LOCUS       NM_019136               1826 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus arginine vasopressin receptor 2 (Avpr2), mRNA.
ACCESSION   NM_019136
VERSION     NM_019136.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1826)
  AUTHORS   Ding,H., Luo,Y., Hu,K., Huang,H., Liu,P., Xiong,M., Zhu,L., Yi,J.
            and Xu,Y.
  TITLE     Hypoxia in utero increases the risk of pulmonary hypertension in
            rat offspring and is associated with vasopressin type-2 receptor
            upregulation
  JOURNAL   Mol Med Rep 22 (5), 4173-4182 (2020)
   PUBMED   33000260
  REMARK    GeneRIF: Hypoxia in utero increases the risk of pulmonary
            hypertension in rat offspring and is associated with vasopressin
            type2 receptor upregulation.
REFERENCE   2  (bases 1 to 1826)
  AUTHORS   Xu,L.H., Yang,Y., Liu,H.X., Xiao,S.F., Qiu,W.X., Wang,J.X.,
            Zhao,C.C., Gui,Y.H., Liu,G.Z., Peng,B., Li,X., Wang,G.H., Zhou,X.
            and Jiang,Z.L.
  TITLE     Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2
            Signaling Pathway Is Involved in the Induction of Motion Sickness
  JOURNAL   J Pharmacol Exp Ther 373 (2), 248-260 (2020)
   PUBMED   32165443
  REMARK    GeneRIF: Inner Ear Arginine Vasopressin-Vasopressin Receptor
            2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of
            Motion Sickness.
REFERENCE   3  (bases 1 to 1826)
  AUTHORS   Dorey,E.S., Walton,S.L., Kalisch-Smith,J.I., Paravicini,T.M.,
            Gardebjer,E.M., Weir,K.A., Singh,R.R., Bielefeldt-Ohmann,H.,
            Anderson,S.T., Wlodek,M.E. and Moritz,K.M.
  TITLE     Periconceptional ethanol exposure induces a sex specific diuresis
            and increase in AQP2 and AVPR2 in the kidneys of aged rat offspring
  JOURNAL   Physiol Rep 7 (21), e14273 (2019)
   PUBMED   31691500
  REMARK    GeneRIF: Periconceptional ethanol exposure induces a sex specific
            diuresis and increase in AQP2 and AVPR2 in the kidneys of aged rat
            offspring.
REFERENCE   4  (bases 1 to 1826)
  AUTHORS   Wang,F., Xu,C., Luo,R., Peng,K., Ramkumar,N., Xie,S., Lu,X.,
            Zhao,L., Zuo,C.J., Kohan,D.E. and Yang,T.
  TITLE     Site-1 protease-derived soluble (pro)renin receptor targets
            vasopressin receptor 2 to enhance urine concentrating capability
  JOURNAL   JCI Insight 4 (7), 124174 (2019)
   PUBMED   30944256
  REMARK    GeneRIF: Site-1 protease-derived (S1P-derived) soluble (pro)renin
            receptor (sPRR) participates in regulation of fluid homeostasis via
            targeting V2R. In cultured rat inner medullary collecting duct
            (IMCD) cells, AVP-induced V2R expression was blunted by a PRR
            antagonist, PRO20; a PRR-neutralizing antibody; or a S1P inhibitor,
            PF-429242. In parallel, sPRR release was increased by AVP and
            reduced by PF-429242.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1826)
  AUTHORS   Goto,I., Dohi,K., Ogihara,Y., Okamoto,R., Yamada,N., Mitani,Y. and
            Ito,M.
  TITLE     Detrimental Impact of Vasopressin V2 Receptor Antagonism in a
            SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial
            Hypertension
  JOURNAL   Circ J 80 (4), 989-997 (2016)
   PUBMED   26924211
  REMARK    GeneRIF: Chronic vasopressin V2R antagonism may contribute to the
            worsening of PAH and the development of RV remodeling.
REFERENCE   6  (bases 1 to 1826)
  AUTHORS   Szpirer,C., Szpirer,J., Van Vooren,P., Tissir,F., Simon,J.S.,
            Koike,G., Jacob,H.J., Lander,E.S., Helou,K., Klinga-Levan,K. and
            Levan,G.
  TITLE     Gene-based anchoring of the rat genetic linkage and cytogenetic
            maps: new regional localizations, orientation of the linkage
            groups, and insights into mammalian chromosome evolution
  JOURNAL   Mamm Genome 9 (9), 721-734 (1998)
   PUBMED   9716657
REFERENCE   7  (bases 1 to 1826)
  AUTHORS   Park,F., Mattson,D.L., Roberts,L.A. and Cowley,A.W. Jr.
  TITLE     Evidence for the presence of smooth muscle alpha-actin within
            pericytes of the renal medulla
  JOURNAL   Am J Physiol 273 (5), R1742-R1748 (1997)
   PUBMED   9374818
REFERENCE   8  (bases 1 to 1826)
  AUTHORS   Thibonnier,M., Preston,J.A., Dulin,N., Wilkins,P.L.,
            Berti-Mattera,L.N. and Mattera,R.
  TITLE     The human V3 pituitary vasopressin receptor: ligand binding profile
            and density-dependent signaling pathways
  JOURNAL   Endocrinology 138 (10), 4109-4122 (1997)
   PUBMED   9322919
REFERENCE   9  (bases 1 to 1826)
  AUTHORS   Firsov,D., Mandon,B., Morel,A., Merot,J., Le Maout,S.,
            Bellanger,A.C., de Rouffignac,C., Elalouf,J.M. and Buhler,J.M.
  TITLE     Molecular analysis of vasopressin receptors in the rat nephron.
            Evidence for alternative splicing of the V2 receptor
  JOURNAL   Pflugers Arch 429 (1), 79-89 (1994)
   PUBMED   7708485
REFERENCE   10 (bases 1 to 1826)
  AUTHORS   Lolait,S.J., O'Carroll,A.M., McBride,O.W., Konig,M., Morel,A. and
            Brownstein,M.J.
  TITLE     Cloning and characterization of a vasopressin V2 receptor and
            possible link to nephrogenic diabetes insipidus
  JOURNAL   Nature 357 (6376), 336-339 (1992)
   PUBMED   1534150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Sep 6, 2022 this sequence version replaced NM_019136.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY338195.1, SRR26643287.38497.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               JAXUCZ010000021.1  156785139-156785314
            177-1061            JAXUCZ010000021.1  156785667-156786551
            1062-1826           JAXUCZ010000021.1  156786713-156787477
FEATURES             Location/Qualifiers
     source          1..1826
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..1826
                     /gene="Avpr2"
                     /note="arginine vasopressin receptor 2"
                     /db_xref="GeneID:25108"
                     /db_xref="RGD:2186"
     exon            1..176
                     /gene="Avpr2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1267
                     /gene="Avpr2"
                     /note="AVPR V2; antidiuretic hormone receptor; renal-type
                     arginine vasopressin receptor; V2R; Vasopressin receptor
                     V2"
                     /codon_start=1
                     /product="vasopressin V2 receptor"
                     /protein_id="NP_062009.1"
                     /db_xref="GeneID:25108"
                     /db_xref="RGD:2186"
                     /translation="MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALL
                     STIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDAT
                     DRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPV
                     LVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPA
                     LGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVI
                     VIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSS
                     ELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS"
     exon            177..1061
                     /gene="Avpr2"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1826
                     /gene="Avpr2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaggacaca cggacagaaa ggcacctgcc tcctggcacc tctatctaat gcagtgatcc
       61 tagacagtgg ggttggccct ttgagtggag actaagtttg cgtcccctcc ctgctgtgac
      121 aggtgtgtag gtcatcatca accaccccat catgctcctg gtgtctaccg tgtccgctgt
      181 gcctgggctc ttttcacccc ctagctctcc cagcaacagc agccaggagg aactactgga
      241 tgaccgagac ccgctgctag tccgggctga actggccctg ctatctacaa tttttgtggc
      301 tgtggccttg agcaatggcc tagtgctggg ggccctaata cggcggggcc ggcgtggacg
      361 ctgggcaccc atgcatgtct tcatcagtca tttgtgcctg gctgacctgg ctgtggctct
      421 gtttcaagtg ctaccccagc tggcttggga tgccactgac cgcttccatg gccctgatgc
      481 cctgtgtcgg gccgtcaagt acctgcagat ggtgggcatg tatgcctcct cctacatgat
      541 cctggccatg acactagacc gccatcgtgc catctgccgc cctatgctag cataccgcca
      601 tggaggtggg gctcgctgga acaggccagt gctggtggcc tgggccttct cactccttct
      661 cagcctgcct cagctcttca tctttgctca gcgtgatgtg ggaaatggca gtggggtgtt
      721 tgattgctgg gcccgatttg cagaaccatg gggccttcgt gcctatgtca cctggattgc
      781 cttgatggtg tttgtggcac ctgccctagg cattgctgcc tgtcaggttc ttatcttccg
      841 ggagatacac gccagtctgg tgccagggcc atccgagagg gcagggaggc gccgcagagg
      901 gcgccggaca ggaagcccca gcgagggagc acatgtatca gcagccatgg ccaagaccgt
      961 gaggatgaca ctggtgattg tgattgtcta cgtgctatgc tgggcaccct tcttcctcgt
     1021 gcagctgtgg gcagcgtggg atccggaagc tcctctggaa agacccccct ttgtgttgct
     1081 catgctgctg gctagcctta acagctgtac caacccttgg atctatgctt ccttcagtag
     1141 cagtgtctcc tcggagttgc gtagcctgct ttgctgtgct cagaggcaca ccacacacag
     1201 cctgggtcct caagatgaat cctgtgccac agccagctcc tctttgatga aggatacacc
     1261 ctcctgagta gctactgggc tctttctact caaaaaccct ctgtagctca actgactatc
     1321 tagggttggc cctgagtgca ccaagaaagg gtaccttggt tatccttggt catccctagg
     1381 tgtcattgtc cccaagtata caagaaggaa tattccaggg ctgtaaagga accctaaagt
     1441 tggctccttt gttgctagac atgggaagca actgggacag atgcctcaag gtctgggagg
     1501 aaaataggca acaaaggtgc ttgtgcttct tactctggca agtaccccag gtgaggaaga
     1561 ctcccaggaa gctggaagca ggaccaggat aggactagta gaccttcctg ttattcttcc
     1621 cttctgtctg tttcctaata aaagttgcag ttcattttcc ccatggaaaa agtctccttg
     1681 gacaaagtat atggtgggct cagaagctga agtacaaaga ttcccacacc catagatgac
     1741 ctatgatcag aaacttgtga tattagcaac caagactaca tttttgggaa caggtcccca
     1801 agtgaaaaga aacagctcca tgtcaa
//
