protection during
            experimental ischemic stroke via phosphorylation at Thr485 in rats
  JOURNAL   J Chem Neuroanat 127, 102204 (2023)
   PUBMED   36464067
  REMARK    GeneRIF: Axin1 participates in blood-brain barrier protection
            during experimental ischemic stroke via phosphorylation at Thr485
            in rats.
REFERENCE   2  (bases 1 to 3599)
  AUTHORS   Zhu,P., Li,H., Zhang,A., Li,Z., Zhang,Y., Ren,M., Zhang,Y. and
            Hou,Y.
  TITLE     MicroRNAs sequencing of plasma exosomes derived from patients with
            atrial fibrillation: miR-124-3p promotes cardiac fibroblast
            activation and proliferation by regulating AXIN1
  JOURNAL   J Physiol Biochem 78 (1), 85-98 (2022)
   PUBMED   34495485
  REMARK    GeneRIF: MicroRNAs sequencing of plasma exosomes derived from
            patients with atrial fibrillation: miR-124-3p promotes cardiac
            fibroblast activation and proliferation by regulating AXIN1.
REFERENCE   3  (bases 1 to 3599)
  AUTHORS   Chen,Q., Lin,G., Chen,Y., Li,C., Wu,L., Hu,X. and Lin,Q.
  TITLE     miR-3574 ameliorates intermittent hypoxia-induced cardiomyocyte
            injury through inhibiting Axin1
  JOURNAL   Aging (Albany NY) 13 (6), 8068-8077 (2021)
   PUBMED   33582657
  REMARK    GeneRIF: miR-3574 ameliorates intermittent hypoxia-induced
            cardiomyocyte injury through inhibiting Axin1.
REFERENCE   4  (bases 1 to 3599)
  AUTHORS   Li,B., Zhang,W., Tan,T., Liu,W., Luo,X., Zhang,J., Yang,Y., Li,R.
            and Ge,Z.
  TITLE     Chinese Herbal Formulas Miao-Yi-Ai-Tang Inhibits the Proliferation
            and Migration of Lung Cancer Cells through Targeting
            beta-Catenin/AXIN and Presents Synergistic Effect with Cisplatin
            Suppressing Lung Cancer
  JOURNAL   Biomed Res Int 2020, 2761850 (2020)
   PUBMED   32051824
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3599)
  AUTHORS   Song,Z., Yu,Z., Chen,L., Zhou,Z., Zou,Q. and Liu,Y.
  TITLE     MicroRNA-1181 supports the growth of hepatocellular carcinoma by
            repressing AXIN1
  JOURNAL   Biomed Pharmacother 119, 109397 (2019)
   PUBMED   31514071
REFERENCE   6  (bases 1 to 3599)
  AUTHORS   Kitagawa,M., Hatakeyama,S., Shirane,M., Matsumoto,M., Ishida,N.,
            Hattori,K., Nakamichi,I., Kikuchi,A., Nakayama,K. and Nakayama,K.
  TITLE     An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of
            beta-catenin
  JOURNAL   EMBO J 18 (9), 2401-2410 (1999)
   PUBMED   10228155
REFERENCE   7  (bases 1 to 3599)
  AUTHORS   Hsu,W., Zeng,L. and Costantini,F.
  TITLE     Identification of a domain of Axin that binds to the
            serine/threonine protein phosphatase 2A and a self-binding domain
  JOURNAL   J Biol Chem 274 (6), 3439-3445 (1999)
   PUBMED   9920888
REFERENCE   8  (bases 1 to 3599)
  AUTHORS   Hart,M.J., de los Santos,R., Albert,I.N., Rubinfeld,B. and
            Polakis,P.
  TITLE     Downregulation of beta-catenin by human Axin and its association
            with the APC tumor suppressor, beta-catenin and GSK3 beta
  JOURNAL   Curr Biol 8 (10), 573-581 (1998)
   PUBMED   9601641
REFERENCE   9  (bases 1 to 3599)
  AUTHORS   Ikeda,S., Kishida,S., Yamamoto,H., Murai,H., Koyama,S. and
            Kikuchi,A.
  TITLE     Axin, a negative regulator of the Wnt signaling pathway, forms a
            complex with GSK-3beta and beta-catenin and promotes
            GSK-3beta-dependent phosphorylation of beta-catenin
  JOURNAL   EMBO J 17 (5), 1371-1384 (1998)
   PUBMED   9482734
REFERENCE   10 (bases 1 to 3599)
  AUTHORS   Zeng,L., Fagotto,F., Zhang,T., Hsu,W., Vasicek,T.J., Perry,W.L.
            3rd, Lee,J.J., Tilghman,S.M., Gumbiner,B.M. and Costantini,F.
  TITLE     The mouse Fused locus encodes Axin, an inhibitor of the Wnt
            signaling pathway that regulates embryonic axis formation
  JOURNAL   Cell 90 (1), 181-192 (1997)
   PUBMED   9230313
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 26, 2021 this sequence version replaced NM_024405.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017756.1, SRR26643294.38652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000010.1  15667958-15668256
            300-1258            JAXUCZ010000010.1  15671900-15672858
            1259-1399           JAXUCZ010000010.1  15700339-15700479
            1400-1496           JAXUCZ010000010.1  15708747-15708843
            1497-1634           JAXUCZ010000010.1  15710835-15710972
            1635-2152           JAXUCZ010000010.1  15712747-15713264
            2153-2323           JAXUCZ010000010.1  15713622-15713792
            2324-2569           JAXUCZ010000010.1  15714852-15715097
            2570-2737           JAXUCZ010000010.1  15718454-15718621
            2738-3599           JAXUCZ010000010.1  15719231-15720092
FEATURES             Location/Qualifiers
     source          1..3599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..3599
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /note="axin 1"
                     /db_xref="GeneID:79257"
                     /db_xref="RGD:620859"
     exon            1..299
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..1258
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2864
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /note="rAxin; axis inhibition protein 1; GSK-3beta
                     interacting protein rAxin"
                     /codon_start=1
                     /product="axin-1"
                     /protein_id="NP_077381.1"
                     /db_xref="GeneID:79257"
                     /db_xref="RGD:620859"
                     /translation="MQSPKMNVQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDSRP
                     VNHSFCSGKGTSIKSETSTATPRRSDLDLGYEPEGSASPTPPYLRWAESLHSLLDDQD
                     GISLFRTFLKQEGCADLLDFWFACSGFRKLEPCDSNEEKRLKLARAIYRKYILDSNGI
                     VSRQTKPATKSFIKDCVMKQQIDPAMFDQAQTEIQSTMEENTYPSFLKSDIYLEYTRT
                     GSESPKVCSDQSSGSGTGKGMSGYLPTLNEDEEWKCDQDADEDDGRDSVPPSRLTQKL
                     LLETAAPRAPSSRRYNEGRELRYGSWREPVNPYYVNSGYALAPATSANDSEQQSLSSD
                     ADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRMPKEIRVEPQK
                     FAEELIHRLEAVQRTREAEEKLEERLKRVRMEEEGEDGEMPSGPMASHKLPSVPAWHH
                     FPPRYVDMGCSGLRDAHEENPESILDEHVQRVMRTPGCQSPGPGHRSPDSGHVAKTAV
                     LGGTASGHGKHAPKLGLKLDSAGLHHHRHVHHHVHHNSARPKEQMEAEAARRVQSSFS
                     WGPETHGHAKPRSYSESTGTNPSAGDLAFGGKASAPSKRNTKKAESGKNASAEVPSTT
                     EDAEKNQKIMQWIIEGEKEISRHRKAGHGSSGMRKQQAHESSRPLSIERPGAVHPWVS
                     AQLRNSVQPSHLFIQDPTMPPNPAPNPLTQLEEARRRLEEEEKRANKLPSKQRTKSQR
                     KAGGGSAPPCDSIVVAYYFCGEPIPYRTLVRGRAVTLGQFKELLTKKGSYRYYFKKVS
                     DEFDCGVVFEEVREDEAILPVFEEKIIGKVEKVD"
     exon            1259..1399
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1496
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1634
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..2152
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2323
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2569
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2737
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..3599
                     /gene="Axin1"
                     /gene_synonym="Axin; axin-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcgcttgc ggccgttgcg gccggtgccg ccgccgccgc aggagcctgc cggggtcggg
       61 ctggagcctc cttccagagt gggctggtga gagtgaacag cgggtcttgg cggcgctctg
      121 cggcctgcct cgcgccgcct ccaggccacg ggtcgccgag ccgtcgccgc cgccgcgatg
      181 ggggcccctc agggccgcgc ccccgccgtg gcccgcccgc tgagccgccg ctgagcgcat
      241 gggcctcgcc gggccgggag ccaggccccg ggccgcgcct ccacagccgc cgcgcgctgg
      301 agagattgat tcccttggga gctgtaagta ctgaggtatt agggtgcagc gctcattgtt
      361 cactgatgca gagtcccaaa atgaatgtcc aggagcaggg tttccccttg gacctcggag
      421 caagtttcac cgaagatgcc ccccggcccc cagtgcctgg agaagaggga gaactggtat
      481 ccactgattc gaggcctgtc aaccacagtt tctgctctgg gaaaggtacc agcattaaaa
      541 gtgagacctc aacagccacc ccaagacgtt cagatctgga tctgggatat gagcctgagg
      601 gcagtgcctc ccccacccca ccatacttga ggtgggctga gtcactgcat tccttactgg
      661 atgaccaaga tgggatcagc ctgttcagga ctttcctgaa gcaggagggc tgtgctgacc
      721 tgctggactt ctggtttgcc tgcagtggct tcagaaagct tgagccttgt gactcaaatg
      781 aggaaaagag gctgaagctg gcaagagcca tctaccgaaa gtacatcctg gatagcaatg
      841 gcattgtgtc cagacaaacc aagccagcca ctaagagctt cataaaggac tgcgtcatga
      901 agcagcagat cgatcctgcc atgtttgacc aggcacagac agaaatccag tccaccatgg
      961 aggagaacac ctacccttcc ttccttaagt ctgacattta tttggagtac acaaggacag
     1021 gctcagaaag tccaaaggtc tgcagtgacc agagctcagg gtccgggaca gggaagggca
     1081 tgtctggata cttgcccact ttgaatgaag atgaagaatg gaaatgtgac caagatgcag
     1141 atgaggatga tggccgagac tctgtccccc ccagcaggct cacccagaag ctgctattgg
     1201 agactgctgc cccgagggcc ccctcaagta gacggtacaa cgaaggcaga gagctcaggt
     1261 atggatcttg gagggagcct gtcaacccct actatgtcaa ctctggctat gccctggccc
     1321 cagccaccag tgccaatgac agtgagcagc agagcctgtc cagtgatgct gacactctat
     1381 ccctcacgga cagtagcgtg gatggaatcc ccccatacag gatccgtaag cagcaccgaa
     1441 gggagatgca ggagagtgtc caagtcaatg ggcgggtacc tctacctcac attcctcgca
     1501 cttaccgaat gccaaaggag atccgggtag agccacagaa atttgctgaa gagcttattc
     1561 accgtctaga ggctgtccag cgtactcgag aggctgaaga aaagttggag gaacggctga
     1621 agcgtgtacg catggaggaa gaaggggaag atggggaaat gccttctggc cccatggcaa
     1681 gtcacaagct gccttctgtc ccagcttggc accatttccc acctcgctat gtggatatgg
     1741 gctgctccgg actgcgggat gcccatgagg agaatcctga gagcatcctg gatgagcatg
     1801 tgcaaagggt catgaggaca cctggctgcc agtcacctgg cccaggccac cgctctcctg
     1861 acagcgggca tgtggccaag actgcagtgc tagggggtac agcatctggg catgggaagc
     1921 atgctcctaa gttagggttg aagctggatt cagctggcct gcaccaccat aggcacgtcc
     1981 accaccacgt tcaccataat tcagctagac ccaaggagca aatggaggct gaagctgccc
     2041 gcagggtcca gagcagcttc tcatggggcc cagaaacaca tggtcatgcc aagccccgaa
     2101 gctattcaga gagcacaggc accaacccca gtgctgggga cttggccttt ggtggtaaag
     2161 ctagtgcacc ctccaaaaga aacaccaaga aggctgaatc tgggaagaat gccagtgctg
     2221 aggtacccag taccacagag gatgcagaga agaaccagaa gatcatgcag tggatcattg
     2281 agggggagaa ggagatcagt agacaccgga aggcaggcca tgggtcttct gggatgagga
     2341 agcagcaggc ccatgaaagc tccaggccct tgtccattga acgtcctggg gccgtgcacc
     2401 cctgggtcag tgctcagctt cggaactctg tccagccttc tcatctcttc atccaagatc
     2461 ccacaatgcc acccaatcca gcccctaatc ctctgaccca gctggaagag gcccgcaggc
     2521 gtttggagga agaagaaaag agagcaaaca aactgccctc caagcagagg acaaaatcac
     2581 aaagaaaggc aggtggcggg agtgcaccac catgtgacag tatcgttgtg gcctactatt
     2641 tctgtggtga accaataccc taccggaccc tggtgagggg ccgtgctgtc accctgggcc
     2701 agttcaagga gctgctaacc aagaagggga gctacagata ctactttaag aaagtgagtg
     2761 acgagtttga ctgtggtgtg gtatttgagg aagtacggga agatgaggcc atcctgcctg
     2821 tctttgaaga aaagatcatc ggcaaggtgg aaaaggtgga ctgagccctg ggcagcacac
     2881 ccagagctac catcactact gtgcagtggc atccgccagg tgggcagcct tgtcctcagg
     2941 agcttggtgt agggaacaac acaagattgt cacgagctct tccaggggat gaggctgggg
     3001 gcctcagatg tctgctaatt tctatccctc tggctctggg aaagtggggg tgggagggtc
     3061 atcctactga gtggttccat gggtttctct gttttgctgt tcaaagggaa agccgcacct
     3121 acccccacac tacccctgaa gcaataccag gagccatctc atgaccctca gcagctcttg
     3181 cttctaaata cagtctgacc tagggatact ttgccctggg cttgtatcct agtgtcctct
     3241 tctctctctg ggacctatcc actgcacctc attgggctca ggtccaggag caggggatcc
     3301 tgtgggggcc tctgtatatt gtacatgtca ctgagtgcct tcaacatagc tgtctcttgc
     3361 ctgccactgt gtgaatctgg cggctgaata tctcaggcct ctttgcctgt ctccagccac
     3421 cagcttggtt cagcagaggg ggggggtctg gtcccttcca agtgtccatg taaatatgta
     3481 catttctcag gccagggcca gcaggggata ccctgagccc gtttttcatg cgatgacttg
     3541 tacaattatc ttttcaaagg tacttggata ataatgaaat aaaatgtttt tgaacctcc
//
