LOCUS       NP_062009                371 aa            linear   ROD 01-MAY-2025
DEFINITION  vasopressin V2 receptor [Rattus norvegicus].
ACCESSION   NP_062009
VERSION     NP_062009.1
DBSOURCE    REFSEQ: accession NM_019136.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 371)
  AUTHORS   Ding,H., Luo,Y., Hu,K., Huang,H., Liu,P., Xiong,M., Zhu,L., Yi,J.
            and Xu,Y.
  TITLE     Hypoxia in utero increases the risk of pulmonary hypertension in
            rat offspring and is associated with vasopressin type-2 receptor
            upregulation
  JOURNAL   Mol Med Rep 22 (5), 4173-4182 (2020)
   PUBMED   33000260
  REMARK    GeneRIF: Hypoxia in utero increases the risk of pulmonary
            hypertension in rat offspring and is associated with vasopressin
            type2 receptor upregulation.
REFERENCE   2  (residues 1 to 371)
  AUTHORS   Xu,L.H., Yang,Y., Liu,H.X., Xiao,S.F., Qiu,W.X., Wang,J.X.,
            Zhao,C.C., Gui,Y.H., Liu,G.Z., Peng,B., Li,X., Wang,G.H., Zhou,X.
            and Jiang,Z.L.
  TITLE     Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2
            Signaling Pathway Is Involved in the Induction of Motion Sickness
  JOURNAL   J Pharmacol Exp Ther 373 (2), 248-260 (2020)
   PUBMED   32165443
  REMARK    GeneRIF: Inner Ear Arginine Vasopressin-Vasopressin Receptor
            2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of
            Motion Sickness.
REFERENCE   3  (residues 1 to 371)
  AUTHORS   Dorey,E.S., Walton,S.L., Kalisch-Smith,J.I., Paravicini,T.M.,
            Gardebjer,E.M., Weir,K.A., Singh,R.R., Bielefeldt-Ohmann,H.,
            Anderson,S.T., Wlodek,M.E. and Moritz,K.M.
  TITLE     Periconceptional ethanol exposure induces a sex specific diuresis
            and increase in AQP2 and AVPR2 in the kidneys of aged rat offspring
  JOURNAL   Physiol Rep 7 (21), e14273 (2019)
   PUBMED   31691500
  REMARK    GeneRIF: Periconceptional ethanol exposure induces a sex specific
            diuresis and increase in AQP2 and AVPR2 in the kidneys of aged rat
            offspring.
REFERENCE   4  (residues 1 to 371)
  AUTHORS   Wang,F., Xu,C., Luo,R., Peng,K., Ramkumar,N., Xie,S., Lu,X.,
            Zhao,L., Zuo,C.J., Kohan,D.E. and Yang,T.
  TITLE     Site-1 protease-derived soluble (pro)renin receptor targets
            vasopressin receptor 2 to enhance urine concentrating capability
  JOURNAL   JCI Insight 4 (7), 124174 (2019)
   PUBMED   30944256
  REMARK    GeneRIF: Site-1 protease-derived (S1P-derived) soluble (pro)renin
            receptor (sPRR) participates in regulation of fluid homeostasis via
            targeting V2R. In cultured rat inner medullary collecting duct
            (IMCD) cells, AVP-induced V2R expression was blunted by a PRR
            antagonist, PRO20; a PRR-neutralizing antibody; or a S1P inhibitor,
            PF-429242. In parallel, sPRR release was increased by AVP and
            reduced by PF-429242.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 371)
  AUTHORS   Goto,I., Dohi,K., Ogihara,Y., Okamoto,R., Yamada,N., Mitani,Y. and
            Ito,M.
  TITLE     Detrimental Impact of Vasopressin V2 Receptor Antagonism in a
            SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial
            Hypertension
  JOURNAL   Circ J 80 (4), 989-997 (2016)
   PUBMED   26924211
  REMARK    GeneRIF: Chronic vasopressin V2R antagonism may contribute to the
            worsening of PAH and the development of RV remodeling.
REFERENCE   6  (residues 1 to 371)
  AUTHORS   Szpirer,C., Szpirer,J., Van Vooren,P., Tissir,F., Simon,J.S.,
            Koike,G., Jacob,H.J., Lander,E.S., Helou,K., Klinga-Levan,K. and
            Levan,G.
  TITLE     Gene-based anchoring of the rat genetic linkage and cytogenetic
            maps: new regional localizations, orientation of the linkage
            groups, and insights into mammalian chromosome evolution
  JOURNAL   Mamm Genome 9 (9), 721-734 (1998)
   PUBMED   9716657
REFERENCE   7  (residues 1 to 371)
  AUTHORS   Park,F., Mattson,D.L., Roberts,L.A. and Cowley,A.W. Jr.
  TITLE     Evidence for the presence of smooth muscle alpha-actin within
            pericytes of the renal medulla
  JOURNAL   Am J Physiol 273 (5), R1742-R1748 (1997)
   PUBMED   9374818
REFERENCE   8  (residues 1 to 371)
  AUTHORS   Thibonnier,M., Preston,J.A., Dulin,N., Wilkins,P.L.,
            Berti-Mattera,L.N. and Mattera,R.
  TITLE     The human V3 pituitary vasopressin receptor: ligand binding profile
            and density-dependent signaling pathways
  JOURNAL   Endocrinology 138 (10), 4109-4122 (1997)
   PUBMED   9322919
REFERENCE   9  (residues 1 to 371)
  AUTHORS   Firsov,D., Mandon,B., Morel,A., Merot,J., Le Maout,S.,
            Bellanger,A.C., de Rouffignac,C., Elalouf,J.M. and Buhler,J.M.
  TITLE     Molecular analysis of vasopressin receptors in the rat nephron.
            Evidence for alternative splicing of the V2 receptor
  JOURNAL   Pflugers Arch 429 (1), 79-89 (1994)
   PUBMED   7708485
REFERENCE   10 (residues 1 to 371)
  AUTHORS   Lolait,S.J., O'Carroll,A.M., McBride,O.W., Konig,M., Morel,A. and
            Brownstein,M.J.
  TITLE     Cloning and characterization of a vasopressin V2 receptor and
            possible link to nephrogenic diabetes insipidus
  JOURNAL   Nature 357 (6376), 336-339 (1992)
   PUBMED   1534150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY338195.1, SRR26643287.38497.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..371
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     Protein         1..371
                     /product="vasopressin V2 receptor"
                     /note="AVPR V2; antidiuretic hormone receptor; renal-type
                     arginine vasopressin receptor; V2R; Vasopressin receptor
                     V2"
                     /calculated_mol_wt=40618
     Site            22
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00788.2)"
     Region          38..326
                     /region_name="7tmA_V2R"
                     /note="vasopressin receptor 2, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd15388"
                     /db_xref="CDD:320510"
     Region          39..65
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320510"
     Site            39..63
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Region          74..101
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320510"
     Site            78..98
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Site            order(97,100..101,112..117,119..120,123,168,170..174,202,
                     205..207,209..211,213..214,284,287..288,290..291,294,
                     303..304,306..308,311,314..315)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320510"
     Region          112..142
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320510"
     Site            114..135
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Region          155..176
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320510"
     Site            160..180
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Site            185
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q00788.2)"
     Site            201..220
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Region          202..231
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320510"
     Region          240..260
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Region          264..294
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320510"
     Site            272..293
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Region          304..326
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320510"
     Site            309..328
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     Region          349..371
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q00788.2)"
     CDS             1..371
                     /gene="Avpr2"
                     /coded_by="NM_019136.2:152..1267"
                     /db_xref="GeneID:25108"
                     /db_xref="RGD:2186"
ORIGIN      
        1 mllvstvsav pglfsppssp snssqeelld drdpllvrae lallstifva valsnglvlg
       61 alirrgrrgr wapmhvfish lcladlaval fqvlpqlawd atdrfhgpda lcravkylqm
      121 vgmyassymi lamtldrhra icrpmlayrh gggarwnrpv lvawafslll slpqlfifaq
      181 rdvgngsgvf dcwarfaepw glrayvtwia lmvfvapalg iaacqvlifr eihaslvpgp
      241 seragrrrrg rrtgspsega hvsaamaktv rmtlvivivy vlcwapfflv qlwaawdpea
      301 plerppfvll mllaslnsct npwiyasfss svsselrsll ccaqrhtths lgpqdescat
      361 assslmkdtp s
//
